Clusterin modulates allergic airway inflammation by attenuating ccl20-mediated dendritic cell recruitment

Journal of Immunology

Volumn 196, Issue 5, 2016, Pages 2021-2030

  Hong, Gyong Hwa ^a,b   Kwon, Hyouk Soo ^c   Moon, Keun Ai ^b   Park, So Young ^c   Park, Sunjoo ^b   Young Lee, Kyoung ^b   Ha, Eun Hee ^a,b   Kim, Tae Bum ^c   Moon, Hee Bom ^c   Lee, Heung Kyu ^a   Cho, You Sook ^c  

^a Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

^b Asan Institute for Life Sciences   (South Korea)

^c University of Ulsan College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CD11B ANTIGEN; CELL PROTEIN; CLUSTERIN; GLYCOPROTEIN P 15095; LY6C PROTEIN; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ALLERGIC AIRWAY INFLAMMATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRONCHOALVEOLAR LAVAGE FLUID; BRONCHUS MUCOSA; CELL COUNT; CELL MIGRATION; CELL POPULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DENDRITIC CELL; DERMATOPHAGOIDES; DOWN REGULATION; EPITHELIUM CELL; FEMALE; IMMUNOCOMPETENT CELL; IMMUNOPATHOGENESIS; MONOCYTE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS REGULATION; UPREGULATION; ANIMAL; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; HUMAN; IMMUNOBLOTTING; IMMUNOLOGY; KNOCKOUT MOUSE; LUNG LAVAGE; NEUTROPHIL CHEMOTAXIS; PNEUMONIA; PYROGLYPHIDAE; RESPIRATORY TRACT ALLERGY; RESPIRATORY TRACT MUCOSA;

ANIMALS; BRONCHOALVEOLAR LAVAGE; CHEMOKINE CCL20; CHEMOTAXIS, LEUKOCYTE; CLUSTERIN; DENDRITIC CELLS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; HUMANS; IMMUNOBLOTTING; MICE; MICE, KNOCKOUT; OXIDATIVE STRESS; PNEUMONIA; PYROGLYPHIDAE; RESPIRATORY HYPERSENSITIVITY; RESPIRATORY MUCOSA;

EID: 84962010486     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1500747     Document Type: Article

References (46)

1. Lloyd, C. M., and E. M. Hessel. 2010. Functions of T cells in asthma: more than just T(H)2 cells. Nat. Rev. Immunol. 10: 838-848
2. Islam, S. A., and A. D. Luster. 2012. T cell homing to epithelial barriers in allergic disease. Nat. Med. 18: 705-715
3. Hammad, H., and B. N. Lambrecht. 2008. Dendritic cells and epithelial cells: linking innate and adaptive immunity in asthma. Nat. Rev. Immunol. 8: 193-204
4. Wang, Y., C. Bai, K. Li, K. B. Adler, and X. Wang. 2008. Role of airway epithelial cells in development of asthma and allergic rhinitis. Respir. Med. 102: 949-955
5. Lambrecht, B. N., and H. Hammad. 2003. Taking our breath away: dendritic cells in the pathogenesis of asthma. Nat. Rev. Immunol. 3: 994-1003
6. Wilson, M. R., and S. B. Easterbrook-Smith. 2000. Clusterin is a secreted mammalian chaperone. Trends Biochem. Sci. 25: 95-98
7. Humphreys, D. T., J. A. Carver, S. B. Easterbrook-Smith, and M. R. Wilson. 1999. Clusterin has chaperone-like activity similar to that of small heat shock proteins. J. Biol. Chem. 274: 6875-6881
8. Kim, J. H., J. H. Kim, H. O. Jun, Y. S. Yu, B. H. Min, K. H. Park, and K. W. Kim. 2010. Protective effect of clusterin from oxidative stress-induced apoptosis in human retinal pigment epithelial cells. Invest. Ophthalmol. Vis. Sci. 51: 561-566
9. Viard, I., P. Wehrli, L. Jornot, R. Bullani, J.-L. Vechietti, J. A. Schifferli, J. Tschopp, and L. E. French. 1999. Clusterin expression mediates resistance to apoptotic cell death induced by heat shock and oxidative stress. J. Invest. Dermatol. 112: 290-296
10. Michel, D., G. Chatelain, S. North, and G. Brun. 1997. Stress-induced transcription of the clusterin/apoJ gene. Biochem. J. 328 (Pt. 1): 45-50
11. Shiota, M., A. Zoubeidi, M. Kumano, E. Beraldi, S. Naito, C. C. Nelson, P. H. Sorensen, and M. E. Gleave. 2011. Clusterin is a critical downstream mediator of stress-induced YB-1 transactivation in prostate cancer. Mol. Cancer Res. 9: 1755-1766
12. Caccamo, A. E., S. Desenzani, L. Belloni, A. F. Borghetti, and S. Bettuzzi. 2006. Nuclear clusterin accumulation during heat shock response: implications for cell survival and thermo-tolerance induction in immortalized and prostate cancer cells. J. Cell. Physiol. 207: 208-219
13. Kwon, H. S., T. B. Kim, Y. S. Lee, S. H. Jeong, Y. J. Bae, K. A. Moon, B. R. Bang, H. B. Moon, and Y. S. Cho. 2014. Clusterin expression level correlates with increased oxidative stress in asthmatics. Ann. Allergy Asthma Immunol. 112: 217-221
14. Ito, T., W. F. Carson, IV, K. A. Cavassani, J. M. Connett, and S. L. Kunkel. 2011. CCR6 as a mediator of immunity in the lung and gut. Exp. Cell Res. 317: 613-619
15. Weckmann, M., A. Collison, J. L. Simpson, M. V. Kopp, P. A. Wark, M. J. Smyth, H. Yagita, K. I. Matthaei, N. Hansbro, B. Whitehead, et al. 2007. Critical link between TRAIL and CCL20 for the activation of TH2 cells and the expression of allergic airway disease. Nat. Med. 13: 1308-1315
16. Pichavant, M., A. S. Charbonnier, S. Taront, A. Brichet, B. Wallaert, J. Pestel, A. B. Tonnel, and P. Gosset. 2005. Asthmatic bronchial epithelium activated by the proteolytic allergen Der p 1 increases selective dendritic cell recruitment. J. Allergy Clin. Immunol. 115: 771-778
17. Lee, A. Y., and H. Körner. 2014. CCR6 and CCL20: emerging players in the pathogenesis of rheumatoid arthritis. Immunol. Cell Biol. 92: 354-358
18. Lee, H.-J., S.-C. Choi, M.-H. Lee, H.-M. Oh, E.-Y. Choi, E.-J. Choi, K.-J. Yun, G.-S. Seo, S.-W. Kim, J.-G. Lee, et al. 2005. Increased expression of MIP- 3alpha/CCL20 in peripheral blood mononuclear cells from patients with ulcerative colitis and its down-regulation by sulfasalazine and glucocorticoid treatment. Inflamm. Bowel Dis. 11: 1070-1079
19. Ryu, J. H., J. Y. Yoo, M. J. Kim, S. G. Hwang, K. C. Ahn, J. C. Ryu, M. K. Choi, J. H. Joo, C. H. Kim, S. N. Lee, et al. 2013. Distinct TLR-mediated pathways regulate house dust mite-induced allergic disease in the upper and lower airways. J. Allergy Clin. Immunol. 131: 549-561
20. Kim, T. B., K. A. Moon, K. Y. Lee, C. S. Park, Y. J. Bae, H. B. Moon, and Y. S. Cho. 2009. Chlamydophila pneumoniae triggers release of CCL20 and vascular endothelial growth factor from human bronchial epithelial cells through enhanced intracellular oxidative stress and MAPK activation. J. Clin. Immunol. 29: 629-636
21. Cho, Y. S., S. Y. Oh, and Z. Zhu. 2008. Tyrosine phosphatase SHP-1 in oxidative stress and development of allergic airway inflammation. Am. J. Respir. Cell Mol. Biol. 39: 412-419
22. Jiang, L., P. T. Diaz, T. M. Best, J. N. Stimpfl, F. He, and L. Zuo. 2014. Molecular characterization of redox mechanisms in allergic asthma. Ann. Allergy Asthma Immunol. 113: 137-142
23. Rosanna, D. P., and C. Salvatore. 2012. Reactive oxygen species, inflammation, and lung diseases. Curr. Pharm. Des. 18: 3889-3900
24. Ahmad, A., M. Shameem, and Q. Husain. 2012. Relation of oxidant-antioxidant imbalance with disease progression in patients with asthma. Ann. Thorac. Med. 7: 226-232
25. Lambrecht, B. N., and H. Hammad. 2009. Biology of lung dendritic cells at the origin of asthma. Immunity 31: 412-424
26. Reizis, B. 2012. Classical dendritic cells as a unique immune cell lineage. J. Exp. Med. 209: 1053-1056
27. Balhara, J., and A. S. Gounni. 2012. The alveolar macrophages in asthma: a double-edged sword. Mucosal Immunol. 5: 605-609
28. Peters-Golden, M. 2004. The alveolar macrophage: the forgotten cell in asthma. Am. J. Respir. Cell Mol. Biol. 31: 3-7
29. Soroosh, P., T. A. Doherty, W. Duan, A. K. Mehta, H. Choi, Y. F. Adams, Z. Mikulski, N. Khorram, P. Rosenthal, D. H. Broide, and M. Croft. 2013. Lungresident tissue macrophages generate Foxp3+ regulatory T cells and promote airway tolerance. J. Exp. Med. 210: 775-788
30. Zasłona, Z., S. Przybranowski, C. Wilke, N. van Rooijen, S. Teitz-Tennenbaum, J. J. Osterholzer, J. E. Wilkinson, B. B. Moore, and M. Peters-Golden. 2014. Resident alveolar macrophages suppress, whereas recruited monocytes promote, allergic lung inflammation in murine models of asthma. J. Immunol. 193: 4245-4253
31. Dalle-Donne, I., R. Rossi, R. Colombo, D. Giustarini, and A. Milzani. 2006. Biomarkers of oxidative damage in human disease. Clin. Chem. 52: 601-623
32. Kim, Y. M., Y. S. Kim, S. G. Jeon, and Y. K. Kim. 2013. Immunopathogenesis of allergic asthma: more than the th2 hypothesis. Allergy Asthma Immunol. Res. 5: 189-196
33. Holgate, S. T. 2012. Innate and adaptive immune responses in asthma. Nat. Med. 18: 673-683
34. Beasley, R., A. Semprini, and E. A. Mitchell. 2015. Risk factors for asthma: is prevention possible? Lancet 386: 1075-1085
35. Ober, C., and T. C. Yao. 2011. The genetics of asthma and allergic disease: a 21st century perspective. Immunol. Rev. 242: 10-30
36. Reddy, K.B., M. C. Karode, A. K. Harmony, and Philip H. Howe. 1996. Interaction of transforming growth factor beta receptors with apolipoprotein J/clusterin. Biochemistry 35: 309-314
37. Santilli, G., B. J. Aronow, and A. Sala. 2003. Essential requirement of apolipoprotein J (clusterin) signaling for IkappaB expression and regulation of NFkappaB activity. J. Biol. Chem. 278: 38214-38219
38. Tschopp, J., A. Chonn, S. Hertig, and L. E. French. 1993. Clusterin, the human apolipoprotein and complement inhibitor, binds to complement C7, C8 beta, and the b domain of C9. J. Immunol. 151: 2159-2165
39. Hall, J. D., M. D. Woolard, B. M. Gunn, R. R. Craven, S. Taft-Benz, J. A. Frelinger, and T. H. Kawula. 2008. Infected-host-cell repertoire and cellular response in the lung following inhalation of Francisella tularensis Schu S4, LVS, or U112. Infect. Immun. 76: 5843-5852
40. Lambrecht, B. N., and H. Hammad. 2012. Lung dendritic cells in respiratory viral infection and asthma: from protection to immunopathology. Annu. Rev. Immunol. 30: 243-270
41. Mesnil, C., C. M. Sabatel, T. Marichal, M. Toussaint, D. Cataldo, P. V. Drion, P. Lekeux, F. Bureau, and C. J. Desmet. 2012. Resident CD11b(+)Ly6c(-) lung dendritic cells are responsible for allergic airway sensitization to house dust mite in mice. PLoS One 7: e53242
42. Osterholzer, J. J., G. H. Chen, M. A. Olszewski, J. L. Curtis, G. B. Huffnagle, and G. B. Toews. 2009. Accumulation of CD11b+ lung dendritic cells in response to fungal infection results from the CCR2-mediated recruitment and differentiation of Ly-6Chigh monocytes. J. Immunol. 183: 8044-8053
43. Nathan, A. T., E. A. Peterson, J. Chakir, and M. Wills-Karp. 2009. Innate immune responses of airway epithelium to house dust mite are mediated through beta-glucan-dependent pathways. J. Allergy Clin. Immunol. 123: 612-618
44. Reibman, J., Y. Hsu, L. C. Chen, B. Bleck, and T. Gordon. 2003. Airway epithelial cells release MIP-3alpha/CCL20 in response to cytokines and ambient particulate matter. Am. J. Respir. Cell Mol. Biol. 28: 648-654
45. Schutyser, E., S. Struyf, and J. Van Damme. 2003. The CC chemokine CCL20 and its receptor CCR6. Cytokine Growth Factor Rev. 14: 409-426
46. Lukacs, N. W., D. M. Prosser, M. Wiekowski, S. A. Lira, and D. N. Cook. 2001. Requirement for the chemokine receptor CCR6 in allergic pulmonary inflammation. J. Exp. Med. 194: 551-555