Immune resilience in HIV-infected individuals seronegative for cytomegalovirus

AIDS

Volumn 28, Issue 14, 2014, Pages 2045-2049

  Barrett, Lisa ^a,b   Stapleton, Staci N ^c   Fudge, Neva J ^c   Grant, Michael D ^c  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b DALHOUSIE UNIVERSITY   (Canada)

^c MEMORIAL UNIVERSITY OF NEWFOUNDLAND   (Canada)

Author keywords

Cytomegalovirus; HAART; HIV; Immune senescence

Indexed keywords

CD28 ANTIGEN; CD57 ANTIGEN;

ADULT; ARTICLE; CANADA; CD4 CD8 RATIO; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTION; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; PRIORITY JOURNAL; PROTEIN EXPRESSION; SERODIAGNOSIS; AGING; AIDS RELATED COMPLEX; COHORT ANALYSIS; COMPLICATION; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; PHENOTYPE;

ADULT; AGING; AIDS-RELATED OPPORTUNISTIC INFECTIONS; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; CD4-CD8 RATIO; COHORT STUDIES; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; FEMALE; HIV INFECTIONS; HUMANS; IMMUNOLOGIC MEMORY; MALE; MIDDLE AGED; PHENOTYPE;

EID: 84906748287     PISSN: 02699370     EISSN: 14735571     Source Type: Journal    
DOI: 10.1097/QAD.0000000000000405     Document Type: Article

References (38)

1. Antiretroviral Therapy Cohort Collaboration. Life expectancy of individuals on combination antiretroviral therapy in high-income countries: a collaborative analysis of 14 cohort studies. Lancet 2008; 372: 293-299.
2. Sterne JA, Hernan MA, Ledergerber B, Tilling K, Weber R, Sendi P, et al. Long-Term effectiveness of potent antiretroviral therapy in preventing AIDS and death: a prospective cohort study. Lancet 2005; 366: 378-384.
3. Margolick JB, Gange SJ, Detels R, O'Gorman MR, Rinaldo CR Jr, Lai S. Impact of inversion of the CD4/CD8 ratio on the natural history of HIV-1 infection. J Acquir Immune Defic Syndr 2006; 42: 620-626.
4. Robbins GK, Spritzler JG, Chan ES, Asmuth DM, Gandhi RT, Rodriguez BA, et al. Incomplete reconstitution of T cell subsets on combination antiretroviral therapy in the AIDS Clinical Trials Group protocol 384. Clin Infect Dis 2009; 48: 350-361.
5. Leung V, Gillis J, Raboud J, Cooper C, Hogg RS, Loutfy MR, et al. Predictors of CD4: CD8 ratio normalization and its effect on health outcomes in the era of combination antiretroviral therapy. PLoS One 2013; 8: e77665.
6. Aberg JA. Aging, inflammation, and HIV infection. Top Antivir Med 2012; 20: 101-105.
7. Deeks SG. Immune dysfunction, inflammation, and accelerated aging in patients on antiretroviral therapy. Top HIV Med 2009; 17: 118-123.
8. Ipp H, Zemlin A. The paradox of the immune response in HIV infection: when inflammation becomes harmful. Clin Chim Acta 2013; 416: 96-99.
9. Douek D. HIV disease progression: immune activation, microbes, and a leaky gut. Top HIV Med 2007; 15: 114-117.
10. Appay V, Almeida JR, Sauce D, Autran B, Papagno L. Accelerated immune senescence and HIV-1 infection. Exp Gerontol 2007; 42: 432-437.
11. Deeks SG, Verdin E, McCune JM. Immunosenescence and HIV. Curr Opin Immunol 2012; 24: 501-506.
12. Kalayjian RC, Landay A, Pollard RB, Taub DD, Gross BH, Francis IR, et al. Age-related immune dysfunction in health and in human immunodeficiency virus (HIV) disease: association of age and HIV infection with naive CD8+ cell depletion, reduced expression of CD28 on CD8+ cells, and reduced thymic volumes. J Infect Dis 2003; 187: 1924-1933.
13. Wittkop L, Bitard J, Lazaro E, Neau D, Bonnet F, Mercie P, et al. Effect of cytomegalovirus-induced immune response, self antigen-induced immune response, and microbial translocation on chronic immune activation in successfully treated HIV type 1-infected patients: the ANRS CO3 Aquitaine Cohort. J Infect Dis 2013; 207: 622-627.
14. Wikby A, Johansson B, Ferguson F,Olsson J. Age-related changes in immune parameters in a very old population of Swedish people: a longitudinal study. Exp Gerontol 1994; 29: 531-541.
15. Wikby A, Maxson P, Olsson J, Johansson B, Ferguson FG. Changes in CD8 and CD4 lymphocyte subsets, T cell proliferation responses and nonsurvival in the very old: the Swedish longitudinal OCTO-immune study. Mech Ageing Dev 1998; 102: 187-198.
16. Olsson J, Wikby A, Johansson B, Lofgren S, Nilsson BO, Ferguson FG. Age-related change in peripheral blood T-lymphocyte subpopulations and cytomegalovirus infection in the very old: the Swedish longitudinal OCTO immune study. Mech Ageing Dev 2000; 121: 187-201.
17. Wikby A, Johansson B, Olsson J, Lofgren S, Nilsson BO, Ferguson F. Expansions of peripheral blood CD8 T-lymphocyte subpopulations and an association with cytomegalovirus seropositivity in the elderly: the Swedish NONA immune study. Exp Gerontol 2002; 37: 445-453.
18. Rowe WP, Huebner RJ, Gilmore LK, Parrott RH, Ward TG. Isolation of a cytopathogenic agent from human adenoids undergoing spontaneous degeneration in tissue culture. Proc Soc Exp Biol Med 1953; 84: 570-573.
19. Kinney JS, Onorato IM, Stewart JA, Pass RF, Stagno S, Cheeseman SH, et al. Cytomegaloviral infection and disease. J Infect Dis 1985; 151: 772-774.
20. Onorato IM, Morens DM, Martone WJ, Stansfield SK. Epidemiology of cytomegaloviral infections: recommendations for prevention and control. Rev Infect Dis 1985; 7: 479-497.
21. Gallant JE, Moore RD, Richman DD, Keruly J, Chaisson RE. Incidence and natural history of cytomegalovirus disease in patients with advanced human immunodeficiency virus disease treated with zidovudine. The Zidovudine Epidemiology Study Group. J Infect Dis 1992; 166: 1223-1227.
22. El Amari EB, Combescure C, Yerly S, Calmy A, Kaiser L, Hasse B, et al. Clinical relevance of cytomegalovirus viraemia(M, dagger). HIV Med 2011; 12: 394-402.
23. Weinberg A, Tierney C, Kendall MA, Bosch RJ, Patterson-Bartlett J, Erice A, et al. Cytomegalovirus-specific immunity and protection against viremia and disease in HIV-infected patients in the era of highly active antiretroviral therapy. J Infect Dis 2006; 193: 488-493.
24. Luetkemeyer AF, Havlir DV, Currier JS. Complications of HIV disease and antiretroviral therapy. Top Antivir Med 2012; 20: 48-60.
25. Hasse B, Ledergerber B, Furrer H, Battegay M, Hirschel B, CavassiniM, et al. Morbidity and aging in HIV-infected persons: the Swiss HIV cohort study. Clin Infect Dis 2011; 53: 1130-1139.
26. Hsue PY, Deeks SG, Hunt PW. Immunologic basis of cardiovascular disease in HIV-infected adults. J Infect Dis 2012; 205(Suppl 3): S375-S382.
27. Hsue PY, Hunt PW, Sinclair E, Bredt B, Franklin A, Killian M, et al. Increased carotid intima-media thickness in HIV patients is associated with increased cytomegalovirus-specific T-cell responses. AIDS 2006; 20: 2275-2283.
28. Parrinello CM, Sinclair E, Landay AL, Lurain N, Sharrett AR, Gange SJ, et al. Cytomegalovirus immunoglobulinGantibody is associated with subclinical carotid artery disease among HIVinfected women. J Infect Dis 2012; 205: 1788-1796.
29. Effros RB. FromHayflick toWalford: the role of T cell replicative senescence in human aging. Exp Gerontol 2004; 39: 885-890.
30. Effros RB. Replicative senescence of CD8 T cells: effect on human ageing. Exp Gerontol 2004; 39: 517-524.
31. Brenchley JM, Karandikar NJ, Betts MR, Ambrozak DR, Hill BJ, Crotty LE, et al. Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells. Blood 2003; 101: 2711-2720.
32. Cao W, Jamieson BD, Hultin LE, Hultin PM, Effros RB, Detels R. Premature aging of T cells is associated with faster HIV-1 disease progression. J Acquir Immune Defic Syndr 2009; 50: 137-147.
33. Posnett DN, Sinha R, Kabak S, Russo C. Clonal populations of T cells in normal elderly humans: the T cell equivalent to 'benign monoclonal gammapathy'. J Exp Med 1994; 179: 609-618.
34. Khan N, Shariff N, Cobbold M, Bruton R, Ainsworth JA, Sinclair AJ, et al. Cytomegalovirus seropositivity drives the CD8 T cell repertoire toward greater clonality in healthy elderly individuals. J Immunol 2002; 169: 1984-1992.
35. Ouyang Q, WagnerWM, Wikby A, Walter S, Aubert G, Dodi AI, et al. Large numbers of dysfunctional CD8+ T lymphocytes bearing receptors for a single dominant CMV epitope in the very old. J Clin Immunol 2003; 23: 247-257.
36. Naeger DM, Martin JN, Sinclair E, Hunt PW, Bangsberg DR, Hecht F, et al. Cytomegalovirus-specific T cells persist at very high levels during long-Term antiretroviral treatment of HIV disease. PLoS One 2010; 5: e8886.
37. Appay V, Fastenackels S, Katlama C, Ait-Mohand H, Schneider L, Guihot A, et al. Old age and anticytomegalovirus immunity are associated with altered T-cell reconstitution in HIV-1-infected patients. AIDS 2011; 25: 1813-1822.
38. Gianella S, Morris SR, Tatro E, Vargas MV, Haubrich RH, Daar ES, et al. Virologic correlates of anti-CMV IgG levels in HIV-1 infected men. J Infect Dis 2014; 209: 452-456.