Therapeutic effects of Citrullus colocynthis fruit in patients with type II diabetes: A clinical trial study

Journal of Pharmacy and Bioallied Sciences

Volumn 8, Issue 2, 2016, Pages 130-134

  Barghamdi, Batol ^a   Ghorat, Fereshteh ^b   Asadollahi, Khairollah ^a   Sayehmiri, Kourosh ^a   Peyghambari, Robab ^c   Abangah, Ghobad ^a  

^a ILAM UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c SABZEVAR UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Citrullus colocynthis; diabetes; fasting blood sugar; HbA1c

Indexed keywords

COLOCYNTH EXTRACT; GLIBENCLAMIDE; GLUCOSE; HEMOGLOBIN A1C; METFORMIN; PLACEBO;

ABSENCE OF SIDE EFFECTS; ADULT; AGED; ARTICLE; BODY MASS; CONTROLLED STUDY; DIET RESTRICTION; DIETARY INTAKE; DOUBLE BLIND PROCEDURE; FEMALE; FRUIT; GLUCOSE BLOOD LEVEL; HEMOGLOBIN BLOOD LEVEL; HUMAN; IRAN; LIFESTYLE; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

EID: 84962467557     PISSN: None     EISSN: 09757406     Source Type: Journal    
DOI: 10.4103/0975-7406.171702     Document Type: Article

References (23)

1. Genuth S, Alberti KG, Bennett P, Buse J, Defronzo R, Kahn R, et al. Follow-up report on the diagnosis of diabetes mellitus. Diabetes Care 2003;26:3160-7.
2. Bearse MA Jr, Han Y, Schneck ME, Barez S, Jacobsen C, Adams AJ. Local multifocal oscillatory potential abnormalities in diabetes and early diabetic retinopathy. Invest Ophthalmol Vis Sci 2004;45:3259-65.
3. Wallace C, Reiber GE, LeMaster J, Smith DG, Sullivan K, Hayes S, et al. Incidence of falls, risk factors for falls, and fall-related fractures in individuals with diabetes and a prior foot ulcer. Diabetes Care 2002;25:1983-6.
4. Power AC. Diabetes mellitus. In: Faucy AS, Braunwald E, Kasper DL, Hauser SL, Longo DL, Jameson JL, et al., editors. Harrison Principle of Internal Medicine. 17th ed. New York: The McGraw Hill Companies; 2012. p. 2274-91.
5. Esteghamati A, Gouya MM, Abbasi M, Delavari A, Alikhani S, Alaedini F, et al. Prevalence of diabetes and impaired fasting glucose in the adult population of Iran: National Survey of Risk Factors for Non-Communicable Diseases of Iran. Diabetes Care 2008;31:96-8.
6. McCune LM, Johns T. Antioxidant activity in medicinal plants associated with the symptoms of diabetes mellitus used by the indigenous peoples of the North American boreal forest. J Ethnopharmacol 2002;82:197-205.
7. Goldfain D, Lavergne A, Galian A, Chauveinc L, Prudhomme F. Peculiar acute toxic colitis after ingestion of colocynth: A clinicopathological study of three cases. Gut 1989;30:1412-8.
8. Al Faraj S. Haemorrhagic colitis induced by Citrullus colocynthis. Ann Trop Med Parasitol 1995;89:695-6.
9. Al-Yahya MA, AL-Farhan AH, Adam SE. Preliminary toxicity study on the individual and combined effects of Citrullus colocynthis and Nerium oleander in rats. Fitoterapia 2000;71:385-91.
10. Diwan FH, Abdel-Hassan IA, Mohammed ST. Effect of saponin on mortality and histopathological changes in mice. East Mediterr Health J 2000;6:345-51.
11. Bakhiet AO, Adam SE. An estimation of Citrullus colocynthis toxicity for chicks. Vet Hum Toxicol 1995;37:356-8.
12. Elawad AA, Abdel Bari EM, Mahmoud OM, Adam SE. The effect of Citrullus colocynthis on sheep. Vet Hum Toxicol 1984;26:481-5.
13. Ziyyat A, Legssyer A, Mekhfi H, Dassouli A, Serhrouchni M, Benjelloun W. Phytotherapy of hypertension and diabetes in oriental Morocco. J Ethnopharmacol 1997;58:45-54.
14. Abdel-Hassan IA, Abdel-Barry JA, Tariq Mohammeda S. The hypoglycaemic and antihyperglycaemic effect of Citrullus colocynthis fruit aqueous extract in normal and alloxan diabetic rabbits. J Ethnopharmacol 2000;71:325-30.
15. Nmila R, Gross R, Rchid H, Roye M, Manteghetti M, Petit P, et al. Insulinotropic effect of Citrullus colocynthis fruit extracts. Planta Med 2000;66:418-23.
16. Paolisso G, Giugliano D. Oxidative stress and insulin action: Is there a relationship? Diabetologia 1996;39:357-63.
17. McGarry JD. Banting lecture 2001: Dysregulation of fatty acid metabolism in the etiology of type 2 diabetes. Diabetes 2002;51:7-18.
18. Boden G. Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. Diabetes 1997;46:3-10.
19. Rösen P, Nawroth PP, King G, Möller W, Tritschler HJ, Packer L. The role of oxidative stress in the onset and progression of diabetes and its complications: A summary of a Congress Series sponsored by UNESCO-MCBN, the American Diabetes Association and the German Diabetes Society. Diabetes Metab Res Rev 2001;17:189-212.
20. Kumar S, Kumar D, Manjusha, Saroha K, Singh N, Vashishta B. Antioxidant and free radical scavenging potential of Citrullus colocynthis (L.) Schrad. methanolic fruit extract. Acta Pharm 2008;58:215-20.
21. Sebbagh N, Cruciani-Guglielmacci C, Ouali F, Berthault MF, Rouch C, Sari DC, et al. Comparative effects of Citrullus colocynthis, sunflower and olive oil-enriched diet in streptozotocin-induced diabetes in rats. Diabetes Metab 2009;35:178-84.
22. Huseini HF, Darvishzadeh F, Heshmat R, Jafariazar Z, Raza M, Larijani B. The clinical investigation of Citrullus colocynthis (L.) Schrad fruit in treatment of type II diabetic patients: A randomized, double-blind, placebo controlled study. J Med Plants 2006;5:31-5.
23. Al-Ghaithi F, El-Ridi MR, Adeghate E, Amiri MH. Biochemical effects of Citrullus colocynthis in normal and diabetic rats. Mol Cell Biochem 2004;261:143-9.