Sonodynamic therapy: Concept, mechanism and application to cancer treatment

Advances in Experimental Medicine and Biology

Volumn 880, Issue , 2016, Pages 429-450

  McHale, Anthony P ^a   Callan, John F ^a   Nomikou, Nikolitsa ^b   Fowley, Colin ^a   Callan, Bridgeen ^a  

^a UNIVERSITY OF ULSTER   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Cancer; Reactive oxygen species; Sonodynamic therapy; Sonosensitizer; Ultrasound

Indexed keywords

ATX 70; PHOTOSENSITIZING AGENT; PROTOPORPHYRIN; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

CANCER THERAPY; CELL MEMBRANE; CLINICAL EFFECTIVENESS; CLINICAL TRIAL (TOPIC); COLON ADENOCARCINOMA; COLON CARCINOMA; DRUG DELIVERY SYSTEM; DRUG SAFETY; HIGH INTENSITY FOCUSED ULTRASOUND; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LUMINESCENCE; MICROWAVE THERAPY; NONHUMAN; PHOTODYNAMIC THERAPY; PRIORITY JOURNAL; RADIOFREQUENCY ABLATION; REVIEW; SONODYNAMIC THERAPY; SONOLUMINESCENCE; ULTRASOUND THERAPY; METABOLISM; NEOPLASMS; PHOTOCHEMOTHERAPY;

CLINICAL TRIALS AS TOPIC; HUMANS; LUMINESCENCE; NEOPLASMS; PHOTOCHEMOTHERAPY; REACTIVE OXYGEN SPECIES; ULTRASONIC THERAPY;

EID: 84962706258     PISSN: 00652598     EISSN: 22148019     Source Type: Book Series    
DOI: 10.1007/978-3-319-22536-4_22     Document Type: Review

References (102)

1. Bhatnagar S, Schiffter H, Coussios CC (2014) Exploitation of acoustic cavitation-induced microstreaming to enhance molecular transport. J Pharm Sci 103:1903-1912.
2. Bianchi PP, Petz W, Luca F, Biffi R, Spinoglio G, Montorsi M (2014) Laparoscopic and robotic total mesorectal excision in the treatment of rectal cancer. Brief review and personal remarks. Front Oncol 4:98
3. Byun KT, Kim KY, Kwak HY (2005) Sonoluminescence characteristics from micron and submicron bubbles. J Korean Phys Soc 47:1010-1022.
4. Castano AP, Mroz P, Hamblin MR (2006) Photodynamic therapy and anti-tumour immunity. Nat Rev Cancer 6:35-545.
5. Chu KF, Dupuy DE (2014) Thermal ablation of tumours: biological mechanisms and advances in therapy. Nat Rev Cancer 14:199-208.
6. Ding C, Da Xing D (2006) Studies on the sonosensitization mechanism of ultrasound with ATX-70 in sonodynamic therapy. Life Sci J 3:85-89.
7. Dolmans DEJGJ, Kadambi A, Hill JS, Flores KR, Gerber JN, Walker JP, Borel Rinkes IH, Jain RK, Fukumura D (2002) Targeting tumor vasculature and cancer cells in orthotopic breast tumor by fractionated dosing photodynamic therapy. Cancer Res 2:4289-4294.
8. Dougherty TJ, Grindley GB, Fiel R, Weishaupt KR, Boyle DG (1975) Photoradiation therapy. II. Cure of animal tumors with hematoporphyrin and light. J Natl Cancer Inst 55:115-121.
9. Fabi A, Mottolese M, Segatto O (2014) Therapeutic targeting of ERBB2 in breast cancer: understanding resistance in the laboratory and combating it in the clinic. J Mol Med 92:681-695.
10. Feril LB, Kondo T, Cui ZG, Tabuchi Y, Zhao QL, Ando H, Misaki T, Yoshikawa H, Umemura S (2005) Apoptosis induced by the sonomechanical effects of low intensity pulsed ultrasound in a human leukemia cell line. Cancer Lett 221:145-152.
11. Fukuzumi S, Ohkubo K, Zheng X, Chen Y, Pandley RK, Zhan R, Kadish KM (2008) Metal bacteriochlorins which act as dual singlet oxygen and superoxide generators. J Phys Chem B 6:2733-2746.
12. Gaitan DF, Crum LA, Church CC, Roy RA (1992) Sonoluminescence and bubble dynamics for a single, stable, cavitation bubble. J Acoust Soc Am 91:3166-3183.
13. Guo S, Sun X, Cheng J, Xu H, Dan J, Shen J, Zhou Q, Zhang Y, Meng L, Cao W, Tian Y (2013) Apoptosis of THP-1 macrophages induced by protoporphyrin IX-mediated sonodynamic therapy. Int J Nanomedicine 8:2239-2246.
14. Hachimine K, Shibaguchi H, Kuroki M, Yamada H, Kinugasa T, Nakae Y, Asano R, Sakata I, Yamashita Y, Shirakusa T, Kuroki M (2007) Sonodynamic therapy of cancer using a novel porphyrin derivative, DCPHP- Na(I), which is devoid of photosensitivity. Cancer Sci 98:916-920.
15. He Y, Xing D, Tan S, Tang Y, Ueda K (2002) In vivo sonoluminescence imaging with the assistance of FCLA. Phys Med Biol 47:1535-1541.
16. Heldin CH, Rubin K, Pietras K, Ostman A (2004) High interstitial fluid pressure - an obstacle in cancer therapy. Nat Rev Cancer 4:806-813.
17. Herrera FG, Santa Cruz O, Achtari C, Bourhis J, Ozsahin M (2014) Long-term outcome and late side effects in endometrial cancer patients treated with surgery and postoperative radiation therapy. Ann Surg Oncol 21:2390-2397.
18. Hiraoka W, Honda H, Feril LB Jr, Kudo N, Kondo T (2006) Comparison between sonodynamic effect and photodynamic effect with photosensitizers on free radical formation and cell killing. Ultrason Sonochem 13:535-542.
19. Hiroishi K, Eguchi J, Toshiyuki B, Shimazaki T, Ishii S, Hiraide A, Sakaki M, Doi H, Uozomi S, Omori R, Matsumura T, Yanagawa T, Ito T, Imawari M (2010) Strong CD8 + T-cell responses against tumor- associated antigens prolong the recurrence-free interval after tumor treatment in patients with hepatocellular carcinoma. J Gastroenterol 45:451-458.
20. Holohan C, Van Schaeybroeck S, Longley DB, Johnston PG (2014) Cancer drug resistance: an evolving paradigm. Nat Rev Cancer 13:714-726.
21. Hsieh YJ, Wu CC, Chang CJ, Yu JS (2003) Subcellular localization of Photofrin® determines the death phenotype of human epidermoid carcinoma A431 cells triggered by photodynamic therapy: when plasma membranes are the main targets. J Cell Physiol 194: 363-375.
22. Huang Z, Moseley H, Bown S (2010) Rationale of combined PDT and SDT modalities for treating cancer patients in terminal stage: the proper use of photosensitizer. Integr Cancer Ther 9:317-319.
23. Huang X, Yuan F, Liang M, Lo HW, Shinohara ML, Robertson C, Zhong P (2012) M-HIFU inhibits tumor growth, suppresses STAT3 activity and enhances tumor specific immunity in a transplant tumor model of prostate cancer. PLoS One 7, e41632
24. Jeong EJ, Seo SJ, Ahn YJ, Choi KH, Kim KH, Kim JK (2012) Sonodynamically induced antitumour effects of 5-aminolevulinic acid and fractionated ultrasound irradiation in an orthotopic rat glioma model. Ultrasound Med Biol 38:2143-2150.
25. Kawabata K, Umemura S (1997) Xanthene dyes for reducing acoustic cavitation threshold in aqueous solution. Ultrasonics 35:469-474.
26. Kenyon JN, Fulle RJ, Lewis TJ (2009) Activated cancer therapy using light and ultrasound - a case series of sonodynamic photodynamic therapy in 115 patients over a 4 year period. Curr Drug Ther 4:179-193.
27. Kessel D, Vicente MG, Reiners JJ (2006) Initiation of apoptosis and autophagy by photodynamic therapy. Lasers Surg Med 38:482-488.
28. Kolarova H, Tomankova K, Bajgar R, Kolar P, Kubinek R (2009) Photodynamic and sonodynamic treatment by phthalocyanine on cancer cell lines. Ultrasound Med Biol 35:1397-1404.
29. Komori C, Okada K, Kawamura K, Chida S, Suzuki T (2009) The sonodynamic antitumor effect of methylene blue on sarcoma180 cells in vitro. Anticancer Res 29:2411-2416.
30. Kondo Y, Kanzawa T, Sawaya T, Kondo S (2005) The role of autophagy in cancer development and response to therapy. Nat Rev Cancer 5:726-734.
31. Kuroki M, Hachimine K, Abe H, Shibaguchi H, Kuroki M, Maekawa S, Yanagisawa J, Kinugasa T, Tanaka T, Yamashita Y (2007) Sonodynamic therapy of cancer using novel sonosensitisers. Anticancer Res 27:3673-3678.
32. Li JH, Song DY, Xu YG, Huang Z, Yue W (2008a) In vitro study of hematoporphyrin monomethyl ether- mediated sonodynamic effects on C6 glioma cells. Neurol Sci 29:229-235.
33. Li YS, Reid CN, McHale AP (2008b) Enhancing ultrasound- mediated cell membrane permeabilisation (sonoporation) using a high frequency pulse regime and implications for ultrasound-aided cancer chemotherapy. Cancer Lett 266:156-162.
34. Li Y, Wang P, Zhao P, Zhu S, Wang X, Liu Q (2012) Apoptosis induced sonodynamic treatment by protoporphyrin IX MDA-MB-231 cells. Ultrasonics 52: 490-496.
35. Li D, Kang J, Madoff DC (2014a) Locally ablative therapies for primary and metastatic liver cancer. Expert Rev Anticancer Ther 14:931-945.
36. Li Q, Liu Q, Wang P, Feng X, Wang H, Wang X (2014b) The effects of Ce6-mediated sono-photodynamic therapy on cell migration, apoptosis and autophagy in mouse mammary 4T1 cell line. Ultrasonics 54:981-989.
37. Li Y, Wang P, Wang X, Su X, Liu Q (2014c) Involvement of mitochondrial and reactive oxygen species in the sonodynamic toxicity of chlorin e6 in human leukemia K562 cells. Ultrasound Med Biol 40:990-1000.
38. Liu S, Kurzrock R (2014) Toxicity of targeted therapy: implications for response and impact of genetic polymorphisms. Cancer Treat Rev 40:883-891.
39. Liu QH, Wang XB, Wang P, Xiao L, Hao Q (2007) Comparison between sonodynamic effect with protoporphyrin IX and hematoporphyrin on sarcoma 180. Cancer Chemother Pharmacol 60:671-680.
40. Macdonald IJ, Dougherty TJ (2001) Basic principles of photodynamic therapy. J Porphyrins Phthalocyanines 5:105-129.
41. Master A, Livingston M, Sen Gupta A (2013) Potodynamic nanomedicine in the treatment of solid tumors: perspectives and challenges. J Control Release 168:88-102.
42. McCaughan B, Rouanet C, Fowley C, Nomikou N, McHale AP, McCarron PA, Callan JF (2011) Enhanced ROS production and cell death through combined photo- and sono-activation of conventional photosensitising drugs. Bioorg Med Chem Lett 21:5750-5752.
43. McEwan C, Owen J, Stride E, Fowley C, Nesbitt H, Cochrane D, Coussios Constantin. C, Borden M, McHale AP, Callan JF (2015) Oxygen carrying microbubbles for enhanced sonodynamic therapy of hypoxic tumours. J Controlled Release 203:51-56.
44. Meng Y, Zou C, Madiyalakan R, Woo T, Huang M, Yang X, Swanson E, Chen J, Xing JZ (2010) Water-soluble and biocompatible sono/photosensitizer nanoparticles for enhanced cancer therapy. Nanomedicine 5: 1559-1569.
45. Misik V, Riesz P (2000) Free radical intermediates in sonodynamic therapy. Ann N Y Acad Sci 899: 335-348.
46. Miyoshi N, Igarashi T, Riesz P (2000) Evidence against singlet oxygen formation by sonolysis of aqueous oxygen-saturated solutions of hematoporphyrin and rose bengal. The mechanism of sonodynamic therapy. Ultrason Sonochem 7:121-124.
47. Moan J, Berg K (1991) The photodegradation of porphyrins in cells can be used to estimate the lifetime of singlet oxygen. Photochem Photobiol 53:549-553.
48. Mokuyasu S, Suzuki Y, Kawahara E, Seto T, Tokuda Y (2014) High-sensitivity cardiac troponin I detection for 2 types of drug-induced cadiotoxicity in patients with breast cancer. Breast Cancer (in press) DOI: 10.1007/s12282-014-0520-8.
49. Moseley H, Eljamel S Moghissi K (2014) Sonodynamic therapy. http://www.yorkshirelasercentre.org/index.php/sonodynamic-therapy. Accessed 26 June 2014
50. Narang AS, Varia S (2011) Role of tumor vascular architecture in drug delivery. Adv Drug Deliv Rev 63: 640-658.
51. Ni Y, Mulier S, Miao Y, Michel L, Marchal G (2005) A review of the general aspects of radiofrequency ablation. Abdom Imaging 30:381-400.
52. Nishikawa H, Osaki Y (2013) Comparison of highintensity focused ultrasound therapy and radiofrequency ablation for recurrent hepatocellular carcinoma. Hepatobiliary Surg Nutr 2:168-170.
53. Nomikou N, Li YS, McHale AP (2010) Ultrasoundenhanced drug dispersion through solid tumours and its possible role in aiding ultrasound-targeted cancer chemotherapy. Cancer Lett 288:94-98.
54. Nomikou N, Fowley C, Byrne NM, McCaughan B, McHale AP, Callan JF (2012a) Microbubblesonosensitiser conjugates as therapeutics in sonodynamic therapy. Chem Commun 48:8332-8334.
55. Nomikou N, Sterrett C, Arthur C, McCaughan B, Callan JF, McHale AP (2012b) The effects of ultrasound and light on indocyanine-green-treated tumour cells and tissues. ChemMedChem 7:1465-1471.
56. Nonaka M, Yamamoto M, Yoshino S, Umemura S, Sasaki K, Fukushima T (2009) Sonodynamic therapy consisting of focused ultrasound and a photosensitiser causes a selective antitumor effect in a rat intracranial glioma model. Anticancer Res 29:943-950.
57. Ohmura T, Fukushima T, Shibaguchi H, Yoshizawa S, Inoue T, Kuroki M, Sasaki K, Umemura S (2011) Sonodynamic therapy with 5-aminolevulinic acid and focused ultrasound for deep-seated intracranial glioma in rat. Anticancer Res 31:2527-2534.
58. Osaki T, Tajima M, Okamoto Y, Takagi S, Tsuka T, Imagawa T, Minami S (2011) Sonodynamic antitumor effect of benzoporphyrin derivative monoacid ring a on KLN205 cells. J Cancer Ther 2:99-104.
59. Pickworth MJW, Dendy PP, Leighton TG, Twentyman PR (1988) Studies of the cavitational effects of clinical ultrasound by sonolumenescence: 2. Thresholds for sonoluminescence from a therapeutic ultrasound beam and the effect of temperature and duty cycle. Phys Med Biol 33:1249-1260.
60. Ren Y, Wang R, Liu Y, Guo H, Zhou X, Yuan X, Liu C, Tian J, Yin H, Wang Y, Zhang N (2014) A hematoporphyrin- based drug delivery system for drug resistance reversal and tumor ablation. Biomaterials 35:2462-2470.
61. Roberts D, Cairnduff F, Driver I, Dixon B, Brown S (1994) Tumor vascular shutdown following photodynamic therapy based on polyhematoporphyrin or 5-aminolevulinic acid. Int J Oncol 5:763-768.
62. Rodriguez N, Sanz X, Dengra J, Foro P, Membrive I, Reig A, Quera J, Fernandez-Velilla E, Pera O, Lio J, Lozano J, Algara M (2013) Five-year outcomes, cosmesis and toxicity with 3-dimensional conformal external beam radiation therapy to deliver accelerated partial breast irradiation. Int J Radiat Oncol Biol Phys 87:1051-1057.
63. Rosenthal I, Sostaric JZ, Riesz P (2004) Sonodynamic therapy - a review of the synergistic effects of drugs and ultrasound. Ultrason Sonochem 11:349-363.
64. Saksena TK, Nyborg WL (1970) Sonoluminescence from stable cavitation. J Chem Phys 53:1722-1733.
65. Sazgarnia A, Shanei A, Meibodi NT, Eshghi H, Nassirli H (2011) A novel sonosensitizer for sonodynamic therapy: in vivo study on a colon tumor model. J Ultrasound Med 30:1321-1329.
66. Sazgarnia A, Shanei A, Eshghi H, Hassanzadeh-Khayyat M, Esmaily H, Shanei MM (2013) Detection of sonoluminescence signals in a gel phantom in the presence of protoporphyrin IX conjugated to gold nanoparticles. Ultrasonics 53:29-35.
67. Sciacovelli M, Gaude E, Hilvo M, Frezza C (2014) The metabolic alterations of cancer cells. Methods Enzymol 542:1-23.
68. Shanei A, Sazgarnia A, Meibodi N, Hassanzadeh-Khayyat M, Esmaily H, Attaran Kakhki N (2012) Sonodynamic therapy using protoporphyrin IX conjugated to gold nanoparticles: an in vivo study on a colon tumor model. Iran J Basic Med Sci 15:759-767.
69. Shi H, Liu Q, Qin X, Wang P, Wang X (2011) Pharmacokinetic study of a novel sonosensitizer chlorin- e6 and its sonodynamic anti-cancer activity in hepatoma-22 tumor-bearing mice. Biopharm Drug Dispos 32:319-332.
70. Siemann DW (2011) The unique characteristics of tumour vasculature and preclinical evidence for its selective disruption of tumour-vascular disrupting agents. Cancer Treat Rev 37:63-74.
71. Starkey JR, Rebane AK, Drobizhev MA, Meng F, Gong A, Elliot A, McInnerney K, Splangler CW (2008) New two-photon activated photodynamic therapy sensitizers induce xenograft tumor regressions after near-IR laser treatment though the body of the host mouse. Clin Cancer Res 14:6564-6573.
72. Stepniewski M, Kepczynski M, Jamroz D, Nowakowska M, Rissanen S, Vattulainen I, Rog T (2012) Interaction of hematoporphyrin with lipid membranes. J Phys Chem B 116:4889-4897.
73. Sugita N, Kawabata K, Sasaki K, Sakata I, Umemura S (2007) Synthesis of amphiphilic derivatives of rose bengal and their tumor accumulation. Bioconjug Chem 18:866-873.
74. Sugita N, Iwase Y, Yumita N, Ikeda T, Umemura S (2010) Sonodynamically induced cell damage using rose bengal derivative. Anticancer Res 30:3361-3366.
75. Suzuki N, Okada K, Chida S, Komori C, Shimada Y, Suzuki T (2007) Antitumor effect of acridine orange under ultrasonic irradiation in vitro. Anticancer Res 27:4179-4184.
76. Tachibana K, Feril LB, Ikeda-Dantsuji Y (2008) Sonodynamic therapy. Ultrasonics 24:253-259.
77. Tang W, Liu Q, Wang X, Mi N, Wang P, Zhang J (2008) Membrane fluidity altering and enzyme inactivating in sarcoma 180 cells post the exposure to sonoactivated hematoporphyrin in vitro. Ultrasonics 48:66-73.
78. Tang W, Liu Q, Wang X, Wang P, Zhang J, Cao B (2009) Potential mechanism in sonodynamic therapy and focused ultrasound induced apoptosis in sarcoma 180 cells in vitro. Ultrasonics 49:86-793.
79. Tonder M, Eisele G, Weiss T, Hofer Sm Seystahl K, Valavanis A, Stupp R, Weller M, Roth P (2014) Addition of lomustine for bevacizumab-refractory recurrent glioblastoma. Acta Oncol 26:1-4.
80. Torchilin V (2001) Tumor delivery of macromolecular drugs based on the EPR effect. Adv Drug Deliv Rev 63:131-135.
81. Tran Cao HS, Lopez N, Chang DC, Lowy A, Bouvet M, Baumgartner JM, Talamini MA, Sicklick JK (2014) Improved perioperative outcomes with minimally invasive distal pancreatectomy: results from a population- based study. JAMA Surg 149:237-243.
82. Tserkovsky DA, Alexandrova EN, Chalau VN, Istomin YP (2012) Effects of combined sonodynamic and photodynamic therapies with photolon on a glioma C6 tumor model. Exp Oncol 34:332-335.
83. Umemura S, Yumita N, Nishigaka R, Umemura K (1990) Mechanism of cell damage by ultrasound in combination with hematoporphyrin. Jpn J Cancer Res 81:962-966.
84. Umemura S, Kawabata K, Nishigaki R, Umemura K (1992) Sonodynamic approach to tumor treatment. Proc IEEE Ultrason Symp 9:1231-1240.
85. Umemura S, Yumita N, Umemura K, Nishigaki R (1999) Sonodynamically induced effect of rose bengal on isolated sarcoma 180 cells. Cancer Chemother Pharmacol 43:389-393.
86. Wang X, Lewis TJ, Mitchell D (2008) The tumoricidal effect of sonodynamic therapy (SDT) on S-180 sarcoma in mice. Integr Cancer Ther 7:96-102.
87. Wang X, Zhang W, Xu Z, Luo Y, Mitchell D, Moss RW (2009) Sonodynamic and photodynamic therapy in advanced breast carcinoma: a report of 3 cases. Integr Cancer Ther 8:283-287.
88. Wang X, Liu Q, Wang Z, Wang P, Zhao P, Zhao X, Yang L, Li Y (2010) Role of autophagy in sonodynamic therapy-induced cytotoxicity in S180 cells. Ultrasound Med Biol 36:1933-1946.
89. Wrenn SP, Small E, Dan N (2013) Bubble nucleation in lipid bilayers: a mechanism for low frequency ultrasound disruption. Biochim Biophys Acta 1828:1192-1197.
90. Xiang J, Xia X, Leung AW, Wang X, Xu J, Wang P, Yu H, Bai D, Xu C (2011) Apoptosis of ovarian cancer cells induced by methylene blue-mediated sonodynamic action. Ultrasonics 1:390-395.
91. Xu ZY, Wang K, Li XQ, Chen S, Deng JM, Cheng Y, Wang ZG (2013) The ABCG2 transporter is a key molecular determinant of the efficacy of sonodynamic therapy with Photofrin in glioma stem-like cells. Ultrasonics 53:232-238.
92. Yoshino SI, Fukushima T, Hayashi S, Nanola M, Ogawa K, Sasaki K, Umemura S (2009) Effects of focused ultrasound sonodynamic treatment on the rat bloodbrain barrier. Anticancer Res 29:889-896.
93. Yumita N, Umemura S (2004a) Sonodynamic antitumour effect of chloroaluminum phthalocyanine tetrasulfonate on murine solid tumor. J Pharm Pharmacol 56: 85-90.
94. Yumita N, Umemura S (2004b) Ultrasonically induced cell damage and membrane lipid peroxidation by photofrin II: mechanism of sonodynamic activation. J Med Ultrason 31:35-40.
95. Yumita N, Nishigaki R, Umemura K, Umemura S (1989) Hematoporphyrin as a sensitizer of cell-damaging effect of ultrasound. Jpn J Cancer Res 80:219-222.
96. Yumita N, Nishigaki R, Umemura K, Umemura S (1990) Synergistic effect of ultrasound and hematoporphyrin on sarcoma 180. Jpn J Cancer Res 81: 304-308.
97. Yumita N, Sasaki K, Umemura S, Nishigaki R (1996) Sonodynamically induced antitumor effect of a gallium- porphyrin complex, ATX-70. Jpn J Cancer Res 87:310-316.
98. Yumita N, Okuyama N, Sasaki K, Umemura S (2007) Sonodynamic therapy on chemically induced mammary tumor: pharmacokinetics, tissue distribution and sonodynamically induced antitumor effect of galliumporphyrin complex ATX-70. Cancer Chemother Pharmacol 60:891-897.
99. Yumita N, Han QS, Kitazumi I, Umemura S (2008) Sonodynamically-induced apoptosis, necrosis, and active oxygen generation by mono-l-aspartyl chlorin e6. Cancer Sci 99:166-172.
100. Yumita N, Iwase Y, Nishi K, Ikeda T, Umemura S, Sakata I, Momose Y (2010) Sonodynamically induced cell damage and membrane lipid peroxidation by novel porphyrin derivative, DCPH-P-Na (I). Anticancer Res 30:2241-2246.
101. Zheng L, Sun X, Zhu X, Lv F, Zhong Z, Zhang F, Guo W, Cao W, Yang L, Tian Y (2014) Apoptosis of THP-1 derived macrophages induced by sonodynamic therapy using a new sonosensitizer hydroxyl acetylated curcumin. PLoS One 9, e93133
102. Zhu B, Liu Q, Want Y, Wang X, Wang P, Zhang L, Su S (2010) Comparison of accumulation, subcellular location and sonodynamic cytotoxicity between hematoporphyrin and protoporphyrin IX in L1210 cells. Chemotherapy 56:403-410.