Management of neonatal sepsis at muhimbili national hospital in dar es salaam: Diagnostic accuracy of c - reactive protein and newborn scale of sepsis and antimicrobial resistance pattern of etiological bacteria

BMC Pediatrics

Volumn 14, Issue 1, 2014, Pages

  Mkony, Martha Franklin ^a   Mizinduko, Mucho Michael ^b   Massawe, Augustine ^c   Matee, Mecky ^c  

^a MUHIMBILI NATIONAL HOSPITAL   (Tanzania)

^b BOSTON UNIVERSITY   (United States)

^c MUHIMBILI UNIVERSITY OF HEALTH AND ALLIED SCIENCES   (Tanzania)

Author keywords

C Reactive protein; Hematological markers; Neonatal sepsis; Newborn scale of sepsis

Indexed keywords

AMIKACIN; AMPICILLIN; C REACTIVE PROTEIN; CEFTRIAXONE; CEFUROXIME; CLOXACILLIN; GENTAMICIN; VANCOMYCIN;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIUM ISOLATE; BLOOD CULTURE; CLINICAL ASSESSMENT; COAGULASE NEGATIVE STAPHYLOCOCCUS; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; ESCHERICHIA COLI; FEMALE; HUMAN; KLEBSIELLA; LIKELIHOOD RATIO; MAJOR CLINICAL STUDY; MALE; NEWBORN; NEWBORN SEPSIS; PHYSICAL EXAMINATION; PREDICTIVE VALUE; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; PSEUDOMONAS; RECEIVER OPERATING CHARACTERISTIC; RUBARTH NEWBORN SCALE OF SEPSIS; SENSITIVITY AND SPECIFICITY; STAPHYLOCOCCUS AUREUS; STATISTICAL ANALYSIS; TANZANIA; WORLD HEALTH ORGANIZATION;

EID: 84928753152     PISSN: None     EISSN: 14712431     Source Type: Journal    
DOI: 10.1186/s12887-014-0293-4     Document Type: Article

References (29)

1. Weber MW, Carlin JB, Gatchalian S, Lehmann D, Muhe L, Mulholland EK: Predictors of neonatalsepsis in developing countries. Pediatr Infect Dis J 2003, 22(8):711-7.2.
2. Musoke RN, Revathi G: Emergence of multidrug-resistant gram-negative organisms in a neonatal unit and the therapeutic implications. J Trop Pediatr 2000, 46(2):86-91.
3. Benitz WE: Adjunct laboratory tests in the diagnosis of early-onset neonatal sepsis. Clin Perinatol 2010, 37(2):421-438.
4. Hengst JM: The role of C-reactive protein in the evaluation and management of infants with suspected sepsis. Adv Neonatal Care 2003, 3(1):3-13.
5. Garland SM, Bowman ED: Reappraisal of C-reactive protein as a screening tool for neonatal sepsis. Pathology 2003, 35(3):240-243.
6. Manucha V, Rusia U, Sikka M, Faridi MM, Madan N: Utility of haematological parameters and C-reactive protein in the detection of neonatal sepsis. J Paediatr Child Health 2002, 38(5):459-464.
7. Mishra UK, Jacobs SE, Doyle LW, Garland SM: Newer approaches to the diagnosis of early onset neonatal sepsis. Arch Dis Child Fetal Neonatal Ed 2006, 91(3):F208-F212.
8. Vigushin DM, Pepys MB, Hawkins PN: Metabolic and scintigraphic studies of radio iodinated human C-reactive protein in health and disease. J Clin Invest 1993, 91(4):1351-1357.
9. Pourcyrous M, Bada HS, Korones SB, Baselski V, Wong SP: Significance of serial C-reactive protein responses in neonatal infection and other disorders. Pediatrics 1993, 92(3):431-435.
10. Nuntnarumit P, Pinkaew O, Kitiwanwanich S: Predictive values of serial C-reactive protein in neonatal sepsis. J Med Assoc Thai 2002, 85(Suppl 4):S1151-S1158.
11. Philip AG, Mills PC: Use of C-reactive protein in minimizing antibiotic exposure: experience with infants initially admitted to a well-baby nursery. Pediatrics 2000, 106(1):E4.
12. Kumar R, Musoke R, Macharia WM, Revathi G: Validation of c-reactive protein in the early diagnosis of neonatal sepsis in a tertiary care hospital in Kenya. East Afr Med J 2010, 87(6):255-261.
13. Bomela HN, Ballot DE, Cory BJ, Cooper PA: Use of C-reactive protein to guide duration of empiric antibiotic therapy in suspected early neonatal sepsis. Pediatr Infect Dis J 2000, 19(6):531-535.
14. Ehl S, Gering B, Bartmann P, Hogel J, Pohlandt F: C-reactive protein is a useful marker for guiding duration of antibiotic therapy in suspected neonatal bacterial infection. Pediatrics 1997, 99(2):216-221.
15. Mhada TV, Fredrick F, Matee MI, Massawe A: Neonatal sepsis at Muhimbili National Hospital, Dar es Salaam, Tanzania; aetiology, antimicrobial sensitivity pattern and clinical outcome. BMC Public Health 2012, 12:904.
16. Blomberg B, Mwakagile DS, Urassa WK, Maselle SY, Mashurano M, Digranes A, Harthug S, Langerland N: Surveillance of antimicrobial resistance at a tertiary hospital in Tanzania. BMC Public Health 2004, 4:45.
17. Kayange N, Kamugisha E, Mwizamholya DL, Jeremiah S, Mshana SE: Predictors of positive blood culture and deaths among neonates with suspected neonatal sepsis in a tertiary hospital, Mwanza-Tanzania. BMC Pediatr 2010, 10:39.
18. Urassa WK, Haule EA, Kagoma C, Langeland N: Antimicrobial susceptibility of Staphylococcus aureus strains at Muhimbili Medical Centre, Tanzania. East Afr Med J 1999, 76(12):693-695.
19. Rubarth L: Nursing patterns of knowing in assessment of newborn sepsis. Clin-Nurse-Spec Clin-Nurse-Spec 2007, 21:2.
20. Murray PR, Baron E, Pfaller MA, Tenovar FC, Yolken RH: Manual of Clinical Microbiology. 7th edition. Washington, DC: American Society for Microbiology; 1999.
21. Wickler MA, Cockrill FR: Performance Standard for Antimicrobial Susceptibility Testing: Eighteenth Supplement. Wayne, PA: Clinical and Laboratory Standard Institute; 2006.
22. Ogunlesi TA, Ogunfowora OB, Osinupebi O, Olanrewaju DM: Changing trends in newborn sepsis in Sagamu, Nigeria: bacterial aetiology, risk factors and antibiotic susceptibility. J Paediatr Child Health 2011, 47(1-2):5-11.
23. West BA, Peterside O, Ugwu RO, Eneh AU: Prospective evaluation of the usefulness of C-reactive protein in the diagnosis of neonatal sepsis in a sub-Saharan African region. Antimicrob Resist Infect Control 2012, 1(1):22.
24. Jankovic B, Pasic S, Markovic M, Veljkovic D, Milicic M: C-reactive protein concentrations during initial (empiric) treatment of neonatal sepsis. Srp Arh Celok Lek 2001, 129(Suppl 1):17-22.
25. Hemels MA, van den Hoogen A, Verboon-Maciolek MA, Fleer A, Krediet TG: Shortening the antibiotic course for the treatment of neonatal coagulase-negative staphylococcal sepsis: fine with three days? Neonatology 2012, 101(2):101-105.
26. Bloomberg B, Manji KP, Urassa WK, Tamim BS, Mwakagile DS, Jureen R, Msangi V, Tellevik MG, Holberg-Petersen M, Harthung S, Maselle SY, Langerland N: Antimicrobial resistance predicts death in Tanzanian children with bloodstream infections: a prospective cohort study. BMC Infect Dis 2007, 7:43.
27. Blomberg B, Jureen R, Manji KP, Tamim BS, Mwakagile DS, Urassa WK, Fataki M, Msangi V, Tellevik MG, Maselle SY, Langerland N: High rate of fatal cases of pediatric septicemia caused by gram-negative bacteria with extended spectrum beta-lactamases in Dar es Salaam, Tanzania. J Clin Microbiol 2005, 43(2):745-749.
28. Mugalu J, Nakakeeto MK, Kiguli S, Kaddu-Mulindwa DH: Aetiology, risk factors and immediate outcome of bacteriologically confirmed neonatal septicaemia in Mulago hospital, Uganda. Afr Health Sci 2006, 6(2):120-126.
29. Viswanathan R, Singh AK, Ghosh C, Dasgupta S, Mukherjee S, Basu S: Profile of neonatal septicaemia at a district-level sick newborn care unit. J Health Popul Nutr 2012, 30(1):418.