Enhanced and suppressed mineralization by acetoacetate and β-hydroxybutyrate in osteoblast cultures

Biochemical and Biophysical Research Communications

Volumn 473, Issue 2, 2016, Pages 537-544

  Saito, Akihiro ^a   Yoshimura, Kentaro ^a   Miyamoto, Yoichi ^a   Kaneko, Kotaro ^a,b   Chikazu, Daichi ^b   Yamamoto, Matsuo ^a   Kamijo, Ryutaro ^a  

^a SHOWA UNIVERSITY SCHOOL OF DENTISTRY   (Japan)

^b TOKYO MEDICAL UNIVERSITY   (Japan)

Author keywords

Alkaline phosphatase; Ketone bodies; Mineralization; Osteoblasts

Indexed keywords

3 HYDROXYBUTYRIC ACID; ACETOACETIC ACID; ALKALINE PHOSPHATASE; MESSENGER RNA; MONOCARBOXYLATE TRANSPORTER 1; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2; ACETOACETIC ACID DERIVATIVE; KETONE BODY;

ANIMAL CELL; ARTICLE; BONE MINERALIZATION; CELL CULTURE; CELL FUNCTION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; ENZYME REGULATION; EXTRACELLULAR MATRIX; GENE SILENCING; MOUSE; NEWBORN; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION; ANIMAL; CELL LINE; CYTOLOGY; METABOLISM;

3-HYDROXYBUTYRIC ACID; ACETOACETATES; ALKALINE PHOSPHATASE; ANIMALS; CALCIFICATION, PHYSIOLOGIC; CELL LINE; CELLS, CULTURED; KETONE BODIES; MICE; OSTEOBLASTS;

EID: 84962090716     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2016.03.109     Document Type: Article

References (30)

1. Y.-Y. Wu, Y. Xia, and D.T. Granes Diabetes mellitus related bone metabolism and periodontal disease J. Oral Sci. 7 2015 63 72
2. R. Liu, G.S. Bal, T. Desta, N. Krothapalli, M. Alyassi, Q. Luan, and D.T. Graves Diabetes enhances periodontal bone loss through enhanced resorption and diminished bone formation J. Dent. Res. 2006 510 514
3. M. Retzepi, and N. Donos The effect of diabetes mellitus on osseous healing Clin. Oral Implants Res. 21 2010 673 681
4. fa rats J. Bone Min. Metab. 30 2012 312 320
5. S. Yamagishi Role of advanced glycation end products (AGEs) in osteoporosis in diabetes Curr. Drug Targets 12 2011 2096 2102
6. G. Hein, C. Weiss, G. Lehmann, T. Niwa, G. Stein, and et al. Advanced glycation end product modification of bone proteins and bone remodelling: hypothesis and preliminary immunohistochemical findings Ann. Rheum. Dis. 65 2006 101 104
7. P. Vestergaard Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes-a meta-analysis Osteoporos. Int. 18 2007 427 444
8. M. Janghorbani, R.M. Van Dam, W.C. Willett, and F.B. Hu Systematic review of type 1 and type 2 diabetes mellitus and risk of fracture Am. J. Epidemiol. 166 2007 495 505
9. M. Saito, and K. Marumo Collagen cross-links as a determinant of bone quality: a possible explanation for bone fragility in aging, osteoporosis, and diabetes mellitus Osteoporos. Int. 21 2010 195 214
10. Qiao JH1, R.B. Mertens, M.C. Fishbein, and S.A. Geller Cartilaginous metaplasia in calcified diabetic peripheral vascular disease: morphologic evidence of enchondral ossification Hum. Pathol. 34 2003 402 407
11. R.G. Micheletti, G.A. Fishbein, J.S. Currier, E.J. Singer, and M.C. Fishbein Calcification of the internal elastic lamina of coronary arteries Mod. Pathol. 21 2008 1019 1028
12. O.E. Owen, P. Felig, A.P. Morgan, J. Wahren, and G.F. Cahill Liver and kidney metabolism during prolonged starvation J. Clin. Invest 48 1969 574 583
13. T. Fukao, G.D. Lopaschuk, and G.A. Mitchell Pathways and control of ketone body metabolism: on the fringe of lipid biochemistry Prostagl. Leukot. Essent. Fat. Acids 70 2004 243 251
14. G.F. Cahill, M.G. Herrera, A.P. Morgan, J.S. Soeldner, J. Steinke, and et al. Hormone-fuel interrelationships during fasting J. Clin. Invest 45 1966 1751 1769
15. A.M. Robinson, and D.H. Williamson Physiological roles of ketone bodies as substrates and signals in mammalian tissues Physiol. Rev. 60 1980 143 187
16. L. Laffel Ketone bodies: a review of physiology, pathophysiology and application of monitoring to diabetes Diabetes Metab. Res. Rev. 15 1999 412 426
17. H.A. Krebs, and L.V. Eggleston Metabolism of acetoacetate in animal tissues Biochem. J. 39 1945 408 419
18. 3 in osteoclast differentiation and function Methods Enzymol. 282 1997 223 235
19. T.A. Hough, M. Polewski, K. Johnson, M. Cheeseman, P.M. Nolan, and et al. Novel mouse model of autosomal semidominant adult hypophosphatasia has a splice site mutation in the tissue nonspecific alkaline phosphatase gene Akp2 J. Bone Min. Res. 22 2007 1397 1407
20. F. Müller, K. Huber, H. Pfannkuche, J.R. Aschenbach, G. Breves, and et al. Transport of ketone bodies and lactate in the sheep ruminal epithelium by monocarboxylate transporter 1 Am. J. Physiol. Gastrointest. Liver Physiol. 283 2002 G1139 G1146
21. A.P. Halestrap, and M.C. Wilson The monocarboxylate transporter family - role and regulation IUBMB Life 64 2012 109 119
22. J.C. Newman, and E. Verdin Ketone bodies as signaling metabolites Trends Endocrinol. Metab. 25 2014 42 52
23. H.S. Berner, S.P. Lyngstadaas, A. Spahr, M. Monjo, L.C. Thommesen, and et al. Adiponectin and its receptors are expressed in bone-forming cells Bone 35 2004 842 849
24. X.H. Luo, L.J. Guo, H. Xie, L.Q. Yuan, X.P. Wu, and et al. Adiponectin stimulates RANKL and inhibits OPG expression in human osteoblasts through the MAPK signaling pathway J. Bone Min. Res. 21 2006 1648 1656
25. N.K. Lee, H. Sowa, E. Hinoi, M. Ferron, J.D. Ahn, and et al. Endocrine regulation of energy metabolism by the skeleton Cell 130 2007 456 469
26. M. Ferron, J. Wei, T. Yoshizawa, A. Del Fattore, R.A. DePinho, and et al. Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism Cell 142 2010 296 308
27. T. Shimazu, M.D. Hirschey, J. Newman, W. He, K. Shirakawa, and et al. Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor Science 339 2013 211 214
28. J.M. Stephens, M.J. Sulway, and P.J. Watkins Relationship of blood acetoacetate and 3-hydroxybutyrate in diabetes Diabetes 20 1971 485 489
29. A.P. Halestrap, and N.T. Price The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation Biochem. J. 343 1999 281 299
30. A.P. Halestrap, and D. Meredith The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond Pflugers Arch. 447 2004 619 628