Etiology, antibiotic resistance and risk factors for neonatal sepsis in a large referral center in Zambia

Pediatric Infectious Disease Journal

Volumn 35, Issue 7, 2016, Pages e191-e198

  Kabwe, Mwila ^a   Tembo, John ^a   Chilukutu, Lophina ^a   Chilufya, Moses ^a   Ngulube, Francis ^a   Lukwesa, Chileshe ^a   Kapasa, Monica ^a   Enne, Virve ^b   Wexner, Hannah ^c   Mwananyanda, Lawrence ^d,e,f   Hamer, Davidson H ^d,e,f   Sinyangwe, Sylvestor ^a   Ahmed, Yusuf ^a   Klein, Nigel ^b   Maeurer, Markus ^g   Zumla, Alimuddin ^a,c,h   Bates, Matthew ^a,c  

^a UNIVERSITY TEACHING HOSPITAL   (Zambia)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c HARVARD MEDICAL SCHOOL   (United States)

^d Zambia Centre for Applied Health Research and Development   (United States)

^e BOSTON UNIVERSITY SCHOOL OF PUBLIC HEALTH   (United States)

^f Department of Global Health ^*  (United States)

^g KAROLINSKA INSTITUTE   (Sweden)

^h UNIVERSITY COLLEGE LONDON HOSPITALS   (United Kingdom)

Author keywords

Africa; antimicrobial resistance; HIV exposed; Klebsiella pneumoniae; neonatal sepsis

Indexed keywords

AMPICILLIN; CEPHALOSPORIN DERIVATIVE; GENTAMICIN; ANTIINFECTIVE AGENT;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BIRTH WEIGHT; BLOOD CULTURE; CANDIDA; CYANOSIS; DRUG SENSITIVITY; ESCHERICHIA COLI; FEMALE; HEPATOMEGALY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFECTION CONTROL; INFECTION RISK; KLEBSIELLA; MALE; MORTALITY RATE; NEWBORN; NEWBORN INTENSIVE CARE; NEWBORN MORTALITY; NEWBORN SEPSIS; PARITY; PRENATAL EXPOSURE; PREVALENCE; PRIORITY JOURNAL; STAPHYLOCOCCUS; STAPHYLOCOCCUS AUREUS; ZAMBIA; BACTEREMIA; CROSS INFECTION; CROSS-SECTIONAL STUDY; EPIDEMIOLOGY; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; MORTALITY; NEONATAL INTENSIVE CARE UNIT; NEONATAL SEPSIS; PATIENT REFERRAL; PREGNANCY; RISK FACTOR;

ANTI-BACTERIAL AGENTS; BACTEREMIA; CROSS INFECTION; CROSS-SECTIONAL STUDIES; DRUG RESISTANCE, MICROBIAL; FEMALE; HUMANS; INFANT, NEWBORN; INTENSIVE CARE UNITS, NEONATAL; MALE; MICROBIAL SENSITIVITY TESTS; NEONATAL SEPSIS; PREGNANCY; PREVALENCE; REFERRAL AND CONSULTATION; RISK FACTORS; ZAMBIA;

EID: 84962127825     PISSN: 08913668     EISSN: 15320987     Source Type: Journal    
DOI: 10.1097/INF.0000000000001154     Document Type: Article

References (48)

1. Seale AC, Blencowe H, Zaidi A, et al; Neonatal Infections Estimation Team. Neonatal severe bacterial infection impairment estimates in South Asia, sub-Saharan Africa, and Latin America for 2010. Pediatr Res. 2013;74(suppl 1):73-85.
2. Liu L, Johnson HL, Cousens S, et al; Child Health Epidemiology Reference Group of WHO and UNICEF. Global, regional, and national causes of child mortality: an updated systematic analysis for 2010 with time trends since 2000. Lancet. 2012;379:2151-2161.
3. Mwaniki MK, Atieno M, Lawn JE, et al. Long-Term neurodevelopmental outcomes after intrauterine and neonatal insults: a systematic review. Lancet. 2012;379:445-452.
4. Acquah SE, Quaye L, Sagoe K, et al. Susceptibility of bacterial etiological agents to commonly-used antimicrobial agents in children with sepsis at the Tamale Teaching Hospital. BMC Infect Dis. 2013;13:89.
5. Ballot DE, Nana T, Sriruttan C, et al. Bacterial bloodstream infections in neonates in a developing country. ISRN Pediatr. 2012;2012:508512.
6. Hamer DH, Darmstadt GL, Carlin JB, et al. Etiology of bacteremia in young infants in six countries. Pediatr Infect Dis J 2014.
7. Kiwanuka J, Bazira J, Mwanga J, et al. The microbial spectrum of neonatal sepsis in Uganda: recovery of culturable bacteria in mother-infant pairs. PLoS One. 2013;8:e72775.
8. Kohli-Kochhar R, Omuse G, Revathi G. A ten-year review of neonatal bloodstream infections in a tertiary private hospital in Kenya. J Infect Dev Ctries. 2011;5:799-803.
9. Landre-Peigne C, Ka AS, Peigne V, et al. Efficacy of an infection control programme in reducing nosocomial bloodstream infections in a Senegalese neonatal unit. J Hosp Infect. 2011;79:161-165.
10. Mhada TV, Fredrick F, Matee MI, et al. Neonatal sepsis at Muhimbili National Hospital, Dar es Salaam, Tanzania; aetiology, antimicrobial sensitivity pattern and clinical outcome. BMC Public Health. 2012;12:904.
11. Mkony MF, Mizinduko MM, Massawe A, et al. Management of neonatal sepsis at Muhimbili National Hospital in Dar es Salaam: diagnostic accuracy of C-reactive protein and newborn scale of sepsis and antimicrobial resistance pattern of etiological bacteria. BMC Pediatr. 2014;14:293.
12. Morkel G, Bekker A, Marais BJ, et al. Bloodstream infections and antimicrobial resistance patterns in a South African neonatal intensive care unit. Paediatr Int Child Health. 2014;34:108-114.
13. Ogunlesi TA, Ogunfowora OB, Osinupebi O, et al. Changing trends in newborn sepsis in Sagamu, Nigeria: bacterial aetiology, risk factors and antibiotic susceptibility. J Paediatr Child Health. 2011;47:5-11.
14. Shitaye D, Asrat D, Woldeamanuel Y, et al. Risk factors and etiology of neonatal sepsis in Tikur Anbessa University Hospital, Ethiopia. Ethiop Med J. 2010;48:11-21.
15. Tann CJ, Nkurunziza P, Nakakeeto M, et al. Prevalence of bloodstream pathogens is higher in neonatal encephalopathy cases vs. controls using a novel panel of real-Time PCR assays. PLoS One. 2014;9:e97259.
16. West BA, Peterside O. Sensitivity pattern among bacterial isolates in neonatal septicaemia in port Harcourt. Ann Clin Microbiol Antimicrob. 2012;11:7.
17. Zaidi AK, Huskins WC, Thaver D, et al. Hospital-Acquired neonatal infections in developing countries. Lancet. 2005;365:1175-1188.
18. World Health Organization. Antimicrobial Resistance: Global Report on Surveillance. Geneva, Switzerland: World Health Organization; 2014.
19. Downie L, Armiento R, Subhi R, et al. Community-Acquired neonatal and infant sepsis in developing countries: efficacy of WHOs currently recommended antibiotics-systematic review and meta-Analysis. Arch Dis Child. 2013;98:146-154.
20. Thaver D, Ali SA, Zaidi AK. Antimicrobial resistance among neonatal pathogens in developing countries. Pediatr Infect Dis J. 2009;28(1 suppl):S19-S21.
21. Aiken AM, Mturi N, Njuguna P, et al; Kilifi Bacteraemia Surveillance Group. Risk and causes of paediatric hospital-Acquired bacteraemia in Kilifi District Hospital, Kenya: a prospective cohort study. Lancet. 2011;378:2021-2027.
22. Bates M, Kabwe M, Zumla A. Neonatal sepsis and antibiotic resistance in developing countries. Pediatr Infect Dis J. 2014;33:1097.
23. Storberg V. ESBL-producing Enterobacteriaceae in Africa-A non-systematic literature review of research published 2008-2012. Infect Ecol Epidemiol. 2014;4.
24. Manenzhe RI, Zar HJ, Nicol MP, et al. The spread of carbapenemase-producing bacteria in Africa: a systematic review. J Antimicrob Chemother. 2015;70:23-40.
25. Zambia Ministry of Health. Lifelong Antiretroviral Drugs (ARVs) for all HIV positive Pregnant Women in Zambia: Policy Guidelines for Health Facilities in Zambia. Lusaka: Zambian Ministry of Health; 2013.
26. Stevens J, Lyall H. Mother to child transmission of HIV: what works and how much is enough?. J Infect. 2014;69(suppl 1):S56-S62.
27. Ayoola OO, Adeyemo AA, Osinusi K. Aetiological agents, clinical features and outcome of septicaemia in infants in Ibadan. West Afr J Med. 2003;22:30-34.
28. Mokuolu AO, Jiya N, Adesiyun OO. Neonatal septicaemia in Ilorin: bacterial pathogens and antibiotic sensitivity pattern. Afr J Med Med Sci. 2002;31:127-130.
29. Musoke RN, Revathi G. Emergence of multidrug-resistant gram-negative organisms in a neonatal unit and the therapeutic implications. J Trop Pediatr. 2000;46:86-91.
30. Ojukwu JU, Abonyi LE, Ugwu J, et al. Neonatal septicemia in high risk babies in South-Eastern Nigeria. J Perinat Med. 2006;34:166-172.
31. Simiyu DE. Neonatal septicaemia in low birth weight infants at Kenyatta National Hospital, Nairobi. East Afr Med J. 2005;82:148-152.
32. Wall SN, Lee AC, Carlo W, et al. Reducing intrapartum-related neonatal deaths in low-And middle-income countries-what works?. Semin Perinatol. 2010;34:395-407.
33. Lukac PJ, Bonomo RA, Logan LK. Extended-spectrum beta-lactamase-producing Enterobacteriaceae in children: old foe, emerging threat. Clin Infect Dis. 2015;60:1389-1397.
34. Iregbu KC, Anwaal U. Extended spectrum beta-lactamase-producing Klebsiella pneumoniae septicaemia outbreak in the neonatal intensive care unit of a tertiary hospital in Nigeria. Afr J Med Med Sci. 2007;36:225-228.
35. Velaphi S, Wadula J, Nakwa F. Mortality rate in neonates infected with extended-spectrum beta lactamase-producing Klebsiella species and selective empirical use of meropenem. Ann Trop Paediatr. 2009;29:101-110.
36. Le Doare K, Heath PT. An overview of global GBS epidemiology. Vaccine. 2013;31(suppl 4):D7-12.
37. Mulholland EK, Ogunlesi OO, Adegbola RA, et al. Etiology of serious infections in young Gambian infants. Pediatr Infect Dis J. 1999;18(10 suppl):S35-S41.
38. Madhi SA, Dangor Z, Heath PT, et al. Considerations for a phase-III trial to evaluate a group B Streptococcus polysaccharide-protein conjugate vaccine in pregnant women for the prevention of early-And late-onset invasive disease in young-infants. Vaccine. 2013;31(suppl 4):D52-D57.
39. Govender T, Coovadia H. Eliminating mother to child transmission of HIV-1 and keeping mothers alive: recent progress. J Infect. 2014;68(suppl 1):S57-S62.
40. Filteau S. The HIV-exposed, uninfected African child. Trop Med Int Health. 2009;14:276-287.
41. Makasa M, Kasonka L, Chisenga M, et al. Early growth of infants of HIV-infected and uninfected Zambian women. Trop Med Int Health. 2007;12:594-602.
42. Huson MA, Grobusch MP, van der Poll T. The effect of HIV infection on the host response to bacterial sepsis. Lancet Infect Dis. 2015;15:95-108.
43. Cutland CL, Schrag SJ, Zell ER, et al; PoPS Trial Team. Maternal HIV infection and vertical transmission of pathogenic bacteria. Pediatrics. 2012;130:e581-e590.
44. Bedri A, Gudetta B, Isehak A, et al; Six Week Extended-Dose Nevirapine (SWEN) Study Team. Extended-dose nevirapine to 6 weeks of age for infants to prevent HIV transmission via breastfeeding in Ethiopia, India, and Uganda: an analysis of three randomised controlled trials. Lancet. 2008;372:300-313.
45. Jackson JB, Dick J, Tekle T, et al. Lack of antimicrobial activity by the antiretroviral drug nevirapine against common bacterial pathogens. Antimicrob Agents Chemother. 2009;53:3606-3607.
46. Lim D, Maas WK. Reverse transcriptase in bacteria. Mol Microbiol. 1989;3:1141-1144.
47. Elwell LP, Ferone R, Freeman GA, et al. Antibacterial activity and mechanism of action of 3-Azido-3-deoxythymidine (BW A509U). Antimicrob Agents Chemother. 1987;31:274-280.
48. Church JA, Fitzgerald F, Walker AS, et al. Corrections. The expanding role of co-Trimoxazole in developing countries. Lancet Infect Dis. 2015;15:263.