Red blood cell Pig-a assay and PIGRET assay in rats with azathioprine

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 811, Issue , 2016, Pages 60-64

  Yoshida, Ikuma ^a   Matsumoto, Akemi ^a   Sakai, Yumi ^a   Harada, Yumiko ^a   Hashizume, Tsuneo ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

Author keywords

Azathioprine; Gene mutation; Pig a gene; Red blood cells; Reticulocytes

Indexed keywords

AZATHIOPRINE; ETHYLNITROSOUREA; MEMBRANE PROTEIN; MUTAGENIC AGENT; PHOSPHATIDYLINOSITOL GLYCAN-CLASS A PROTEIN;

ARTICLE; CELL ASSAY; COMPARATIVE STUDY; CONTROLLED STUDY; ERYTHROCYTE; IN VIVO STUDY; MALE; MUTAGENICITY; NONHUMAN; PIG A ASSAY; PIGRET ASSAY; PRIORITY JOURNAL; RAT; RETICULOCYTE; WEIGHT GAIN; ANIMAL; DRUG EFFECTS; GENETICS; MUTAGEN TESTING; PROCEDURES; SPRAGUE DAWLEY RAT;

ANIMALS; AZATHIOPRINE; ERYTHROCYTES; MALE; MEMBRANE PROTEINS; MUTAGENICITY TESTS; MUTAGENS; RATS; RATS, SPRAGUE-DAWLEY; RETICULOCYTES;

EID: 84962074427     PISSN: 13835718     EISSN: 18793592     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2016.01.009     Document Type: Article

References (23)

1. [1] Kimoto, T., Introduction to a special issue on the Pig-a gene mutation assay. Genes Environ. 36 (2014), 167–168.
2. [2] Miura, D., The in vivo Pig-a gene mutation assay. Genes Environ. 36 (2014), 169–173.
3. [3] Gollapudi, B.B., Lynch, A.M., Heflich, R.H., Dertinger, S.D., Dobrovolsky, V.N., Froetschl, R., et al. The in vivo Pig-a assay: a report of the international workshop on genotoxicity testing (IWGT) workgroup. Mutat. Res. 783 (2015), 23–25.
4. [4] Kimoto, T., Chikura, S., Suzuki, K., Kobayashi, X.M., Itano, Y., Horibata, K., et al. Further development of the rat Pig-a mutation assay: measuring rat Pig-a mutant bone marrow erythroids and a high throughput assay for mutant peripheral blood reticulocytes. Environ. Mol. Mutagen. 52 (2011), 774–783.
5. [5] Flowers, C.R., Melmon, K.L., Clinical investigators as critical determinants in pharmaceutical innovation. Nat. Med. 3 (1997), 136–143.
6. [6] Nelson, J.A., Carpenter, J.W., Rose, L.M., Adamson, D.J., Mechanisms of action of 6-thioguanine, 6-mercaptopurine, and 8-azaguanine. Cancer Res. 35 (1975), 2872–2878.
7. [7] IARC, Azathioprine In Some Antineoplastic and Immunosuppressive Agents. IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Humans, 26 International Agency for Research on Cancer Lyon (1981).
8. [8] IARC, Azathioprine In Overall Evaluations of Carcinogenicity IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Humans, Suppl. (7) Lyon (1987).
9. [9] Cohen, S.M., Erturk, E., Skibba, J.L., Bryan, G.T., Azathioprine induction of lymphomas and squamous cell carcinomas in rats. Cancer Res. 43 (1983), 2768–2772.
10. [10] Speck, W.T., Rosenkranz, H.S., Mutagenicity of azathioprine. Cancer Res. 36 (1976), 108–109.
11. [11] Bruce, W.R., Heddle, J.A., The mutagenic activity of 61 agents as determined by the micronucleus salmonella, and sperm abnormality assays. Can. J. Genet. Cytol. 21 (1979), 319–333.
12. [12] Kucerová, M., Polívková, Z., Mutagenic effects of different mutagens on human chromosomes in vitro and in vivo as detected by conventional and harlequin method. Dev. Toxicol. Environ. Sci. 2 (1977), 319–325.
13. [13] Vian, L., Bichet, N., Gouy, D., The in vitro micronucleus test on isolated human lymphocytes. Mutat. Res. 291 (1993), 93–102.
14. [14] Wakata, A., Miyamae, Y., Sato, S., Suzuki, T., Morita, T., Asano, N., et al. Evaluation of the rat micronucleus test with bone marrow and peripheral blood: summary of the 9th collaborative study by CSGMT/JEMS.MMS. Environ. Mol. Mutagen. 32 (1998), 84–100.
15. [15] Bendre, S.V., Shaddock, J.G., Patton, R.E., Dobrovolsky, V.N., Albertini, R.J., Heflich, R.H., Lymphocyte Hprt mutant frequency and sperm toxicity in C57BL/6 mice treated chronically with Azathioprine. Mutat. Res. 578 (2005), 1–14.
16. [16] Smith, C.C., Archer, G.E., Forster, E.J., Lambert, T.R., Rees, R.W., Lynch, A.M., Analysis of gene mutations and clastogenicity following short-term treatment with azathioprine in Muta™Mouse. Environ. Mol. Mutagen. 34 (1999), 131–139.
17. [17] Dertinger, S.D., Phonethepswath, S., Avlasevich, S.L., Torous, D.K., Mereness, J., Bryce, S.M., et al. Efficient monitoring of In vivo Pig-a gene mutation and chromosomal damage: summary of 7 published studies and results from 11 new reference compounds. Toxicol. Sci. 130 (2012), 328–348.
18. [18] Itoh, S., Nagata, M., Hattori, C., Takasaki, W., In vivo mutagenicity of ethyl methanesulfonate detected by Pig-a and PIGRET assays. Genes Environ. 36 (2014), 174–178.
19. [19] Sanada, H., Okamoto, M., Ohsumi, T., Nakamura, T., Evaluation for a mutagenicity of 4,4'-methylenedianiline on hematopoietic cells by a Pig-a gene mutation assay in rats. Genes Environ. 36 (2014), 179–185.
20. [20] Muto, S., Yamada, K., Kato, T., Iwase, Y., Uno, Y., Pig-a gene mutation and micronucleus induction in rat peripheral blood by methyl methanesulfonate. Genes Environ. 36 (2014), 186–190.
21. [21] Horibata, K., Ukai, A., Honma, M., Evaluation of rats’ in vivo genotoxicity induced by N-ethyl-N-nitrosourea in the RBC Pig-a, PIGRET, and gpt assays. Genes Environ 36 (2014), 199–202.
22. [22] Kimoto, T., Horibata, K., Chikura, S., Hashimoto, K., Itoh, S., Sanada, H., et al. Interlaboratory trial of the rat Pig-a mutation assay using an erythroid marker HIS49 antibody. Mutat. Res. 755 (2013), 126–134.
23. [23] D. Miura, et al. Potential value of the Pig-a gene mutation assay in reticulocytes (PIGRET Assay) using rats as a short-term genotoxicity test: Summary of the collaborative study across 16 laboratories using 24 chemicals by the Mammalian Mutagenicity Study (MMS) Group of the Japanese Environmental Mutagenicity Society (JEMS).