Hyaluronic acid-based nanoge ls produced by microfluidics-facilitated self-assembly improves the safety profile of the cationic host defense peptide novicidin

Pharmaceutical Research

Volumn 32, Issue 8, 2015, Pages 2727-2735

  Water, Jorrit J ^a   Kim, Yongtae ^b   Maltesen, Morten J ^c   Franzyk, Henrik ^a   Foged, Camilla ^a   Nielsen, Hanne M ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^c NOVOZYMES A S   (Denmark)

Author keywords

Antimicrobial peptides; Hyaluronic acid; Hydrogel nanoparticles; Microfluidics; Nanogels

Indexed keywords

ANTIMICROBIAL CATIONIC PEPTIDE; HYALURONIC ACID; NOVICIDIN; UNCLASSIFIED DRUG; COLLOID; MACROGOL DERIVATIVE; NANOGEL; POLYETHYLENEIMINE;

3T3 CELL LINE; ANIMAL CELL; ANTIMICROBIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG SAFETY; GEL; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; IONIC STRENGTH; MICROFLUIDICS; MINIMUM INHIBITORY CONCENTRATION; NANOENCAPSULATION; NANOGEL; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; SUSTAINED DRUG RELEASE; UMBILICAL VEIN ENDOTHELIAL CELL; ZETA POTENTIAL; BACTERIUM; CELL SURVIVAL; CHEMISTRY; COLLOID; DRUG EFFECTS; ELECTROCHEMISTRY; MICROBIAL SENSITIVITY TEST;

ANTIMICROBIAL CATIONIC PEPTIDES; BACTERIA; CELL SURVIVAL; COLLOIDS; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; ELECTROCHEMISTRY; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; HYALURONIC ACID; MICROBIAL SENSITIVITY TESTS; MICROFLUIDICS; PARTICLE SIZE; POLYETHYLENE GLYCOLS; POLYETHYLENEIMINE;

EID: 84962482900     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-015-1658-6     Document Type: Article

References (38)

1. Zasloff M. Antimicrobial peptides of multicellular organisms. Nature. 2002;415:389–95.
2. Nguyen LT, Haney EF, Vogel HJ. The expanding scope of antimicrobial peptide structures and their modes of action. Trends Biotechnol. 2011;29:464–72.
3. Huang W, Seo J, Willingham SB, Czyzewski AM, Gonzalgo ML, Weissman IL, et al. Learning from host-defense peptides: cationic, amphipathic peptoids with potent anticancer activity. PLoS ONE. 2014;9:e90397.
4. Gaspar D, Veiga AS, Castanho MARB. From antimicrobial to anticancer peptides. A review. Front Microbiol. 2013;4:294
5. Mulder KCL, Lima LA, Miranda VJ, Dias SC, Franco OL. Current scenario of peptide-based drugs: the key roles of cationic antitumor and antiviral peptides. Front Microbiol. 2013;4:321.
6. Hilchie AL, Wuerth K, Hancock REW. Immune modulation by multifaceted cationic host defense (antimicrobial) peptides. Nat Chem Biol. 2013;9:761–8.
7. Mayer ML, Blohmke CJ, Falsafi R, Fjell CD, Madera L, Turvey SE, et al. Rescue of dysfunctional autophagy attenuates hyperinflammatory responses from cystic fibrosis cells. J Immunol. 2013;190:1227–38.
8. Hancock RE. Cationic peptides: effectors in innate immunity and novel antimicrobials. Lancet Infect Dis. 2001;1:156–64.
9. Giuliani A, Pirri G, Nicoletto SF. Antimicrobial peptides: an overview of a promising class of therapeutics. Cent Eur J Biol. 2007;2:1–33.
10. Hancock REW, Sahl H-G. Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies. Nat Biotechnol. 2006;24: 1551–7.
11. Van’t Hof W, Veerman EC, Helmerhorst EJ, Amerongen AV. Antimicrobial peptides: properties and applicability. Biol Chem. 2001;382:597–619.
12. Nochi T, Yuki Y, Takahashi H, Sawada S, Mejima M, Kohda T, et al. Nanogel antigenic protein-delivery system for adjuvant-free intranasal vaccines. Nat Mater. 2010;9:572–8.
13. Yan M, Ge J, Liu Z, Ouyang P. Encapsulation of single enzyme in nanogel with enhanced biocatalytic activity and stability. J AmChem Soc. 2006;128:11008–9.
14. Takahashi H, Sawada S, Akiyoshi K. Amphiphilic polysaccharide nanoballs: a new building block for nanogel biomedical engineering and artificial chaperones. ACS Nano. 2010;5:337–45.
15. Moghimi SM, Hunter AC, Murray JC. Long-circulating and targetspecific nanoparticles: theory to practice. Pharmacol Rev. 2001;53: 283–318.
16. Peppas NA, Bures P, Leobandung W, Ichikawa H. Hydrogels in pharmaceutical formulations. Eur J Pharm Biopharm. 2000;50:27–46.
17. Capretto L, Cheng W, Hill M, Zhang X. Micromixing within microfluidic devices. Top Curr Chem. 2011;304:27–68.
18. Jahn A, Reiner JE, Vreeland WN, DeVoe DL, Locascio LE, Gaitan M. Preparation of nanoparticles by continuous-flow microfluidics. J Nanoparticle Res. 2008;10:925–34.
19. De Smedt SC, Demeester J, Hennink WE. Cationic polymer based gene delivery systems. Pharm Res. 2000;17:113–26.
20. Jeong JH, Park TG, Kim SH. Self-assembled and nanostructured siRNA delivery systems. Pharm Res. 2011;28:2072–85.
21. Balakrishnan VS, Vad BS, Otzen DE. Novicidin’s membrane permeabilizing activity is driven by membrane partitioning but not by helicity: a biophysical study of the impact of lipid charge and cholesterol. Biochim Biophys Acta. 2013;1834:996–1002.
22. Dorosz J, Gofman Y, Kolusheva S, Otzen D, Ben-Tal N, Nielsen NC, et al. Membrane interactions of novicidin, a novel antimicrobial peptide: phosphatidylglycerol promotes bilayer insertion. J Phys Chem B. 2010;114:11053–60.
23. Gottlieb CT, Thomsen LE, Ingmer H, Mygind PH, Kristensen H-H, Gram L. Antimicrobial peptides effectively kill a broad spectrum of Listeria monocytogenes and Staphylococcus aureus strains independently of origin, sub-type, or virulence factor expression. BMC Microbiol. 2008;8:205.
24. Hoskin DW, Ramamoorthy A. Studies on anticancer activities of antimicrobial peptides. Biochim Biophys Acta. 2008;1778:357–75.
25. Vandamme D, Landuyt B, Luyten W, Schoofs L. A comprehensive summary of LL-37, the factotum human cathelicidin peptide. Cell Immunol. 2012;280:22–35.
26. Eenschooten C, Guillaumie F, Kontogeorgis GM, Stenby EH, Schwach-Abdellaoui K. Preparation and structural characterisation of novel and versatile amphiphilic octenyl succinic anhydride–modified hyaluronic acid derivatives. Carbohydr Polym. 2010;79:597–605.
27. Ossipov DA. Nanostructured hyaluronic acid-based materials for active delivery to cancer. Expert Opin Drug Deliv. 2010;7:681–703.
28. Kim Y, Lee Chung B, Ma M, Mulder WJM, Fayad ZA, Farokhzad OC, et al. Mass production and size control of lipid-polymer hybrid nanoparticles through controlled microvortices. Nano Lett. 2012;12: 3587–91.
29. Cory AH, Owen TC, Barltrop JA, Cory JG. Use of an aqueous soluble tetrazolium/formazan assay for cell growth assays in culture. Cancer Commun. 1991;3:207–12.
30. CLSI. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically; approved standard—ninth edition. CLSI document M07-A9. Wayne: Clinical and Laboratory Standards Institute; 2012.
31. Kim Y, Fay F, Cormode DP, Sanchez-Gaytan BL, Tang J, Hennessy EJ, et al. Single step reconstitution of multifunctional high-density lipoprotein-derived nanomaterials using microfluidics. ACS Nano. 2013;7:9975–83.
32. Karayianni M, Pispas S, Chryssikos GD, Gionis V, Giatrellis S, Noesis G. Complexatio noflysoz yme wi t h poly(sodium(sulfamate-carboxylate)isoprene). Biomacromolecules. 2011;12:1697–706.
33. Slaninová J, Mlsová V, Kroupová H, Alán L, Tůmová T, Monincová L, et al. Toxicity study of antimicrobial peptides from wild bee venom and their analogs toward mammalian normal and cancer cells. Peptides. 2012;33:18–26.
34. Park JH, Cho HJ, Yoon HY, Yoon IS, Ko SH, Shim JS, et al. Hyaluronic acid derivative-coated nanohybrid liposomes for cancer imaging and drug delivery. J Control Release. 2014;174:98–108.
35. He M, Zhao Z, Yin L, Tang C, Yin C. Hyaluronic acid coated poly(butyl cyanoacrylate) nanoparticles as anticancer drug carriers. Int J Pharm. 2009;373:165–73.
36. Zhang W, Cheng Q, Guo S, Lin D, Huang P, Liu J, et al. Gene transfection efficacy and biocompatibility of polycation/DNA complexes coated with enzyme degradable PEGylated hyaluronic acid. Biomaterials. 2013;34:6495–503.
37. Yang XY, Li YX, Li M, Zhang L, Feng LX, Zhang N. Hyaluronic acid-coated nanostructured lipid carriers for targeting paclitaxel to cancer. Cancer Lett. 2013;334:338–45.
38. Tossi A, Sandri L, Giangaspero A. Amphipathic, α-helical antimicrobial peptides. Biopolymers. 2000;55:4–30.