A convenient synthesis of 5′-triantennary N-acetyl-galactosamine clusters based on nitromethanetrispropionic acid

Bioorganic and Medicinal Chemistry Letters

Volumn 26, Issue 9, 2016, Pages 2194-2197

  Migawa, Michael T ^a   Prakash, Thazha P ^a   Vasquez, Guillermo ^a   Wan, W Brad ^a   Yu, Jinghua ^a   Kinberger, Garth A ^a   Stergaard, Michael E ^a   Swayze, Eric E ^a   Seth, Punit P ^a  

^a ISIS PHARMACEUTICALS   (United States)

Author keywords

Conjugate; GalNAc; Nucleic acid; Synthesis

Indexed keywords

5' TRIANTENNARY N ACETYL GALACTOSAMINE; ANTISENSE OLIGONUCLEOTIDE; N ACETYLGALACTOSAMINE; NITROMETHANETRISPROPIONIC ACID; PROPIONIC ACID; UNCLASSIFIED DRUG; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; NITRO DERIVATIVE; PROPIONIC ACID DERIVATIVE; SCARB1 PROTEIN, MOUSE; SCAVENGER RECEPTOR B;

ARTICLE; EVALUATION STUDY; HYDROGENATION; LIVER CELL; MICHAEL ADDITION; MOUSE; NONHUMAN; ONE POT SYNTHESIS; SYNTHESIS; ANALOGS AND DERIVATIVES; ANIMAL; DRUG EFFECTS; METABOLISM;

ACETYLGALACTOSAMINE; ANIMALS; HEPATOCYTES; INDICATORS AND REAGENTS; MICE; NITRO COMPOUNDS; OLIGONUCLEOTIDES, ANTISENSE; PROPIONATES; SCAVENGER RECEPTORS, CLASS B;

EID: 84961782173     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2016.03.070     Document Type: Article

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