Combination of Tolfenamic acid and curcumin induces colon cancer cell growth inhibition through modulating specific transcription factors and reactive oxygen species

Oncotarget

Volumn 7, Issue 3, 2016, Pages 3186-3200

  Sankpal, Umesh T ^a,b   Nagaraju, Ganji Purnachandra ^c   Gottipolu, Sriharika R ^b   Hurtado, Myrna ^b   Jordan, Christopher G ^a,d   Simecka, Jerry W ^a   Shoji, Mamoru ^c   El Rayes, Bassel ^c   Basha, Riyaz ^a,b  

^a UNIVERSITY OF NORTH TEXAS   (United States)

^b UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER   (United States)

^c EMORY UNIVERSITY   (United States)

^d JPS Center for Cancer Care   (United States)

Author keywords

Colon cancer; Curcumin; NF kB; Sp1; Tolfenamic acid

Indexed keywords

CASPASE 3; CASPASE 7; CURCUMIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; REACTIVE OXYGEN METABOLITE; SURVIVIN; TOLFENAMIC ACID; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR SP1; ANTHRANILIC ACID DERIVATIVE; ANTINEOPLASTIC AGENT; BIRC5 PROTEIN, HUMAN; INHIBITOR OF APOPTOSIS PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PARP1 PROTEIN, HUMAN; SP1 PROTEIN, HUMAN;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL LINE; CANCER COMBINATION CHEMOTHERAPY; CANCER INHIBITION; CELL VIABILITY; CELLULAR DISTRIBUTION; COLON CANCER CELL LINE; COLORECTAL CANCER; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DOWN REGULATION; DRUG EFFICACY; DRUG MECHANISM; DRUG TARGETING; ENZYME ACTIVITY; FLOW CYTOMETRY; HCT116 CELL LINE; HEART MUSCLE CELL; HT 29 CELL LINE; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; MITOCHONDRIAL MEMBRANE POTENTIAL; MONOTHERAPY; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; UPREGULATION; WESTERN BLOTTING; ACTIVE TRANSPORT; BIOSYNTHESIS; CELL PROLIFERATION; CELL SURVIVAL; COLONIC NEOPLASMS; DRUG EFFECTS; HCT 116 CELL LINE; HT-29 CELL LINE; METABOLISM; TUMOR CELL LINE;

ACTIVE TRANSPORT, CELL NUCLEUS; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; CASPASE 3; CASPASE 7; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; COLONIC NEOPLASMS; CURCUMIN; FLOW CYTOMETRY; HCT116 CELLS; HT29 CELLS; HUMANS; INHIBITOR OF APOPTOSIS PROTEINS; MEMBRANE POTENTIAL, MITOCHONDRIAL; NF-KAPPA B; ORTHO-AMINOBENZOATES; POLY (ADP-RIBOSE) POLYMERASE-1; REACTIVE OXYGEN SPECIES; SP1 TRANSCRIPTION FACTOR;

EID: 84962324145     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.6553     Document Type: Article

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