Does subtle disturbance of neuronal migration contribute to schizophrenia and other neurodevelopmental disorders? Potential genetic mechanisms with possible treatment implications

European Neuropsychopharmacology

Volumn 20, Issue 5, 2010, Pages 281-287

  Deutsch, Stephen I ^a   Burket, Jessica A ^a   Katz, Elionora ^a  

^a EASTERN VIRGINIA MEDICAL SCHOOL   (United States)

Author keywords

DISC1; Microtubules; Reelin; Schizophrenia; Very low density lipoprotein receptor

Indexed keywords

ADAPTOR PROTEIN; CHROMOSOME PROTEIN; DISABLED 1; DISRUPTED IN SCHIZOPHRENIA 1 PROTEIN; DISRUPTED IN SCHIZOPHRENIA 2 PROTEIN; REELIN; TAU PROTEIN; UNCLASSIFIED DRUG; VERY LOW DENSITY LIPOPROTEIN; VERY LOW DENSITY LIPOPROTEIN RECEPTOR;

AGYRIA; AUTOSOMAL RECESSIVE DISORDER; CELL MIGRATION; DEVELOPMENTAL DISORDER; GENE DELETION; GENE EXPRESSION; GENE FREQUENCY; GENE FUNCTION; GENE MUTATION; GENETIC DISORDER; GENETIC LINKAGE; GENETIC VARIABILITY; HOMOZYGOSITY; HUMAN; IMMUNOREACTIVITY; MICROTUBULE; MISSENSE MUTATION; NERVE CELL; NERVE CELL PLASTICITY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; REVIEW; SCHIZOPHRENIA; SIGNAL TRANSDUCTION;

ANIMALS; CELL ADHESION MOLECULES, NEURONAL; CELL MOVEMENT; EXTRACELLULAR MATRIX PROTEINS; HUMANS; LISSENCEPHALY; MICROTUBULE-ASSOCIATED PROTEINS; NERVE TISSUE PROTEINS; NEURONS; SCHIZOPHRENIA; SERINE ENDOPEPTIDASES;

EID: 77950297971     PISSN: 0924977X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.euroneuro.2010.02.005     Document Type: Review

References (40)

1. Akahane A., Kuynugi H., Tanaka H., Nanko S. Association analysis of polymorphic CGG repeat in 5′ UTR of the reelin and VLDLR genes with schizophrenia. Schizophr. Res. 2002, 58:37-41.
2. Bock H.H., Herz J. Reelin activates Src family tyrosine kinases in neurons. Curr. Biol. 2003, 13:18-26.
3. Boycott K.M., Flavelle S., Bureau A., Glass H.C., Fujiwara T.M., Wirrell E., et al. Homozygous deletion of the very low density lipoprotein receptor gene causes autosomal recessive cerebellar hypoplasia with cerebral gyral simplification. Am. J. Hum. Genet. 2005, 77:477-483.
4. Boycott K.M., Parboosingh J.S., Chodirker B.N., Lowry R.B., McLeod D.R., Morris J., Greenberg C.R., Chudley A.E., Bernier F.P., Midgley J., Møller L.B., Innes A.M. Clinical genetics and the Hutterite population: a review of Mendelian disorders. Am. J. Med. Genet. 2008, 146A(8):1088-1098.
5. Boycott K.M., Bonnemann C., Herz J., Neuert S., Beaulieu C., Scott J.N., et al. Mutations in VLDLR as a cause for autosomal recessive cerebellar ataxia with mental retardation (disequilibrium syndrome). J. Child Neurol. 2009, 24(10):1310-1315.
6. Callicott J.H., Straub R.E., Pezawas L., Egan M.F., Mattay V.S., Hariri A.R., et al. Variation in DISC1 affects hippocampal structure and function and increases risk for schizophrenia. Proc. Natl. Acad. Sci. U. S. A. 2005, 102(24):8627-8632.
7. Davies N., Russell A., Jones P., Murray R.M. Which characteristics of schizophrenia predate psychosis?. J. Psychiatr. Res. 1998, 32:121-131.
8. Deutsch S.I., Rosse R.B., Lakshman R.M. Dysregulation of tau phosphorylation is a hypothesized point of convergence in the pathogenesis of Alzheimer's disease, frontotemporal dementia and schizophrenia with therapeutic implications. Prog. Neuropsychopharmacol. Biol. Psychiatry 2006, 30:1369-1380.
9. Deutsch S.I., Rosse R.B., Mastropaolo J., Long K.D., Gaskins B.A. Epigenetic therapeutic strategies for the treatment of neuropsychiatric disorders: ready for prime time?. Clin. Neuropharmacol. 2008, 31(2):104-119.
10. Deutsch S.I., Schwartz B.L., Rosse R.B., Mastropaolo J., Fanous A.H., Weizman A., et al. Schizophrenia endophenotypes as treatment targets. The Handbook of Neuropsychiatric Biomarkers, Endophenotypes and Genes 2009, 113-122. Springer, Dordrecht, Netherlands. M.S. Ritsner (Ed.).
11. Deutsch S.I., Burket J.A., Rosse R.B., Schwartz B.L. Genetic variation of chromosome 1q42: etiologic mechanism of congenital disorders of neuronal migration and synaptogenesis. Curr. Psychiatry Rev. 2009, 5(4):236-249.
12. Deutsch, S.I., Rosse, R.B., Schwartz, B.L., Mastropaolo, J., Burket, J.A., Weizman, A., in press. Regulation of intermittent oscillatory activity of pyramidal cell neurons by GABA inhibitory interneurons is impaired in schizophrenia: rational for pharmacotherapeutic GABAergic interventions. Isr. J. Psychiatry.
13. Dewachter I., Ris L., Jaworski T., Seymour C.M., Kremer A., Borghgraef P., De Vijver H., Godaux E., Van Leuven F. GSK3beta, a centre-staged kinase in neuropsychiatric disorders, modulates long term memory by inhibitory phosphorylation at serine-9. Neurobiol. Dis. 2009, 35(2):193-200.
14. Ekelund J., Lichtermann D., Hovatta I., Ellonen P., Suvisaari J., Terwilliger J.D., et al. Genome-wide scan for schizophrenia in the Finnish population: evidence for a locus on chromosome 7q22. Hum. Mol. Genet. 2000, 9(7):1049-1057.
15. Fatemi S.H. Reelin mutations in mouse and man: from reeler mouse to schizophrenia, mood disorders, autism and lissencephaly. Mol. Psychiatry 2001, 6:129-133.
16. Garrido J.J., Simón D., Varea O., Wandosell F. GSK3 alpha and GSK3 beta are necessary for axon formation. FEBS Lett. 2007, 581(8):1579-1586.
17. Grunblatt E., Salkovic-Petrisi M., Osmanovic J., Riederer P., Hoyer S. Brain insulin system dysfunction in streptozotocin intracerebroventricularly treated rats generates hyperphosphorylated tau protein. J. Neurochem. 2007, 101:757-770.
18. Guidotti A., Auta J., Davis J.M., Dwivedi Y., Gerevini V.D., Impagnatiello F., Pandey G., Pesold C., Sharma R., Uzunov D.P., Costa E. Decrease in reelin and glutamic acid decarboxylase67 (GAD67) expression in schizophrenia and bipolar disorder: A postmortem brain study. Arch. Gen. Psychiatry 2000, 57:1061-1069.
19. Hiesberger T., Trommsdorff M., Howell B.W., Goffinet A., Mumby M.C., Cooper J.A., et al. Direct binding of reelin to VLDL receptor and ApoE receptor 2 induces tyrosine phosphorylation of disabled-1 and modulates tau phosphorylation. Neuron 1999, 24:481-489.
20. Hong S.E., Shugart Y.Y., Huang D.T., Al Shahwan A., Grant P.E., Hourihane J.O., et al. Autosomal recessive lissencephaly with cerebellar hypoplasia is associated with human RELN mutations. Nat. Genet. 2000, 26:93-96.
21. Impagnatiello F., Guidotti A.R., Pesold C., Dwivedi Y., Caruncho H., Pisu M.G., Uzunov D.P., Smalheiser N.R., Davis J.M., Pandey G.N., Pappas G.D., Tueting P., Sharma R.P., Costa E. A decrease of reelin expression as a putative vulnerability factor in schizophrenia. Proc. Natl. Acad. Sci. U. S. A. 1998, 95(26):15718-15723.
22. Jope R.S., Roh M.S. Glycogen synthase kinase-3 (GSK3) in psychiatric diseases and therapeutic interventions. Curr. Drug Targets 2006, 7(11):1421-1434.
23. Koike H., Arguello P.A., Kvajo M., Karayiorgou M., Gogos J.A. Disc1 is mutated in the 129S6/SvEv strain and modulates working memory in mice. Proc. Natl. Acad. Sci. U. S. A. 2006, 103(10):3693-3697.
24. Kozlovsky N., Belmaker R.H., Agam G. GSK-3 and the neurodevelopmental hypothesis of schizophrenia. Eur. Neuropsychopharmacol. 2002, 12(1):13-25.
25. Kvajo M., McKellar H., Arguello P.A., Drew L.J., Moore H., MacDermott A.B., et al. A mutation in mouse Disc1 that models a schizophrenia risk allele leads to specific alterations in neural architecture and cognition. Proc. Natl. Acad. Sci. U. S. A. 2008, 105(19):7076-7081.
26. Lee G., Newman S.T., Gard D.L., Band H., Panchamoorthy G. Tau interacts with src-family non-receptor tyrosine kinases. J. Cell Sci. 1998, 111:3167-3177.
27. Li X., Rosborough K.M., Friedman A.B., Zhu W., Roth K.A. Regulation of mouse brain glycogen synthase kinase-3 by atypical antipsychotics. Int. J. Neuropsychopharmacol. 2007, 10(1):7-19.
28. Liu W.S., Pesold C., Rodriguez M.A., Carboni G., Auta J., Lacor P., Larson J., Condie B.G., Guidotti A., Costa E. Down-regulation of dendritic spine and glutamic acid decarboxylase 67 expressions in the reelin haploinsufficient heterozygous reeler mouse. Proc. Natl. Acad. Sci. U. S. A. 2001, 98(6):3477-3482.
29. Mao Y., Ge X., Frank C.L., Madison J.M., Koehler A.N., Doud M.K., Tassa C., Berry E.M., Soda T., Singh K.K., Biechele T., Petryshen T.L., Moon R.T., Haggarty S.J., Tsai L.-H. DISC1 regulates neural progenitor proliferation via modulation of GSK3β/β-catenin signaling. Cell 2009, 136(6):1017-1031.
30. Millar J.K., Wilson-Annan J.C., Anderson S., Christie S., Taylor M.S., Semple C.A., et al. Disruption of two novel genes by a translocation co-segregating with schizophrenia. Hum. Mol. Genet. 2000, 9:1415-1423.
31. Moheb L.A., Tzschach A., Garshasbi M., Kahrizi K., Darvish H., Heshmati Y., et al. Identification of a nonsense mutation in the very low-density lipoprotein receptor gene (VLDLR) in an Iranian family with dysequilibrium syndrome. Eur. J. Hum. Genet. 2008, 16:270-273.
32. Ozcelik T., Akarsu N., Uz E., Caglayan S., Gulsuner S., Onat O.E., et al. Mutations in the very low-density lipoprotein receptor VLDLR cause cerebellar hypoplasia and quadrupedal locomotion in humans. Proc. Natl. Acad. Sci. U. S. A. 2008, 105(11):4232-4236.
33. Rice D.S., Curran T. Mutant mice with scrambled brains: understanding the signaling pathways that control cell positioning in the CNS. Genes Dev. 1999, 13:2758-2773.
34. Roh M.S., Seo M.S., Kim Y., Kim S.H., Jeon W.J., Ahn Y.M., Kang U.G., Juhnn Y.S., Kim Y.S. Haloperidol and clozapine differentially regulate signals upstream of glycogen synthase kinase 3 in the rat frontal cortex. Exp. Mol. Med. 2007, 39(3):353-360.
35. Shen S., Lang B., Nakamoto C., Zhang F., Pu J., Kuan S.L. Schizophrenia-related neural and behavioral phenotypes in transgenic mice expressing truncated Disc1. J. Neurosci. 2008, 28(43):10893-10904.
36. Suzuki K., Nakamura K., Iwata Y., Sekine Y., Kawai M., Sugihara G., et al. Decreased expression of reelin receptor VLDLR in peripheral lymphocytes of drug-naïve schizophrenic patients. Schizophr. Res. 2008, 98:148-156.
37. Trommsdorff M., Gotthardt M., Hiesberger T., Shelton J., Stockinger W., Nimpf J., et al. Reeler/disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and apoE receptor 2. Cell 1999, 97:689-701.
38. Turkmen S., Hoffmann K., Demirhan O., Aruoba D., Humphrey N., Mundlos S. Cerebellar hypoplasia, with quadrupedal locomotion, caused by mutations in the very low-density lipoprotein receptor gene. Eur. J. Hum. Genet. 2008, 16:1070-1074.
39. Vallee R.B., Tsai J.W. The cellular roles of the lissencephaly gene LIS1, and what they tell us about brain development. Genes Dev. 2006, 20(11):1384-1393.
40. Weinberger D.R. Implications of normal brain development for the pathogenesis of schizophrenia. Arch. Gen. Psychiatry 1987, 44:660-669.