Metabolic reprogramming supports IFN-γ production by CD56bright NK cells

Journal of Immunology

Volumn 196, Issue 6, 2016, Pages 2552-2560

  Keating, Sinéad E ^a   Zaiatz Bittencourt, Vanessa ^a   Loftus, Roisín M ^a   Keane, Ciara ^a   Brennan, Kiva ^a   Finlay, David K ^a   Gardiner, Clair M ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

CD56 ANTIGEN; GAMMA INTERFERON; GLUCOSE TRANSPORTER 1; INTERLEUKIN 12; INTERLEUKIN 15; INTERLEUKIN 2; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; RAPAMYCIN; NCAM1 PROTEIN, HUMAN;

ARTICLE; CELL METABOLIC REPROGRAMMING; CELL METABOLISM; CYTOTOXICITY; DEGRANULATION; ENZYME INHIBITION; GLUCOSE METABOLISM; GLYCOLYSIS; HUMAN; HUMAN CELL; INTERFERON PRODUCTION; METABOLIC REGULATION; NATURAL KILLER CELL; NUCLEAR REPROGRAMMING; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION; BIOSYNTHESIS; FLOW CYTOMETRY; IMMUNOLOGY; LYMPHOCYTE SUBPOPULATION; METABOLISM;

ANTIGENS, CD56; FLOW CYTOMETRY; GLYCOLYSIS; HUMANS; INTERFERON-GAMMA; KILLER CELLS, NATURAL; LYMPHOCYTE SUBSETS;

EID: 84962537967     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1501783     Document Type: Article

References (34)

1. Caligiuri, M. A. 2008. Human natural killer cells. Blood 112:461-469.
2. Yu, J., A. G. Freud, and M. A. Caligiuri. 2013. Location and cellular stages of natural killer cell development. Trends Immunol. 34:573-582.
3. Chan, A., D. L. Hong, A. Atzberger, S. Kollnberger, A. D. Filer, C. D. Buckley, A. McMichael, T. Enver, and P. Bowness. 2007. CD56bright human NK cells differentiate into CD56dim cells: role of contact with peripheral fibroblasts. J. Immunol. 179:89-94.
4. Romagnani, C., K. Juelke, M. Falco, B. Morandi, A. D'Agostino, R. Costa, G. Ratto, G. Forte, P. Carrega, G. Lui, et al. 2007. CD56brightCD16-killer Iglike receptor-NK cells display longer telomeres and acquire features of CD56dim NK cells upon activation. J. Immunol. 178:4947-4955.
5. Lanier, L. L., A. M. Le, C. I. Civin, M. R. Loken, and J. H. Phillips. 1986. The relationship of CD16 (Leu-11) and Leu-19 (NKH-1) antigen expression on human peripheral blood NK cells and cytotoxic T lymphocytes. J. Immunol. 136:4480-4486.
6. Cooper, M. A., T. A. Fehniger, and M. A. Caligiuri. 2001. The biology of human natural killer-cell subsets. Trends Immunol. 22:633-640.
7. Nagler, A., L. L. Lanier, S. Cwirla, and J. H. Phillips. 1989. Comparative studies of human FcRIII-positive and negative natural killer cells. J. Immunol. 143:3183-3191.
8. Caligiuri, M. A., A. Zmuidzinas, T. J. Manley, H. Levine, K. A. Smith, and J. Ritz. 1990. Functional consequences of interleukin 2 receptor expression on resting human lymphocytes. Identification of a novel natural killer cell subset with high affinity receptors. J. Exp. Med. 171:1509-1526.
9. Nagler, A., L. L. Lanier, and J. H. Phillips. 1990. Constitutive expression of high affinity interleukin 2 receptors on human CD16-natural killer cells in vivo. J. Exp. Med. 171:1527-1533.
10. White, M. J., C. M. Nielsen, R. H. McGregor, E. H. Riley, and M. R. Goodier. 2014. Differential activation of CD57-defined natural killer cell subsets during recall responses to vaccine antigens. Immunology 142:140-150.
11. Kunikata, T., K. Torigoe, S. Ushio, T. Okura, C. Ushio, H. Yamauchi, M. Ikeda, H. Ikegami, and M. Kurimoto. 1998. Constitutive and induced IL-18 receptor expression by various peripheral blood cell subsets as determined by anti-hIL-18R monoclonal antibody. Cell. Immunol. 189:135-143.
12. Cooper, M. A., T. A. Fehniger, S. C. Turner, K. S. Chen, B. A. Ghaheri, T. Ghayur, W. E. Carson, and M. A. Caligiuri. 2001. Human natural killer cells: a unique innate immunoregulatory role for the CD56 (bright) subset. Blood 97:3146-3151.
13. Pearce, E. L., and E. J. Pearce. 2013. Metabolic pathways in immune cell activation and quiescence. Immunity 38:633-643.
14. Pearce, E. L., M. C. Poffenberger, C. H. Chang, and R. G. Jones. 2013. Fueling immunity: insights into metabolism and lymphocyte function. Science 342:1242454.
15. Wang, R., and D. R. Green. 2012. Metabolic reprogramming and metabolic dependency in T cells. Immunol. Rev. 249:14-26.
16. Donnelly, R. P., R. M. Loftus, S. E. Keating, K. T. Liou, C. A. Biron, C. M. Gardiner, and D. K. Finlay. 2014. mTORC1-dependent metabolic reprogramming is a prerequisite for NK cell effector function. J. Immunol. 193:4477-4484.
17. Mestas, J., and C. C. Hughes. 2004. Of mice and not men: differences between mouse and human immunology. J. Immunol. 172:2731-2738.
18. Vilches, C., and P. Parham. 2002. KIR: diverse, rapidly evolving receptors of innate and adaptive immunity. Annu. Rev. Immunol. 20:217-251.
19. + human thymocytes with high CXCR4-induced chemotaxis. Proc. Natl. Acad. Sci. USA 102:12867-12872.
20. Macintyre, A. N., V. A. Gerriets, A. G. Nichols, R. D. Michalek, M. C. Rudolph, D. Deoliveira, S. M. Anderson, E. D. Abel, B. J. Chen, L. P. Hale, and J. C. Rathmell. 2014. The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function. Cell Metab. 20:61-72.
21. Marçais, A., J. Cherfils-Vicini, C. Viant, S. Degouve, S. Viel, A. Fenis, J. Rabilloud, K. Mayol, A. Tavares, J. Bienvenu, et al. 2014. The metabolic checkpoint kinase mTOR is essential for IL-15 signaling during the development and activation of NK cells. Nat. Immunol. 15:749-757.
22. + T cells. J. Exp. Med. 209:2441-2453.
23. Renner, K., A. L. Geiselhoringer, M. Fante, C. Bruss, S. Farber, G. Schonhammer, K. Peter, K. Singer, R. Andreesen, P. Hoffmann, et al. 2015. Metabolic plasticity of human T cells: preserved cytokine production under glucose deprivation or mitochondrial restriction, but 2-deoxy-glucose affects effector functions. Eur J Immunol. 45:2504-2516.
24. Dunn, C., M. Brunetto, G. Reynolds, T. Christophides, P. T. Kennedy, P. Lampertico, A. Das, A. R. Lopes, P. Borrow, K. Williams, et al. 2007. Cytokines induced during chronic hepatitis B virus infection promote a pathway for NK cell-mediated liver damage. J. Exp. Med. 204:667-680.
25. Esin, S., G. Batoni, C. Counoupas, A. Stringaro, F. L. Brancatisano, M. Colone, G. Maisetta, W. Florio, G. Arancia, and M. Campa. 2008. Direct binding of human NK cell natural cytotoxicity receptor NKp44 to the surfaces of mycobacteria and other bacteria. Infect. Immun. 76:1719-1727.
26. Chang, C. H., J. D. Curtis, L. B. Maggi, Jr., B. Faubert, A. V. Villarino, D. O'Sullivan, S. C. Huang, G. J. Van Der Windt, J. Blagih, J. Qiu, et al. 2013. Posttranscriptional control of T cell effector function by aerobic glycolysis. Cell 153:1239-1251.
27. Wang, R., C. P. Dillon, L. Z. Shi, S. Milasta, R. Carter, D. Finkelstein, L. L. McCormick, P. Fitzgerald, H. Chi, J. Munger, and D. R. Green. 2011. The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation. Immunity 35:871-882.
28. Fehniger, T. A., M. A. Cooper, G. J. Nuovo, M. Cella, F. Facchetti, M. Colonna, and M. A. Caligiuri. 2003. CD56bright natural killer cells are present in human lymph nodes and are activated by T cell-derived IL-2: a potential new link between adaptive and innate immunity. Blood 101:3052-3057.
29. Björkström, N. K., T. Lindgren, M. Stoltz, C. Fauriat, M. Braun, M. Evander, J. Michaëlsson, K. J. Malmberg, J. Klingström, C. Ahlm, and H. G. Ljunggren. 2011. Rapid expansion and long-term persistence of elevated NK cell numbers in humans infected with hantavirus. J. Exp. Med. 208:13-21.
30. Teirlinck, A. C., M. B. McCall, M. Roestenberg, A. Scholzen, R. Woestenenk, Q. De Mast, A. J. Van Der Ven, C. C. Hermsen, A. J. Luty, and R. W. Sauerwein. 2011. Longevity and composition of cellular immune responses following experimental Plasmodium falciparum malaria infection in humans. PLoS Pathog. 7:e1002389.
31. Jost, S., H. Quillay, J. Reardon, E. Peterson, R. P. Simmons, B. A. Parry, N. N. Bryant, W. D. Binder, and M. Altfeld. 2011. Changes in cytokine levels and NK cell activation associated with influenza. PLoS One 6:e25060.
32. + T cell-dependent activation of NK cells following vaccination. J. Immunol. 185:2808-2818.
33. + T cells requires an immediate-early glycolytic switch. Nat. Immunol. 14:1064-1072.
34. Doughty, C. A., B. F. Bleiman, D. J. Wagner, F. J. Dufort, J. M. Mataraza, M. F. Roberts, and T. C. Chiles. 2006. Antigen receptor-mediated changes in glucose metabolism in B lymphocytes: role of phosphatidylinositol 3-kinase signaling in the glycolytic control of growth. Blood 107:4458-4465.