Stability of the human polymerase δ holoenzyme and its implications in lagging strand DNA synthesis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 13, 2016, Pages E1777-E1786

  Hedglin, Mark ^a   Pandey, Binod ^a   Benkovic, Stephen J ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

DNA polymerase delta; Lagging strand; PCNA; Stability; Translesion DNA synthesis

Indexed keywords

DNA DIRECTED DNA POLYMERASE DELTA; HOLOENZYME; OKAZAKI FRAGMENT; CYCLINE; DNA; DNA DIRECTED DNA POLYMERASE GAMMA; PRIMER DNA; REPLICATION FACTOR A; REPLICATION FACTOR C; SINGLE STRANDED DNA;

ARTICLE; BINDING SITE; CELL CYCLE S PHASE; CELL PROLIFERATION; CONJUGATION; CONTROLLED STUDY; DNA BINDING; DNA STRAND; DNA SYNTHESIS; DNA TEMPLATE; ENZYME ACTIVE SITE; ENZYME PURIFICATION; ENZYME STABILITY; ESCHERICHIA COLI; HUMAN; HUMAN CELL; IN VITRO STUDY; IONIC STRENGTH; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROCESSING; PROTEIN PURIFICATION; SACCHAROMYCES CEREVISIAE; BIOSYNTHESIS; CHEMISTRY; DNA REPLICATION; FLUORESCENCE RESONANCE ENERGY TRANSFER; METABOLISM; UBIQUITINATION;

DNA; DNA POLYMERASE III; DNA PRIMERS; DNA REPLICATION; DNA, SINGLE-STRANDED; ENZYME STABILITY; FLUORESCENCE RESONANCE ENERGY TRANSFER; HOLOENZYMES; HUMANS; PROLIFERATING CELL NUCLEAR ANTIGEN; REPLICATION PROTEIN A; REPLICATION PROTEIN C; UBIQUITINATION;

EID: 84962167085     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1523653113     Document Type: Article

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