Chlorogenic acid induces apoptosis to inhibit inflammatory proliferation of IL-6-induced fibroblast-like synoviocytes through modulating the activation of JAK/stat and NF-κB signaling pathways

Experimental and Therapeutic Medicine

Volumn 11, Issue 5, 2016, Pages 2054-2060

  Lou, Lixia ^a   Zhou, Jingwei ^b   Liu, Yujun ^c   Wei, Yi ^a   Zhao, Jiuli ^a   Deng, Jiagang ^d   Dong, Bin ^a   Zhu, Lingqun ^a   Wu, Aiming ^a   Yang, Yingxi ^a   Chai, Limin ^a  

^a BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^b BEIJING UNIVERSITY OF CHINESE MEDICINE   (China)

^c Putuo District Center Hospital   (China)

^d GUANGXI UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Apoptosis; Chlorogenic acid; Fibroblast like synoviocytes; Interleukin 6; Janus activated kinase signal transducer and activator of transcription 3; Nuclear factor B

Indexed keywords

CHLOROGENIC ACID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; JANUS KINASE; STAT PROTEIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL VIABILITY; CHEMICAL STRUCTURE; CONTROLLED STUDY; CYTOTOXICITY; FLOW CYTOMETRY; INFLAMMATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MTT ASSAY; NONHUMAN; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; SYNOVIOCYTE; WESTERN BLOTTING;

EID: 84961855566     PISSN: 17920981     EISSN: 17921015     Source Type: Journal    
DOI: 10.3892/etm.2016.3136     Document Type: Article

References (33)

1. Gibofsky A: Overview of epidemiology, pathophysiology, and diagnosis of rheumatoid arthritis. Am J Manag Care 18: S295-S302, 2012.
2. Semerano L, Minichiello E, Bessis N and Boissier MC: Novel immunotherapeutic avenues for rheumatoid arthritis. Trends Mol Med 22: 214-229, 2016.
3. Müller-Ladner U, Pap T, Gay RE, Neidhart M and Gay S: Mechanisms of disease: The molecular and cellular basis of joint destruction in rheumatoid arthritis. Nat Clin Pract Rheumatol 1: 102-110, 2005.
4. Firestein GS: Evolving concepts of rheumatoid arthritis. Nature 423: 356-361, 2003.
5. Bartok B and Firestein GS: Fibroblast-like synoviocytes: Key effector cells in rheumatoid arthritis. Immunol Rev 233: 233-255, 2010.
6. Huber LC, Distler O, Tarner I, Gay RE, Gay S and Pap T: Synovial fibroblasts: Key players in rheumatoid arthritis. Rheumatology (Oxford) 45: 669-675, 2006.
7. Hirano T: Interleukin 6 and its receptor: Ten years later. Int Rev Immunol 16: 249-284, 1998.
8. Okamoto H, Yamamura M, Morita Y, Harada S, Makino H and Ota Z: The synovial expression and serum levels of interleukin-6, interleukin-11, leukemia inhibitory factor, and oncostatin M in rheumatoid arthritis. Arthritis and Rheum 40: 1096-1105, 1997.
9. Hirano T, Matsuda T, Turner M, Miyasaka N, Buchan G, Tang B, Sato K, Shimizu M, Maini R, Feldmann M et al: Excessive production of interleukin 6/B cell stimulatory factor-2 in rheumatoid arthritis. Eur J Immunol 18: 1797-1801, 1988.
10. Dasgupta B, Corkill M, Kirkham B, Gibson T and Panayi G: Serial estimation of interleukin 6 as a measure of systemic disease in rheumatoid arthritis. J Rheumatol 19: 22-25, 1992.
11. Ishihara K and Hirano T: IL-6 in autoimmune disease and chronic inflammatory proliferative disease. Cytokine Growth Factor Rev 13: 357-368, 2002.
12. Feldmann M, Brennan FM and Maini RN: Role of cytokines in rheumatoid arthritis. Annu Rev Immunol 14: 397-440, 1996.
13. Alonzi T, Fattori E, Lazzaro D, Costa P, Probert L, Kollias G, De Benedetti F, Poli V and Ciliberto G: Interleukin 6 is required for the development of collagen-induced arthritis. J Exp Med 187: 461-468, 1998.
14. Ohshima S, Saeki Y, Mima T, Sasai M, Nishioka K, Nomura S, Kopf M, Katada Y, Tanaka T, Suemura M and Kishimoto T: Interleukin 6 plays a key role in the development of antigen-induced arthritis. Proc Natl Acad Sci USA 95: 8222-8226, 1998.
15. Hirano T, Ishihara K and Hibi M: Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors. Oncogene 19: 2548-2556, 2000.
16. Kong X, Liu C, Zhang C, Zhao J, Wang J, Wan H, Zhu H, Zhang P, Chen W, Xiao Y and Lin N: The suppressive effects of Saposhnikovia divaricata (Fangfeng) chromone extract on rheumatoid arthritis via inhibition of nuclear factor-κB and mitogen activated proteinkinases activation on collagen-induced arthritis model. J Ethnopharmacol 148: 842-850, 2013.
17. Andreas K, Lübke C, Häupl T, Dehne T, Morawietz L, Ringe J, Kaps C and Sittinger M: Key regulatory molecules of cartilage destruction in rheumatoid arthritis: An in vitro study. Arthritis Res Ther 10: R9, 2008.
18. Ruan Z, Liu S, Zhou Y, Mi S, Liu G, Wu X, Yao K, Assaad H, Deng Z, Hou Y, et al: Chlorogenic acid decreases intestinal permeability and increases expression of intestinal tight junction proteins in weaned rats challenged with LPS. PLoS One 9: e97815, 2014.
19. dos Santos MD, Almeida MC, Lopes NP and de Souza GE: Evaluation of the anti-inflammatory, analgesic and antipyretic activities of the natural polyphenol chlorogenic acid. Biol Pharm Bull 29: 2236-2240, 2006.
20. Tatefuji T, Izumi N, Ohta T, Arai S, Ikeda M and Kurimoto M: Isolation and identification of compounds from Brazilian propolis which enhance macrophage spreading and mobility. Biol Pharm Bull 19: 966-970, 1996.
21. Wang J, Ma J, Dong L, Hou Y, Jia X, Niu X and Fan Y: Effect of anatase TiO2 nanoparticles on the growth of RSC-364 rat synovial cell. J Nanosci Nanotechnol 13: 3874-3879, 2013.
22. Guo HF, Liu SX, Zhang YJ, Liu QJ, Hao J and Gao LX: High mobility group box 1 induces synoviocyte proliferation in rheumatoid arthritis by activating the signal transducer and activator transcription signal pathway. Clin Exp Med 11: 65-74, 2011.
23. Kwak SC, Lee C, Kim JY, Oh HM, So HS, Lee MS, Rho MC and Oh J: Chlorogenic acid inhibits osteoclast differentiation and bone resorption by down-regulation of receptor activator of nuclear factor kappa-B ligand-induced nuclear factor of activated T cells c1 expression. Biol Pharm Bull 36: 1779-1786, 2013.
24. Fan L, Wang Q, Liu R, Zong M, He D, Zhang H, Ding Y and Ma J: Citrullinated fibronectin inhibits apoptosis and promotes the secretion of pro-inflammatory cytokines in fibroblast-like synoviocytes in rheumatoid arthritis. Arthritis Res Ther 14: R266, 2012.
25. Li G, Liu D, Guo S, Sunagawa M, Hisamitsu T and Liu Y: Anti-invasive effects of Celastrus Orbiculatus extract on interleukin-1 beta and tumour necrosis factor-alpha combination-stimulated fibroblast-like synoviocytes. BMC Complement Altern Med 14: 62, 2014.
26. Marinova-Mutafchieva L, Williams RO, Funa K, Maini RN and Zvaifler NJ: Inflammation is preceded by tumor necrosis factor-dependent infiltration of mesenchymal cells in experimental arthritis. Arthritis and Rheum 46: 507-513, 2002.
27. Nakajima T, Aono H, Hasunuma T, Yamamoto K, Shirai T, Hirohata K and Nishioka K: Apoptosis and functional Fas antigen in rheumatoid arthritis synoviocytes. Arthritis and Rheum 38: 485-491, 1995.
28. Liu YJ, Zhou CY, Qiu CH, Lu XM and Wang YT: Chlorogenic acid induced apoptosis and inhibition of proliferation in human acute promyelocytic leukemia HL60 cells. Mol Med Rep 8: 1106-1110, 2013.
29. Wu C, Luan H, Zhang X, Wang S, Zhang X, Sun X and Guo P: Chlorogenic acid protects against atherosclerosis in ApoE-/-mice and promotes cholesterol efflux from RAW264.7 macrophages. PLoS One 9: e95452, 2014.
30. Guo YJ, Luo T, Wu F, Mei YW, Peng J, Liu H, Li HR, Zhang SL, Dong JH, Fang Y and Zhao L: Involvement of TLR2 and TLR9 in the anti-inflammatory effects of chlorogenic acid in HSV-1-infected microglia. Life Sci 127: 12-18, 2015.
31. Migita K, Komori A, Torigoshi T, Maeda Y, Izumi Y, Jiuchi Y, Miyashita T, Nakamura M, Motokawa S and Ishibashi H: CP690,550 inhibits oncostatin M-induced JAK/STAT signaling pathway in rheumatoid synoviocytes. Arthritis Res Ther 13: R72, 2011.
32. Borie DC, O'Shea JJ and Changelian PS: JAK3 inhibition, a viable new modality of immunosuppression for solid organ transplants. Trends Mol Med 10: 532-541, 2004.
33. Hayden MS and Ghosh S: Shared principles in NF-kappaB signaling. Cell 132: 344-362, 2008.