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Volumn 57, Issue 3, 2016, Pages 1284-1292

Effect of the rho-associated kinase inhibitor eye drop (Ripasudil) on corneal endothelial wound healing

Author keywords

Bullous keratopathy; Corneal endothelial cells; Rho kinase inhibitor

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); KI 67 ANTIGEN; NERVE CELL ADHESION MOLECULE; RHO KINASE; RIPASUDIL; EYE DROPS; ISOQUINOLINE DERIVATIVE; K-115; SULFONAMIDE;

EID: 84961641140     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.15-18586     Document Type: Article
Times cited : (109)

References (45)
  • 2
    • 68349114963 scopus 로고    scopus 로고
    • Enhancement onprimate corneal endothelial cell survival in vitro by a ROCKinhibitor
    • Okumura N, Ueno M, Koizumi N, et al. Enhancement on primate corneal endothelial cell survival in vitro by a ROCK inhibitor. Invest Ophthalmol Vis Sci. 2009;50:3680-3687.
    • (2009) Invest Ophthalmol Vis Sci , vol.50 , pp. 3680-3687
    • Okumura, N.1    Ueno, M.2    Koizumi, N.3
  • 3
    • 79959334438 scopus 로고    scopus 로고
    • Enhancementof corneal endothelium wound healing by Rho-associated kinase (ROCK) inhibitor eye drops
    • Okumura N, Koizumi N, Ueno M, et al. Enhancement of corneal endothelium wound healing by Rho-associated kinase (ROCK) inhibitor eye drops. Br J Ophthalmol. 2011;95:1006-1009.
    • (2011) Br J Ophthalmol , vol.95 , pp. 1006-1009
    • Okumura, N.1    Koizumi, N.2    Ueno, M.3
  • 4
    • 84875929599 scopus 로고    scopus 로고
    • The ROCK inhibitor eye drop accelerates corneal endothelium wound healing
    • Okumura N, Koizumi N, Kay EP, et al. The ROCK inhibitor eye drop accelerates corneal endothelium wound healing. Invest Ophthalmol Vis Sci. 2013;54:2493-2502.
    • (2013) Invest Ophthalmol Vis Sci , vol.54 , pp. 2493-2502
    • Okumura, N.1    Koizumi, N.2    Kay, E.P.3
  • 5
    • 84880573578 scopus 로고    scopus 로고
    • Rho-associated kinase inhibitor eye drop treatmentasapossiblemedicaltreatmentforfuchscorneal dystrophy
    • Koizumi N, Okumura N, Ueno M, Nakagawa H, Hamuro J, Kinoshita S. Rho-associated kinase inhibitor eye drop treatment as a possible medical treatment for fuchs corneal dystrophy. Cornea. 2013;32:1167-1170.
    • (2013) Cornea , vol.32 , pp. 1167-1170
    • Koizumi, N.1    Okumura, N.2    Ueno, M.3    Nakagawa, H.4    Hamuro, J.5    Kinoshita, S.6
  • 6
    • 0035164065 scopus 로고    scopus 로고
    • Effectsofrho-associated protein kinase inhibitor Y-27632 on intraocular pressureand outflow facility
    • Honjo M, Tanihara H, Inatani M, et al. Effects of rho-associated protein kinase inhibitor Y-27632 on intraocular pressure and outflow facility. Invest Ophthalmol Vis Sci. 2001;42:137-144.
    • (2001) Investophthalmolvissci , vol.42 , pp. 137-144
    • Honjo, M.1    Tanihara, H.2    Inatani, M.3
  • 7
    • 34548073671 scopus 로고    scopus 로고
    • Effects of topical administration of y-39983, a selective rho-associated protein kinase inhibitor, on ocular tissues in rabbits and monkeys
    • Tokushige H, Inatani M, Nemoto S, et al. Effects of topical administration of y-39983, a selective rho-associated protein kinase inhibitor, on ocular tissues in rabbits and monkeys. Invest Ophthalmol Vis Sci. 2007;48:3216-3222.
    • (2007) Invest Ophthalmol Vis Sci , vol.48 , pp. 3216-3222
    • Tokushige, H.1    Inatani, M.2    Nemoto, S.3
  • 8
    • 80054998108 scopus 로고    scopus 로고
    • Ocular hypotensive effect of the Rho kinase inhibitor AR-12286 in patients with glaucoma and ocular hypertension
    • Williams R D, Novack G D, van Haarlem T, Kopczynski C. Group ARPAS. Ocular hypotensive effect of the Rho kinase inhibitor AR-12286 in patients with glaucoma and ocular hypertension. Am J Ophthalmol. 2011;152:834-841.
    • (2011) Am J Ophthalmol , vol.152 , pp. 834-841
    • Williams, R.D.1    Novack, G.D.2    Van Haarlem, T.3    Kopczynski, C.4
  • 9
    • 84887410136 scopus 로고    scopus 로고
    • Rho-associated kinase inhibitors: A novel glaucoma therapy
    • Inoue T, Tanihara H. Rho-associated kinase inhibitors: a novel glaucoma therapy. Prog Retin Eye Res. 2013;37:12.
    • (2013) Prog Retin Eye Res , vol.37
    • Inoue, T.1    Tanihara, H.2
  • 10
    • 84894099557 scopus 로고    scopus 로고
    • AMA0076, a novel, locally acting Rho kinase inhibitor, potently lowersintraocularpressureinNewZealandwhiterabbitswithminimalhyperemia
    • Van de Velde S, Van Bergen T, Sijnave D, et al. AMA0076, a novel, locally acting Rho kinase inhibitor, potently lowers intraocular pressure in New Zealand white rabbits with minimal hyperemia. Invest Ophthalmol Vis Sci. 2014;55: 1006-1016.
    • (2014) Investophthalmolvissci , vol.55 , pp. 1006-1016
    • Van De Velde, S.1    Van Bergen, T.2    Sijnave, D.3
  • 11
    • 84885929097 scopus 로고    scopus 로고
    • Phase 1 clinical trials of a selective Rho kinase inhibitor, K-115
    • Tanihara H, Inoue T, Yamamoto T, et al. Phase 1 clinical trials of a selective Rho kinase inhibitor, K-115. JAMA Ophthalmol. 2013;131:1288-1295.
    • (2013) JAMA Ophthalmol , vol.131 , pp. 1288-1295
    • Tanihara, H.1    Inoue, T.2    Yamamoto, T.3
  • 12
    • 84884595041 scopus 로고    scopus 로고
    • Phase 2 randomized clinical study of a Rho kinase inhibitor, K-115, in primary open-angle glaucoma and ocular hypertension
    • Tanihara H, Inoue T, Yamamoto T, et al. Phase 2 randomized clinical study of a Rho kinase inhibitor, K-115, in primary open-angle glaucoma and ocular hypertension. Am J Ophthalmol. 2013;156:731-736.
    • (2013) Am J Ophthalmol , vol.156 , pp. 731-736
    • Tanihara, H.1    Inoue, T.2    Yamamoto, T.3
  • 13
    • 84929395741 scopus 로고    scopus 로고
    • Intra-ocular pressure-lowering effects of a Rho kinase inhibitor, ripasudil (K-115), over 24 hours in primary open-angle glaucoma and ocular hypertension: A randomized, open-label, crossover study
    • Tanihara H, Inoue T, Yamamoto T, et al. Intra-ocular pressure-lowering effects of a Rho kinase inhibitor, ripasudil (K-115), over 24 hours in primary open-angle glaucoma and ocular hypertension: a randomized, open-label, crossover study. Acta Ophthalmol. 2015;93:e254-260.
    • (2015) Acta Ophthalmol , vol.93 , pp. e254-e260
    • Tanihara, H.1    Inoue, T.2    Yamamoto, T.3
  • 14
    • 84922102262 scopus 로고    scopus 로고
    • Ripasudil:Firstglobalapproval
    • Garnock-Jones KP. Ripasudil: first global approval. Drugs. 2014;74:2211-2215.
    • (2014) Drugs , vol.74 , pp. 2211-2215
    • Garnock-Jones, K.P.1
  • 15
    • 84904348321 scopus 로고    scopus 로고
    • Effects of K-115, a rho-kinase inhibitor, on aqueous humor dynamics in rabbits
    • Isobe T, Mizuno K, Kaneko Y, Ohta M, Koide T, Tanabe S. Effects of K-115, a rho-kinase inhibitor, on aqueous humor dynamics in rabbits. Curr Eye Res. 2014;39:813-822.
    • (2014) Curr Eye Res , vol.39 , pp. 813-822
    • Isobe, T.1    Mizuno, K.2    Kaneko, Y.3    Ohta, M.4    Koide, T.5    Tanabe, S.6
  • 16
    • 84901357361 scopus 로고    scopus 로고
    • Toward better drug repositioning: Prioritizing and integrating existing methods into efficient pipelines
    • Jin G, Wong ST. Toward better drug repositioning: prioritizing and integrating existing methods into efficient pipelines. Drug Discov Today. 2014;19:637-644.
    • (2014) Drug Discov Today , vol.19 , pp. 637-644
    • Jin, G.1    Wong, S.T.2
  • 18
    • 84960199759 scopus 로고    scopus 로고
    • Drug-repositioning opportunitiesfor cancertherapy: Novel molecular targets for known compounds
    • Wurth R, Thellung S, Bajetto A, Mazzanti M, Florio T, Barbieri F. Drug-repositioning opportunities for cancer therapy: novel molecular targets for known compounds. Drug Discov Today. 2016;21:190-199.
    • (2016) Drug Discov Today , vol.21 , pp. 190-199
    • Wurth, R.1    Thellung, S.2    Bajetto, A.3    Mazzanti, M.4    Florio, T.5    Barbieri, F.6
  • 19
    • 84943274852 scopus 로고    scopus 로고
    • Density-gradient centrifugationenablesthe purification ofcultured corneal endothelialcells for cell therapyby eliminatingsenescent cells
    • Okumura N, Kusakabe A, Hirano H, et al. Density-gradient centrifugation enables the purification of cultured corneal endothelial cells for cell therapy by eliminating senescent cells. Sci Rep. 2015;5:15005.
    • (2015) Sci Rep , vol.5 , pp. 15005
    • Okumura, N.1    Kusakabe, A.2    Hirano, H.3
  • 20
    • 84880704070 scopus 로고    scopus 로고
    • Corneal endothelial expansion promoted by human bone marrow mesenchymal stemcell-derivedconditioned medium
    • Nakahara M, Okumura N, Kay EP, et al. Corneal endothelial expansion promoted by human bone marrow mesenchymal stem cell-derived conditioned medium. PLoS One. 2013;8: e69009.
    • (2013) Plosone , vol.8
    • Nakahara, M.1    Okumura, N.2    Kay, E.P.3
  • 21
    • 0019961233 scopus 로고
    • Wound-healingofthecorneal endothelium in the monkey: A morphometric study
    • Matsubara M, Tanishima T. Wound-healing of the corneal endothelium in the monkey: a morphometric study. Jpn J Ophthalmol. 1982;26:264-273.
    • (1982) Jpn J Ophthalmol , vol.26 , pp. 264-273
    • Matsubara, M.1    Tanishima, T.2
  • 22
    • 0021088982 scopus 로고
    • Wound-healing of corneal endotheliuminmonkey:Anautoradiographicstudy
    • Matsubara M, Tanishima T. Wound-healing of corneal endothelium in monkey: an autoradiographic study. Jpn J Ophthalmol. 1983;27:444-450.
    • (1983) Jpnj Ophthalmol , vol.27 , pp. 444-450
    • Matsubara, M.1    Tanishima, T.2
  • 24
    • 43049181349 scopus 로고    scopus 로고
    • Trendsin penetrating keratoplasty in the United States 1980-2005
    • Ghosheh FR, Cremona FA, Rapuano CJ, et al. Trends in penetrating keratoplasty in the United States 1980-2005. Int Ophthalmol. 2008;28:147-153.
    • (2008) Int Ophthalmol , vol.28 , pp. 147-153
    • Ghosheh, F.R.1    Cremona, F.A.2    Rapuano, C.J.3
  • 25
    • 84860895595 scopus 로고    scopus 로고
    • Trendsinthe indications for corneal graft surgery in the United Kingdom 1999 through 2009
    • Keenan TD, Jones MN, Rushton S, et al. Trends in the indications for corneal graft surgery in the United Kingdom: 1999 through 2009. Arch Ophthalmol. 2012;130:621-628.
    • (2012) Arch Ophthalmol , vol.130 , pp. 621-628
    • Keenan, T.D.1    Jones, M.N.2    Rushton, S.3
  • 26
    • 80053607731 scopus 로고    scopus 로고
    • Eye Bank Association of America, Washington, DC
    • Eye Bank Association of America. Eye Banking Statistical Report. Washington, DC; 2013.
    • (2013) Eye Banking Statistical Report
  • 27
    • 0030658010 scopus 로고    scopus 로고
    • Survival analysis and visual outcome in a large series of corneal transplants in India
    • Dandona L, Naduvilath TJ, Janarthanan M, Ragu K, Rao GN. Survival analysis and visual outcome in a large series of corneal transplants in India. Br J Ophthalmol. 1997;81:726-731.
    • (1997) Br J Ophthalmol , vol.81 , pp. 726-731
    • Dandona, L.1    Naduvilath, T.J.2    Janarthanan, M.3    Ragu, K.4    Rao, G.N.5
  • 28
    • 34147098905 scopus 로고    scopus 로고
    • National survey on bullous keratopathy in Japan
    • Shimazaki J, Amano S, Uno T, Maeda N, Yokoi N. National survey on bullous keratopathy in Japan. Cornea. 2007;26:274-278.
    • (2007) Cornea , vol.26 , pp. 274-278
    • Shimazaki, J.1    Amano, S.2    Uno, T.3    Maeda, N.4    Yokoi, N.5
  • 29
    • 44349154611 scopus 로고    scopus 로고
    • Penetrating keratoplasty inAsianeyes:TheSingaporeCornealTransplantStudy
    • Tan DT, Janardhanan P, Zhou H, et al. Penetrating keratoplasty in Asian eyes: the Singapore Corneal Transplant Study. Ophthalmology. 2008;115:975-982.
    • (2008) Ophthalmology , vol.115 , pp. 975-982
    • Tan, D.T.1    Janardhanan, P.2    Zhou, H.3
  • 30
    • 84860218310 scopus 로고    scopus 로고
    • Global estimates of visual impairment 2010
    • Pascolini D, Mariotti SP. Global estimates of visual impairment: 2010. Br J Ophthalmol. 2012;96:614-618.
    • (2012) Br J Ophthalmol , vol.96 , pp. 614-618
    • Pascolini, D.1    Mariotti, S.P.2
  • 31
    • 0041302199 scopus 로고    scopus 로고
    • Proliferative capacity of the corneal endothelium
    • Joyce NC. Proliferative capacity of the corneal endothelium. Prog Retin Eye Res. 2003;22:359-389.
    • (2003) Prog Retin Eye Res , vol.22 , pp. 359-389
    • Joyce, N.C.1
  • 32
    • 0032424924 scopus 로고    scopus 로고
    • Clinical estimation of corneal endothelial pump function
    • discussion 239-242
    • Bourne WM. Clinical estimation of corneal endothelial pump function. Trans Am Ophthalmol Soc. 1998;96:229-239.discussion 239-242.
    • (1998) Transamophthalmolsoc , vol.96 , pp. 229-239
    • Bourne, W.M.1
  • 34
    • 0028118722 scopus 로고
    • Effects of platelet-derived growth factor on endothelial wound healing of human corneas
    • Hoppenreijs VP, Pels E, Vrensen GF, Treffers WF. Effects of platelet-derived growth factor on endothelial wound healing of human corneas. Invest Ophthalmol Vis Sci. 1994;35:150-161.
    • (1994) Invest Ophthalmol Vis Sci , vol.35 , pp. 150-161
    • Hoppenreijs, V.P.1    Pels, E.2    Vrensen, G.F.3    Treffers, W.F.4
  • 35
    • 33749134219 scopus 로고    scopus 로고
    • TGF-beta2 inhibits AKT activation and FGF-2-induced corneal endothelial cell proliferation
    • Lu J, Lu Z, Reinach P, et al. TGF-beta2 inhibits AKT activation and FGF-2-induced corneal endothelial cell proliferation. Exp Cell Res. 2006;312:3631-3640.
    • (2006) Exp Cell Res , vol.312 , pp. 3631-3640
    • Lu, J.1    Lu, Z.2    Reinach, P.3
  • 36
    • 84942097837 scopus 로고    scopus 로고
    • Effect of the Rho kinase inhibitorY-27632oncornealendothelialwoundhealing
    • Okumura N, Inoue R, Okazaki Y, et al. Effect of the Rho kinase inhibitor Y-27632 on corneal endothelial wound healing. Invest Ophthalmol Vis Sci. 2015;56:6067-6074.
    • (2015) Invest Ophthalmol Vis Sci , vol.56 , pp. 6067-6074
    • Okumura, N.1    Inoue, R.2    Okazaki, Y.3
  • 37
    • 0033777636 scopus 로고    scopus 로고
    • Keratopathy in pseu-doexfoliationsyndromeasacauseofcornealendothelial decompensation: A clinicopathologic study
    • Naumann GO, Schlotzer-Schrehardt U. Keratopathy in pseu-doexfoliation syndrome as a cause of corneal endothelial decompensation: a clinicopathologic study. Ophthalmology. 2000;107:1111-1124.
    • (2000) Ophthalmology , vol.107 , pp. 1111-1124
    • Naumann, G.O.1    Schlotzer-Schrehardt, U.2
  • 38
    • 0035158373 scopus 로고    scopus 로고
    • Extracellularmatrixcomponentsinacaseof retrocorneal membrane associated with syphilitic interstitial keratitis
    • Kawaguchi R, Saika S, Wakayama M, Ooshima A, Ohnishi Y, Yabe H. Extracellular matrix components in a case of retrocorneal membrane associated with syphilitic interstitial keratitis. Cornea. 2001;20:100-103.
    • (2001) Cornea , vol.20 , pp. 100-103
    • Kawaguchi, R.1    Saika, S.2    Wakayama, M.3    Ooshima, A.4    Ohnishi, Y.5    Yabe, H.6
  • 39
    • 3543028591 scopus 로고    scopus 로고
    • FGF-2 induced by interleukin-1 betathroughtheactionofphosphatidylinositol3-kinase mediates endothelial mesenchymal transformation in corneal endothelial cells
    • Lee HT, Lee JG, Na M, Kay EP. FGF-2 induced by interleukin-1 beta through the action of phosphatidylinositol 3-kinase mediates endothelial mesenchymal transformation in corneal endothelial cells. J Biol Chem. 2004;279:32325-32332.
    • (2004) J Biol Chem , vol.279 , pp. 32325-32332
    • Lee, H.T.1    Lee, J.G.2    Na, M.3    Kay, E.P.4
  • 40
    • 84874363905 scopus 로고    scopus 로고
    • Inhibition of TGF-beta signaling enables human cornealendothelialcellexpansioninvitroforusein regenerative medicine
    • Okumura N, Kay EP, Nakahara M, Hamuro J, Kinoshita S, Koizumi N. Inhibition of TGF-beta signaling enables human corneal endothelial cell expansion in vitro for use in regenerative medicine. PLoS One. 2013;8:e58000.
    • (2013) Plos One , vol.8
    • Okumura, N.1    Kay, E.P.2    Nakahara, M.3    Hamuro, J.4    Kinoshita, S.5    Koizumi, N.6
  • 42
    • 41749091574 scopus 로고    scopus 로고
    • Applications for ROCK kinase inhibition
    • Olson MF. Applications for ROCK kinase inhibition. Curr Opin Cell Biol. 2008;20:242-248.
    • (2008) Curr Opin Cell Biol , vol.20 , pp. 242-248
    • Olson, M.F.1
  • 43
    • 23644453653 scopus 로고    scopus 로고
    • Rho kinase as potential therapeutic target forcardiovascular diseases: Opportunities and challenges
    • Hu E, Lee D. Rho kinase as potential therapeutic target for cardiovascular diseases: opportunities and challenges. Expert Opin Ther Targets. 2005;9:715-736.
    • (2005) Expert Opin Ther Targets , vol.9 , pp. 715-736
    • Hu, E.1    Lee, D.2
  • 44
    • 84947806214 scopus 로고    scopus 로고
    • Morphological changes of human corneal endothelial cellsafterrho-associatedkinaseinhibitoreyedrop (Ripasudil) administration: A prospective open-label clinical study
    • e0136802
    • Nakagawa H, Koizumi N, Okumura N, Suganami H, Kinoshita S. Morphological changes of human corneal endothelial cells after rho-associated kinase inhibitor eye drop (ripasudil) administration: a prospective open-label clinical study. PLoS One. 2015;10:e0136802.
    • (2015) Plos One , vol.10
    • Nakagawa, H.1    Koizumi, N.2    Okumura, N.3    Suganami, H.4    Kinoshita, S.5
  • 45
    • 84982740507 scopus 로고    scopus 로고
    • Rho-associated kinaseinhibitor eye drop (Ripasudil) transiently alters the morphology of corneal endothelial cells
    • Okumura N, Okazaki Y, Inoue R, et al. Rho-associated kinase inhibitor eye drop (ripasudil) transiently alters the morphology of corneal endothelial cells. Invest Ophthalmol Vis Sci. 2015;56:7560-7567.
    • (2015) Invest Ophthalmol Vis Sci , vol.56 , pp. 7560-7567
    • Okumura, N.1    Okazaki, Y.2    Inoue, R.3


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