Metabolomic network analysis of estrogen-stimulated MCF-7 cells: a comparison of overrepresentation analysis, quantitative enrichment analysis and pathway analysis versus metabolite network analysis

Archives of Toxicology

Volumn 91, Issue 1, 2017, Pages 217-230

  Maertens, Alexandra ^a   Bouhifd, Mounir ^a   Zhao, Liang ^a   Odwin DaCosta, Shelly ^a   Kleensang, Andre ^a   Yager, James D ^a   Hartung, Thomas ^a,b,c  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^c UNIVERSITY OF KONSTANZ   (Germany)

Author keywords

Bioinformatics; Computational toxicology; Endocrine disruption; Estrogen; Metabolomics; Pathway analysis

Indexed keywords

2 OXOGLUTARIC ACID; ACETIC ACID DERIVATIVE; ADENOSINE; BETAINE; BIOTIN; CARNITINE; CYSTEINE; DEOXYCYTIDINE; ESTRADIOL; ESTROGEN; FOLIC ACID; FRUCTOSE; GLUTATHIONE; GLYCEROLIPID; GLYCINE; HYPOXANTHINE; MANNOSE; METHIONINE; PHENYLALANINE; POLYAMINE; PTERIN; PURINE; PUTRESCINE; PYRUVIC ACID; SERINE; SUCCINIC ACID; TAURINE; THREONINE; TYROSINE; UNINDEXED DRUG; ENDOCRINE DISRUPTOR;

ACCURACY; ANALYTICAL ERROR; ARTICLE; CATECHOLAMINE METABOLISM; CELL PROLIFERATION; CELL STIMULATION; COMPARATIVE STUDY; CONTROLLED STUDY; DEGRADATION; FATTY ACID OXIDATION; GLUTATHIONE METABOLISM; GLYCOLYSIS; HUMAN; HUMAN CELL; LIPID METABOLISM; LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY; MCF-7 CELL LINE; METABOLISM; METABOLITE; METABOLOMICS; PHENOTYPE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REPRODUCIBILITY; SPHINGOLIPID METABOLISM; BIOLOGICAL MODEL; BIOLOGY; DATA MINING; DRUG EFFECTS; ELECTROSPRAY MASS SPECTROMETRY; ENERGY METABOLISM; FACTUAL DATABASE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLOME; PROCEDURES; SECONDARY METABOLISM; TOXICOLOGY;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COMPUTATIONAL BIOLOGY; DATA MINING; DATABASES, FACTUAL; ENDOCRINE DISRUPTORS; ENERGY METABOLISM; ESTRADIOL; ESTROGENS; HUMANS; MCF-7 CELLS; METABOLOME; METABOLOMICS; MODELS, BIOLOGICAL; REPRODUCIBILITY OF RESULTS; SECONDARY METABOLISM; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TOXICOLOGY;

EID: 84962019521     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-016-1695-x     Document Type: Article

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