메뉴 건너뛰기




Volumn 2016, Issue 3, 2016, Pages

Teriflunomide for multiple sclerosis

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ALEMTUZUMAB; BETA INTERFERON; BETA1A INTERFERON; FINGOLIMOD; FUMARIC ACID DIMETHYL ESTER; GLATIRAMER; MITOXANTRONE; NATALIZUMAB; PLACEBO; TERIFLUNOMIDE; CROTONIC ACID DERIVATIVE; IMMUNOLOGIC FACTOR; IMMUNOSUPPRESSIVE AGENT; TOLUIDINE DERIVATIVE;

EID: 84961927169     PISSN: 14651858     EISSN: None     Source Type: Journal    
DOI: 10.1002/14651858.CD009882.pub3     Document Type: Review
Times cited : (16)

References (83)
  • 1
    • 84921367793 scopus 로고    scopus 로고
    • Effect of teriflunomide on lymphocyte and neutrophil counts in patients with relapsing multiple sclerosis: results from the TOWER study
    • Comi G, Freedman MS, Kappos L, Miller A, Olsson TP, Wolinsky JS, et al. Effect of teriflunomide on lymphocyte and neutrophil counts in patients with relapsing multiple sclerosis: results from the TOWER study. Journal of the Neurological Sciences 2013;333:e376.
    • (2013) Journal of the Neurological Sciences , vol.333 , pp. e376
    • Comi, G.1    Freedman, M.S.2    Kappos, L.3    Miller, A.4    Olsson, T.P.5    Wolinsky, J.S.6
  • 2
    • 84894271594 scopus 로고    scopus 로고
    • Oral teriflunomide for patients with relapsing multiple sclerosis (TOWER): a randomised, double-blind, placebo-controlled, phase 3 trial
    • Confavreux C, O'Connor P, Comi G, Freedman MS, Miller AE, Olsson TP, et al. Oral teriflunomide for patients with relapsing multiple sclerosis (TOWER): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet Neurology 2014;13(3):247-56.
    • (2014) Lancet Neurology , vol.13 , Issue.3 , pp. 247-256
    • Confavreux, C.1    O'Connor, P.2    Comi, G.3    Freedman, M.S.4    Miller, A.E.5    Olsson, T.P.6
  • 3
    • 84885848919 scopus 로고    scopus 로고
    • The efficacy and safety of teriflunomide in patients with relapsing MS: results from TOWER, a phase , placebo-controlled study
    • Kappos L, Comi G, Confavreux C, Freedman MS, Miller AE, Olsson TP, et al. The efficacy and safety of teriflunomide in patients with relapsing MS: results from TOWER, a phase , placebo-controlled study. Multiple Sclerosis 2012;18:50-1.
    • (2012) Multiple Sclerosis , vol.18 , pp. 50-51
    • Kappos, L.1    Comi, G.2    Confavreux, C.3    Freedman, M.S.4    Miller, A.E.5    Olsson, T.P.6
  • 4
    • 84885237877 scopus 로고    scopus 로고
    • Teriflunomide efficacy and safety in patients with relapsing multiple sclerosis: results from tower, a second, pivotal, phase 3 placebo-controlled study
    • Miller A, Kappos L, Comi G, Confavreux C, Freedman M, Olsson T, et al. Teriflunomide efficacy and safety in patients with relapsing multiple sclerosis: results from tower, a second, pivotal, phase 3 placebo-controlled study. Neurology. 2013; Vol. 80.
    • (2013) Neurology , vol.80
    • Miller, A.1    Kappos, L.2    Comi, G.3    Confavreux, C.4    Freedman, M.5    Olsson, T.6
  • 5
    • 84939883753 scopus 로고    scopus 로고
    • Teriflunomide reduces relapses with sequelae and relapses leading to hospitalizations: results from the TOWER study
    • Miller AE, Macdonell R, Comi G, Freedman MS, Kappos L, Maurer M, et al. Teriflunomide reduces relapses with sequelae and relapses leading to hospitalizations: results from the TOWER study. Journal of Neurology 2014;261(9):1781-8.
    • (2014) Journal of Neurology , vol.261 , Issue.9 , pp. 1781-1788
    • Miller, A.E.1    Macdonell, R.2    Comi, G.3    Freedman, M.S.4    Kappos, L.5    Maurer, M.6
  • 8
    • 84863567558 scopus 로고    scopus 로고
    • Teriflunomide added to interferon-β in relapsing multiple sclerosis: a randomized phase trial
    • Freedman MS, Wolinsky JS, Wamil B, Confavreux C, Comi G, Kappos L, et al. Teriflunomide added to interferon-β in relapsing multiple sclerosis: a randomized phase trial. Neurology 2012;78(23):1877-85.
    • (2012) Neurology , vol.78 , Issue.23 , pp. 1877-1885
    • Freedman, M.S.1    Wolinsky, J.S.2    Wamil, B.3    Confavreux, C.4    Comi, G.5    Kappos, L.6
  • 9
    • 84864319222 scopus 로고    scopus 로고
    • Efficacy and Safety of Teriflunomide in Patients with Relapsing Multiple Sclerosis and Treated with Interferon-beta (TERACLES)
    • (accessed 12 January 2016)
    • NCT01252355 . Efficacy and Safety of Teriflunomide in Patients with Relapsing Multiple Sclerosis and Treated with Interferon-beta (TERACLES). www.clinicaltrials.gov/ct2/show/results/NCT01252355 (accessed 12 January 2016).
  • 10
    • 84921367793 scopus 로고    scopus 로고
    • Effect of teriflunomide on lymphocyte and neutrophil levels in patients with relapsing multiple sclerosis: results from the TEMSO study
    • Comi G, Benzerdjeb H, Wang L, Truffinet P, O'Connor P. Effect of teriflunomide on lymphocyte and neutrophil levels in patients with relapsing multiple sclerosis: results from the TEMSO study. Journal of Neurological Science 2013;333(Suppl 1):e376.
    • (2013) Journal of Neurological Science , vol.333 , pp. e376
    • Comi, G.1    Benzerdjeb, H.2    Wang, L.3    Truffinet, P.4    O'Connor, P.5
  • 11
    • 84857334051 scopus 로고    scopus 로고
    • Extension of a phase trial (TEMSO) of oral teriflunomide in multiple sclerosis with relapses: safety outcomes with up to 4 years of follow-Up
    • Comi G, O'Connor P, Wolinsky J, Confavreux C, Kappos L, Olsson T, et al. Extension of a phase trial (TEMSO) of oral teriflunomide in multiple sclerosis with relapses: safety outcomes with up to 4 years of follow-Up. Multiple Sclerosis 2011;17:S182-3.
    • (2011) Multiple Sclerosis , vol.17 , pp. S182-S183
    • Comi, G.1    O'Connor, P.2    Wolinsky, J.3    Confavreux, C.4    Kappos, L.5    Olsson, T.6
  • 12
    • 84899417883 scopus 로고    scopus 로고
    • Long-term safety and efficacy of teriflunomide in patients with relapsing forms of multiple sclerosis in the TEMSO extension trial
    • Freedman M, Wolinsky J, Comi G, Kappos L, Olsson T, Miller A, et al. Long-term safety and efficacy of teriflunomide in patients with relapsing forms of multiple sclerosis in the TEMSO extension trial. Multiple Sclerosis 2013;19:225.
    • (2013) Multiple Sclerosis , vol.19 , pp. 225
    • Freedman, M.1    Wolinsky, J.2    Comi, G.3    Kappos, L.4    Olsson, T.5    Miller, A.6
  • 13
    • 84921334427 scopus 로고    scopus 로고
    • Safety and efficacy of teriflunomide for up to 9 years in relapsing forms of multiple sclerosis: Update of the TEMSO extension trial
    • Freedman M, Wolinsky J, Comi G, Kappos L, Olsson T, Miller A, et al. Safety and efficacy of teriflunomide for up to 9 years in relapsing forms of multiple sclerosis: Update of the TEMSO extension trial. Neurology 2014; Vol. 82, issue Suppl 10:3-150.
    • (2014) Neurology , vol.82 , pp. 3-150
    • Freedman, M.1    Wolinsky, J.2    Comi, G.3    Kappos, L.4    Olsson, T.5    Miller, A.6
  • 14
    • 85027088144 scopus 로고    scopus 로고
    • Gastrointestinal symptoms infrequently lead to discontinuation of teriflunomide therapy
    • Freedman MS, Delhay JL, Benamor M. Gastrointestinal symptoms infrequently lead to discontinuation of teriflunomide therapy. Multiple Sclerosis 2012;18:S13.
    • (2012) Multiple Sclerosis , vol.18 , pp. S13
    • Freedman, M.S.1    Delhay, J.L.2    Benamor, M.3
  • 15
    • 84890183590 scopus 로고    scopus 로고
    • Impact of relapses with sequelae on disability, health-related quality of life, and fatigue in a population with relapsing forms of multiple sclerosis using data from TEMSO, a pivotal phase teriflunomide trial
    • Miller A, Lublin F, O'Connor P, Taniou C, Dive-Pouletty C. Impact of relapses with sequelae on disability, health-related quality of life, and fatigue in a population with relapsing forms of multiple sclerosis using data from TEMSO, a pivotal phase teriflunomide trial. Neurology 2012;78:P07.082.
    • (2012) Neurology , vol.78 , pp. P07082
    • Miller, A.1    Lublin, F.2    O'Connor, P.3    Taniou, C.4    Dive-Pouletty, C.5
  • 16
    • 84993817421 scopus 로고    scopus 로고
    • Effect of teriflunomide on relapses with sequelae and relapse leading to hospitalization in a population with relapsing forms of multiple sclerosis: results from the TEMSO study
    • Miller A, Lublin F, O'Connor P, Wolinsky J, Comi G, Kappos L, et al. Effect of teriflunomide on relapses with sequelae and relapse leading to hospitalization in a population with relapsing forms of multiple sclerosis: results from the TEMSO study. Neurology 2012;78:S30.003.
    • (2012) Neurology , vol.78 , pp. S30003
    • Miller, A.1    Lublin, F.2    O'Connor, P.3    Wolinsky, J.4    Comi, G.5    Kappos, L.6
  • 17
    • 85027089376 scopus 로고    scopus 로고
    • Efficacy of oral teriflunomide in multiple sclerosis with relapses: cognitive outcomes from a phase trial (TEMSO)
    • Miller A, O'Connor P, Wolinsky J, Confavreux C, Comi G, Kappos L, et al. Efficacy of oral teriflunomide in multiple sclerosis with relapses: cognitive outcomes from a phase trial (TEMSO). Multiple Sclerosis 2011;17:S182.
    • (2011) Multiple Sclerosis , vol.17 , pp. S182
    • Miller, A.1    O'Connor, P.2    Wolinsky, J.3    Confavreux, C.4    Comi, G.5    Kappos, L.6
  • 18
    • 84868013737 scopus 로고    scopus 로고
    • Pre-specified subgroup analyses of a placebo-controlled phase trial (TEMSO) of oral teriflunomide in relapsing multiple sclerosis
    • Miller AE, O'Connor P, Wolinsky JS, Confavreux C, Kappos L, Olsson TP, et al. Pre-specified subgroup analyses of a placebo-controlled phase trial (TEMSO) of oral teriflunomide in relapsing multiple sclerosis. Multiple Sclerosis 2012;18(11):1625-32.
    • (2012) Multiple Sclerosis , vol.18 , Issue.11 , pp. 1625-1632
    • Miller, A.E.1    O'Connor, P.2    Wolinsky, J.S.3    Confavreux, C.4    Kappos, L.5    Olsson, T.P.6
  • 19
    • 84961908841 scopus 로고    scopus 로고
    • Impact on health-related quality of life of teriflunomide treatment by estimating utilities in patients with relapsing multiple sclerosis: results from TEMSO post hoc analysis
    • O'Connor P, Briggs A, Carita P, Bego-Le-Bagousse G. Impact on health-related quality of life of teriflunomide treatment by estimating utilities in patients with relapsing multiple sclerosis: results from TEMSO post hoc analysis. Journal of Neurology 2012;259:S107.
    • (2012) Journal of Neurology , vol.259 , pp. S107
    • O'Connor, P.1    Briggs, A.2    Carita, P.3    Bego-Le-Bagousse, G.4
  • 20
    • 84857248654 scopus 로고    scopus 로고
    • Effect of teriflunomide on longitudinal patterns of relapse and relapse-related hospitalization in multiple sclerosis
    • O'Connor P, Burrell A, Wang L, Wei L, Carita P, Zhang Q. Effect of teriflunomide on longitudinal patterns of relapse and relapse-related hospitalization in multiple sclerosis. Multiple Sclerosis 2011;17:S414.
    • (2011) Multiple Sclerosis , vol.17 , pp. S414
    • O'Connor, P.1    Burrell, A.2    Wang, L.3    Wei, L.4    Carita, P.5    Zhang, Q.6
  • 21
    • 84890172879 scopus 로고    scopus 로고
    • Effect of teriflunomide on relapses leading to healthcare resource use: results from the TEMSO study
    • O'Connor P, Lublin F, Wolinsky J, Comi G, Kappos L, Freedman M, et al. Effect of teriflunomide on relapses leading to healthcare resource use: results from the TEMSO study. Multiple Sclerosis 2011;17:S95-6.
    • (2011) Multiple Sclerosis , vol.17 , pp. S95-S96
    • O'Connor, P.1    Lublin, F.2    Wolinsky, J.3    Comi, G.4    Kappos, L.5    Freedman, M.6
  • 22
    • 84857248654 scopus 로고    scopus 로고
    • Extension of a phase trial (TEMSO) of oral teriflunomide in multiple sclerosis with relapses: clinical and MRI data 5 years after initial randomization
    • O'Connor P, Wolinsky J, Confavreux C, Comi G, Kappos L, Olsson T, et al. Extension of a phase trial (TEMSO) of oral teriflunomide in multiple sclerosis with relapses: clinical and MRI data 5 years after initial randomization. Multiple Sclerosis 2011;17:S414-5.
    • (2011) Multiple Sclerosis , vol.17 , pp. S414-S415
    • O'Connor, P.1    Wolinsky, J.2    Confavreux, C.3    Comi, G.4    Kappos, L.5    Olsson, T.6
  • 27
    • 84885384570 scopus 로고    scopus 로고
    • A multicenter, randomized, parallel-group, rater-blinded study comparing the effectiveness and safety of teriflunomide and subcutaneous interferon beta-1a in patients with relapsing multiple sclerosis
    • Vermersch P, Czlonkowska A, Grimaldi LM, Confavreux C, Comi G, Kappos L, et al. A multicenter, randomized, parallel-group, rater-blinded study comparing the effectiveness and safety of teriflunomide and subcutaneous interferon beta-1a in patients with relapsing multiple sclerosis. Multiple Sclerosis 2012;18:S9-10.
    • (2012) Multiple Sclerosis , vol.18 , pp. S9-10
    • Vermersch, P.1    Czlonkowska, A.2    Grimaldi, L.M.3    Confavreux, C.4    Comi, G.5    Kappos, L.6
  • 28
    • 84901715475 scopus 로고    scopus 로고
    • Evaluation of patient satisfaction from the TENERE study: a comparison of teriflunomide and subcutaneous interferon beta-1a in patients with relapsing multiple sclerosis
    • Vermersch P, Czlonkowska A, Grimaldi LM, Confavreux C, Comi G, Kappos L, et al. Evaluation of patient satisfaction from the TENERE study: a comparison of teriflunomide and subcutaneous interferon beta-1a in patients with relapsing multiple sclerosis. Journal of Neurology 2012;259:S38.
    • (2012) Journal of Neurology , vol.259 , pp. S38
    • Vermersch, P.1    Czlonkowska, A.2    Grimaldi, L.M.3    Confavreux, C.4    Comi, G.5    Kappos, L.6
  • 29
    • 84897022266 scopus 로고    scopus 로고
    • Teriflunomide versus subcutaneous interferon beta-1a in patients with relapsing multiple sclerosis: a randomised, controlled phase 3 trial
    • Vermersch P, Czlonkowska A, Grimaldi LM, Confavreux C, Comi G, Kappos L, et al. Teriflunomide versus subcutaneous interferon beta-1a in patients with relapsing multiple sclerosis: a randomised, controlled phase 3 trial. Multiple Sclerosis 2014;20(6):705-16.
    • (2014) Multiple Sclerosis , vol.20 , Issue.6 , pp. 705-716
    • Vermersch, P.1    Czlonkowska, A.2    Grimaldi, L.M.3    Confavreux, C.4    Comi, G.5    Kappos, L.6
  • 30
    • 84961906658 scopus 로고    scopus 로고
    • The effect of teriflunomide on lymphocyte and neutrophil count in patients with a first clinical episode consistent with multiple sclerosis: results from the TOPIC study
    • Comi G, Miller AE, Wolinsky JS, Benamor M, Bauer D, Truffinet P, et al. The effect of teriflunomide on lymphocyte and neutrophil count in patients with a first clinical episode consistent with multiple sclerosis: results from the TOPIC study. European Journal of Neurology 2014;21:127-8.
    • (2014) European Journal of Neurology , vol.21 , pp. 127-128
    • Comi, G.1    Miller, A.E.2    Wolinsky, J.S.3    Benamor, M.4    Bauer, D.5    Truffinet, P.6
  • 31
    • 84908657313 scopus 로고    scopus 로고
    • TOPIC: efficacy and safety of once-daily oral teriflunomide in patients with first clinical episode consistent with multiple sclerosis
    • Miller A, Wolinsky J, Kappos L, Comi G, Freedman M, Olsson T, et al. TOPIC: efficacy and safety of once-daily oral teriflunomide in patients with first clinical episode consistent with multiple sclerosis. Neurology. 2014; Vol. 82.
    • (2014) Neurology , vol.82
    • Miller, A.1    Wolinsky, J.2    Kappos, L.3    Comi, G.4    Freedman, M.5    Olsson, T.6
  • 32
    • 84899459137 scopus 로고    scopus 로고
    • TOPIC main outcomes: efficacy and safety of once-daily oral teriflunomide in patients with clinically isolated syndrome
    • Miller A, Wolinsky J, Kappos L, Comi G, Freedman MS, Olsson T, et al. TOPIC main outcomes: efficacy and safety of once-daily oral teriflunomide in patients with clinically isolated syndrome. Multiple Sclerosis 2013;19:25-6.
    • (2013) Multiple Sclerosis , vol.19 , pp. 25-26
    • Miller, A.1    Wolinsky, J.2    Kappos, L.3    Comi, G.4    Freedman, M.S.5    Olsson, T.6
  • 33
    • 84907963174 scopus 로고    scopus 로고
    • Oral teriflunomide for patients with a first clinical episode suggestive of multiple sclerosis (TOPIC): a randomised, double-blind, placebo-controlled, phase 3 trial
    • Miller AE, Wolinsky JS, Kappos L, Comi G, Freedman MS, Olsson TP, et al. Oral teriflunomide for patients with a first clinical episode suggestive of multiple sclerosis (TOPIC): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet Neurology 2014;13(10):977-86.
    • (2014) Lancet Neurology , vol.13 , Issue.10 , pp. 977-986
    • Miller, A.E.1    Wolinsky, J.S.2    Kappos, L.3    Comi, G.4    Freedman, M.S.5    Olsson, T.P.6
  • 36
    • 84961899229 scopus 로고    scopus 로고
    • Efficacy of teriflunomide in patients with early stage MS: analysis of the TOPIC study using 2010 McDonald diagnostic criteria
    • Wolinsky JS, Truffinet P, Bauer D, Miller AE. Efficacy of teriflunomide in patients with early stage MS: analysis of the TOPIC study using 2010 McDonald diagnostic criteria. Multiple Sclerosis 2014;20:109-10.
    • (2014) Multiple Sclerosis , vol.20 , pp. 109-110
    • Wolinsky, J.S.1    Truffinet, P.2    Bauer, D.3    Miller, A.E.4
  • 37
    • 84961891400 scopus 로고    scopus 로고
    • MRI outcomes in patients with early multiple sclerosis treated with teriflunomide: subgroup analyses from the TOPIC phase 3 study
    • Wolinsky JS, Truffinet P, Bauer D, Miller AE. MRI outcomes in patients with early multiple sclerosis treated with teriflunomide: subgroup analyses from the TOPIC phase 3 study. Multiple Sclerosis 2014;20:84.
    • (2014) Multiple Sclerosis , vol.20 , pp. 84
    • Wolinsky, J.S.1    Truffinet, P.2    Bauer, D.3    Miller, A.E.4
  • 38
    • 84860199056 scopus 로고    scopus 로고
    • Long-term follow-up of a phase 2 study of oral teriflunomide in relapsing multiple sclerosis: safety and efficacy results up to 8.5 years
    • Confavreux C, Li DK, Freedman MS, Truffinet P, Benzerdjeb H, Wang D, et al. Long-term follow-up of a phase 2 study of oral teriflunomide in relapsing multiple sclerosis: safety and efficacy results up to 8.5 years. Multiple Sclerosis 2012;18(9):1278-89.
    • (2012) Multiple Sclerosis , vol.18 , Issue.9 , pp. 1278-1289
    • Confavreux, C.1    Li, D.K.2    Freedman, M.S.3    Truffinet, P.4    Benzerdjeb, H.5    Wang, D.6
  • 39
    • 84857288430 scopus 로고    scopus 로고
    • Long term safety and tolerability of teriflunomide in multiple sclerosis: 9-year follow-up of a phase study
    • Confavreux C, O'Connor P, Freedman M, Benzerdjeb H, Wang D, Bar-Or A. Long term safety and tolerability of teriflunomide in multiple sclerosis: 9-year follow-up of a phase study. Multiple Sclerosis 2011;17:S409-10.
    • (2011) Multiple Sclerosis , vol.17 , pp. S409-S410
    • Confavreux, C.1    O'Connor, P.2    Freedman, M.3    Benzerdjeb, H.4    Wang, D.5    Bar-Or, A.6
  • 40
    • 84961960208 scopus 로고    scopus 로고
    • Long-term clinical and magnetic resonance imaging outcomes from patients treated with teriflunomide: results from a phase 2 extension study
    • Jumah MA, Li DB, Yamout B, Truffinet P, Dukovic D, O'Connor PW. Long-term clinical and magnetic resonance imaging outcomes from patients treated with teriflunomide: results from a phase 2 extension study. Multiple Sclerosis and Related Disorders 2014;3:755-56.
    • (2014) Multiple Sclerosis and Related Disorders , vol.3 , pp. 755-756
    • Jumah, M.A.1    Li, D.B.2    Yamout, B.3    Truffinet, P.4    Dukovic, D.5    O'Connor, P.W.6
  • 41
    • 84857257319 scopus 로고    scopus 로고
    • Efficacy of teriflunomide in relapsing multiple sclerosis: phase extension study with 8-year follow-up
    • Li D, O'Connor P, Confavreux C, Truffinet P, Wang D, Traboulsee A. Efficacy of teriflunomide in relapsing multiple sclerosis: phase extension study with 8-year follow-up. Multiple Sclerosis 2011;17:S183-4.
    • (2011) Multiple Sclerosis , vol.17 , pp. S183-S184
    • Li, D.1    O'Connor, P.2    Confavreux, C.3    Truffinet, P.4    Wang, D.5    Traboulsee, A.6
  • 42
    • 84961893146 scopus 로고    scopus 로고
    • Long-term MRI outcomes from patients treated with teriflunomide: results from a phase 2 extension study
    • Li DBK, Traboulsee AL, Truffinet P, Dukovic D, O'Connor PW. Long-term MRI outcomes from patients treated with teriflunomide: results from a phase 2 extension study. Multiple Sclerosis 2014;20:102-3.
    • (2014) Multiple Sclerosis , vol.20 , pp. 102-103
    • Li, D.B.K.1    Traboulsee, A.L.2    Truffinet, P.3    Dukovic, D.4    O'Connor, P.W.5
  • 43
    • 33645799680 scopus 로고    scopus 로고
    • A Phase study of the safety and efficacy of teriflunomide in multiple sclerosis with relapses
    • O'Connor PW, Li D, Freedman MS, Bar-Or A, Rice GP, Confavreux C, et al. A Phase study of the safety and efficacy of teriflunomide in multiple sclerosis with relapses. Neurology 2006;66(6):894-900.
    • (2006) Neurology , vol.66 , Issue.6 , pp. 894-900
    • O'Connor, P.W.1    Li, D.2    Freedman, M.S.3    Bar-Or, A.4    Rice, G.P.5    Confavreux, C.6
  • 44
    • 0032374063 scopus 로고    scopus 로고
    • Purification of human dihydro-orotate dehydrogenase and its inhibition by A77 1726, the active metabolite of leflunomide
    • Bruneau JM, Yea CM, Spinella-Jaegle S, Fudali C, Woodward K, Robson PA, et al. Purification of human dihydro-orotate dehydrogenase and its inhibition by A77 1726, the active metabolite of leflunomide. Biochemical Journal 1998;336(Pt 2):299-303.
    • (1998) Biochemical Journal , vol.336 , Issue.Pt 2 , pp. 299-303
    • Bruneau, J.M.1    Yea, C.M.2    Spinella-Jaegle, S.3    Fudali, C.4    Woodward, K.5    Robson, P.A.6
  • 45
    • 8944222564 scopus 로고    scopus 로고
    • Validation of the functional assessment of multiple sclerosis quality of life instrument
    • Cella DF, Dineen K, Arnason B, Reder A, Webster KA, Karabatsos G, et al. Validation of the functional assessment of multiple sclerosis quality of life instrument. Neurology 1996;47(1):129-39.
    • (1996) Neurology , vol.47 , Issue.1 , pp. 129-139
    • Cella, D.F.1    Dineen, K.2    Arnason, B.3    Reder, A.4    Webster, K.A.5    Karabatsos, G.6
  • 47
    • 33244466021 scopus 로고    scopus 로고
    • Natural history of multiple sclerosis: a unifying concept
    • Confavreux C, Vukusic S. Natural history of multiple sclerosis: a unifying concept. Brain 2006;129(Pt 3):606-16.
    • (2006) Brain , vol.129 , Issue.Pt 3 , pp. 606-616
    • Confavreux, C.1    Vukusic, S.2
  • 48
    • 0345491507 scopus 로고    scopus 로고
    • Exposure of T lymphocytes to leflunomide but not to dexamethasone favors the production by monocytic cells of interleukin-1 receptor antagonist and the tissue-inhibitor of metalloproteinases-1 over that of interleukin-1beta and metalloproteinases
    • Deage V, Burger D, Dayer JM. Exposure of T lymphocytes to leflunomide but not to dexamethasone favors the production by monocytic cells of interleukin-1 receptor antagonist and the tissue-inhibitor of metalloproteinases-1 over that of interleukin-1beta and metalloproteinases. European Cytokine Network 1998;9(4):663-8.
    • (1998) European Cytokine Network , vol.9 , Issue.4 , pp. 663-668
    • Deage, V.1    Burger, D.2    Dayer, J.M.3
  • 51
    • 0029050136 scopus 로고
    • Inhibition of dihydroorotate dehydrogenase by the immunosuppressive agent leflunomide
    • Greene S, Watanabe K, Braatz-Trulson J, Lou L. Inhibition of dihydroorotate dehydrogenase by the immunosuppressive agent leflunomide. Biochemical Pharmacology 1995;50(6):861-7.
    • (1995) Biochemical Pharmacology , vol.50 , Issue.6 , pp. 861-867
    • Greene, S.1    Watanabe, K.2    Braatz-Trulson, J.3    Lou, L.4
  • 52
    • 0022035942 scopus 로고
    • Estimation of a common effect parameter from sparse follow-up data
    • Greenland S, Robins JM. Estimation of a common effect parameter from sparse follow-up data. Biometrics 1985;41(1):55-68.
    • (1985) Biometrics , vol.41 , Issue.1 , pp. 55-68
    • Greenland, S.1    Robins, J.M.2
  • 53
    • 84886950127 scopus 로고    scopus 로고
    • A network meta-analysis of randomized controlled trials for comparing the effectiveness and safety profile of treatments with marketing authorization for relapsing multiple sclerosis
    • Hadjigeorgiou GM, Doxani C, Miligkos M, Ziakas P, Bakalos G, Papadimitriou D, et al. A network meta-analysis of randomized controlled trials for comparing the effectiveness and safety profile of treatments with marketing authorization for relapsing multiple sclerosis. Journal of Clinical Pharmacy and Therapeutics 2013;38(6):433-9.
    • (2013) Journal of Clinical Pharmacy and Therapeutics , vol.38 , Issue.6 , pp. 433-439
    • Hadjigeorgiou, G.M.1    Doxani, C.2    Miligkos, M.3    Ziakas, P.4    Bakalos, G.5    Papadimitriou, D.6
  • 54
    • 0032773737 scopus 로고    scopus 로고
    • A771726, the active metabolite of leflunomide, directly inhibits the activity of cyclo-oxygenase-2 in vitro and in vivo in a substrate-sensitive manner
    • Hamilton LC, Vojnovic I, Warner TD. A771726, the active metabolite of leflunomide, directly inhibits the activity of cyclo-oxygenase-2 in vitro and in vivo in a substrate-sensitive manner. British Journal of Pharmacology 1999;127(7):1589-96.
    • (1999) British Journal of Pharmacology , vol.127 , Issue.7 , pp. 1589-1596
    • Hamilton, L.C.1    Vojnovic, I.2    Warner, T.D.3
  • 57
    • 7644223637 scopus 로고    scopus 로고
    • Modulation of effector cell functions in experimental autoimmune encephalomyelitis by leflunomide - mechanisms independent of pyrimidine depletion
    • Korn T, Magnus T, Toyka K, Jung S. Modulation of effector cell functions in experimental autoimmune encephalomyelitis by leflunomide - mechanisms independent of pyrimidine depletion. Journal of Leukocyte Biology 2004;76:950-60.
    • (2004) Journal of Leukocyte Biology , vol.76 , pp. 950-960
    • Korn, T.1    Magnus, T.2    Toyka, K.3    Jung, S.4
  • 58
    • 0021035886 scopus 로고
    • Rating neurological impairment in multiple sclerosis: an Expanded Disability Status Scale (EDSS)
    • Kurtzke JF. Rating neurological impairment in multiple sclerosis: an Expanded Disability Status Scale (EDSS). Neurology 1983;33:1444-52.
    • (1983) Neurology , vol.33 , pp. 1444-1452
    • Kurtzke, J.F.1
  • 59
    • 0029913882 scopus 로고    scopus 로고
    • Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis
    • Lublin FD, Reingold SC. Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis. Neurology 1996;46:907-11.
    • (1996) Neurology , vol.46 , pp. 907-911
    • Lublin, F.D.1    Reingold, S.C.2
  • 61
    • 84926365592 scopus 로고    scopus 로고
    • New multiple sclerosis phenotypic classification
    • Lublin FD. New multiple sclerosis phenotypic classification. European Neurology 2014;72 Suppl:1-5.
    • (2014) European Neurology , vol.72 , pp. 1-5
    • Lublin, F.D.1
  • 62
    • 0033557695 scopus 로고    scopus 로고
    • Immunosuppressive leflunomide metabolite (A77 1726) blocks TNF-dependent nuclear factor-kappa B activation and gene expression
    • Manna SK, Aggarwal BB. Immunosuppressive leflunomide metabolite (A77 1726) blocks TNF-dependent nuclear factor-kappa B activation and gene expression. Journal of Immunology 1999;162(4):2095-102.
    • (1999) Journal of Immunology , vol.162 , Issue.4 , pp. 2095-2102
    • Manna, S.K.1    Aggarwal, B.B.2
  • 63
    • 84959801619 scopus 로고
    • Statistical aspects of the analysis of data from retrospective studies of disease
    • Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. Journal of the National Cancer Institute 1959;22(4):719-48.
    • (1959) Journal of the National Cancer Institute , vol.22 , Issue.4 , pp. 719-748
    • Mantel, N.1    Haenszel, W.2
  • 64
    • 0034955141 scopus 로고    scopus 로고
    • Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis
    • McDonald WI, Compston A, Edan G, Goodkin D, Hartung HP, Lublin FD, et al. Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis. Annals of Neurology 2001;50(1):121-7.
    • (2001) Annals of Neurology , vol.50 , Issue.1 , pp. 121-127
    • McDonald, W.I.1    Compston, A.2    Edan, G.3    Goodkin, D.4    Hartung, H.P.5    Lublin, F.D.6
  • 65
    • 62149096116 scopus 로고    scopus 로고
    • Teriflunomide reduces behavioral, electrophysiological, and histopathological deficits in the Dark Agouti rat model of experimental autoimmune encephalomyelitis
    • Merrill JE, Hanak S, Pu SF, Liang J, Dang C, Iglesias-Bregna D, et al. Teriflunomide reduces behavioral, electrophysiological, and histopathological deficits in the Dark Agouti rat model of experimental autoimmune encephalomyelitis. Journal of Neurology 2009;256(1):89-103.
    • (2009) Journal of Neurology , vol.256 , Issue.1 , pp. 89-103
    • Merrill, J.E.1    Hanak, S.2    Pu, S.F.3    Liang, J.4    Dang, C.5    Iglesias-Bregna, D.6
  • 67
    • 84856356607 scopus 로고    scopus 로고
    • Burden of a multiple sclerosis relapse: the patients perspective
    • Oleen-Burkey M, Castelli-Haley J, Lage MJ, Johnson KP. Burden of a multiple sclerosis relapse: the patients perspective. Patient 2012;5(1):57-69.
    • (2012) Patient , vol.5 , Issue.1 , pp. 57-69
    • Oleen-Burkey, M.1    Castelli-Haley, J.2    Lage, M.J.3    Johnson, K.P.4
  • 68
    • 84878586522 scopus 로고    scopus 로고
    • Direct and indirect cost burden associated with multiple sclerosis relapses: excess costs of persons with MS and their spouse caregivers
    • Parisé H, Laliberté F, Lefebvre P, Duh MS, Kim E, Agashivala N, et al. Direct and indirect cost burden associated with multiple sclerosis relapses: excess costs of persons with MS and their spouse caregivers. Journal of the Neurological Sciences 2013;330(1-2):71-7.
    • (2013) Journal of the Neurological Sciences , vol.330 , Issue.1-2 , pp. 71-77
    • Parisé, H.1    Laliberté, F.2    Lefebvre, P.3    Duh, M.S.4    Kim, E.5    Agashivala, N.6
  • 72
    • 84960427724 scopus 로고    scopus 로고
    • Review Manager (RevMan)
    • Version 5.3. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration,
    • The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). Version 5.3. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2015.
    • (2015)
  • 73
    • 0032519992 scopus 로고    scopus 로고
    • Inhibition of JAK3 and STAT6 tyrosine phosphorylation by the immunosuppressive drug leflunomide leads to a block in IgG1 production
    • Siemasko K, Chong AS, Jäck HM, Gong H, Williams JW, Finnegan A. Inhibition of JAK3 and STAT6 tyrosine phosphorylation by the immunosuppressive drug leflunomide leads to a block in IgG1 production. Journal of Immunology 1998;160(4):1581-8.
    • (1998) Journal of Immunology , vol.160 , Issue.4 , pp. 1581-1588
    • Siemasko, K.1    Chong, A.S.2    Jäck, H.M.3    Gong, H.4    Williams, J.W.5    Finnegan, A.6
  • 76
  • 78
    • 0026877917 scopus 로고
    • The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection
    • Ware JE Jr, Sherbourne CD. The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Medical Care 1992;30(6):473-83.
    • (1992) Medical Care , vol.30 , Issue.6 , pp. 473-483
    • Ware, J.E.1    Sherbourne, C.D.2
  • 79
    • 0029052321 scopus 로고
    • Inhibition of protein tyrosine phosphorylation in T cells by a novel immunosuppressive agent, leflunomide
    • Xu X, Williams JW, Bremer EG, Finnegan A, Chong AS. Inhibition of protein tyrosine phosphorylation in T cells by a novel immunosuppressive agent, leflunomide. Journal of Biological Chemistry 1995;270(21):12398-403.
    • (1995) Journal of Biological Chemistry , vol.270 , Issue.21 , pp. 12398-12403
    • Xu, X.1    Williams, J.W.2    Bremer, E.G.3    Finnegan, A.4    Chong, A.S.5
  • 80
    • 0030014489 scopus 로고    scopus 로고
    • Two activities of the immunosuppressive metabolite of leflunomide, A77 1726. Inhibition of pyrimidine nucleotide synthesis and protein tyrosine phosphorylation
    • Xu X, Williams JW, Gong H, Finnegan A, Chong AS. Two activities of the immunosuppressive metabolite of leflunomide, A77 1726. Inhibition of pyrimidine nucleotide synthesis and protein tyrosine phosphorylation. Biochemical Pharmacology 1996;52(4):527-34.
    • (1996) Biochemical Pharmacology , vol.52 , Issue.4 , pp. 527-534
    • Xu, X.1    Williams, J.W.2    Gong, H.3    Finnegan, A.4    Chong, A.S.5
  • 81
    • 84942297646 scopus 로고    scopus 로고
    • Meta-analysis of adverse events in recent randomized clinical trials for dimethyl fumarate, glatiramer acetate and teriflunomide for the treatment of relapsing forms of multiple sclerosis
    • Zagmutt FJ, Carroll CA. Meta-analysis of adverse events in recent randomized clinical trials for dimethyl fumarate, glatiramer acetate and teriflunomide for the treatment of relapsing forms of multiple sclerosis. International Journal of Neuroscience 2015;125(11):798-807.
    • (2015) International Journal of Neuroscience , vol.125 , Issue.11 , pp. 798-807
    • Zagmutt, F.J.1    Carroll, C.A.2
  • 82
    • 25444448197 scopus 로고    scopus 로고
    • Disruption of the interaction of T cells with antigen-presenting cells by the active leflunomide metabolite teriflunomide: involvement of impaired integrin activation and immunologic synapse formation
    • Zeyda M, Poglitsch M, Geyeregger R, Smolen JS, Zlabinger GJ, Hörl WH, et al. Disruption of the interaction of T cells with antigen-presenting cells by the active leflunomide metabolite teriflunomide: involvement of impaired integrin activation and immunologic synapse formation. Arthritis and Rheumatism 2005;52(9):2730-9.
    • (2005) Arthritis and Rheumatism , vol.52 , Issue.9 , pp. 2730-2739
    • Zeyda, M.1    Poglitsch, M.2    Geyeregger, R.3    Smolen, J.S.4    Zlabinger, G.J.5    Hörl, W.H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.