Modification on the O-glucoside of Sergliflozin-A: A new strategy for SGLT2 inhibitor design

Bioorganic and Medicinal Chemistry Letters

Volumn 26, Issue 9, 2016, Pages 2170-2173

  Cao, Xuefeng ^a   Zhang, Wenpeng ^b   Yan, Xu ^a   Huang, Zhi ^a   Zhang, Zhenqing ^b   Wang, Peng ^a   Shen, Jie ^a  

^a NANKAI UNIVERSITY   (China)

^b BEIJING INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (China)

Author keywords

O Glucoside; Pharmacokinetic stability; Sergliflozin A; SGLT2 inhibitor

Indexed keywords

GLUCOSE; GLUCOSIDE; HYDROXYL GROUP; SERGLIFLOZIN A; SODIUM GLUCOSE COTRANSPORTER 2 INHIBITOR; UNCLASSIFIED DRUG; 2-((4-METHOXYPHENYL)METHYL)PHENYL-4-O-METHYL-BETA-D-GLUCOPYRANOSIDE; ANTIDIABETIC AGENT; BENZHYDRYL DERIVATIVE; MONOSACCHARIDE; SERGLIFLOZIN-A; SGLT2 PROTEIN, RAT; SODIUM GLUCOSE COTRANSPORTER 2;

ANTIDIABETIC ACTIVITY; ARTICLE; BENZYLATION; DEACETYLATION; DEBENZYLATION; DRUG ACETYLATION; DRUG DESIGN; DRUG HYDROLYSIS; DRUG POTENCY; DRUG STABILITY; DRUG SYNTHESIS; GLUCOSE URINE LEVEL; GLYCOSYLATION; HYDROGEN BOND; INTESTINE ABSORPTION; METABOLIC STABILITY; NONHUMAN; RAT; RING OPENING; SUBSTITUTION REACTION; URINALYSIS; URINARY EXCRETION; ANIMAL; ANTAGONISTS AND INHIBITORS; IN VITRO STUDY; SYNTHESIS; URINE;

ANIMALS; BENZHYDRYL COMPOUNDS; HYPOGLYCEMIC AGENTS; IN VITRO TECHNIQUES; MONOSACCHARIDES; RATS; SODIUM-GLUCOSE TRANSPORTER 2;

EID: 84961839290     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2016.03.065     Document Type: Article

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