메뉴 건너뛰기




Volumn 11, Issue 3, 2016, Pages 346-360

Validation of SCT methylation as a hallmark biomarker for lung cancers

(20)  Zhang, Yu An a,b   Ma, Xiaotu c,d   Sathe, Adwait c   Fujimoto, Junya e   Wistuba, Ignacio I e   Lam, Stephen f   Yatabe, Yasushi g   Wang, Yi Wei a   Stastny, Victor a   Gao, Boning a   Larsen, Jill E a   Girard, Luc a   Liu, Xiaoyun a   Song, Kai a,h   Behrens, Carmen e   Kalhor, Neda e   Xie, Yang a   Zhang, Michael Q c,i   Minna, John D a,b,j   Gazdar, Adi F a,b,j  


Author keywords

Cancer biomarker; FFPE DNA SCT qMSP; Lung cancer; SCT methylation; Secretin

Indexed keywords

BIOLOGICAL MARKER; BISULFITE; SECRETIN; TUMOR MARKER;

EID: 84962621516     PISSN: 15560864     EISSN: 15561380     Source Type: Journal    
DOI: 10.1016/j.jtho.2015.11.004     Document Type: Article
Times cited : (11)

References (59)
  • 3
    • 40849139208 scopus 로고    scopus 로고
    • Epigenetics in cancer
    • Esteller M. Epigenetics in cancer. N Engl J Med. 2008; 358: 1148-1159.
    • (2008) N Engl J Med , vol.358 , pp. 1148-1159
    • Esteller, M.1
  • 4
    • 84879092628 scopus 로고    scopus 로고
    • DNA methylation data analysis and its application to cancer research
    • Ma X, Wang YW, Zhang MQ, et al. DNA methylation data analysis and its application to cancer research. Epigenomics. 2013; 5: 301-316.
    • (2013) Epigenomics , vol.5 , pp. 301-316
    • Ma, X.1    Wang, Y.W.2    Zhang, M.Q.3
  • 5
    • 84863550037 scopus 로고    scopus 로고
    • Genome-scale analysis of DNA methylation in lung adenocarcinoma and integration with mRNA expression
    • Selamat SA, Chung BS, Girard L, et al. Genome-scale analysis of DNA methylation in lung adenocarcinoma and integration with mRNA expression. Genome Res. 2012; 22: 1197-1211.
    • (2012) Genome Res , vol.22 , pp. 1197-1211
    • Selamat, S.A.1    Chung, B.S.2    Girard, L.3
  • 6
    • 57349184083 scopus 로고    scopus 로고
    • Mining the epigenome for methylated genes in lung cancer
    • Tessema M, Belinsky SA. Mining the epigenome for methylated genes in lung cancer. Proc Am Thorac Soc. 2008; 5: 806-810.
    • (2008) Proc Am Thorac Soc , vol.5 , pp. 806-810
    • Tessema, M.1    Belinsky, S.A.2
  • 7
    • 79959568138 scopus 로고    scopus 로고
    • DNA methylation changes in atypical adenomatous hyperplasia, adenocarcinoma in situ, and lung adenocarcinoma
    • Selamat SA, Galler JS, Joshi AD, et al. DNA methylation changes in atypical adenomatous hyperplasia, adenocarcinoma in situ, and lung adenocarcinoma. PLoS One. 2011; 6: e21443.
    • (2011) PLoS One , vol.6 , pp. e21443
    • Selamat, S.A.1    Galler, J.S.2    Joshi, A.D.3
  • 8
    • 84872607202 scopus 로고    scopus 로고
    • Genomewide DNA methylation profiling predicts relapse in childhood B-cell acute lymphoblastic leukaemia
    • Sandoval J, Heyn H, Mendez-Gonzalez J, et al. Genomewide DNA methylation profiling predicts relapse in childhood B-cell acute lymphoblastic leukaemia. Br J Haematol. 2013; 160: 406-409.
    • (2013) Br J Haematol , vol.160 , pp. 406-409
    • Sandoval, J.1    Heyn, H.2    Mendez-Gonzalez, J.3
  • 9
    • 84891801684 scopus 로고    scopus 로고
    • A prognostic DNA methylation signature for stage i nonsmall-cell lung cancer
    • Sandoval J, Mendez-Gonzalez J, Nadal E, et al. A prognostic DNA methylation signature for stage I nonsmall-cell lung cancer. J Clin Oncol. 2013; 31: 4140-4147.
    • (2013) J Clin Oncol , vol.31 , pp. 4140-4147
    • Sandoval, J.1    Mendez-Gonzalez, J.2    Nadal, E.3
  • 10
    • 84888205771 scopus 로고    scopus 로고
    • Epigenetic biomarkers in lung cancer
    • Liloglou T, Bediaga NG, Brown BR, et al. Epigenetic biomarkers in lung cancer. Cancer Lett. 2014; 342: 200-212.
    • (2014) Cancer Lett , vol.342 , pp. 200-212
    • Liloglou, T.1    Bediaga, N.G.2    Brown, B.R.3
  • 11
    • 19944429818 scopus 로고    scopus 로고
    • Distinct DNA methylation profiles in malignant mesothelioma, lung adenocarcinoma, and non-Tumor lung
    • Tsou JA, Shen LY, Siegmund KD, et al. Distinct DNA methylation profiles in malignant mesothelioma, lung adenocarcinoma, and non-Tumor lung. Lung Cancer. 2005; 47: 193-204.
    • (2005) Lung Cancer , vol.47 , pp. 193-204
    • Tsou, J.A.1    Shen, L.Y.2    Siegmund, K.D.3
  • 12
    • 38349173162 scopus 로고    scopus 로고
    • Identification of a panel of sensitive and specific DNA methylation markers for lung adenocarcinoma
    • Tsou JA, Galler JS, Siegmund KD, et al. Identification of a panel of sensitive and specific DNA methylation markers for lung adenocarcinoma. Mol Cancer. 2007; 6: 70.
    • (2007) Mol Cancer , vol.6 , pp. 70
    • Tsou, J.A.1    Galler, J.S.2    Siegmund, K.D.3
  • 13
    • 33845662751 scopus 로고    scopus 로고
    • Application of a methylation gene panel by quantitative PCR for lung cancers
    • Shivapurkar N, Stastny V, Suzuki M, et al. Application of a methylation gene panel by quantitative PCR for lung cancers. Cancer Lett. 2007; 247: 56-71.
    • (2007) Cancer Lett , vol.247 , pp. 56-71
    • Shivapurkar, N.1    Stastny, V.2    Suzuki, M.3
  • 14
    • 40849124009 scopus 로고    scopus 로고
    • DNA methylation markers and early recurrence in stage i lung cancer
    • Brock MV, Hooker CM, Ota-Machida E, et al. DNA methylation markers and early recurrence in stage I lung cancer. N Engl J Med. 2008; 358: 1118-1128.
    • (2008) N Engl J Med , vol.358 , pp. 1118-1128
    • Brock, M.V.1    Hooker, C.M.2    Ota-Machida, E.3
  • 15
    • 84869209119 scopus 로고    scopus 로고
    • DNA methylation biomarkers offer improved diagnostic efficiency in lung cancer
    • Nikolaidis G, Raji OY, Markopoulou S, et al. DNA methylation biomarkers offer improved diagnostic efficiency in lung cancer. Cancer Res. 2012; 72: 5692-5701.
    • (2012) Cancer Res , vol.72 , pp. 5692-5701
    • Nikolaidis, G.1    Raji, O.Y.2    Markopoulou, S.3
  • 16
    • 78049345913 scopus 로고    scopus 로고
    • SHOX2 DNA methylation is a biomarker for the diagnosis of lung cancer based on bronchial aspirates
    • Schmidt B, Liebenberg V, Dietrich D, et al. SHOX2 DNA methylation is a biomarker for the diagnosis of lung cancer based on bronchial aspirates. BMC Cancer. 2010; 10: 600.
    • (2010) BMC Cancer , vol.10 , pp. 600
    • Schmidt, B.1    Liebenberg, V.2    Dietrich, D.3
  • 17
    • 79953072405 scopus 로고    scopus 로고
    • Correlation of SHOX2 gene amplification and DNA methylation in lung cancer tumors
    • Schneider KU, Dietrich D, Fleischhacker M, et al. Correlation of SHOX2 gene amplification and DNA methylation in lung cancer tumors. BMC Cancer. 2011; 11: 102.
    • (2011) BMC Cancer , vol.11 , pp. 102
    • Schneider, K.U.1    Dietrich, D.2    Fleischhacker, M.3
  • 18
    • 84944484435 scopus 로고
    • The mechanism of pancreatic secretion
    • Bayliss WM, Starling EH. The mechanism of pancreatic secretion. J Physiol. 1902; 28: 325-353.
    • (1902) J Physiol , vol.28 , pp. 325-353
    • Bayliss, W.M.1    Starling, E.H.2
  • 19
    • 84873055573 scopus 로고    scopus 로고
    • Metabolic effects of secretin
    • Sekar R, Chow BK. Metabolic effects of secretin. Gen Comp Endocrinol. 2013; 181: 18-24.
    • (2013) Gen Comp Endocrinol , vol.181 , pp. 18-24
    • Sekar, R.1    Chow, B.K.2
  • 20
    • 0017100755 scopus 로고
    • Secretion cells in the gastrointestinal tract
    • Chey WY, Escoffery R. Secretion cells in the gastrointestinal tract. Endocrinology. 1976; 98: 1390-1395.
    • (1976) Endocrinology , vol.98 , pp. 1390-1395
    • Chey, W.Y.1    Escoffery, R.2
  • 21
    • 0036996270 scopus 로고    scopus 로고
    • The human secretin gene: Fine structure in 11p15.5 and sequence variation in patients with autism
    • Yamagata T, Aradhya S, Mori M, et al. The human secretin gene: fine structure in 11p15.5 and sequence variation in patients with autism. Genomics. 2002; 80: 185-194.
    • (2002) Genomics , vol.80 , pp. 185-194
    • Yamagata, T.1    Aradhya, S.2    Mori, M.3
  • 22
    • 38949106118 scopus 로고    scopus 로고
    • Multiple actions of secretin in the human body
    • Lam IP, Siu FK, Chu JY, et al. Multiple actions of secretin in the human body. Int Rev Cytol. 2008; 265: 159-190.
    • (2008) Int Rev Cytol , vol.265 , pp. 159-190
    • Lam, I.P.1    Siu, F.K.2    Chu, J.Y.3
  • 23
    • 0033758846 scopus 로고    scopus 로고
    • Human secretin (SCT): Gene structure, chromosome location, and distribution of mRNA
    • Whitmore TE, Holloway JL, Lofton-Day CE, et al. Human secretin (SCT): gene structure, chromosome location, and distribution of mRNA. Cytogenet Cell Genet. 2000; 90: 47-52.
    • (2000) Cytogenet Cell Genet , vol.90 , pp. 47-52
    • Whitmore, T.E.1    Holloway, J.L.2    Lofton-Day, C.E.3
  • 24
    • 3042788955 scopus 로고    scopus 로고
    • Regulation of the human secretin gene is controlled by the combined effects of CpG methylation Sp1/Sp3 ratio and the E-box element
    • Lee LT, Tan-Un KC, Pang RT, et al. Regulation of the human secretin gene is controlled by the combined effects of CpG methylation, Sp1/Sp3 ratio, and the E-box element. Mol Endocrinol. 2004; 18: 1740-1755.
    • (2004) Mol Endocrinol , vol.18 , pp. 1740-1755
    • Lee, L.T.1    Tan-Un, K.C.2    Pang, R.T.3
  • 25
    • 77953395337 scopus 로고    scopus 로고
    • Secretin inhibits cholangiocarcinoma growth via dysregulation of the cAMPdependent signaling mechanisms of secretin receptor
    • Onori P, Wise C, Gaudio E, et al. Secretin inhibits cholangiocarcinoma growth via dysregulation of the cAMPdependent signaling mechanisms of secretin receptor. Int J Cancer. 2010; 127: 43-54.
    • (2010) Int J Cancer , vol.127 , pp. 43-54
    • Onori, P.1    Wise, C.2    Gaudio, E.3
  • 27
    • 84905029258 scopus 로고    scopus 로고
    • Cancer Genome Atlas Research N. Comprehensive molecular profiling of lung adenocarcinoma
    • Cancer Genome Atlas Research N. Comprehensive molecular profiling of lung adenocarcinoma. Nature. 2014; 511: 543-550.
    • (2014) Nature , vol.511 , pp. 543-550
  • 28
    • 84860782006 scopus 로고    scopus 로고
    • Absolute quantification of somatic DNA alterations in human cancer
    • Carter SL, Cibulskis K, Helman E, et al. Absolute quantification of somatic DNA alterations in human cancer. Nat Biotechnol. 2012; 30: 413-421.
    • (2012) Nat Biotechnol , vol.30 , pp. 413-421
    • Carter, S.L.1    Cibulskis, K.2    Helman, E.3
  • 29
    • 84885673911 scopus 로고    scopus 로고
    • Inferring tumour purity and stromal and immune cell admixture from expression data
    • Yoshihara K, Shahmoradgoli M, Martinez E, et al. Inferring tumour purity and stromal and immune cell admixture from expression data. Nat Commun. 2013; 4: 2612.
    • (2013) Nat Commun , vol.4 , pp. 2612
    • Yoshihara, K.1    Shahmoradgoli, M.2    Martinez, E.3
  • 30
    • 84901814887 scopus 로고    scopus 로고
    • A pan-cancer proteomic perspective on the Cancer Genome Atlas
    • Akbani R, Ng PK, Werner HM, et al. A pan-cancer proteomic perspective on The Cancer Genome Atlas. Nat Commun. 2014; 5: 3887.
    • (2014) Nat Commun , vol.5 , pp. 3887
    • Akbani, R.1    Ng, P.K.2    Werner, H.M.3
  • 31
    • 77954143943 scopus 로고    scopus 로고
    • DNA hypermethylation of tumors from non-small cell lung cancer (NSCLC) patients is associated with gender and histologic type
    • Hawes SE, Stern JE, Feng Q, et al. DNA hypermethylation of tumors from non-small cell lung cancer (NSCLC) patients is associated with gender and histologic type. Lung Cancer. 2010; 69: 172-179.
    • (2010) Lung Cancer , vol.69 , pp. 172-179
    • Hawes, S.E.1    Stern, J.E.2    Feng, Q.3
  • 32
    • 84876207852 scopus 로고    scopus 로고
    • Human lung epithelial cells progressed to malignancy through specific oncogenic manipulations
    • Sato M, Larsen JE, Lee W, et al. Human lung epithelial cells progressed to malignancy through specific oncogenic manipulations. Mol Cancer Res. 2013; 11: 638-650.
    • (2013) Mol Cancer Res , vol.11 , pp. 638-650
    • Sato, M.1    Larsen, J.E.2    Lee, W.3
  • 33
    • 5644228885 scopus 로고    scopus 로고
    • DNA extraction from archival formalin-fixed, paraffin-embedded tissues: Heat-induced retrieval in alkaline solution
    • Shi SR, Datar R, Liu C, et al. DNA extraction from archival formalin-fixed, paraffin-embedded tissues: heat-induced retrieval in alkaline solution. Histochem Cell Biol. 2004; 122: 211-218.
    • (2004) Histochem Cell Biol , vol.122 , pp. 211-218
    • Shi, S.R.1    Datar, R.2    Liu, C.3
  • 34
    • 84870451374 scopus 로고    scopus 로고
    • Improved PCR amplification for molecular analysis using DNA from longterm preserved formalin-fixed, paraffin-embedded lung cancer tissue specimens
    • Taga M, Eguchi H, Shinohara T, et al. Improved PCR amplification for molecular analysis using DNA from longterm preserved formalin-fixed, paraffin-embedded lung cancer tissue specimens. Int J Clin Exp Pathol. 2013; 6: 76-79.
    • (2013) Int J Clin Exp Pathol , vol.6 , pp. 76-79
    • Taga, M.1    Eguchi, H.2    Shinohara, T.3
  • 35
    • 33745914971 scopus 로고    scopus 로고
    • DNA methylation mapping by tag-modified bisulfite genomic sequencing
    • Han W, Cauchi S, Herman JG, et al. DNA methylation mapping by tag-modified bisulfite genomic sequencing. Anal Biochem. 2006; 355: 50-61.
    • (2006) Anal Biochem , vol.355 , pp. 50-61
    • Han, W.1    Cauchi, S.2    Herman, J.G.3
  • 36
    • 2942548985 scopus 로고    scopus 로고
    • Aberrant methylation of the adenomatous polyposis coli promoter 1A in bronchial aspirates from patients with suspected lung cancer
    • Grote HJ, Schmiemann V, Kiel S, et al. Aberrant methylation of the adenomatous polyposis coli promoter 1A in bronchial aspirates from patients with suspected lung cancer. Int J Cancer. 2004; 110: 751-755.
    • (2004) Int J Cancer , vol.110 , pp. 751-755
    • Grote, H.J.1    Schmiemann, V.2    Kiel, S.3
  • 37
    • 84859847507 scopus 로고    scopus 로고
    • DNA methylation profiling defines clinically relevant biological subsets of non-small cell lung cancer
    • Walter K, Holcomb T, Januario T, et al. DNA methylation profiling defines clinically relevant biological subsets of non-small cell lung cancer. Clin Cancer Res. 2012; 18: 2360-2373.
    • (2012) Clin Cancer Res , vol.18 , pp. 2360-2373
    • Walter, K.1    Holcomb, T.2    Januario, T.3
  • 39
    • 84866894408 scopus 로고    scopus 로고
    • Comprehensive genomic characterization of squamous cell lung cancers
    • Cancer Genome Atlas Research N.
    • Cancer Genome Atlas Research N. Comprehensive genomic characterization of squamous cell lung cancers. Nature. 2012; 489: 519-525.
    • (2012) Nature , vol.489 , pp. 519-525
  • 40
    • 84875945705 scopus 로고    scopus 로고
    • ENCODE data in the UCSC Genome Browser: Year 5 update
    • Rosenbloom KR, Sloan CA, Malladi VS, et al. ENCODE data in the UCSC Genome Browser: year 5 update. Nucleic Acids Res. 2013; 41: D56-D63.
    • (2013) Nucleic Acids Res , vol.41 , pp. D56-D63
    • Rosenbloom, K.R.1    Sloan, C.A.2    Malladi, V.S.3
  • 41
    • 84962513966 scopus 로고    scopus 로고
    • SCT promoter methylation is a highly discriminative biomarker for lung and many other cancers
    • Sathe A, Zhang Y-A, Ma X, et al. SCT promoter methylation is a highly discriminative biomarker for lung and many other cancers. IEEE Life Sciences Letters. 2015; 1: 30-33.
    • (2015) IEEE Life Sciences Letters , vol.1 , pp. 30-33
    • Sathe, A.1    Zhang, Y.-A.2    Ma, X.3
  • 42
    • 84855753539 scopus 로고    scopus 로고
    • Why do results conflict regarding the prognostic value of the methylation status in colon cancers? the role of the preservation method
    • Tournier B, Chapusot C, Courcet E, et al. Why do results conflict regarding the prognostic value of the methylation status in colon cancers? The role of the preservation method. BMC Cancer. 2012; 12: 12.
    • (2012) BMC Cancer , vol.12 , pp. 12
    • Tournier, B.1    Chapusot, C.2    Courcet, E.3
  • 43
    • 0037633991 scopus 로고    scopus 로고
    • PCR analysis in archival postmortem tissues
    • Bonin S, Petrera F, Niccolini B, et al. PCR analysis in archival postmortem tissues. Mol Pathol. 2003; 56: 184-186.
    • (2003) Mol Pathol , vol.56 , pp. 184-186
    • Bonin, S.1    Petrera, F.2    Niccolini, B.3
  • 44
    • 34547814653 scopus 로고    scopus 로고
    • Evaluation of DNA extraction methods and real time PCR optimization on formalin-fixed paraffin-embedded tissues
    • Dedhia P, Tarale S, Dhongde G, et al. Evaluation of DNA extraction methods and real time PCR optimization on formalin-fixed paraffin-embedded tissues. Asian Pac J Cancer Prev. 2007; 8: 55-59.
    • (2007) Asian Pac J Cancer Prev , vol.8 , pp. 55-59
    • Dedhia, P.1    Tarale, S.2    Dhongde, G.3
  • 45
    • 79551563284 scopus 로고    scopus 로고
    • International association for the study of lung cancer/American thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma
    • Travis WD, Brambilla E, Noguchi M, et al. International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society International Multidisciplinary Classification of Lung Adenocarcinoma. J Thorac Oncol. 2011; 6: 244-285.
    • (2011) J Thorac Oncol , vol.6 , pp. 244-285
    • Travis, W.D.1    Brambilla, E.2    Noguchi, M.3
  • 47
    • 10844284696 scopus 로고    scopus 로고
    • Immortalization of human bronchial epithelial cells in the absence of viral oncoproteins
    • Ramirez RD, Sheridan S, Girard L, et al. Immortalization of human bronchial epithelial cells in the absence of viral oncoproteins. Cancer Res. 2004; 64: 9027-9034.
    • (2004) Cancer Res , vol.64 , pp. 9027-9034
    • Ramirez, R.D.1    Sheridan, S.2    Girard, L.3
  • 48
    • 34250329445 scopus 로고    scopus 로고
    • EGFR-T790M is a rare lung cancer susceptibility allele with enhanced kinase activity
    • Vikis H, Sato M, James M, et al. EGFR-T790M is a rare lung cancer susceptibility allele with enhanced kinase activity. Cancer Res. 2007; 67: 4665-4670.
    • (2007) Cancer Res , vol.67 , pp. 4665-4670
    • Vikis, H.1    Sato, M.2    James, M.3
  • 49
    • 84870326702 scopus 로고    scopus 로고
    • Genome-scale discovery of DNA-methylation biomarkers for bloodbased detection of colorectal cancer
    • Lange CP, Campan M, Hinoue T, et al. Genome-scale discovery of DNA-methylation biomarkers for bloodbased detection of colorectal cancer. PLoS One. 2012; 7: e50266.
    • (2012) PLoS One , vol.7 , pp. e50266
    • Lange, C.P.1    Campan, M.2    Hinoue, T.3
  • 50
    • 84898717571 scopus 로고    scopus 로고
    • Transcriptomic architecture of the adjacent airway field cancerization in non-small cell lung cancer
    • Kadara H, Fujimoto J, Yoo SY, et al. Transcriptomic architecture of the adjacent airway field cancerization in non-small cell lung cancer. J Natl Cancer Inst. 2014; 106: dju004.
    • (2014) J Natl Cancer Inst , vol.106 , pp. dju004
    • Kadara, H.1    Fujimoto, J.2    Yoo, S.Y.3
  • 52
    • 84962598584 scopus 로고    scopus 로고
    • American Cancer Society, Thyroid cancer survival by type and stage Accessed July 30, 2015
    • American Cancer Society. Thyroid cancer survival by type and stage. http: //www.cancer.org/cancer/thyroidcancer/detailedguide/thyroid-cancer-survivalrates. Accessed July 30, 2015.
  • 53
    • 2342510977 scopus 로고    scopus 로고
    • Tumor recurrence and survival in patients treated for thymomas and thymic squamous cell carcinomas: A retrospective analysis
    • Strobel P, Bauer A, Puppe B, et al. Tumor recurrence and survival in patients treated for thymomas and thymic squamous cell carcinomas: A retrospective analysis. J Clin Oncol. 2004; 22: 1501-1509.
    • (2004) J Clin Oncol , vol.22 , pp. 1501-1509
    • Strobel, P.1    Bauer, A.2    Puppe, B.3
  • 55
    • 84860643156 scopus 로고    scopus 로고
    • Recurrent variations in DNA methylation in human pluripotent stem cells and their differentiated derivatives
    • Nazor KL, Altun G, Lynch C, et al. Recurrent variations in DNA methylation in human pluripotent stem cells and their differentiated derivatives. Cell Stem Cell. 2012; 10: 620-634.
    • (2012) Cell Stem Cell , vol.10 , pp. 620-634
    • Nazor, K.L.1    Altun, G.2    Lynch, C.3
  • 56
    • 84892406751 scopus 로고    scopus 로고
    • Placental pseudo-malignancy from a DNA methylation perspective: Unanswered questions and future directions
    • Novakovic B, Saffery R. Placental pseudo-malignancy from a DNA methylation perspective: unanswered questions and future directions. Front Genet. 2013; 4: 285.
    • (2013) Front Genet , vol.4 , pp. 285
    • Novakovic, B.1    Saffery, R.2
  • 57
    • 78149457879 scopus 로고    scopus 로고
    • DNA methylation profiling highlights the unique nature of the human placental epigenome
    • Novakovic B, Saffery R. DNA methylation profiling highlights the unique nature of the human placental epigenome. Epigenomics. 2010; 2: 627-638.
    • (2010) Epigenomics , vol.2 , pp. 627-638
    • Novakovic, B.1    Saffery, R.2
  • 59
    • 84962512107 scopus 로고    scopus 로고
    • The Human Protein Atlas SCT Accessed October 20, 2015
    • The Human Protein Atlas. SCT. http: //www.proteinatlas. org/ENSG00000070031-SCT/tissue. Accessed October 20, 2015.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.