Adipocyte metrnl antagonizes insulin resistance through pparg signaling

Diabetes

Volumn 64, Issue 12, 2015, Pages 4011-4022

  Li, Zhi Yong ^a   Song, Jie ^a   Zheng, Si Li ^a   Fan, Mao Bing ^a   Guan, Yun Feng ^a   Qu, Yi ^a   Xu, Jian ^b   Wang, Pei ^a   Miao, Chao Yu ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOCYTOKINE; INSULIN; INSULIN SENSITIZING AGENT; METRNL PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; UNCLASSIFIED DRUG; COMETIN PROTEIN, MOUSE; LEPTIN; NERVE GROWTH FACTOR; RECOMBINANT PROTEIN; SUBFATIN PROTEIN, HUMAN;

ANIMAL CELL; ARTICLE; BODY MASS; BODY WEIGHT; CELL DIFFERENTIATION; CONTROLLED STUDY; DISEASE EXACERBATION; DRUG ANTAGONISM; DRUG SENSITIZATION; ENERGY EXPENDITURE; HUMAN; HUMAN CELL; IN VITRO STUDY; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID DIET; LIPID METABOLISM; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; WHITE ADIPOCYTE; 3T3 CELL LINE; ADIPOGENESIS; ADVERSE EFFECTS; AGONISTS; ANIMAL; ANTAGONISTS AND INHIBITORS; BLOOD; CHO CELL LINE; COMPARATIVE STUDY; CRICETULUS; CROSS BREEDING; CYTOLOGY; GENETICS; KNOCKOUT MOUSE; METABOLISM; OBESITY; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

3T3-L1 CELLS; ADIPOCYTES, WHITE; ADIPOGENESIS; ADIPOKINES; ADIPOSITY; ANIMALS; BODY MASS INDEX; CHO CELLS; CRICETULUS; CROSSES, GENETIC; DIET, HIGH-FAT; INSULIN RESISTANCE; LEPTIN; MALE; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; NERVE GROWTH FACTORS; PPAR GAMMA; RECOMBINANT PROTEINS; RNA INTERFERENCE; SIGNAL TRANSDUCTION;

EID: 84962192876     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db15-0274     Document Type: Article

References (38)

1. Johnson AM, Olefsky JM. The origins and drivers of insulin resistance. Cell 2013;152:673-684
2. Ahima RS, Lazar MA. Physiology. The health risk of obesity-better metrics imperative. Science 2013;341:856-858
3. Okada-Iwabu M, Yamauchi T, Iwabu M, et al. A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity. Nature 2013;503:493-499
4. Miao CY. Introduction: adipokines and cardiovascular disease. Clin Exp Pharmacol Physiol 2011;38:860-863
5. Ouchi N, Parker JL, Lugus JJ, Walsh K. Adipokines in inflammation and metabolic disease. Nat Rev Immunol 2011;11:85-97
6. Tran TT, Yamamoto Y, Gesta S, Kahn CR. Beneficial effects of subcutaneous fat transplantation on metabolism. Cell Metab 2008;7:410-420
7. Cristancho AG, Lazar MA. Forming functional fat: a growing understanding of adipocyte differentiation. Nat Rev Mol Cell Biol 2011;12:722-734
8. Li P, Fan W, Xu J, et al. Adipocyte NCoR knockout decreases PPARg phosphorylation and enhances PPARg activity and insulin sensitivity. Cell 2011; 147:815-826
9. Li ZY, Zheng SL, Wang P, et al. Subfatin is a novel adipokine and unlike Meteorin in adipose and brain expression. CNS Neurosci Ther 2014;20: 344-354
10. Wang P, Xu TY, Guan YF, Su DF, Fan GR, Miao CY. Perivascular adipose tissue-derived visfatin is a vascular smooth muscle cell growth factor: role of nicotinamide mononucleotide. Cardiovasc Res 2009;81:370-380
11. Wang P, Xu TY, Guan YF, et al. Nicotinamide phosphoribosyltransferase protects against ischemic stroke through SIRT1-dependent adenosine mono-phosphate-activated kinase pathway. Ann Neurol 2011;69:360-374
12. Wang P, Zhang RY, Song J, et al. Loss of AMP-activated protein kinase-a2 impairs the insulin-sensitizing effect of calorie restriction in skeletal muscle. Diabetes 2012;61:1051-1061
13. Wang P, Guan YF, Du H, Zhai QW, Su DF, Miao CY. Induction of autophagy contributes to the neuroprotection of nicotinamide phosphoribosyltransferase in cerebral ischemia. Autophagy 2012;8:77-87
14. Jørgensen JR, Fransson A, Fjord-Larsen L, et al. Cometin is a novel neu-rotrophic factor that promotes neurite outgrowth and neuroblast migration in vitro and supports survival of spiral ganglion neurons in vivo. Exp Neurol 2012;233: 172-181
15. Rao RR, Long JZ, White JP, et al. Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis. Cell 2014; 157:1279-1291
16. Ushach I, Burkhardt AM, Martinez C, et al. METEORIN-LIKE is a cytokine associated with barrier tissues and alternatively activated macrophages. Clin Immunol 2015;156:119-127
17. Naveiras O, Nardi V, Wenzel PL, Hauschka PV, Fahey F, Daley GQ. Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment. Nature 2009;460:259-263
18. Liao W, Nguyen MT, Yoshizaki T, et al. Suppression of PPAR-gamma attenuates insulin-stimulated glucose uptake by affecting both GLUT1 and GLUT4 in 3T3-L1 adipocytes. Am J Physiol Endocrinol Metab 2007;293: E219-E227
19. Ayala JE, Bracy DP, Malabanan C, et al. Hyperinsulinemic-euglycemic clamps in conscious, unrestrained mice. J Vis Exp 2011;pii:3188
20. Bligh EG, Dyer WJ. A rapid method of total lipid extraction and purification. Can J Biochem Physiol 1959;37:911-917
21. Khan T, Muise ES, Iyengar P, et al. Metabolic dysregulation and adipose tissue fibrosis: role of collagen VI. Mol Cell Biol 2009;29:1575-1591
22. Song DD, Chen Y, Li ZY, Guan YF, Zou DJ, Miao CY. Protein tyrosine phosphatase 1B inhibits adipocyte differentiation and mediates TNFalpha action in obesity. Biochim Biophys Acta 2013;1831:1368-1376
23. Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 1993;259:87-91
24. Savage DB, Petersen KF, Shulman GI. Disordered lipid metabolism and the pathogenesis of insulin resistance. Physiol Rev 2007;87:507-520
25. Frayn KN. Adipose tissue as a buffer for daily lipid flux. Diabetologia 2002; 45:1201-1210
26. Wang H, Eckel RH. Lipoprotein lipase: from gene to obesity. Am J Physiol Endocrinol Metab 2009;297:E271-E288
27. Evans JL, Goldfine ID, Maddux BA, Grodsky GM. Are oxidative stress-activated signaling pathways mediators of insulin resistance and beta-cell dysfunction? Diabetes 2003;52:1-8
28. Kim JK, Gavrilova O, Chen Y, Reitman ML, Shulman GI. Mechanism of insulin resistance in A-ZIP/F-1 fatless mice. J Biol Chem 2000;275:8456-8460
29. Guilherme A, Virbasius JV, Puri V, Czech MP. Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes. Nat Rev Mol Cell Biol 2008;9: 367-377
30. Tontonoz P, Spiegelman BM. Fat and beyond: the diverse biology of PPARgamma. Annu Rev Biochem 2008;77:289-312
31. Ahmadian M, Suh JM, Hah N, et al. PPARg signaling and metabolism: the good, the bad and the future. Nat Med 2013;19:557-566
32. Sugii S, Olson P, Sears DD, et al. PPARgamma activation in adipocytes is sufficient for systemic insulin sensitization. Proc Natl Acad Sci U S A 2009;106: 22504-22509
33. Martens K, Bottelbergs A, Baes M. Ectopic recombination in the central and peripheral nervous system by aP2/FABP4-Cre mice: implications for metabolism research. FEBS Lett 2010;584:1054-1058
34. Makowski L, Boord JB, Maeda K, et al. Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis. Nat Med 2001;7:699-705
35. Virtue S, Vidal-Puig A. It's not how fat you are, it's what you do with it that counts. PLoS Biol 2008;6:e237
36. Kim JY, van de Wall E, Laplante M, et al. Obesity-associated improvements in metabolic profile through expansion of adipose tissue. J Clin Invest 2007;117: 2621-2637
37. Arner P, Bernard S, Salehpour M, et al. Dynamics of human adipose lipid turnover in health and metabolic disease. Nature 2011;478:110-113
38. Gray SL, Nora ED, Grosse J, et al. Leptin deficiency unmasks the deleterious effects of impaired peroxisome proliferator-activated receptor gamma function (P465L PPARgamma) in mice. Diabetes 2006;55:2669-2677