DNA polymerase-α regulates the activation of type i interferons through cytosolic RNA:DNA synthesis

Nature Immunology

Volumn 17, Issue 5, 2016, Pages 495-504

  Starokadomskyy, Petro ^a   Gemelli, Terry ^b   Rios, Jonathan J ^a,b,c   Xing, Chao ^b   Wang, Richard C ^a   Li, Haiying ^a   Pokatayev, Vladislav ^a   Dozmorov, Igor ^b   Khan, Shaheen ^b   Miyata, Naoteru ^a   Fraile, Guadalupe ^d   Raj, Prithvi ^b   Xu, Zhe ^e   Xu, Zigang ^e   Ma, Lin ^e   Lin, Zhimiao ^f   Wang, Huijun ^f,g,h   Yang, Yong ^f,g   Ben Amitai, Dan ^i,j   Orenstein, Naama ⁱ   Mussaffi, Huda ^i,j   Baselga, Eulalia ^k   Tadini, Gianluca ^l,m   Grunebaum, Eyal ⁿ   Sarajlija, Adrijan ^o,p   Krzewski, Konrad ^q   Wakeland, Edward K ^b   Yan, Nan ^a   De La Morena, Maria Teresa ^a,r   Zinn, Andrew R ^a,b   Burstein, Ezra ^a,b   more..

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c TEXAS SCOTTISH RITE HOSPITAL FOR CHILDREN   (United States)

^d HOSPITAL RAMÓN Y CAJAL   (Spain)

^e CAPITAL MEDICAL UNIVERSITY   (China)

^f PEKING UNIVERSITY FIRST HOSPITAL   (China)

^g Tsinghua University   (China)

^h PEKING UNIVERSITY   (China)

ⁱ SCHNEIDER CHILDREN S MEDICAL CENTER OF ISRAEL   (Israel)

^j TEL AVIV UNIVERSITY   (Israel)

^k HOSPITAL DE LA SANTA CREU I SANT PAU   (Spain)

^l UNIVERSITY OF MILAN   (Italy)

^m FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

ⁿ HOSPITAL FOR SICK CHILDREN   (Canada)

^o Mother and Child Health Care Institute of Serbia   (Serbia)

^p UNIVERSITY OF BELGRADE   (Serbia)

^q NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^r Children's Health   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

DNA DIRECTED DNA POLYMERASE ALPHA; INTERFERON; RNA; DNA; DNA DIRECTED DNA POLYMERASE BETA;

ANIMAL CELL; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DNA REPLICATION; DNA RNA HYBRIDIZATION; EMBRYO; ENZYME ACTIVE SITE; ENZYME REGULATION; FEMALE; FIBROBLAST; GENE; GENE EXPRESSION; GENE MUTATION; HEK293 CELL LINE; HELA CELL LINE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE DEFICIENCY; MALE; NONHUMAN; PATHOGENESIS; PIGMENT DISORDER; POLA1 GENE; PRIORITY JOURNAL; X CHROMOSOME LINKED DISORDER; X LINKED RETICULATE PIGMENTARY DISORDER; BIOSYNTHESIS; CELL CULTURE; CONFOCAL MICROSCOPY; CYTOLOGY; CYTOSOL; DNA MICROARRAY; FAMILY HEALTH; GENE EXPRESSION PROFILING; GENETICS; IMMUNOBLOTTING; METABOLISM; MUTATION; NUCLEOTIDE SEQUENCE; PEDIGREE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

BASE SEQUENCE; CELLS, CULTURED; CYTOSOL; DNA; DNA POLYMERASE I; FAMILY HEALTH; FEMALE; FIBROBLASTS; GENE EXPRESSION PROFILING; GENETIC DISEASES, X-LINKED; HEK293 CELLS; HELA CELLS; HUMANS; IMMUNOBLOTTING; INTERFERON TYPE I; MALE; MICROSCOPY, CONFOCAL; MUTATION; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PEDIGREE; PIGMENTATION DISORDERS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA;

EID: 84961696302     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.3409     Document Type: Article

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