메뉴 건너뛰기




Volumn 101, Issue , 2016, Pages 213-220

Learning from the "tsunami" of immune checkpoint inhibitors in 2015

Author keywords

2015; Cancer; Immune checkpoint inhibitors; Round up; Treatment

Indexed keywords

ANTINEOPLASTIC AGENT; ATEZOLIZUMAB; AVELUMAB; CARBOPLATIN; DACARBAZINE; DOCETAXEL; DURVALUMAB; IMMUNE CHECKPOINT INHIBITOR; IPILIMUMAB; NIVOLUMAB; PACLITAXEL; PEMBROLIZUMAB; PROGRAMMED DEATH 1 LIGAND 1 ANTIBODY; PROGRAMMED DEATH 1 RECEPTOR ANTIBODY; PROTEIN ANTIBODY; RECEPTOR ANTIBODY; TICILIMUMAB; UNCLASSIFIED DRUG;

EID: 84961878101     PISSN: 10408428     EISSN: 18790461     Source Type: Journal    
DOI: 10.1016/j.critrevonc.2016.03.017     Document Type: Review
Times cited : (39)

References (45)
  • 1
    • 84928773222 scopus 로고    scopus 로고
    • IFN-(from lymphocytes induces PD-l1 expression and promotes progression of ovarian cancer
    • (Apr 28)
    • Abiko K., Matsumura N., Hamanishi J., et al. IFN-(from lymphocytes induces PD-l1 expression and promotes progression of ovarian cancer. Br. J. Cancer 2015, 112(9):1501-1509. (Apr 28).
    • (2015) Br. J. Cancer , vol.112 , Issue.9 , pp. 1501-1509
    • Abiko, K.1    Matsumura, N.2    Hamanishi, J.3
  • 2
    • 84925221855 scopus 로고    scopus 로고
    • PD-1 blockade with nivolumab in relapsed or refractory Hodgkin's lymphoma
    • (Jan 22)
    • Ansell S.M., Lesokhin A.M., Borrello I., et al. PD-1 blockade with nivolumab in relapsed or refractory Hodgkin's lymphoma. N. Engl. J. Med. 2015, 372(4):311-319. (Jan 22).
    • (2015) N. Engl. J. Med. , vol.372 , Issue.4 , pp. 311-319
    • Ansell, S.M.1    Lesokhin, A.M.2    Borrello, I.3
  • 3
    • 84939518267 scopus 로고    scopus 로고
    • Phase I/II study of nivolumab with or without ipilimumab for treatment of recurrent small cell lung cancer (SCLC): CA209-032
    • Antonia S.J., Bendell J.C., Taylor M.H., et al. Phase I/II study of nivolumab with or without ipilimumab for treatment of recurrent small cell lung cancer (SCLC): CA209-032. J. Clin. Oncol. 2015, 33. (suppl; abstr 7503).
    • (2015) J. Clin. Oncol. , vol.33
    • Antonia, S.J.1    Bendell, J.C.2    Taylor, M.H.3
  • 4
    • 84938309673 scopus 로고    scopus 로고
    • Phase Ib study of MEDI4736, a programmed cell death ligand-1 (PD-l1) antibody, in combination with tremelimumab, a cytotoxic T-lymphocyte-associated protein-4 (CTLA-4) antibody, in patients (pts) with advanced NSCLC
    • Antonia S.J., Goldberg S.B., Balmanoukian A.N., et al. Phase Ib study of MEDI4736, a programmed cell death ligand-1 (PD-l1) antibody, in combination with tremelimumab, a cytotoxic T-lymphocyte-associated protein-4 (CTLA-4) antibody, in patients (pts) with advanced NSCLC. J. Clin. Oncol. 2015, 33. (suppl; abstr 3014).
    • (2015) J. Clin. Oncol. , vol.33
    • Antonia, S.J.1    Goldberg, S.B.2    Balmanoukian, A.N.3
  • 5
    • 84998639474 scopus 로고    scopus 로고
    • Safety and efficacy of pembrolizumab (MK-3475) in patients (pts) with advanced biliary tract cancer: Interim results of KEYNOTE-028
    • Bang Y.J., Doi T., De Braud F., et al., Safety and efficacy of pembrolizumab (MK-3475) in patients (pts) with advanced biliary tract cancer: Interim results of KEYNOTE-028. ECC, 2015, abstract 525.
    • (2015) ECC
    • Bang, Y.J.1    Doi, T.2    De Braud, F.3
  • 6
    • 84944937210 scopus 로고    scopus 로고
    • Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer
    • (Oct 22)
    • Borghaei H., Paz-Ares L., Horn L., et al. Nivolumab versus docetaxel in advanced nonsquamous non-small-cell lung cancer. N. Engl. J. Med. 2015, 373(17):1627-1639. (Oct 22).
    • (2015) N. Engl. J. Med. , vol.373 , Issue.17 , pp. 1627-1639
    • Borghaei, H.1    Paz-Ares, L.2    Horn, L.3
  • 7
    • 84936791837 scopus 로고    scopus 로고
    • Nivolumab versus docetaxel in advanced squamous-cell non-small-cell lung cancer
    • (Jul 9)
    • Brahmer J., Reckamp K.L., Baas P., et al. Nivolumab versus docetaxel in advanced squamous-cell non-small-cell lung cancer. N. Engl. J. Med. 2015, 373(2):123-135. (Jul 9).
    • (2015) N. Engl. J. Med. , vol.373 , Issue.2 , pp. 123-135
    • Brahmer, J.1    Reckamp, K.L.2    Baas, P.3
  • 8
    • 79952428550 scopus 로고    scopus 로고
    • Prognostic significance of tumor infiltrating lymphocytes in melanoma
    • Burton A.L., Roach B.A., Mays M.P., et al. Prognostic significance of tumor infiltrating lymphocytes in melanoma. Am. Surg. 2011, 77:188-192.
    • (2011) Am. Surg. , vol.77 , pp. 188-192
    • Burton, A.L.1    Roach, B.A.2    Mays, M.P.3
  • 9
    • 84937690774 scopus 로고    scopus 로고
    • Avelumab (MSB0010718C), an anti-pD-L1 antibody, in patients with previously treated, recurrent or refractory ovarian cancer: a phase Ib, open-label expansion trial
    • Disis M.L., Patel M.R., Pant S., et al. Avelumab (MSB0010718C), an anti-pD-L1 antibody, in patients with previously treated, recurrent or refractory ovarian cancer: a phase Ib, open-label expansion trial. J. Clin. Oncol. 2015, 33. (suppl; abstr 5509).
    • (2015) J. Clin. Oncol. , vol.33
    • Disis, M.L.1    Patel, M.R.2    Pant, S.3
  • 10
    • 84933678156 scopus 로고    scopus 로고
    • Adjuvant ipilimumab versus placebo after complete resection of high-risk stage III melanoma (EORTC 18071): a randomised, double-blind, phase 3 trial
    • Eggermont A.M., Chiarion-Sileni V., Grob J.J., et al. Adjuvant ipilimumab versus placebo after complete resection of high-risk stage III melanoma (EORTC 18071): a randomised, double-blind, phase 3 trial. Lancet Oncol. 2015, 16(May (5)):522-530.
    • (2015) Lancet Oncol. , vol.16 , Issue.MAY 5 , pp. 522-530
    • Eggermont, A.M.1    Chiarion-Sileni, V.2    Grob, J.J.3
  • 11
    • 84937067787 scopus 로고    scopus 로고
    • Phase I/II safety and antitumor activity of nivolumab in patients with advanced hepatocellular carcinoma (HCC): CA209-040
    • El-Khoueiry A., Melero I., Crocenz T., et al. Phase I/II safety and antitumor activity of nivolumab in patients with advanced hepatocellular carcinoma (HCC): CA209-040. J. Clin. Oncol. 2015, 33. (suppl; abstr LBA101).
    • (2015) J. Clin. Oncol. , vol.33
    • El-Khoueiry, A.1    Melero, I.2    Crocenz, T.3
  • 12
    • 84929481480 scopus 로고    scopus 로고
    • Pembrolizumab for the treatment of non-small-cell lung cancer
    • (May 21)
    • Garon E.B., Rizvi N.A., Hui R., et al. Pembrolizumab for the treatment of non-small-cell lung cancer. N. Engl. J. Med. 2015, 372(21):2018-2028. (May 21).
    • (2015) N. Engl. J. Med. , vol.372 , Issue.21 , pp. 2018-2028
    • Garon, E.B.1    Rizvi, N.A.2    Hui, R.3
  • 13
    • 84897890387 scopus 로고    scopus 로고
    • Immune checkpoint blockade in cancer treatment: a double-edged sword cross-targeting the host as an innocent bystander
    • (Mar 3)
    • Gelao L., Criscitiello C., Esposito A., et al. Immune checkpoint blockade in cancer treatment: a double-edged sword cross-targeting the host as an innocent bystander. Toxins (Basel) 2014, 6(3):914-933. (Mar 3).
    • (2014) Toxins (Basel) , vol.6 , Issue.3 , pp. 914-933
    • Gelao, L.1    Criscitiello, C.2    Esposito, A.3
  • 14
    • 84944751040 scopus 로고    scopus 로고
    • Avelumab (MSB0010718C), an anti-pD-L1 antibody, in advanced NSCLC patients: a phase 1b, open-label expansion trial in patients progressing after platinum-based chemotherapy
    • Gulley J.L., Spigel D., Kelly K., et al. Avelumab (MSB0010718C), an anti-pD-L1 antibody, in advanced NSCLC patients: a phase 1b, open-label expansion trial in patients progressing after platinum-based chemotherapy. J. Clin. Oncol. 2015, 33. (suppl; abstr 8034).
    • (2015) J. Clin. Oncol. , vol.33
    • Gulley, J.L.1    Spigel, D.2    Kelly, K.3
  • 15
    • 84951126341 scopus 로고    scopus 로고
    • Safety and antitumor activity of anti-pD-1 antibody nivolumab, in patients with platinum-resistant ovarian cancer
    • (Dec 1)
    • Hamanishi J., Mandai M., Ikeda T., et al. Safety and antitumor activity of anti-pD-1 antibody nivolumab, in patients with platinum-resistant ovarian cancer. J. Clin. Oncol. 2015, 33(34):4015-4022. (Dec 1).
    • (2015) J. Clin. Oncol. , vol.33 , Issue.34 , pp. 4015-4022
    • Hamanishi, J.1    Mandai, M.2    Ikeda, T.3
  • 16
    • 2542465496 scopus 로고    scopus 로고
    • (website)
    • Hematology and oncology (cancer) approvals and safety notifications US Food and Drug Administration (FDA) 2016, (website). http://www.fda.gov/Drugs/InformationOnDrugs/ApprovedDrugs/ucm279174.htm.
    • (2016) US Food and Drug Administration (FDA)
  • 17
    • 84963969190 scopus 로고    scopus 로고
    • An open-label, randomized, phase 2 study of nivolumab (NIVO) given sequentially with ipilimumab (IPI) in patients with advanced melanoma (CheckMate 064)
    • LBA.
    • Hodi F., Gibney G., Sullivan R., et al. An open-label, randomized, phase 2 study of nivolumab (NIVO) given sequentially with ipilimumab (IPI) in patients with advanced melanoma (CheckMate 064). ECC, 2015, Abstract 23 LBA.
    • (2015) ECC
    • Hodi, F.1    Gibney, G.2    Sullivan, R.3
  • 18
    • 77957273591 scopus 로고    scopus 로고
    • Improved endpoints for cancer immunotherapy trials
    • Hoos A., Eggermont A.M., Janetzki S., et al. Improved endpoints for cancer immunotherapy trials. J. Natl. Cancer Inst. 2010, 102:1388-1397.
    • (2010) J. Natl. Cancer Inst. , vol.102 , pp. 1388-1397
    • Hoos, A.1    Eggermont, A.M.2    Janetzki, S.3
  • 19
    • 84963969204 scopus 로고    scopus 로고
    • Antitumor activity and safety of pembrolizumab in patients with PD-L1-positive nasopharyngeal carcinoma: Interim results from a phase 1b study
    • Hsu C., Lee S., Ejadi S., et al. Antitumor activity and safety of pembrolizumab in patients with PD-L1-positive nasopharyngeal carcinoma: Interim results from a phase 1b study. ECC, 2015, abstract 2801.
    • (2015) ECC
    • Hsu, C.1    Lee, S.2    Ejadi, S.3
  • 20
    • 84936147067 scopus 로고    scopus 로고
    • Combined nivolumab and ipilimumab or monotherapy in untreated melanoma
    • (Jul 2)
    • Larkin J., Chiarion-Sileni V., Gonzalez R., et al. Combined nivolumab and ipilimumab or monotherapy in untreated melanoma. N. Engl. J. Med. 2015, 373(1):23-34. (Jul 2).
    • (2015) N. Engl. J. Med. , vol.373 , Issue.1 , pp. 23-34
    • Larkin, J.1    Chiarion-Sileni, V.2    Gonzalez, R.3
  • 21
    • 84932628341 scopus 로고    scopus 로고
    • PD-1 blockade in tumors with mismatch-repair deficiency
    • (Jun 25)
    • Le D.T., Uram J.N., Wang H., et al. PD-1 blockade in tumors with mismatch-repair deficiency. N. Engl. J. Med. 2015, 372(26):2509-2520. (Jun 25).
    • (2015) N. Engl. J. Med. , vol.372 , Issue.26 , pp. 2509-2520
    • Le, D.T.1    Uram, J.N.2    Wang, H.3
  • 22
    • 84944739668 scopus 로고    scopus 로고
    • Safety and efficacy of MPDL3280A (anti-pDL1) in combination with platinum-based doublet chemotherapy in patients with advanced non-small cell lung cancer (NSCLC)
    • Liu S., Powderly J., Camidge D., et al. Safety and efficacy of MPDL3280A (anti-pDL1) in combination with platinum-based doublet chemotherapy in patients with advanced non-small cell lung cancer (NSCLC). J. Clin. Oncol. 2015, 33. (suppl; abstr 8030).
    • (2015) J. Clin. Oncol. , vol.33
    • Liu, S.1    Powderly, J.2    Camidge, D.3
  • 23
    • 84875722651 scopus 로고    scopus 로고
    • Prognostic and predictive value of tumor-infiltrating lymphocytes in a phase III randomized adjuvant breast cancer trial in node-positive breast cancer comparing the addition of docetaxel to doxorubicin with doxorubicin-based chemotherapy: bIG 02-98
    • Loi S., Sirtaine N., Piette F., et al. Prognostic and predictive value of tumor-infiltrating lymphocytes in a phase III randomized adjuvant breast cancer trial in node-positive breast cancer comparing the addition of docetaxel to doxorubicin with doxorubicin-based chemotherapy: bIG 02-98. J. Clin. Oncol. 2013, 31(7):860-867.
    • (2013) J. Clin. Oncol. , vol.31 , Issue.7 , pp. 860-867
    • Loi, S.1    Sirtaine, N.2    Piette, F.3
  • 24
    • 84929572937 scopus 로고    scopus 로고
    • Nivolumab for metastatic renal cell carcinoma: results of a randomized phase II trial
    • (May 1)
    • Motzer R.J., Rini B.I., McDermott D.F., et al. Nivolumab for metastatic renal cell carcinoma: results of a randomized phase II trial. J. Clin. Oncol. 2015, 33(13):1430-1437. (May 1).
    • (2015) J. Clin. Oncol. , vol.33 , Issue.13 , pp. 1430-1437
    • Motzer, R.J.1    Rini, B.I.2    McDermott, D.F.3
  • 25
    • 84946607195 scopus 로고    scopus 로고
    • Nivolumab versus everolimus in advanced renal-cell carcinoma
    • (Nov 5)
    • Motzer R.J., Escudier B., McDermott D.F., et al. Nivolumab versus everolimus in advanced renal-cell carcinoma. N. Engl. J. Med. 2015, 373(19):1803-1813. (Nov 5).
    • (2015) N. Engl. J. Med. , vol.373 , Issue.19 , pp. 1803-1813
    • Motzer, R.J.1    Escudier, B.2    McDermott, D.F.3
  • 26
    • 85015764678 scopus 로고    scopus 로고
    • LATE BREAKING ABSTRACT: Activity of PD-1 blockade with pembrolizumab as first systemic therapy in patients with advanced Merkel cell carcinoma
    • Nghiem P., Bhatia S., Daud A., et al. LATE BREAKING ABSTRACT: Activity of PD-1 blockade with pembrolizumab as first systemic therapy in patients with advanced Merkel cell carcinoma. ECC, 2015, abstract 22LBA.
    • (2015) ECC
    • Nghiem, P.1    Bhatia, S.2    Daud, A.3
  • 27
    • 84963963581 scopus 로고    scopus 로고
    • Pembrolizumab (MK-3475) for PD-L1-positive squamous cell carcinoma (SCC) of the anal canal: Preliminary safety and efficacy results from KEYNOTE-028
    • Ott P.A., Piha-Paul S.A., Munster P., et al. Pembrolizumab (MK-3475) for PD-L1-positive squamous cell carcinoma (SCC) of the anal canal: Preliminary safety and efficacy results from KEYNOTE-028. ECC, 2015, abstract 500.
    • (2015) ECC
    • Ott, P.A.1    Piha-Paul, S.A.2    Munster, P.3
  • 28
    • 84939548996 scopus 로고    scopus 로고
    • Pembrolizumab (MK-3475) in patients (pts) with extensive-stage small cell lung cancer (SCLC): preliminary safety and efficacy results from KEYNOTE-028
    • Ott P.A., Fernandez M.E., Hiret S., et al. Pembrolizumab (MK-3475) in patients (pts) with extensive-stage small cell lung cancer (SCLC): preliminary safety and efficacy results from KEYNOTE-028. J. Clin. Oncol. 2015, 33. (suppl; abstr 7502).
    • (2015) J. Clin. Oncol. , vol.33
    • Ott, P.A.1    Fernandez, M.E.2    Hiret, S.3
  • 29
    • 84942138310 scopus 로고    scopus 로고
    • Phase 1 study of pembrolizumab (pembro; MK-3475) plus ipilimumab (IPI) as second-line therapy for advanced non-small cell lung cancer (NSCLC): KEYNOTE-021 cohort D
    • Patnaik A., Mark Socinski A., Matthew Gubens A., et al. Phase 1 study of pembrolizumab (pembro; MK-3475) plus ipilimumab (IPI) as second-line therapy for advanced non-small cell lung cancer (NSCLC): KEYNOTE-021 cohort D. J. Clin. Oncol. 2015, 33. (suppl; abstr 8011).
    • (2015) J. Clin. Oncol. , vol.33
    • Patnaik, A.1    Mark Socinski, A.2    Matthew Gubens, A.3
  • 30
    • 84947267135 scopus 로고    scopus 로고
    • Pembrolizumab (MK-3475) for advanced urothelial cancer: updated results and biomarker analysis from KEYNOTE-012
    • Plimack E., Bellmunt J., Gupta S., et al. Pembrolizumab (MK-3475) for advanced urothelial cancer: updated results and biomarker analysis from KEYNOTE-012. J. Clin. Oncol. 2015, 33. (suppl; abstr 4502).
    • (2015) J. Clin. Oncol. , vol.33
    • Plimack, E.1    Bellmunt, J.2    Gupta, S.3
  • 31
    • 84929481482 scopus 로고    scopus 로고
    • Nivolumab and ipilimumab versus ipilimumab in untreated melanoma
    • (2015 May)
    • Postow M.A., Chesney J., Pavlick A.C., et al. Nivolumab and ipilimumab versus ipilimumab in untreated melanoma. N. Engl. J. Med. 2015, 372(21):2006-2017. (2015 May).
    • (2015) N. Engl. J. Med. , vol.372 , Issue.21 , pp. 2006-2017
    • Postow, M.A.1    Chesney, J.2    Pavlick, A.C.3
  • 32
    • 84963987463 scopus 로고    scopus 로고
    • Immune checkpoint blockade for glioblastoma: preclinical activity of single agent and combinatorial therapy
    • (suppl
    • Reardon D., Gokhale P., Hodi F., et al. Immune checkpoint blockade for glioblastoma: preclinical activity of single agent and combinatorial therapy. J. Clin. Oncol. 2016, 32(5s). (suppl; abstr 2084).
    • (2016) J. Clin. Oncol. , vol.32 , Issue.5
    • Reardon, D.1    Gokhale, P.2    Hodi, F.3
  • 33
    • 84938205998 scopus 로고    scopus 로고
    • Pembrolizumab versus investigator-choice chemotherapy for ipilimumab-refractory melanoma (KEYNOTE-002): a randomised, controlled, phase 2 trial
    • Ribas A., Puzanov I., Dummer R., et al. Pembrolizumab versus investigator-choice chemotherapy for ipilimumab-refractory melanoma (KEYNOTE-002): a randomised, controlled, phase 2 trial. Lancet Oncol. 2015, 16(August (8)):908-918.
    • (2015) Lancet Oncol. , vol.16 , Issue.AUGUST 8 , pp. 908-918
    • Ribas, A.1    Puzanov, I.2    Dummer, R.3
  • 34
    • 84928761118 scopus 로고    scopus 로고
    • Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer
    • Rizvi N.A., Hellmann M.D., Snyder A., et al. Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer. Science 2015, 348:124-128.
    • (2015) Science , vol.348 , pp. 124-128
    • Rizvi, N.A.1    Hellmann, M.D.2    Snyder, A.3
  • 35
    • 84925222119 scopus 로고    scopus 로고
    • Nivolumab in previously untreated melanoma without BRAF mutation
    • (Jan 22)
    • Robert C., Long G.V., Brady B., et al. Nivolumab in previously untreated melanoma without BRAF mutation. N. Engl. J. Med. 2015, 372(4):320-330. (Jan 22).
    • (2015) N. Engl. J. Med. , vol.372 , Issue.4 , pp. 320-330
    • Robert, C.1    Long, G.V.2    Brady, B.3
  • 36
    • 84929481481 scopus 로고    scopus 로고
    • Pembrolizumab versus ipilimumab in advanced melanoma
    • (Jun 25)
    • Robert C., Schachter J., Long G.V., et al. Pembrolizumab versus ipilimumab in advanced melanoma. N. Engl. J. Med. 2015, 372(26):2521-2532. (Jun 25).
    • (2015) N. Engl. J. Med. , vol.372 , Issue.26 , pp. 2521-2532
    • Robert, C.1    Schachter, J.2    Long, G.V.3
  • 37
    • 84961365432 scopus 로고    scopus 로고
    • Atezolizumab in patients (pts) with locally-advanced or metastatic urothelial carcinoma (mUC): Results from a pivotal multicenter phase II study (IMvigor 210)
    • Rosenberg J., Petrylak D., Abidoye O., et al. Atezolizumab in patients (pts) with locally-advanced or metastatic urothelial carcinoma (mUC): Results from a pivotal multicenter phase II study (IMvigor 210). ECC, 2015, abstract 21LBA.
    • (2015) ECC
    • Rosenberg, J.1    Petrylak, D.2    Abidoye, O.3
  • 38
    • 84941080042 scopus 로고    scopus 로고
    • Safety and efficacy of MEDI4736, an anti-pD-L1 antibody, in patients from a squamous cell carcinoma of the head and neck (SCCHN) expansion cohort
    • Segal N.H., Ignatius S.H., Balmanoukian A.S., et al. Safety and efficacy of MEDI4736, an anti-pD-L1 antibody, in patients from a squamous cell carcinoma of the head and neck (SCCHN) expansion cohort. J. Clin. Oncol. 2015, 33. (suppl; abstr 3011).
    • (2015) J. Clin. Oncol. , vol.33
    • Segal, N.H.1    Ignatius, S.H.2    Balmanoukian, A.S.3
  • 39
    • 84907521155 scopus 로고    scopus 로고
    • A phase Ib study of MK-3475 in patients with human papillomavirus (HPV)-associated and non-hPV-associated head and neck (H/N) cancer
    • Seiwert T., Weiss B., et al. A phase Ib study of MK-3475 in patients with human papillomavirus (HPV)-associated and non-hPV-associated head and neck (H/N) cancer. J. Clin. Oncol. 2014, 32:5s. (suppl; abstr 6011).
    • (2014) J. Clin. Oncol. , vol.32 , pp. 5s
    • Seiwert, T.1    Weiss, B.2
  • 40
    • 84940606077 scopus 로고    scopus 로고
    • Antitumor activity and safety of pembrolizumab in patients (pts) with advanced squamous cell carcinoma of the head and neck (SCCHN): preliminary results from KEYNOTE-012 expansion cohort
    • Seiwert T., Haddad R., Gupta S., et al. Antitumor activity and safety of pembrolizumab in patients (pts) with advanced squamous cell carcinoma of the head and neck (SCCHN): preliminary results from KEYNOTE-012 expansion cohort. J. Clin. Oncol. 2015, 33:A6008. (suppl; abstr LBA6008).
    • (2015) J. Clin. Oncol. , vol.33 , pp. A6008
    • Seiwert, T.1    Haddad, R.2    Gupta, S.3
  • 41
    • 84918828514 scopus 로고    scopus 로고
    • Genetic basis for clinical response to CTLA-4 blockade in melanoma
    • Snyder A., Makarov V., Merghoub T., et al. Genetic basis for clinical response to CTLA-4 blockade in melanoma. N. Engl. J. Med. 2014, 371:2189-2199.
    • (2014) N. Engl. J. Med. , vol.371 , pp. 2189-2199
    • Snyder, A.1    Makarov, V.2    Merghoub, T.3
  • 43
    • 84937721776 scopus 로고    scopus 로고
    • Antitumor activity and safety of pembrolizumab in patients (pts) with PD-l1 positive advanced ovarian cancer: interim results from a phase Ib study
    • Varga A., Piha-Paul S.A., Ott P.A., et al. Antitumor activity and safety of pembrolizumab in patients (pts) with PD-l1 positive advanced ovarian cancer: interim results from a phase Ib study. J. Clin. Oncol. 2015, 33. (suppl; abstr 5510).
    • (2015) J. Clin. Oncol. , vol.33
    • Varga, A.1    Piha-Paul, S.A.2    Ott, P.A.3
  • 44
    • 58049202334 scopus 로고    scopus 로고
    • Phase I/II study of ipilimumab for patients with metastatic melanoma
    • (Dec 20)
    • Weber J.S., O'Day S., Urba W., et al. Phase I/II study of ipilimumab for patients with metastatic melanoma. J. Clin. Oncol. 2008, 26(36):5950-5956. (Dec 20).
    • (2008) J. Clin. Oncol. , vol.26 , Issue.36 , pp. 5950-5956
    • Weber, J.S.1    O'Day, S.2    Urba, W.3
  • 45
    • 84931083080 scopus 로고    scopus 로고
    • Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-cTLA-4 treatment (CheckMate 037): a randomised, controlled, open-label, phase 3 trial
    • Weber J.S., D'Angelo S.P., Minor D., et al. Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-cTLA-4 treatment (CheckMate 037): a randomised, controlled, open-label, phase 3 trial. Lancet Oncol. 2015, 16(April (4)):375-384.
    • (2015) Lancet Oncol. , vol.16 , Issue.APRIL 4 , pp. 375-384
    • Weber, J.S.1    D'Angelo, S.P.2    Minor, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.