C-kit+ cardiac stem cells spontaneous creation or a perplexing reality

Circulation Research

Volumn 118, Issue 5, 2016, Pages 783-785

  Khan, Mohsin ^a   Koch, Walter J ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN; STEM CELL FACTOR RECEPTOR;

ARTICLE; CARDIAC STEM CELL; CELL DEDIFFERENTIATION; CELL DIFFERENTIATION; EMBRYONIC STEM CELL; EX VIVO STUDY; HEART; HEART MUSCLE CELL; HOMEOSTASIS; NEURAL CREST; NONHUMAN; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; SMOOTH MUSCLE FIBER; ANIMAL; CARDIAC MUSCLE CELL; CYTOLOGY; GENETICS; METABOLISM; STEM CELL;

ANIMALS; MYOCYTES, CARDIAC; NEURAL CREST; PROTO-ONCOGENE PROTEINS C-KIT; STEM CELLS;

EID: 84962569488     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.115.308103     Document Type: Article

References (20)

1. Beltrami AP, Barlucchi L, Torella D, Baker M, Limana F, Chimenti S, Kasahara H, Rota M, Musso E, Urbanek K, Leri A, Kajstura J, Nadal-Ginard B, Anversa P. Adult cardiac stem cells are multipotent and support myocardial regeneration. Cell. 2003;114:763-776.
2. Mohsin S, Khan M, Toko H, et al. Human cardiac progenitor cells engineered with Pim-I kinase enhance myocardial repair. J Am Coll Cardiol. 2012;60:1278-1287. doi: 10.1016/j.jacc.2012.04.047.
3. Keith MC, Tang XL, Tokita Y, et al. Safety of intracoronary infusion of 20 million C-kit positive human cardiac stem cells in pigs. PLoS One. 2015;10:e0124227. doi: 10.1371/journal.pone.0124227.
4. Keith MC, Bolli R. "String theory" of c-kit(pos) cardiac cells: a new paradigm regarding the nature of these cells that may reconcile apparently discrepant results. Circ Res. 2015;116:1216-1230. doi: 10.1161/CIRCRESAHA.116.305557.
5. Hatzistergos KE, Takeuchi LM, Saur D, Seidler B, Dymecki SM, Mai JJ, White IA, Balkan W, Kanashiro-Takeuchi RM, Schally AV, Hare JM. cKit+ cardiac progenitors of neural crest origin. Proc Natl Acad Sci USA. 2015;112:13051-13056. doi: 10.1073/pnas.1517201112.
6. Engleka KA, Manderfeld LJ, Brust RD, Li L, Cohen A, Dymecki SM, Epstein JA. Islet1 derivatives in the heart are of both neural crest and second heart feld origin. Circ Res. 2012;110:922-926. doi: 10.1161/CIRCRESAHA.112.266510.
7. Tomita Y, Matsumura K, Wakamatsu Y, Matsuzaki Y, Shibuya I, Kawaguchi H, Ieda M, Kanakubo S, Shimazaki T, Ogawa S, Osumi N, Okano H, Fukuda K. Cardiac neural crest cells contribute to the dormant multipotent stem cell in the mammalian heart. J Cell Biol. 2005;170:1135-1146. doi: 10.1083/jcb.200504061.
8. Stoller JZ, Epstein JA. Cardiac neural crest. Semin Cell Dev Biol. 2005;16:704-715. doi: 10.1016/j.semcdb.2005.06.004.
9. Jiang X, Rowitch DH, Soriano P, McMahon AP, Sucov HM. Fate of the mammalian cardiac neural crest. Development. 2000;127:1607-1616.
10. Stottmann RW, Choi M, Mishina Y, Meyers EN, Klingensmith J. BMP receptor IA is required in mammalian neural crest cells for development of the cardiac outfow tract and ventricular myocardium. Development. 2004;131:2205-2218. doi: 10.1242/dev.01086.
11. Moore AW, McInnes L, Kreidberg J, Hastie ND, Schedl A. YAC complementation shows a requirement for Wt1 in the development of epi-cardium, adrenal gland and throughout nephrogenesis. Development. 1999;126:1845-1857.
12. Nichols CA, Creazzo TL. L-type Ca2+ channel function in the avian embryonic heart after cardiac neural crest ablation. Am J Physiol Heart Circ Physiol. 2005;288:H1173-H1178. doi: 10.1152/ajpheart.00792.2004.
13. Conway SJ, Godt RE, Hatcher CJ, Leatherbury L, Zolotouchnikov VV, Brotto MA, Copp AJ, Kirby ML, Creazzo TL. Neural crest is involved in development of abnormal myocardial function. J Mol Cell Cardiol. 1997;29:2675-2685. doi: 10.1006/jmcc.1997.0499.
14. van Berlo JH, Kanisicak O, Maillet M, Vagnozzi RJ, Karch J, Lin SC, Middleton RC, Marbán E, Molkentin JD. c-kit+ cells minimally contribute cardiomyocytes to the heart. Nature. 2014;509:337-341. doi: 10.1038/nature13309.
15. Sultana N, Zhang L, Yan J, Chen J, Cai W, Razzaque S, Jeong D, Sheng W, Bu L, Xu M, Huang GY, Hajjar RJ, Zhou B, Moon A, Cai CL. Resident c-kit(+) cells in the heart are not cardiac stem cells. Nat Commun. 2015;6:8701. doi: 10.1038/ncomms9701.
16. Karantalis V, Balkan W, Schulman IH, Hatzistergos KE, Hare JM. Cell-based therapy for prevention and reversal of myocardial remodeling. Am J Physiol Heart Circ Physiol. 2012;303:H256-H270. doi: 10.1152/ajpheart.00221.2012.
17. Wu SM, Fujiwara Y, Cibulsky SM, Clapham DE, Lien CL, Schultheiss TM, Orkin SH. Developmental origin of a bipotential myocardial and smooth muscle cell precursor in the mammalian heart. Cell. 2006;127:1137-1150. doi: 10.1016/j.cell.2006.10.028.
18. Kubin T, Pöling J, Kostin S, Gajawada P, Hein S, Rees W, Wietelmann A, Tanaka M, Lörchner H, Schimanski S, Szibor M, Warnecke H, Braun T. Oncostatin M is a major mediator of cardiomyocyte dedifferen-tiation and remodeling. Cell Stem Cell. 2011;9:420-432. doi: 10.1016/j. stem.2011.08.013.
19. Bolli R, Chugh AR, D'Amario D, et al. Cardiac stem cells in patients with ischaemic cardiomyopathy (SCIPIO): initial results of a randomised phase 1 trial. Lancet. 2011;378:1847-1857. doi: 10.1016/S0140-6736(11)61590-0.
20. Karantalis V, Suncion-Loescher V Y, Bagno L, et al. Synergistic effects of combined cell therapy for chronic ischemic cardiomyopathy. J Am Coll Cardiol. 2015;66:1990-1999. doi: 10.1016/j.jacc.2015.08.879.