Redox regulation of epidermal growth factor receptor signaling during the development of pulmonary hypertension

Free Radical Biology and Medicine

Volumn 95, Issue , 2016, Pages 96-111

  Rafikova, Olga ^a   Rafikov, Ruslan ^a   Kangath, Archana ^a   Qu, Ning ^a   Aggarwal, Saurabh ^b   Sharma, Shruti ^c   Desai, Julin ^c   Fields, Taylor ^c   Ludewig, Britta ^d   Yuan, Jason X Y ^a   Jonigk, Danny ^d   Black, Stephen M ^a  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c MEDICAL COLLEGE OF GEORGIA   (United States)

^d HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Catalase; EGFR; Oxidative stress; Proliferation; Pulmonary hypertension

Indexed keywords

CATALASE; DIMER; DODECYL SULFATE SODIUM; EPIDERMAL GROWTH FACTOR RECEPTOR; GEFITINIB; LIGAND; MONOCROTALINE; MONOCROTALINE PYRROLE; PROTEIN KINASE P60; TYROSINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOPHOSPHORYLATION; CONTROLLED STUDY; COVALENT BOND; CROSS LINKING; DIMERIZATION; FEMALE; HUMAN; HUMAN TISSUE; MALE; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PULMONARY ARTERY; PULMONARY HYPERTENSION; RAT; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; ANIMAL; CHEMICALLY INDUCED; DRUG EFFECTS; GENETICS; METABOLISM; PATHOLOGY; PHOSPHORYLATION; PROTEIN MULTIMERIZATION; VASCULAR SMOOTH MUSCLE;

ANIMALS; HUMANS; HYPERTENSION, PULMONARY; MONOCROTALINE; MUSCLE, SMOOTH, VASCULAR; OXIDATION-REDUCTION; OXIDATIVE STRESS; PHOSPHORYLATION; PROTEIN MULTIMERIZATION; PULMONARY ARTERY; RATS; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION; TYROSINE;

EID: 84962245418     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2016.02.029     Document Type: Article

References (57)

1. R. Bowers, C. Cool, R.C. Murphy, R.M. Tuder, M.W. Hopken, S.C. Flores, and N.F. Voelkel Oxidative stress in severe pulmonary hypertension Am. J. Respir. Crit. Care Med. 169 2004 764 769
2. D.M. Tabima, S. Frizzell, and M.T. Gladwin Reactive oxygen and nitrogen species in pulmonary hypertension Free Radic. Biol. Med. 52 2012 1970 1986
3. F. Perez-Vizcaino, A. Cogolludo, and L. Moreno Reactive oxygen species signaling in pulmonary vascular smooth muscle Respir. Physiol. Neurobiol. 174 2010 212 220
4. S. Altenhofer, P.W. Kleikers, K.A. Radermacher, P. Scheurer, J.J. Rob Hermans, P. Schiffers, H. Ho, K. Wingler, and H.H. Schmidt The NOX toolbox: validating the role of NADPH oxidases in physiology and disease Cell Mol. Life Sci. 69 2012 2327 2343
5. P. Higgins, J. Dawson, K.R. Lees, K. McArthur, T.J. Quinn, and M.R. Walters Xanthine oxidase inhibition for the treatment of cardiovascular disease: a systematic review and meta-analysis Cardiovasc. Ther. 30 2012 217 226
6. L.V. d'Uscio eNOS uncoupling in pulmonary hypertension Cardiovasc. Res. 92 2011 359 360
7. J. Kang, and S. Pervaiz Mitochondria: redox metabolism and dysfunction Biochem. Res. Int. 2012 896751
8. T. Fukai, and M. Ushio-Fukai Superoxide dismutases: role in redox signaling, vascular function, and diseases Antioxid. Redox Signal. 15 2011 1583 1606
9. P.A. Walton, and M. Pizzitelli Effects of peroxisomal catalase inhibition on mitochondrial function Front. Physiol. 3 2012 108
10. E. Lubos, J. Loscalzo, and D.E. Handy Glutathione peroxidase-1 in health and disease: from molecular mechanisms to therapeutic opportunities Antioxid. Redox Signal. 15 2011 1957 1997
11. J. Lu, and A. Holmgren The thioredoxin antioxidant system Free Radic. Biol. Med. 66 2014 75 87
12. E. Schroder, and P. Eaton Hydrogen peroxide as an endogenous mediator and exogenous tool in cardiovascular research: issues and considerations Curr. Opin. Pharmacol. 8 2008 153 159
13. S.G. Rhee, Y.S. Bae, S.R. Lee, J. Kwon, Hydrogen peroxide: a key messenger that modulates protein phosphorylation through cysteine oxidation. Sci STKE 2000:pe1.
14. 2 in studies of signal transduction Free Radic. Biol. Med. 42 2007 926 932
15. Z.S. Nedeljkovic, N. Gokce, and J. Loscalzo Mechanisms of oxidative stress and vascular dysfunction Postgrad. Med. J. 79 2003 195 198 (quiz pp. 198-200)
16. G.N. Rao, and B.C. Berk Active oxygen species stimulate vascular smooth muscle cell growth and proto-oncogene expression Circ. Res. 70 1992 593 599
17. 2 for platelet-derived growth factor signal transduction Science (New York, NY) 270 1995 296 299
18. G.E. Pourmahram, V.A. Snetkov, Y. Shaifta, S. Drndarski, G.A. Knock, P.I. Aaronson, and J.P. Ward Constriction of pulmonary artery by peroxide: role of Ca2+ release and PKC Free Radic. Biol. Med. 45 2008 1468 1476
19. R.S. Herbst Review of epidermal growth factor receptor biology Int. J. Radiat. Oncol. Biol. Phys. 59 2004 21 26
20. C.E. Norton, B.R. Broughton, N.L. Jernigan, B.R. Walker, and T.C. Resta Enhanced depolarization-induced pulmonary vasoconstriction following chronic hypoxia requires EGFR-dependent activation of NAD(P)H oxidase 2 Antioxid. Redox Signal. 18 2013 1777 1788
21. B.K. Dahal, T. Cornitescu, A. Tretyn, S.S. Pullamsetti, D. Kosanovic, R. Dumitrascu, H.A. Ghofrani, N. Weissmann, R. Voswinckel, G.A. Banat, W. Seeger, F. Grimminger, and R.T. Schermuly Role of epidermal growth factor inhibition in experimental pulmonary hypertension Am. J. Respir. Crit. Care Med. 181 2010 158 167
22. S.L. Merklinger, P.L. Jones, E.C. Martinez, and M. Rabinovitch Epidermal growth factor receptor blockade mediates smooth muscle cell apoptosis and improves survival in rats with pulmonary hypertension Circulation 112 2005 423 431
23. I.T. Toby, L.G. Chicoine, H. Cui, B. Chen, and L.D. Nelin Hypoxia-induced proliferation of human pulmonary microvascular endothelial cells depends on epidermal growth factor receptor tyrosine kinase activation Am. J. Physiol. 298 2010 L600 L606
24. D. Jonigk, H. Golpon, C.L. Bockmeyer, L. Maegel, M.M. Hoeper, J. Gottlieb, N. Nickel, K. Hussein, U. Maus, U. Lehmann, S. Janciauskiene, T. Welte, A. Haverich, J. Rische, H. Kreipe, and F. Laenger Plexiform lesions in pulmonary arterial hypertension composition, architecture, and microenvironment Am. J. Pathol. 179 2011 167 179
25. D. Jonigk, H. Golpon, C.L. Bockmeyer, L. Maegel, M.M. Hoeper, J. Gottlieb, N. Nickel, K. Hussein, U. Maus, U. Lehmann, S. Janciauskiene, T. Welte, A. Haverich, J. Rische, H. Kreipe, and F. Laenger Plexiform lesions in pulmonary arterial hypertension composition, architecture, and microenvironment Am. J. Pathol. 179 2011 167 179
26. S. Wedgwood, and S.M. Black Molecular mechanisms of nitric oxide-induced growth arrest and apoptosis in fetal pulmonary arterial smooth muscle cells Nitric Oxide 9 2003 201 210
27. L.K. Kelly, S. Wedgwood, R.H. Steinhorn, and S.M. Black Nitric oxide decreases endothelin-1 secretion through the activation of soluble guanylate cyclase Am. J. Physiol. 286 2004 L984 L991
28. S. Wedgwood, and S.M. Black Endothelin-1 decreases endothelial NOS expression and activity through ETA receptor-mediated generation of hydrogen peroxide Am. J. Physiol. 288 2005 L480 L487
29. K. Ravi, L.A. Brennan, S. Levic, P.A. Ross, and S.M. Black S-nitrosylation of endothelial nitric oxide synthase is associated with monomerization and decreased enzyme activity Proc. Natl. Acad. Sci. USA 101 2004 2619 2624
30. S. Kumar, N. Sud, F.V. Fonseca, Y. Hou, and S.M. Black Shear stress stimulates nitric oxide signaling in pulmonary arterial endothelial cells via a reduction in catalase activity: role of protein kinase C delta Am. J. Physiol. 298 2010 L105 L116
31. H. Catalase Aebi Methods Enzymatic Analysis 2 1974 121 126
32. E. Krieger, and G. Vriend New ways to boost molecular dynamics simulations J. Comput. Chem. 36 2015 996 1007
33. B.A. Foster, H.A. Coffey, M.J. Morin, and F. Rastinejad Pharmacological rescue of mutant p53 conformation and function Science (New York, NY) 286 1999 2507 2510
34. A.R. Mattocks Toxicity of pyrrolizidine alkaloids Nature 217 1968 723 728
35. M.W. Lame, A.D. Jones, D.W. Wilson, and H.J. Segall Monocrotaline pyrrole targets proteins with and without cysteine residues in the cytosol and membranes of human pulmonary artery endothelial cells Proteomics 5 2005 4398 4413
36. M. Ueda, H. Kinoshita, S.I. Maeda, W. Zou, and A. Tanaka Structure-function study of the amino-terminal stretch of the catalase subunit molecule in oligomerization, heme binding, and activity expression Appl. Microbiol. Biotechnol. 61 2003 488 494
37. A. van der Vliet, M. Hristova, C.E. Cross, J.P. Eiserich, and T. Goldkorn Peroxynitrite induces covalent dimerization of epidermal growth factor receptors in A431 epidermoid carcinoma cells J. Biol. Chem. 273 1998 31860 31866
38. D.A. Tice, J.S. Biscardi, A.L. Nickles, and S.J. Parsons Mechanism of biological synergy between cellular Src and epidermal growth factor receptor Proc. Natl. Acad. Sci. USA 96 1999 1415 1420
39. T.H. Leu, and M.C. Maa Functional implication of the interaction between EGF receptor and c-Src Front. Biosci. 8 2003 s28 s38
40. R.T. Schermuly, E. Dony, H.A. Ghofrani, S. Pullamsetti, R. Savai, M. Roth, A. Sydykov, Y.J. Lai, N. Weissmann, W. Seeger, and F. Grimminger Reversal of experimental pulmonary hypertension by PDGF inhibition J. Clin. Invest. 115 2005 2811 2821
41. R.J. Barst PDGF signaling in pulmonary arterial hypertension J. Clin. Invest. 115 2005 2691 2694
42. H. Daub, C. Wallasch, A. Lankenau, A. Herrlich, and A. Ullrich Signal characteristics of G protein-transactivated EGF receptor EMBO J. 16 1997 7032 7044
43. W. Tsai, A.D. Morielli, and E.G. Peralta The m1 muscarinic acetylcholine receptor transactivates the EGF receptor to modulate ion channel activity EMBO J. 16 1997 4597 4605
44. E.M. Khan, R. Lanir, A.R. Danielson, and T. Goldkorn Epidermal growth factor receptor exposed to cigarette smoke is aberrantly activated and undergoes perinuclear trafficking FASEB J. 22 2008 910 917
45. G.N. Rao Hydrogen peroxide induces complex formation of SHC-Grb2-SOS with receptor tyrosine kinase and activates Ras and extracellular signal-regulated protein kinases group of mitogen-activated protein kinases Oncogene 13 1996 713 719
46. S. Filosto, E.M. Khan, E. Tognon, C. Becker, M. Ashfaq, T. Ravid, and T. Goldkorn EGF receptor exposed to oxidative stress acquires abnormal phosphorylation and aberrant activated conformation that impairs canonical dimerization PLoS One 6 2011 e23240
47. L.A. MacMillan-Crow, and J.A. Thompson Tyrosine modifications and inactivation of active site manganese superoxide dismutase mutant (Y34F) by peroxynitrite Arch. Biochem. Biophys. 366 1999 82 88
48. 2 J. Neurochem. 84 2003 1128 1142
49. L.A. Bazley, and W.J. Gullick The epidermal growth factor receptor family Endocr. Relat. Cancer 12 Suppl. 1 2005 S17 S27
50. M.A. Heidaran, J.H. Pierce, R.A. Jensen, T. Matsui, and S.A. Aaronson Chimeric alpha- and beta-platelet-derived growth factor (PDGF) receptors define three immunoglobulin-like domains of the alpha-PDGF receptor that determine PDGF-AA binding specificity J. Biol. Chem. 265 1990 18741 18744
51. S. Ghosh, A.J. Janocha, M.A. Aronica, S. Swaidani, S.A. Comhair, W. Xu, L. Zheng, S. Kaveti, M. Kinter, S.L. Hazen, and S.C. Erzurum Nitrotyrosine proteome survey in asthma identifies oxidative mechanism of catalase inactivation J. Immunol. 176 2006 5587 5597
52. A. Takeda, K. Hirano, Y. Shiroya, and T. Samejima On the denaturation of porcine erythrocyte catalase with alkali, urea, and guanidine hydrochloride in relation to its subunit structure J. Biochem. 93 1983 967 975
53. S. Prajapati, V. Bhakuni, K.R. Babu, and S.K. Jain Alkaline unfolding and salt-induced folding of bovine liver catalase at high pH Eur. J. Biochem./FEBS 255 1998 178 184
54. T. Samejima, T. Miyahara, A. Takeda, A. Hachimori, and K. Hirano On the acid denaturation of porcine erythrocyte catalase in relation to its subunit structure J. Biochem. 89 1981 1325 1332
55. L.A. Brennan, S. Wedgwood, and S.M. Black The overexpression catalase reduces NO-mediated inhibition of endothelial NO synthase IUBMB life 54 2002 261 265
56. P.S. Hammerman, P.A. Janne, and B.E. Johnson Resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer Clin. Cancer Res. 15 2009 7502 7509
57. D. Montani, E. Bergot, S. Gunther, L. Savale, A. Bergeron, A. Bourdin, H. Bouvaist, M. Canuet, C. Pison, M. Macro, P. Poubeau, B. Girerd, D. Natali, C. Guignabert, F. Perros, D.S. O'Callaghan, X. Jais, P. Tubert-Bitter, G. Zalcman, O. Sitbon, G. Simonneau, and M. Humbert Pulmonary arterial hypertension in patients treated by dasatinib Circulation 125 2012 2128 2137