Increasing placebo responses over time in U.S. clinical trials of neuropathic pain

Pain

Volumn 156, Issue 12, 2015, Pages 2616-2626

  Tuttle, Alexander H ^a   Tohyama, Sarasa ^a   Ramsay, Tim ^b   Kimmelman, Jonathan ^c   Schweinhardt, Petra ^a   Bennett, Gary J ^a   Mogil, Jeffrey S ^a  

^a MCGILL UNIVERSITY   (Canada)

^b OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^c MCGILL UNIVERSITY   (Canada)

Author keywords

Clinical trials; Geography; Neuropathic; Placebo; Trends

Indexed keywords

4,6 DICHLORO 3 (2 OXO 1 PHENYL 3 PYRROLIDINYLIDENEMETHYL) 1H INDOLE 2 CARBOXYLIC ACID; AJULEMIC ACID; AMFEBUTAMONE; ANALGESIC AGENT; ASCORBIC ACID; BOTULINUM TOXIN A; DILMAPIMOD; DULOXETINE; GABAPENTIN; GW 406381; HARKOSERIDE; LAMOTRIGINE; LEVACECARNINE; LEVODOPA; MEMANTINE; MEXILETINE; MORPHINE; NABIXIMOLS; NORTRIPTYLINE; OXCARBAZEPINE; PLACEBO; PREGABALIN; PROSTAGLANDIN B; RILUZOLE; TEBANICLINE; TOPIRAMATE; TRAMADOL; UNINDEXED DRUG; VALPROATE SEMISODIUM; ZONISAMIDE;

ANALGESIA; ARTICLE; CHRONIC PAIN; CROSSOVER PROCEDURE; DISEASE DURATION; DRUG DOSE REGIMEN; DRUG RESPONSE; GEOGRAPHIC DISTRIBUTION; HUMAN; INTENTION TO TREAT ANALYSIS; META ANALYSIS; NEUROPATHIC PAIN; PAIN INTENSITY; PARALLEL DESIGN; PLACEBO EFFECT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); SAMPLE SIZE; SEX DIFFERENCE; SYSTEMATIC REVIEW; UNITED STATES; VISUAL ANALOG SCALE; NEURALGIA;

ANALGESICS; CHRONIC PAIN; HUMANS; NEURALGIA; PLACEBO EFFECT; RANDOMIZED CONTROLLED TRIALS AS TOPIC; UNITED STATES;

EID: 84962079402     PISSN: 03043959     EISSN: 18726623     Source Type: Journal    
DOI: 10.1097/j.pain.0000000000000333     Document Type: Article

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