Betulinic acid inhibits cell proliferation and fibronectin accumulation in rat glomerular mesangial cells cultured under high glucose condition

Biomedicine and Pharmacotherapy

Volumn 80, Issue , 2016, Pages 338-342

  Liu, Chun Mei ^a   Qi, Xue Lin ^a   Yang, Ya Feng ^a   Zhang, Xiu de ^a  

^a Xianyang Central Hospital   (China)

Author keywords

Betulinic acid; Diabetic nephropathy; Fibronectin; Mesangial cells (MCs)

Indexed keywords

BETULIC ACID; FIBRONECTIN; GLUCOSE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN P21; PROTEIN P27; CELL CYCLE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; TRITERPENE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL CULTURE; CELL CYCLE PROGRESSION; CELL PROLIFERATION; CONTROLLED STUDY; DIABETIC NEPHROPATHY; ENZYME PHOSPHORYLATION; EXTRACELLULAR MATRIX; MESANGIUM CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; ANIMAL; CELL CYCLE CHECKPOINT; CYTOLOGY; DRUG EFFECTS; ENZYMOLOGY; METABOLISM; PHOSPHORYLATION;

ANIMALS; CELL CYCLE CHECKPOINTS; CELL CYCLE PROTEINS; CELL PROLIFERATION; CELLS, CULTURED; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FIBRONECTINS; GLUCOSE; MESANGIAL CELLS; MICE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; RATS; TRITERPENES;

EID: 84962644543     PISSN: 07533322     EISSN: 19506007     Source Type: Journal    
DOI: 10.1016/j.biopha.2016.02.040     Document Type: Article

References (24)

1. Reutens A.T., Atkins R.C. Epidemiology of diabetic nephropathy. Contrib. Nephrol. 2011, 170:1-7.
2. Danesh F.R., Sadeghi M.M., Amro N., Philips C., Zeng L., Lin S., et al. 3-Hydroxy-3-methylglutaryl CoA reductase inhibitors prevent high glucose-induced proliferation of mesangial cells via modulation of Rho GTPase/p21 signaling pathway: implications for diabetic nephropathy. Proc. Natl. Acad. Sci. U. S. A. 2002, 99:8301-8305.
3. Ha H., Yu M.R., Choi Y.J., Kitamura M., Lee H.B. Role of high glucose-induced nuclear factor-κB activation in monocyte chemoattractant protein-1 expression by mesangial cells. J. Am. Soc. Nephrol. 2002, 13:894-902.
4. Kolm-Litty V., Sauer U., Nerlich A., Lehmann R., Schleicher E. High glucose-induced transforming growth factor beta1 production is mediated by the hexosamine pathway in porcine glomerular mesangial cells. J. Clin. Invest. 1998, 101:160-169.
5. Park C., Kim J., Lee J., Kim Y., Ahn H., Shin Y., et al. High glucose-induced intercellular adhesion molecule-1 (ICAM-1) expression through an osmotic effect in rat mesangial cells is PKC-NF-κ{script}B-dependent. Diabetologia 2000, 43:1544-1553.
6. Baccora M., Cortes P., Hassett C., Taube D., Yee J. Effects of long-term elevated glucose on collagen formation by mesangial cells. Kidney Int. 2007, 72:1216-1225.
7. Alqahtani A., Hamid K., Kam A., Wong K., Abdelhak Z., Razmovski-Naumovski V., et al. The pentacyclic triterpenoids in herbal medicines and their pharmacological activities in diabetes and diabetic complications. Curr. Med. Chem. 2013, 20:908-931.
8. Majeed R., Hamid A., Sangwan P., Chinthakindi P., Koul S., Rayees S., et al. Inhibition of phosphotidylinositol-3 kinase pathway by a novel naphthol derivative of betulinic acid induces cell cycle arrest and apoptosis in cancer cells of different origin. Cell Death Dis. 2014, 5:e1459.
9. Xia A., Xue Z., Li Y., Wang W., Xia J., Wei T., et al. Cardioprotective effect of betulinic acid on myocardial ischemia reperfusion injury in rats. Evid. Based Complement. Altern. Med. 2014, 2014:573745.
10. Nader M.A., Baraka H.N. Effect of betulinic acid on neutrophil recruitment and inflammatory mediator expression in lipopolysaccharide-induced lung inflammation in rats. Eur. J. Pharm. Sci. 2012, 46:106-113.
11. Dang Z., Qian K., Ho P., Zhu L., Lee K.-H., Huang L., et al. Synthesis of betulinic acid derivatives as entry inhibitors against HIV-1 and bevirimat-resistant HIV-1 variants. Bioorg. Med. Chem. Lett. 2012, 22:5190-5194.
12. Kim S.J., Quan H.Y., Jeong K.J., Kim D.Y., Kim Gw Jo H.K., et al. Beneficial effect of betulinic acid on hyperglycemia via suppression of hepatic glucose production. J. Agric. Food Chem. 2013, 62:434-442.
13. Kim Y.-S., Reddy M.A., Lanting L., Adler S.G., Natarajan R. Differential behavior of mesangial cells derived from 12/15-lipoxygenase knockout mice relative to control mice1. Kidney Int. 2003, 64:1702-1714.
14. Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2-δδCT method. Methods 2001, 25:402-408.
15. McLennan S.V., Fisher E.J., Yue D.K., Turtle J.R. High glucose concentration causes a decrease in mesangium degradation: a factor in the pathogenesis of diabetic nephropathy. Diabetes 1994, 43:1041-1045.
16. King G.L., Kunisaki M., Nishio Y., Inoguchi T., Shiba T., Xia P. Biochemical and molecular mechanisms in the development of diabetic vascular complications. Diabetes 1996, 45:S105-S108.
17. Okada T., Wada J., Hida K., Eguchi J., Hashimoto I., Baba M., et al. Thiazolidinediones ameliorate diabetic nephropathy via cell cycle-dependent mechanisms. Diabetes 2006, 55:1666-1677.
18. Wolf G., Schroeder R., Ziyadeh F.N., Thaiss F., Zahner G., Stahl R. High glucose stimulates expression of p27Kip1 in cultured mouse mesangial cells: relationship to hypertrophy. Am. J. Physiol. Renal Physiol. 1997, 273:F348-F356.
19. Raptis A., Viberti G. Pathogenesis of diabetic nephropathy. Exp. Clin. Endocrinol. Diabetes 2000, 109:S424-37.
20. Young B.A., Johnson R.J., Alpers C.E., Eng E., Gordon K., Floege J., et al. Cellular events in the evolution of experimental diabetic nephropathy. Kidney Int. 1995, 47:935-944.
21. Haneda M., Araki S-i, Togawa M., Sugimoto T., Motohide I., Kikkawa R. Mitogen-activated protein kinase cascade is activated in glomeruli of diabetic rats and glomerular mesangial cells cultured under high glucose conditions. Diabetes 1997, 46:847-853.
22. Awazu M., Ishikura K., Hida M., Hoshiya M. Mechanisms of mitogen-activated protein kinase activation in experimental diabetes. J. Am. Soc. Nephrol. 1999, 10:738-745.
23. Chin B.Y., Mohsenin A., Li S.X., Choi A.M., Choi M.E. Stimulation of pro-α1(I) collagen by TGF-β1 in mesangial cells: role of the p38 MAPK pathway. Am. J. Physiol. Renal. Physiol. 2001, 280:F495-F504.
24. Li X., Liu W., Wang Q., Liu P., Deng Y., Lan T., et al. Emodin suppresses cell proliferation and fibronectin expression via p38MAPK pathway in rat mesangial cells cultured under high glucose. Mol. Cell. Endocrinol. 2009, 307:157-162.