Blood Exosomes Endowed with Magnetic and Targeting Properties for Cancer Therapy

ACS Nano

Volumn 10, Issue 3, 2016, Pages 3323-3333

  Qi, Hongzhao ^a   Liu, Chaoyong ^b   Long, Lixia ^a   Ren, Yu ^b   Zhang, Shanshan ^a   Chang, Xiaodan ^a   Qian, Xiaomin ^a   Jia, Huanhuan ^b   Zhao, Jin ^a   Sun, Jinjin ^c   Hou, Xin ^a   Yuan, Xubo ^a   Kang, Chunsheng ^b  

^a TIANJIN UNIVERSITY   (China)

^b TIANJIN MEDICAL UNIVERSITY   (China)

^c SECOND HOSPITAL OF TIANJIN MEDICAL UNIVERSITY   (China)

Author keywords

cancer targeting; drug delivery; exosome; scalable separation; superparamagnetic nanoparticle clusters

Indexed keywords

BLOOD; DRUG DELIVERY; MAGNETIC FIELDS; MAGNETIC LEVITATION VEHICLES; MAGNETISM; MAMMALS; NANOMAGNETICS; NANOPARTICLES; ONCOLOGY; SUPERPARAMAGNETISM; VEHICLES;

CANCER-TARGETING; CLINICAL APPLICATION; DRUG DELIVERY VEHICLES; EXOSOME; EXTERNAL MAGNETIC FIELD; SUPERPARAMAGNETIC BEHAVIOR; SUPERPARAMAGNETIC NANOPARTICLES; TARGETED DRUG DELIVERY;

DISEASES;

ANTINEOPLASTIC ANTIBIOTIC; DOXORUBICIN; NANOPARTICLE;

ANIMAL; CARCINOMA, HEPATOCELLULAR; CHEMISTRY; DRUG DELIVERY SYSTEM; DRUG EFFECTS; EXOSOME; LIVER; LIVER NEOPLASMS; MAGNET; MAGNETIC FIELD; MOUSE; PATHOLOGY; PROCEDURES; TUMOR CELL LINE; ULTRASTRUCTURE;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; DOXORUBICIN; DRUG DELIVERY SYSTEMS; EXOSOMES; LIVER; LIVER NEOPLASMS; MAGNETIC FIELDS; MAGNETS; MICE; NANOPARTICLES;

EID: 84961885150     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/acsnano.5b06939     Document Type: Article

References (36)

1. Wadih, A.; Pasqualini, R.; Ruoslahti, E. Cancer Treatment by Targeted Drug Delivery to Tumor Vasculature in a Mouse Model Science 1998, 279, 377-380 10.1126/science.279.5349.377
2. Elzoghby, A. O.; Samy, W. M.; Elgindy, N. A. Albumin-Based Nanoparticles as Potential Controlled Release Drug Delivery Systems J. Controlled Release 2012, 157, 168-182 10.1016/j.jconrel.2011.07.031
3. MaHam, A.; Tang, Z.; Wu, H.; Wang, J.; Lin, Y. Protein-Based Nanomedicine Platforms for Drug Delivery Small 2009, 5, 1706-1721 10.1002/smll.200801602
4. Liu, Z.; Jiao, Y.; Wang, Y.; Zhou, C.; Zhang, Z. Polysaccharides-Based Nanoparticles as Drug Delivery Systems Adv. Drug Delivery Rev. 2008, 60, 1650-1662 10.1016/j.addr.2008.09.001
5. Sinha, V. R.; Kumria, R. Polysaccharides in Colon-Specific Drug Delivery Int. J. Pharm. 2001, 224, 19-38 10.1016/S0378-5173(01)00720-7
6. Lai, R. C.; Yeo, R. W. Y.; Tan, K. H.; Lim, S. K. Exosomes for Drug Delivery-a Novel Application for the Mesenchymal Stem Cell Biotechnol. Adv. 2013, 31, 543-551 10.1016/j.biotechadv.2012.08.008
7. Tan, A.; Rajadas, J.; Seifalian, A. M. Exosomes as Nano-Theranostic Delivery Platforms for Gene Therapy Adv. Drug Delivery Rev. 2013, 65, 357-367 10.1016/j.addr.2012.06.014
8. Sharma, S.; Rasool, H. I.; Palanisamy, V.; Mathisen, C.; Schmidt, M.; Wong, D. T.; Gimzewski, J. K. Structural-Mechanical Characterization of Nanoparticle Exosomes in Human Saliva, Using Correlative AFM, FESEM, and Force Spectroscopy ACS Nano 2010, 4, 1921-1926 10.1021/nn901824n
9. Sun, D.; Zhuang, X.; Zhang, S.; Deng, Z.; Grizzle, W.; Miller, D.; Zhang, H. Exosomes Are Endogenous Nanoparticles That Can Deliver Biological Information Between Cells Adv. Drug Delivery Rev. 2013, 65, 342-347 10.1016/j.addr.2012.07.002
10. Tian, Y.; Li, S.; Song, J.; Ji, T.; Zhu, M.; Anderson, G. J.; Wei, J.; Nie, G. A Doxorubicin Delivery Platform Using Engineered Natural Membrane Vesicle Exosomes for Targeted Tumor Therapy Biomaterials 2014, 35, 2383-2390 10.1016/j.biomaterials.2013.11.083
11. Zhuang, X.; Xiang, X.; Grizzle, W.; Sun, D.; Zhang, S.; Axtell, R. C.; Ju, S.; Mu, J.; Zhang, L.; Steinman, L.; Miller, D.; Zhang, H. G. Treatment of Brain Inflammatory Diseases by Delivering Exosome Encapsulated Anti-Inflammatory Drugs from the Nasal Region to the Brain Mol. Ther. 2011, 19, 1769-1779 10.1038/mt.2011.164
12. Pegtel, D. M.; Cosmopoulos, K.; Thorley-Lawson, D. A.; van Eijndhoven, M. A. J.; Hopmans, E. S.; Lindenberg, J. L.; de Gruijl, T. D.; Würdinger, T.; Middeldorp, J. M. Functional Delivery of Viral MiRNAs via Exosomes Proc. Natl. Acad. Sci. U. S. A. 2010, 107, 6328-6333 10.1073/pnas.0914843107
13. Alvarez-Erviti, L.; Seow, Y.; Yin, H.; Betts, C.; Lakhal, S.; Wood, M. J. A. Delivery of siRNA to the Mouse Brain by Systemic Injection of Targeted Exosomes Nat. Biotechnol. 2011, 29, 341-345 10.1038/nbt.1807
14. Théry, C.; Amiqorena, S.; Raposo, G.; Clayton, A. Isolation and Characterization of Exosomes from Cell Culture Supernatants and Biological Fluids Curr. Protoc. Cell Biol. 2006, 3-22 10.1002/0471143030.cb0322s30
15. Wolfers, J.; Lozier, A.; Raposo, G.; Regnault, A.; Théry, C.; Masurier, C.; Flament, C.; Pouzieux, S.; Faure, F.; Tursz, T.; Angevin, E.; Amigorena, S.; Zitvogel, L. Tumor-Derived Exosomes Are a Source of Shared Tumor Rejection Antigens for CTL Cross-Priming Nat. Med. 2001, 7, 297-303 10.1038/85438
16. Iero, M.; Valenti, R.; Huber, V.; Filipazzi, P.; Parmiani, G.; Fais, S.; Rivoltin, L. Tumour-Released Exosomes and Their Implications in Cancer Immunity Cell Death Differ. 2008, 15, 80-88 10.1038/sj.cdd.4402237
17. Grange, C.; Tapparo, M.; Collino, F.; Vitillo, L.; Damasco, C.; Deregibus, M. C.; Tetta, C.; Bussolati, B.; Camussi, G. Microvesicles Released from Human Renal Cancer Stem Cells Stimulate Angiogenesis and Formation of Lung Premetastatic Niche Cancer Res. 2011, 71, 5346-5356 10.1158/0008-5472.CAN-11-0241
18. Blanc, L.; De Gassart, A.; Géminard, C.; Bette-Bobillo, P.; Vidal, M. Exosome Release by Reticulocytes-an Integral Part of the Red Blood Cell Differentiation System Blood Cells, Mol., Dis. 2005, 35, 21-26 10.1016/j.bcmd.2005.04.008
19. Johnstone, R. M.; Bianchini, A.; Teng, K. Reticulocyte Maturation and Exosome Release: Transferrin Receptor Containing Exosomes Shows Multiple Plasma Membrane Functions Blood 1989, 74, 1844-1851
20. Caby, M. P.; Lankar, D.; Vincendeau-Scherrer, C.; Raposo, G.; Bonnerot, C. Exosomal-Like Vesicles Are Present in Human Blood Plasma Int. Immunol. 2005, 17, 879-887 10.1093/intimm/dxh267
21. Clayton, A.; Court, J.; Navabi, H.; Adams, M.; Mason, M. D.; Hobot, J. A.; Newman, G. R.; Jasani, B. Analysis of Antigen Presenting Cell Derived Exosomes, Based on Immuno-magnetic Isolation and Flow Cytometry J. Immunol. Methods 2001, 247, 163-174 10.1016/S0022-1759(00)00321-5
22. Silva, A. K. A.; Luciani, N.; Gazeau, F.; Aubertin, K.; Bonneau, S.; Chauvierre, C.; Letourneur, D.; Wilhelm, C. Combining Magnetic Nanoparticles with Cell Derived Microvesicles for Drug Loading and Targeting Nanomedicine 2015, 11, 645-655 10.1016/j.nano.2014.11.009
23. Ge, J.; Hu, Y.; Biasini, M.; Beyermann, W. P.; Yin, Y. Superparamagnetic Magnetite Colloidal Nanocrystal Clusters Angew. Chem., Int. Ed. 2007, 46, 4342-4345 10.1002/anie.200700197
24. Mitchell, J. P.; Court, J.; Mason, M. D.; Tabi, Z.; Clayton, A. Increased Exosome Production from Tumour Cell Cultures Using the Integra CELLine Culture System J. Immunol. Methods 2008, 335, 98-105 10.1016/j.jim.2008.03.001
25. Mathivanan, S.; Simpson, R. J. ExoCarta: A Compendium of Exosomal Proteins and RNA Proteomics 2009, 9, 4997-5000 10.1002/pmic.200900351
26. Simons, M.; Raposo, G. Exosomes-Vesicular Carriers for Intercellular Communication Curr. Opin. Cell Biol. 2009, 21, 575-581 10.1016/j.ceb.2009.03.007
27. Dautry-Varsat, A.; Ciechanover, A.; Lodish, H. F. pH and the Recycling of Transferrin during Receptor-Mediated Endocytosis Proc. Natl. Acad. Sci. U. S. A. 1983, 80, 2258-2262 10.1073/pnas.80.8.2258
28. Edelman, R. R.; Mattle, H. P.; Kleefield, J.; Silver, M. S. Quantification of Blood Flow with Dynamic MR Imaging and Presaturation Bolus Tracking Radiology 1989, 171, 551-556 10.1148/radiology.171.2.2704823
29. Pelc, L. R.; Pelc, N. J.; Rayhill, S. C.; Castro, L. J.; Glover, G. H.; Herfkens, R. J.; Miller, D. C.; Jeffrey, R. B. Arterial and Venous Blood Flow: Noninvasive Quantitation with MR Imaging Radiology 1992, 185, 809-812 10.1148/radiology.185.3.1438767
30. Wolf, S.; Arend, O.; Schulte, K.; Ittel, T. H.; Reim, M. Quantification of Retinal Capillary Density and Flow Velocity in Patients with Essential Hypertension Hypertension 1994, 23, 464-467 10.1161/01.HYP.23.4.464
31. Arruebo, M.; Fernández-Pacheco, R.; Irarra, M. R.; Santamaría, J. Magnetic Nanoparticles for Drug Delivery Nano Today 2007, 2, 22-32 10.1016/S1748-0132(07)70084-1
32. Algire, G. H.; Chalkley, H. W.; Legallais, F. Y.; Park, H. D. Vasculae Reactions of Normal and Malignant Tissues in vivo. I. Vascular Reactions of Mice to Wounds and to Normal and Neoplastic Transplants J. Natl. Cancer Inst. 1945, 6, 73-85
33. Vaupel, P.; Kallinowski, F.; Okunieff, P. Blood Flow, Oxygen and Nutrient Supply, and Metabolic Microenvironment of Human Tumors: a Review Cancer Res. 1989, 49, 6449-6465
34. Liu, C.; Wen, J.; Meng, Y.; Zhang, K.; Zhu, J.; Ren, Y.; Qian, X.; Yuan, X.; Lu, Y.; Kang, C. Efficient Delivery of Therapeutic miRNA Nanocapsules for Tumor Suppression Adv. Mater. 2015, 27, 292-297 10.1002/adma.201403387
35. Tay, Y. M. S.; Tam, W. L.; Ang, Y. S.; Gaughwin, P. M.; Yang, H.; Wang, W.; Liu, R.; George, J.; Ng, H. H.; Perera, R. J.; Lufkin, T.; Rigoutsos, I.; Thomson, A. M.; Bing Lim, M. D. MicroRNA-134 Modulates the Differentiation of Mouse Embryonic Stem Cells, Where It Causes Post-Transcriptional Attenuation of Nanog and LRH1 Stem Cells 2008, 26, 17-29 10.1634/stemcells.2007-0295
36. Lin, J.; Zhu, J.; Chen, T.; Lin, S.; Cai, C.; Zhang, L.; Zhuang, Y.; Wang, X. Drug Releasing Behavior of Hybrid Micelles Containing Polypeptide Triblock Copolymer Biomaterials 2009, 30, 108-117 10.1016/j.biomaterials.2008.09.010