메뉴 건너뛰기




Volumn 21, Issue 1, 2016, Pages 190-199

Drug-repositioning opportunities for cancer therapy: Novel molecular targets for known compounds

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ANTINEOPLASTIC AGENT; DIGITOXIN; DIGOXIN; DISULFIRAM; ITRACONAZOLE; METFORMIN; THALIDOMIDE;

EID: 84960199759     PISSN: 13596446     EISSN: 18785832     Source Type: Journal    
DOI: 10.1016/j.drudis.2015.09.017     Document Type: Review
Times cited : (130)

References (127)
  • 1
    • 84940614379 scopus 로고    scopus 로고
    • Drug repositioning and repurposing: Terminology and definitions in literature
    • J. Langedijk, and et al. Drug repositioning and repurposing: terminology and definitions in literature Drug Discov. Today 20 2015 1027 1034
    • (2015) Drug Discov. Today , vol.20 , pp. 1027-1034
    • Langedijk, J.1
  • 2
    • 26444534291 scopus 로고    scopus 로고
    • Sildenafil citrate therapy for pulmonary arterial hypertension
    • N. Galie, and et al. Sildenafil citrate therapy for pulmonary arterial hypertension N. Engl. J. Med. 353 2005 2148 2157
    • (2005) N. Engl. J. Med. , vol.353 , pp. 2148-2157
    • Galie, N.1
  • 3
    • 84926616289 scopus 로고    scopus 로고
    • Drug repurposing identifies a synergistic combination therapy with imatinib mesylate for gastrointestinal stromal tumor
    • Z.Y. Pessetto, and et al. Drug repurposing identifies a synergistic combination therapy with imatinib mesylate for gastrointestinal stromal tumor Mol. Cancer Ther. 13 2014 2276 2287
    • (2014) Mol. Cancer Ther. , vol.13 , pp. 2276-2287
    • Pessetto, Z.Y.1
  • 4
    • 34548827350 scopus 로고    scopus 로고
    • Nelfinavir, A lead HIV protease inhibitor, is a broad-spectrum, anticancer agent that induces endoplasmic reticulum stress, autophagy, and apoptosis in vitro and in vivo
    • J.J. Gills, and et al. Nelfinavir, A lead HIV protease inhibitor, is a broad-spectrum, anticancer agent that induces endoplasmic reticulum stress, autophagy, and apoptosis in vitro and in vivo Clin. Cancer Res. 13 2007 5183 5194
    • Clin. Cancer Res. , pp. 5183-5194
    • Gills, J.J.1
  • 5
    • 84889848938 scopus 로고    scopus 로고
    • Reduced tumorigenicity and pathogenicity of cervical carcinoma SiHa cells selected for resistance to cidofovir
    • T. De Schutter, and et al. Reduced tumorigenicity and pathogenicity of cervical carcinoma SiHa cells selected for resistance to cidofovir Mol. Cancer 12 2013 158
    • (2013) Mol. Cancer , vol.12 , pp. 158
    • De Schutter, T.1
  • 6
    • 84925013625 scopus 로고    scopus 로고
    • The broad-spectrum anti-DNA virus agent cidofovir inhibits lung metastasis of virus-independent, FGF2-driven tumors
    • S. Liekens, and et al. The broad-spectrum anti-DNA virus agent cidofovir inhibits lung metastasis of virus-independent, FGF2-driven tumors Oncotarget 6 2015 4633 4648
    • (2015) Oncotarget , vol.6 , pp. 4633-4648
    • Liekens, S.1
  • 7
    • 84922285922 scopus 로고    scopus 로고
    • Computational and experimental advances in drug repositioning for accelerated therapeutic stratification
    • K. Shameer, and et al. Computational and experimental advances in drug repositioning for accelerated therapeutic stratification Curr. Top. Med. Chem. 15 2015 5 20
    • (2015) Curr. Top. Med. Chem. , vol.15 , pp. 5-20
    • Shameer, K.1
  • 8
    • 84928658794 scopus 로고    scopus 로고
    • Validating drug repurposing signals using electronic health records: A case study of metformin associated with reduced cancer mortality
    • H. Xu, and et al. Validating drug repurposing signals using electronic health records: A case study of metformin associated with reduced cancer mortality J. Am. Med. Inform. Assoc. 22 2015 179 191
    • (2015) J. Am. Med. Inform. Assoc. , vol.22 , pp. 179-191
    • Xu, H.1
  • 9
    • 84858978535 scopus 로고    scopus 로고
    • Drug repositioning for personalized medicine
    • Y.Y. Li, and S.J. Jones Drug repositioning for personalized medicine Genome Med. 4 2012 27
    • (2012) Genome Med. , vol.4 , pp. 27
    • Li, Y.Y.1    Jones, S.J.2
  • 10
    • 77954721903 scopus 로고    scopus 로고
    • Drug repurposing for drug development in stroke
    • S.C. Fagan Drug repurposing for drug development in stroke Pharmacotherapy 30 2010 51S 54S
    • (2010) Pharmacotherapy , vol.30 , pp. 51S-54S
    • Fagan, S.C.1
  • 11
    • 84876936620 scopus 로고    scopus 로고
    • Repurposing the antimycotic drug flucytosine for suppression of Pseudomonas aeruginosa pathogenicity
    • F. Imperi, and et al. Repurposing the antimycotic drug flucytosine for suppression of Pseudomonas aeruginosa pathogenicity Proc. Natl. Acad. Sci. U. S. A. 110 2013 7458 7463
    • (2013) Proc. Natl. Acad. Sci. U. S. A. , vol.110 , pp. 7458-7463
    • Imperi, F.1
  • 12
    • 79959515584 scopus 로고    scopus 로고
    • New sources of drugs for hematologic malignancies
    • M.A. Sukhai, and et al. New sources of drugs for hematologic malignancies Blood 117 2011 6747 6755
    • (2011) Blood , vol.117 , pp. 6747-6755
    • Sukhai, M.A.1
  • 13
    • 84862777666 scopus 로고    scopus 로고
    • ApoE-directed therapeutics rapidly clear beta-amyloid and reverse deficits in AD mouse models
    • P.E. Cramer, and et al. ApoE-directed therapeutics rapidly clear beta-amyloid and reverse deficits in AD mouse models Science 335 2012 1503 1506
    • (2012) Science , vol.335 , pp. 1503-1506
    • Cramer, P.E.1
  • 14
    • 84874445236 scopus 로고    scopus 로고
    • Cell-based screening identifies paroxetine as an inhibitor of diabetic endothelial dysfunction
    • D. Gero, and et al. Cell-based screening identifies paroxetine as an inhibitor of diabetic endothelial dysfunction Diabetes 62 2013 953 964
    • (2013) Diabetes , vol.62 , pp. 953-964
    • Gero, D.1
  • 15
    • 78049485263 scopus 로고    scopus 로고
    • Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008
    • J. Ferlay, and et al. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008 Int. J. Cancer 127 2010 2893 2917
    • (2010) Int. J. Cancer , vol.127 , pp. 2893-2917
    • Ferlay, J.1
  • 16
    • 84883776568 scopus 로고    scopus 로고
    • Cancer drug discovery by repurposing: Teaching new tricks to old dogs
    • S.C. Gupta, and et al. Cancer drug discovery by repurposing: teaching new tricks to old dogs Trends Pharmacol. Sci. 34 2013 508 517
    • (2013) Trends Pharmacol. Sci. , vol.34 , pp. 508-517
    • Gupta, S.C.1
  • 17
    • 84892153139 scopus 로고    scopus 로고
    • Clinical development success rates for investigational drugs
    • M. Hay, and et al. Clinical development success rates for investigational drugs Nat. Biotechnol. 32 2014 40 51
    • (2014) Nat. Biotechnol. , vol.32 , pp. 40-51
    • Hay, M.1
  • 18
    • 84875211731 scopus 로고    scopus 로고
    • Cancer heterogeneity: Implications for targeted therapeutics
    • R. Fisher, and et al. Cancer heterogeneity: implications for targeted therapeutics Br. J. Cancer 108 2013 479 485
    • (2013) Br. J. Cancer , vol.108 , pp. 479-485
    • Fisher, R.1
  • 19
    • 84866731616 scopus 로고    scopus 로고
    • The status of the art of human malignant glioma management: The promising role of targeting tumor-initiating cells
    • T. Florio, and F. Barbieri The status of the art of human malignant glioma management: The promising role of targeting tumor-initiating cells Drug Discov. Today 17 2012 1103 1110
    • (2012) Drug Discov. Today , vol.17 , pp. 1103-1110
    • Florio, T.1    Barbieri, F.2
  • 20
    • 84884368877 scopus 로고    scopus 로고
    • Influence of tumour micro-environment heterogeneity on therapeutic response
    • M.R. Junttila, and F.J. de Sauvage Influence of tumour micro-environment heterogeneity on therapeutic response Nature 501 2013 346 354
    • (2013) Nature , vol.501 , pp. 346-354
    • Junttila, M.R.1    De Sauvage, F.J.2
  • 21
    • 84901623974 scopus 로고    scopus 로고
    • CXCL12 modulation of CXCR4 and CXCR7 activity in human glioblastoma stem-like cells and regulation of the tumor microenvironment
    • R. Wurth, and et al. CXCL12 modulation of CXCR4 and CXCR7 activity in human glioblastoma stem-like cells and regulation of the tumor microenvironment Front. Cell. Neurosci. 8 2014 144
    • (2014) Front. Cell. Neurosci. , vol.8 , pp. 144
    • Wurth, R.1
  • 22
    • 84922952448 scopus 로고    scopus 로고
    • Translational horizons in the tumor microenvironment: Harnessing breakthroughs and targeting cures
    • Y. Sun Translational horizons in the tumor microenvironment: harnessing breakthroughs and targeting cures Med. Res. Rev. 35 2015 408 436
    • (2015) Med. Res. Rev. , vol.35 , pp. 408-436
    • Sun, Y.1
  • 23
    • 84928749945 scopus 로고    scopus 로고
    • New horizons in tumor microenvironment biology: Challenges and opportunities
    • F. Chen, and et al. New horizons in tumor microenvironment biology: challenges and opportunities BMC Med. 13 2015 45
    • (2015) BMC Med. , vol.13 , pp. 45
    • Chen, F.1
  • 24
    • 84887516591 scopus 로고    scopus 로고
    • Inhibition of CXCL12/CXCR4 autocrine/paracrine loop reduces viability of human glioblastoma stem-like cells affecting self-renewal activity
    • M. Gatti, and et al. Inhibition of CXCL12/CXCR4 autocrine/paracrine loop reduces viability of human glioblastoma stem-like cells affecting self-renewal activity Toxicology 314 2013 209 220
    • (2013) Toxicology , vol.314 , pp. 209-220
    • Gatti, M.1
  • 25
    • 84875174768 scopus 로고    scopus 로고
    • The role of tumour-stromal interactions in modifying drug response: Challenges and opportunities
    • D.W. McMillin, and et al. The role of tumour-stromal interactions in modifying drug response: challenges and opportunities Nat. Rev. Drug Discov. 12 2013 217 228
    • (2013) Nat. Rev. Drug Discov. , vol.12 , pp. 217-228
    • McMillin, D.W.1
  • 26
    • 79955649526 scopus 로고    scopus 로고
    • Expression of CXCR7 chemokine receptor in human meningioma cells and in intratumoral microvasculature
    • R. Wurth, and et al. Expression of CXCR7 chemokine receptor in human meningioma cells and in intratumoral microvasculature J. Neuroimmunol. 234 2011 115 123
    • (2011) J. Neuroimmunol. , vol.234 , pp. 115-123
    • Wurth, R.1
  • 27
    • 84858990965 scopus 로고    scopus 로고
    • Thalidomide: An old drug with new action
    • V. Kumar, and S. Chhibber Thalidomide: an old drug with new action J. Chemother. 23 2011 326 334
    • (2011) J. Chemother. , vol.23 , pp. 326-334
    • Kumar, V.1    Chhibber, S.2
  • 28
    • 84937789581 scopus 로고    scopus 로고
    • Promising therapies in multiple myeloma
    • G. Bianchi, and et al. Promising therapies in multiple myeloma Blood 126 2015 300 310
    • (2015) Blood , vol.126 , pp. 300-310
    • Bianchi, G.1
  • 29
    • 84892593087 scopus 로고    scopus 로고
    • The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins
    • G. Lu, and et al. The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins Science 343 2014 305 309
    • (2014) Science , vol.343 , pp. 305-309
    • Lu, G.1
  • 30
    • 84880917508 scopus 로고    scopus 로고
    • Cardiac glycosides in cancer therapy: from preclinical investigations towards clinical trials
    • M. Slingerland, and et al. Cardiac glycosides in cancer therapy: from preclinical investigations towards clinical trials Invest. New Drugs 31 2013 1087 1094
    • (2013) Invest. New Drugs , vol.31 , pp. 1087-1094
    • Slingerland, M.1
  • 31
    • 9244265018 scopus 로고    scopus 로고
    • + in apoptosis of CHO cells
    • + in apoptosis of CHO cells Cell Calcium 36 2004 421 430
    • (2004) Cell Calcium , vol.36 , pp. 421-430
    • Pigozzi, D.1
  • 32
    • 84864648362 scopus 로고    scopus 로고
    • Digitoxin and its analogs as novel cancer therapeutics
    • H.A. Elbaz, and et al. Digitoxin and its analogs as novel cancer therapeutics Exp. Hematol. Oncol. 1 2012 4
    • (2012) Exp. Hematol. Oncol. , vol.1 , pp. 4
    • Elbaz, H.A.1
  • 33
    • 84883233976 scopus 로고    scopus 로고
    • Trial watch: Cardiac glycosides and cancer therapy
    • L. Menger, and et al. Trial watch: cardiac glycosides and cancer therapy Oncoimmunology 2 2013 e23082
    • (2013) Oncoimmunology , vol.2 , pp. e23082
    • Menger, L.1
  • 34
    • 79959922456 scopus 로고    scopus 로고
    • A novel two-stage, transdisciplinary study identifies digoxin as a possible drug for prostate cancer treatment
    • E.A. Platz, and et al. A novel two-stage, transdisciplinary study identifies digoxin as a possible drug for prostate cancer treatment Cancer Discov. 1 2011 68 77
    • (2011) Cancer Discov. , vol.1 , pp. 68-77
    • Platz, E.A.1
  • 35
    • 84864128654 scopus 로고    scopus 로고
    • Cardiac glycosides exert anticancer effects by inducing immunogenic cell death
    • L. Menger, and et al. Cardiac glycosides exert anticancer effects by inducing immunogenic cell death Sci. Transl. Med. 4 2012 143ra199
    • (2012) Sci. Transl. Med. , vol.4 , pp. 143ra199
    • Menger, L.1
  • 36
    • 84872773175 scopus 로고    scopus 로고
    • Disulfiram, a drug widely used to control alcoholism, suppresses the self-renewal of glioblastoma and over-rides resistance to temozolomide
    • J. Triscott, and et al. Disulfiram, a drug widely used to control alcoholism, suppresses the self-renewal of glioblastoma and over-rides resistance to temozolomide Oncotarget 3 2012 1112 1123
    • (2012) Oncotarget , vol.3 , pp. 1112-1123
    • Triscott, J.1
  • 37
    • 84869177666 scopus 로고    scopus 로고
    • Aldehyde dehydrogenase 1A1: A new mediator of resistance to temozolomide in glioblastoma
    • A. Schafer, and et al. Aldehyde dehydrogenase 1A1: A new mediator of resistance to temozolomide in glioblastoma Neuro Oncol. 14 2012 1452 1464
    • (2012) Neuro Oncol. , vol.14 , pp. 1452-1464
    • Schafer, A.1
  • 38
    • 84867897977 scopus 로고    scopus 로고
    • Cytotoxic effect of disulfiram/copper on human glioblastoma cell lines and ALDH-positive cancer-stem-like cells
    • P. Liu, and et al. Cytotoxic effect of disulfiram/copper on human glioblastoma cell lines and ALDH-positive cancer-stem-like cells Br. J. Cancer 107 2012 1488 1497
    • (2012) Br. J. Cancer , vol.107 , pp. 1488-1497
    • Liu, P.1
  • 39
    • 84943196124 scopus 로고    scopus 로고
    • Disulfiram modulates stemness and metabolism of brain tumor initiating cells in atypical teratoid/rhabdoid tumors
    • S.A. Choi, and et al. Disulfiram modulates stemness and metabolism of brain tumor initiating cells in atypical teratoid/rhabdoid tumors Neuro Oncol. 17 2015 810 821
    • (2015) Neuro Oncol. , vol.17 , pp. 810-821
    • Choi, S.A.1
  • 40
    • 79951702170 scopus 로고    scopus 로고
    • Disulfiram, and disulfiram derivatives as novel potential anticancer drugs targeting the ubiquitin-proteasome system in both preclinical and clinical studies
    • F.R. Kona, and et al. Disulfiram, and disulfiram derivatives as novel potential anticancer drugs targeting the ubiquitin-proteasome system in both preclinical and clinical studies Curr. Cancer Drug Targets 11 2011 338 346
    • (2011) Curr. Cancer Drug Targets , vol.11 , pp. 338-346
    • Kona, F.R.1
  • 41
    • 84907552070 scopus 로고    scopus 로고
    • Liposome encapsulated Disulfiram inhibits NFkappaB pathway and targets breast cancer stem cells in vitro and in vivo
    • P. Liu, and et al. Liposome encapsulated Disulfiram inhibits NFkappaB pathway and targets breast cancer stem cells in vitro and in vivo Oncotarget 5 2014 7471 7485
    • (2014) Oncotarget , vol.5 , pp. 7471-7485
    • Liu, P.1
  • 42
    • 79251473704 scopus 로고    scopus 로고
    • Disulfiram is a DNA demethylating agent and inhibits prostate cancer cell growth
    • J. Lin, and et al. Disulfiram is a DNA demethylating agent and inhibits prostate cancer cell growth Prostate 71 2011 333 343
    • (2011) Prostate , vol.71 , pp. 333-343
    • Lin, J.1
  • 43
    • 84899675978 scopus 로고    scopus 로고
    • NUP98-PHF23 is a chromatin-modifying oncoprotein that causes a wide array of leukemias sensitive to inhibition of PHD histone reader function
    • S.M. Gough, and et al. NUP98-PHF23 is a chromatin-modifying oncoprotein that causes a wide array of leukemias sensitive to inhibition of PHD histone reader function Cancer Discov. 4 2014 564 577
    • (2014) Cancer Discov. , vol.4 , pp. 564-577
    • Gough, S.M.1
  • 44
    • 84943452269 scopus 로고    scopus 로고
    • Copper improves the anti-angiogenic activity of disulfiram through the EGFR/Src/VEGF pathway in gliomas
    • Y. Li, and et al. Copper improves the anti-angiogenic activity of disulfiram through the EGFR/Src/VEGF pathway in gliomas Cancer Lett. 2015 10.1016/j.canlet.2015.07.029
    • (2015) Cancer Lett.
    • Li, Y.1
  • 45
    • 84898003500 scopus 로고    scopus 로고
    • Disulfiram eradicates tumor-initiating hepatocellular carcinoma cells in ROS-p38 MAPK pathway-dependent and -independent manners
    • T. Chiba, and et al. Disulfiram eradicates tumor-initiating hepatocellular carcinoma cells in ROS-p38 MAPK pathway-dependent and -independent manners PLOS ONE 9 2014 e84807
    • (2014) PLOS ONE , vol.9 , pp. e84807
    • Chiba, T.1
  • 46
    • 84896823645 scopus 로고    scopus 로고
    • Multi-targeted inhibition of tumor growth and lung metastasis by redox-sensitive shell crosslinked micelles loading disulfiram
    • X. Duan, and et al. Multi-targeted inhibition of tumor growth and lung metastasis by redox-sensitive shell crosslinked micelles loading disulfiram Nanotechnology 25 2014 125102
    • (2014) Nanotechnology , vol.25 , pp. 125102
    • Duan, X.1
  • 47
    • 84888857652 scopus 로고    scopus 로고
    • A binuclear complex constituted by diethyldithiocarbamate and copper(I) functions as a proteasome activity inhibitor in pancreatic cancer cultures and xenografts
    • J. Han, and et al. A binuclear complex constituted by diethyldithiocarbamate and copper(I) functions as a proteasome activity inhibitor in pancreatic cancer cultures and xenografts Toxicol. Appl. Pharmacol. 273 2013 477 483
    • (2013) Toxicol. Appl. Pharmacol. , vol.273 , pp. 477-483
    • Han, J.1
  • 48
    • 84903632887 scopus 로고    scopus 로고
    • Disulfiram targeting lymphoid malignant cell lines via ROS-JNK activation as well as Nrf2 and NF-kB pathway inhibition
    • J. Zha, and et al. Disulfiram targeting lymphoid malignant cell lines via ROS-JNK activation as well as Nrf2 and NF-kB pathway inhibition J. Transl. Med. 12 2014 163
    • (2014) J. Transl. Med. , vol.12 , pp. 163
    • Zha, J.1
  • 49
    • 84925665433 scopus 로고    scopus 로고
    • Concise review: Bullseye: Targeting cancer stem cells to improve the treatment of gliomas by repurposing disulfiram
    • J. Triscott, and et al. Concise review: bullseye: targeting cancer stem cells to improve the treatment of gliomas by repurposing disulfiram Stem Cells 33 2015 1042 1046
    • (2015) Stem Cells , vol.33 , pp. 1042-1046
    • Triscott, J.1
  • 50
    • 80054888464 scopus 로고    scopus 로고
    • Itraconazole inhibits angiogenesis and tumor growth in non-small cell lung cancer
    • B.T. Aftab, and et al. Itraconazole inhibits angiogenesis and tumor growth in non-small cell lung cancer Cancer Res. 71 2011 6764 6772
    • (2011) Cancer Res. , vol.71 , pp. 6764-6772
    • Aftab, B.T.1
  • 51
    • 84903842393 scopus 로고    scopus 로고
    • Itraconazole suppresses the growth of glioblastoma through induction of autophagy: Involvement of abnormal cholesterol trafficking
    • R. Liu, and et al. Itraconazole suppresses the growth of glioblastoma through induction of autophagy: involvement of abnormal cholesterol trafficking Autophagy 10 2014 1241 1255
    • (2014) Autophagy , vol.10 , pp. 1241-1255
    • Liu, R.1
  • 52
    • 77950492233 scopus 로고    scopus 로고
    • Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth
    • J. Kim, and et al. Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth Cancer Cell 17 2010 388 399
    • (2010) Cancer Cell , vol.17 , pp. 388-399
    • Kim, J.1
  • 53
    • 84897949607 scopus 로고    scopus 로고
    • Open-label, exploratory phase II trial of oral itraconazole for the treatment of basal cell carcinoma
    • D.J. Kim, and et al. Open-label, exploratory phase II trial of oral itraconazole for the treatment of basal cell carcinoma J. Clin. Oncol. 32 2014 745 751
    • (2014) J. Clin. Oncol. , vol.32 , pp. 745-751
    • Kim, D.J.1
  • 54
    • 84872417679 scopus 로고    scopus 로고
    • Itraconazole and arsenic trioxide inhibit Hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists
    • J. Kim, and et al. Itraconazole and arsenic trioxide inhibit Hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists Cancer Cell 23 2013 23 34
    • (2013) Cancer Cell , vol.23 , pp. 23-34
    • Kim, J.1
  • 55
    • 84896380125 scopus 로고    scopus 로고
    • High-dose itraconazole as a noncastrating therapy for a patient with biochemically recurrent prostate cancer
    • D.L. Suzman, and E.S. Antonarakis High-dose itraconazole as a noncastrating therapy for a patient with biochemically recurrent prostate cancer Clin. Genitourin. Cancer 12 2014 e51 e53
    • (2014) Clin. Genitourin. Cancer , vol.12 , pp. e51-e53
    • Suzman, D.L.1    Antonarakis, E.S.2
  • 56
    • 84906318465 scopus 로고    scopus 로고
    • Impact of itraconazole on the survival of heavily pre-treated patients with triple-negative breast cancer
    • H. Tsubamoto, and et al. Impact of itraconazole on the survival of heavily pre-treated patients with triple-negative breast cancer Anticancer Res. 34 2014 3839 3844
    • (2014) Anticancer Res. , vol.34 , pp. 3839-3844
    • Tsubamoto, H.1
  • 57
    • 84876411054 scopus 로고    scopus 로고
    • Phase 2 study of pemetrexed and itraconazole as second-line therapy for metastatic nonsquamous non-small-cell lung cancer
    • C.M. Rudin, and et al. Phase 2 study of pemetrexed and itraconazole as second-line therapy for metastatic nonsquamous non-small-cell lung cancer J. Thorac. Oncol. 8 2013 619 623
    • (2013) J. Thorac. Oncol. , vol.8 , pp. 619-623
    • Rudin, C.M.1
  • 58
    • 84902985388 scopus 로고    scopus 로고
    • Impact of combination chemotherapy with itraconazole on survival of patients with refractory ovarian cancer
    • H. Tsubamoto, and et al. Impact of combination chemotherapy with itraconazole on survival of patients with refractory ovarian cancer Anticancer Res. 34 2014 2481 2487
    • (2014) Anticancer Res. , vol.34 , pp. 2481-2487
    • Tsubamoto, H.1
  • 59
    • 84937131279 scopus 로고    scopus 로고
    • Combination chemotherapy with itraconazole for treating metastatic pancreatic cancer in the second-line or additional setting
    • H. Tsubamoto, and et al. Combination chemotherapy with itraconazole for treating metastatic pancreatic cancer in the second-line or additional setting Anticancer Res. 35 2015 4191 4196
    • (2015) Anticancer Res. , vol.35 , pp. 4191-4196
    • Tsubamoto, H.1
  • 60
    • 84904193620 scopus 로고    scopus 로고
    • Prevention and treatment of cancer with aspirin: Where do we stand?
    • B. Pasche, and et al. Prevention and treatment of cancer with aspirin: where do we stand? Semin. Oncol. 41 2014 397 401
    • (2014) Semin. Oncol. , vol.41 , pp. 397-401
    • Pasche, B.1
  • 61
    • 33644837942 scopus 로고    scopus 로고
    • Non-steroidal anti-inflammatory drugs for cancer prevention: Promise, perils and pharmacogenetics
    • C.M. Ulrich, and et al. Non-steroidal anti-inflammatory drugs for cancer prevention: promise, perils and pharmacogenetics Nat. Rev. Cancer 6 2006 130 140
    • (2006) Nat. Rev. Cancer , vol.6 , pp. 130-140
    • Ulrich, C.M.1
  • 62
    • 65349152488 scopus 로고    scopus 로고
    • Aspirin and non-steroidal anti-inflammatory drugs for cancer prevention: An international consensus statement
    • J. Cuzick, and et al. Aspirin and non-steroidal anti-inflammatory drugs for cancer prevention: an international consensus statement Lancet Oncol. 10 2009 501 507
    • (2009) Lancet Oncol. , vol.10 , pp. 501-507
    • Cuzick, J.1
  • 63
    • 84863412124 scopus 로고    scopus 로고
    • Short-term effects of daily aspirin on cancer incidence, mortality, and non-vascular death: Analysis of the time course of risks and benefits in 51 randomised controlled trials
    • P.M. Rothwell, and et al. Short-term effects of daily aspirin on cancer incidence, mortality, and non-vascular death: analysis of the time course of risks and benefits in 51 randomised controlled trials Lancet 379 2012 1602 1612
    • (2012) Lancet , vol.379 , pp. 1602-1612
    • Rothwell, P.M.1
  • 64
    • 84863399038 scopus 로고    scopus 로고
    • Effect of daily aspirin on risk of cancer metastasis: A study of incident cancers during randomised controlled trials
    • P.M. Rothwell, and et al. Effect of daily aspirin on risk of cancer metastasis: A study of incident cancers during randomised controlled trials Lancet 379 2012 1591 1601
    • (2012) Lancet , vol.379 , pp. 1591-1601
    • Rothwell, P.M.1
  • 65
    • 84930573126 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory medications are cytostatic against human vestibular schwannomas
    • S. Dilwali, and et al. Nonsteroidal anti-inflammatory medications are cytostatic against human vestibular schwannomas Transl. Res. 166 2015 1 11
    • (2015) Transl. Res. , vol.166 , pp. 1-11
    • Dilwali, S.1
  • 66
    • 84890038901 scopus 로고    scopus 로고
    • Role of aspirin in cancer prevention
    • M.A. Thorat, and J. Cuzick Role of aspirin in cancer prevention Curr. Oncol. Rep. 15 2013 533 540
    • (2013) Curr. Oncol. Rep. , vol.15 , pp. 533-540
    • Thorat, M.A.1    Cuzick, J.2
  • 67
    • 84055161444 scopus 로고    scopus 로고
    • Aspirin or enoxaparin thromboprophylaxis for patients with newly diagnosed multiple myeloma treated with lenalidomide
    • quiz 1093
    • A. Larocca, and et al. Aspirin or enoxaparin thromboprophylaxis for patients with newly diagnosed multiple myeloma treated with lenalidomide Blood 119 2012 933 939 quiz 1093
    • (2012) Blood , vol.119 , pp. 933-939
    • Larocca, A.1
  • 68
    • 84877143409 scopus 로고    scopus 로고
    • Aspirin as a treatment for cancer
    • I. Phillips, and et al. Aspirin as a treatment for cancer Clin. Oncol. 25 2013 333 335
    • (2013) Clin. Oncol. , vol.25 , pp. 333-335
    • Phillips, I.1
  • 69
    • 84906893446 scopus 로고    scopus 로고
    • Combined cancer therapy with non-conventional drugs: All roads lead to AMPK
    • S. Chen, and et al. Combined cancer therapy with non-conventional drugs: all roads lead to AMPK Mini Rev. Med. Chem. 14 2014 642 654
    • (2014) Mini Rev. Med. Chem. , vol.14 , pp. 642-654
    • Chen, S.1
  • 70
    • 84939860188 scopus 로고    scopus 로고
    • Metformin combined with aspirin significantly inhibit pancreatic cancer cell growth in vitro and in vivo by suppressing anti-apoptotic proteins Mcl-1 and Bcl-2
    • W. Yue, and et al. Metformin combined with aspirin significantly inhibit pancreatic cancer cell growth in vitro and in vivo by suppressing anti-apoptotic proteins Mcl-1 and Bcl-2 Oncotarget 6 2015 21208 21224
    • (2015) Oncotarget , vol.6 , pp. 21208-21224
    • Yue, W.1
  • 71
    • 84983464535 scopus 로고    scopus 로고
    • Aspirin delays mesothelioma growth by inhibiting HMGB1-mediated tumor progression
    • H. Yang, and et al. Aspirin delays mesothelioma growth by inhibiting HMGB1-mediated tumor progression Cell Death Dis. 6 2015 e1786
    • (2015) Cell Death Dis. , vol.6 , pp. e1786
    • Yang, H.1
  • 72
    • 84933056042 scopus 로고    scopus 로고
    • Aspirin blocks growth of breast tumor cells and tumor-initiating cells and induces reprogramming factors of mesenchymal to epithelial transition
    • G. Maity, and et al. Aspirin blocks growth of breast tumor cells and tumor-initiating cells and induces reprogramming factors of mesenchymal to epithelial transition Lab. Invest. 95 2015 702 717
    • (2015) Lab. Invest. , vol.95 , pp. 702-717
    • Maity, G.1
  • 73
    • 84929598282 scopus 로고    scopus 로고
    • Aspirin counteracts cancer stem cell features, desmoplasia and gemcitabine resistance in pancreatic cancer
    • Y. Zhang, and et al. Aspirin counteracts cancer stem cell features, desmoplasia and gemcitabine resistance in pancreatic cancer Oncotarget 6 2015 9999 10015
    • (2015) Oncotarget , vol.6 , pp. 9999-10015
    • Zhang, Y.1
  • 74
    • 84888013612 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drugs suppress cancer stem cells via inhibiting PTGS2 (cyclooxygenase 2) and NOTCH/HES1 and activating PPARG in colorectal cancer
    • C.M. Moon, and et al. Nonsteroidal anti-inflammatory drugs suppress cancer stem cells via inhibiting PTGS2 (cyclooxygenase 2) and NOTCH/HES1 and activating PPARG in colorectal cancer Int. J. Cancer 134 2014 519 529
    • (2014) Int. J. Cancer , vol.134 , pp. 519-529
    • Moon, C.M.1
  • 75
    • 84860250352 scopus 로고    scopus 로고
    • Use of aspirin postdiagnosis improves survival for colon cancer patients
    • E. Bastiaannet, and et al. Use of aspirin postdiagnosis improves survival for colon cancer patients Br. J. Cancer 106 2012 1564 1570
    • (2012) Br. J. Cancer , vol.106 , pp. 1564-1570
    • Bastiaannet, E.1
  • 76
    • 84926518325 scopus 로고    scopus 로고
    • Aspirin and COX-2 inhibitor use in patients with stage III colon cancer
    • K. Ng, and et al. Aspirin and COX-2 inhibitor use in patients with stage III colon cancer J. Natl. Cancer Inst. 107 2015 345
    • (2015) J. Natl. Cancer Inst. , vol.107 , pp. 345
    • Ng, K.1
  • 77
    • 84879165730 scopus 로고    scopus 로고
    • A conceptually new treatment approach for relapsed glioblastoma: Coordinated undermining of survival paths with nine repurposed drugs (CUSP9) by the International Initiative for Accelerated Improvement of Glioblastoma Care
    • R.E. Kast, and et al. A conceptually new treatment approach for relapsed glioblastoma: coordinated undermining of survival paths with nine repurposed drugs (CUSP9) by the International Initiative for Accelerated Improvement of Glioblastoma Care Oncotarget 4 2013 502 530
    • (2013) Oncotarget , vol.4 , pp. 502-530
    • Kast, R.E.1
  • 78
    • 84907971362 scopus 로고    scopus 로고
    • CUSP9∗treatment protocol for recurrent glioblastoma: Aprepitant, artesunate, auranofin, captopril, celecoxib, disulfiram, itraconazole, ritonavir, sertraline augmenting continuous low dose temozolomide
    • R.E. Kast, and et al. CUSP9∗treatment protocol for recurrent glioblastoma: aprepitant, artesunate, auranofin, captopril, celecoxib, disulfiram, itraconazole, ritonavir, sertraline augmenting continuous low dose temozolomide Oncotarget 5 2014 8052 8082
    • (2014) Oncotarget , vol.5 , pp. 8052-8082
    • Kast, R.E.1
  • 79
    • 0015220921 scopus 로고
    • Age-associated elevation of hypothalamic, threshold to feedback control, and its role in development, ageine, and disease
    • V.M. Dilman Age-associated elevation of hypothalamic, threshold to feedback control, and its role in development, ageine, and disease Lancet 1 1971 1211 1219
    • (1971) Lancet , vol.1 , pp. 1211-1219
    • Dilman, V.M.1
  • 80
    • 34249314771 scopus 로고    scopus 로고
    • Treating the metabolic syndrome
    • C. Bianchi, and et al. Treating the metabolic syndrome Expert Rev. Cardiovasc. Ther. 5 2007 491 506
    • (2007) Expert Rev. Cardiovasc. Ther. , vol.5 , pp. 491-506
    • Bianchi, C.1
  • 81
    • 84857060386 scopus 로고    scopus 로고
    • Medical management of metabolic dysfunction in PCOS
    • A.J. Duleba Medical management of metabolic dysfunction in PCOS Steroids 77 2012 306 311
    • (2012) Steroids , vol.77 , pp. 306-311
    • Duleba, A.J.1
  • 82
    • 0037034257 scopus 로고    scopus 로고
    • Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
    • W.C. Knowler, and et al. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin N. Engl. J. Med. 346 2002 393 403
    • (2002) N. Engl. J. Med. , vol.346 , pp. 393-403
    • Knowler, W.C.1
  • 83
    • 34248156160 scopus 로고    scopus 로고
    • Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action
    • Y. Shu, and et al. Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action J. Clin. Invest. 117 2007 1422 1431
    • (2007) J. Clin. Invest. , vol.117 , pp. 1422-1431
    • Shu, Y.1
  • 84
    • 0034773404 scopus 로고    scopus 로고
    • Role of AMP-activated protein kinase in mechanism of metformin action
    • G. Zhou, and et al. Role of AMP-activated protein kinase in mechanism of metformin action J. Clin. Invest. 108 2001 1167 1174
    • (2001) J. Clin. Invest. , vol.108 , pp. 1167-1174
    • Zhou, G.1
  • 85
    • 84880974660 scopus 로고    scopus 로고
    • Metformin therapy and risk of cancer in patients with type 2 diabetes: Systematic review
    • M. Franciosi, and et al. Metformin therapy and risk of cancer in patients with type 2 diabetes: systematic review PLoS ONE 8 2013 e71583
    • (2013) PLoS ONE , vol.8 , pp. e71583
    • Franciosi, M.1
  • 86
    • 84858695046 scopus 로고    scopus 로고
    • Cancer risk in diabetic patients treated with metformin: A systematic review and meta-analysis
    • H. Noto, and et al. Cancer risk in diabetic patients treated with metformin: A systematic review and meta-analysis PLoS ONE 7 2012 e33411
    • (2012) PLoS ONE , vol.7 , pp. e33411
    • Noto, H.1
  • 87
    • 84908399011 scopus 로고    scopus 로고
    • Metformin decreases lung cancer risk in diabetic patients in a dose-dependent manner
    • M.J. Tsai, and et al. Metformin decreases lung cancer risk in diabetic patients in a dose-dependent manner Lung Cancer 86 2014 137 143
    • (2014) Lung Cancer , vol.86 , pp. 137-143
    • Tsai, M.J.1
  • 88
    • 84935873481 scopus 로고    scopus 로고
    • Pharmacologic therapy of diabetes and overall cancer risk and mortality: A meta-analysis of 265 studies
    • L. Wu, and et al. Pharmacologic therapy of diabetes and overall cancer risk and mortality: A meta-analysis of 265 studies Sci. Rep. 5 2015 10147
    • (2015) Sci. Rep. , vol.5 , pp. 10147
    • Wu, L.1
  • 89
    • 84922220567 scopus 로고    scopus 로고
    • The biguanides metformin and phenformin inhibit angiogenesis, local and metastatic growth of breast cancer by targeting both neoplastic and microenvironment cells
    • S. Orecchioni, and et al. The biguanides metformin and phenformin inhibit angiogenesis, local and metastatic growth of breast cancer by targeting both neoplastic and microenvironment cells Int. J. Cancer 136 2015 E534 E544
    • (2015) Int. J. Cancer , vol.136 , pp. E534-E544
    • Orecchioni, S.1
  • 90
    • 84927666790 scopus 로고    scopus 로고
    • In vitro and in vivo antiproliferative activity of metformin on stem-like cells isolated from spontaneous canine mammary carcinomas: Translational implications for human tumors
    • F. Barbieri, and et al. In vitro and in vivo antiproliferative activity of metformin on stem-like cells isolated from spontaneous canine mammary carcinomas: translational implications for human tumors BMC Cancer 15 2015 228
    • (2015) BMC Cancer , vol.15 , pp. 228
    • Barbieri, F.1
  • 91
    • 84903208075 scopus 로고    scopus 로고
    • Metformin impairs growth of endometrial cancer cells via cell cycle arrest and concomitant autophagy and apoptosis
    • A. Takahashi, and et al. Metformin impairs growth of endometrial cancer cells via cell cycle arrest and concomitant autophagy and apoptosis Cancer Cell Int. 14 2014 53
    • (2014) Cancer Cell Int. , vol.14 , pp. 53
    • Takahashi, A.1
  • 92
    • 84861540166 scopus 로고    scopus 로고
    • Antiproliferative action of metformin in human lung cancer cell lines
    • H. Ashinuma, and et al. Antiproliferative action of metformin in human lung cancer cell lines Oncol. Rep. 28 2012 8 14
    • (2012) Oncol. Rep. , vol.28 , pp. 8-14
    • Ashinuma, H.1
  • 93
    • 84989316816 scopus 로고    scopus 로고
    • Metformin induces ER stress-dependent apoptosis through miR-708-5p/NNAT pathway in prostate cancer
    • J. Yang, and et al. Metformin induces ER stress-dependent apoptosis through miR-708-5p/NNAT pathway in prostate cancer Oncogenesis 4 2015 e158
    • (2015) Oncogenesis , vol.4 , pp. e158
    • Yang, J.1
  • 94
    • 84860317111 scopus 로고    scopus 로고
    • Metformin suppresses growth of human head and neck squamous cell carcinoma via global inhibition of protein translation
    • A. Sikka, and et al. Metformin suppresses growth of human head and neck squamous cell carcinoma via global inhibition of protein translation Cell Cycle 11 2012 1374 1382
    • (2012) Cell Cycle , vol.11 , pp. 1374-1382
    • Sikka, A.1
  • 95
    • 84928902734 scopus 로고    scopus 로고
    • Metformin inhibits growth of human glioblastoma cells and enhances therapeutic response
    • J. Sesen, and et al. Metformin inhibits growth of human glioblastoma cells and enhances therapeutic response PLOS ONE 10 2015 e0123721
    • (2015) PLOS ONE , vol.10 , pp. e0123721
    • Sesen, J.1
  • 96
    • 84964315943 scopus 로고    scopus 로고
    • Metformin impairs Rho GTPase signaling to induce apoptosis in neuroblastoma cells and inhibits growth of tumors in the xenograft mouse model of neuroblastoma
    • A. Kumar, and et al. Metformin impairs Rho GTPase signaling to induce apoptosis in neuroblastoma cells and inhibits growth of tumors in the xenograft mouse model of neuroblastoma Oncotarget 5 2014 11709 11722
    • (2014) Oncotarget , vol.5 , pp. 11709-11722
    • Kumar, A.1
  • 97
    • 84903406795 scopus 로고    scopus 로고
    • Metformin inhibition of neuroblastoma cell proliferation is differently modulated by cell differentiation induced by retinoic acid or overexpression of NDM29 non-coding RNA
    • D. Costa, and et al. Metformin inhibition of neuroblastoma cell proliferation is differently modulated by cell differentiation induced by retinoic acid or overexpression of NDM29 non-coding RNA Cancer Cell Int. 14 2014 59
    • (2014) Cancer Cell Int. , vol.14 , pp. 59
    • Costa, D.1
  • 98
    • 84919459438 scopus 로고    scopus 로고
    • Metformin displays anti-myeloma activity and synergistic effect with dexamethasone in in vitro and in vivo xenograft models
    • F.M. Zi, and et al. Metformin displays anti-myeloma activity and synergistic effect with dexamethasone in in vitro and in vivo xenograft models Cancer Lett. 356 2015 443 453
    • (2015) Cancer Lett. , vol.356 , pp. 443-453
    • Zi, F.M.1
  • 99
    • 84946491442 scopus 로고    scopus 로고
    • Pharmacologic screens reveal metformin that suppresses GRP78-dependent autophagy to enhance the anti-myeloma effect of bortezomib
    • S. Jagannathan, and et al. Pharmacologic screens reveal metformin that suppresses GRP78-dependent autophagy to enhance the anti-myeloma effect of bortezomib Leukemia. 2015 10.1038/leu.2015.157
    • (2015) Leukemia.
    • Jagannathan, S.1
  • 100
    • 84883014367 scopus 로고    scopus 로고
    • Metformin induces apoptosis through AMPK-dependent inhibition of UPR signaling in ALL lymphoblasts
    • G.M. Leclerc, and et al. Metformin induces apoptosis through AMPK-dependent inhibition of UPR signaling in ALL lymphoblasts PLoS ONE 8 2013 e74420
    • (2013) PLoS ONE , vol.8 , pp. e74420
    • Leclerc, G.M.1
  • 101
    • 84925865428 scopus 로고    scopus 로고
    • Changes in insulin receptor signaling underlie neoadjuvant metformin administration in breast cancer: A prospective window of opportunity neoadjuvant study
    • R.J. Dowling, and et al. Changes in insulin receptor signaling underlie neoadjuvant metformin administration in breast cancer: A prospective window of opportunity neoadjuvant study Breast Cancer Res. 17 2015 32
    • (2015) Breast Cancer Res. , vol.17 , pp. 32
    • Dowling, R.J.1
  • 102
    • 84924856986 scopus 로고    scopus 로고
    • Potential anti-cancer drugs commonly used for other indications
    • V. Hanusova, and et al. Potential anti-cancer drugs commonly used for other indications Curr. Cancer Drug Targets 15 2015 35 52
    • (2015) Curr. Cancer Drug Targets , vol.15 , pp. 35-52
    • Hanusova, V.1
  • 103
    • 84857975015 scopus 로고    scopus 로고
    • Metformin: Multi-faceted protection against cancer
    • S. Del Barco, and et al. Metformin: multi-faceted protection against cancer Oncotarget 2 2011 896 917
    • (2011) Oncotarget , vol.2 , pp. 896-917
    • Del Barco, S.1
  • 104
    • 79959764729 scopus 로고    scopus 로고
    • Metformin, independent of AMPK, induces mTOR inhibition and cell-cycle arrest through REDD1
    • I. Ben Sahra, and et al. Metformin, independent of AMPK, induces mTOR inhibition and cell-cycle arrest through REDD1 Cancer Res. 71 2011 4366 4372
    • (2011) Cancer Res. , vol.71 , pp. 4366-4372
    • Ben Sahra, I.1
  • 105
    • 84893361058 scopus 로고    scopus 로고
    • Discrete mechanisms of mTOR and cell cycle regulation by AMPK agonists independent of AMPK
    • X. Liu, and et al. Discrete mechanisms of mTOR and cell cycle regulation by AMPK agonists independent of AMPK Proc. Natl. Acad. Sci. U. S. A. 111 2014 E435 E444
    • (2014) Proc. Natl. Acad. Sci. U. S. A. , vol.111 , pp. E435-E444
    • Liu, X.1
  • 106
    • 84890353160 scopus 로고    scopus 로고
    • Direct inhibition of hexokinase activity by metformin at least partially impairs glucose metabolism and tumor growth in experimental breast cancer
    • C. Marini, and et al. Direct inhibition of hexokinase activity by metformin at least partially impairs glucose metabolism and tumor growth in experimental breast cancer Cell Cycle 12 2013 3490 3499
    • (2013) Cell Cycle , vol.12 , pp. 3490-3499
    • Marini, C.1
  • 107
    • 84890538979 scopus 로고    scopus 로고
    • Another surprise from Metformin: Novel mechanism of action via K-Ras influences endometrial cancer response to therapy
    • D.A. Iglesias, and et al. Another surprise from Metformin: novel mechanism of action via K-Ras influences endometrial cancer response to therapy Mol. Cancer Ther. 12 2013 2847 2856
    • (2013) Mol. Cancer Ther. , vol.12 , pp. 2847-2856
    • Iglesias, D.A.1
  • 108
    • 84922625184 scopus 로고    scopus 로고
    • Immune-mediated antitumor effect by type 2 diabetes drug, metformin
    • S. Eikawa, and et al. Immune-mediated antitumor effect by type 2 diabetes drug, metformin Proc. Natl. Acad. Sci. U. S. A. 112 2015 1809 1814
    • (2015) Proc. Natl. Acad. Sci. U. S. A. , vol.112 , pp. 1809-1814
    • Eikawa, S.1
  • 109
    • 85015475971 scopus 로고    scopus 로고
    • Metformin may function as anti-cancer agent via targeting cancer stem cells: The potential biological significance of tumor-associated miRNAs in breast and pancreatic cancers
    • B. Bao, and et al. Metformin may function as anti-cancer agent via targeting cancer stem cells: The potential biological significance of tumor-associated miRNAs in breast and pancreatic cancers Ann. Transl. Med. 2 2014 59
    • (2014) Ann. Transl. Med. , vol.2 , pp. 59
    • Bao, B.1
  • 110
    • 84893371003 scopus 로고    scopus 로고
    • New molecules and old drugs as emerging approaches to selectively target human glioblastoma cancer stem cells
    • R. Wurth, and et al. New molecules and old drugs as emerging approaches to selectively target human glioblastoma cancer stem cells Biomed. Res. Int. 2014 2014 126586
    • (2014) Biomed. Res. Int. , vol.2014 , pp. 126586
    • Wurth, R.1
  • 111
    • 70350236538 scopus 로고    scopus 로고
    • Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission
    • H.A. Hirsch, and et al. Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission Cancer Res. 69 2009 7507 7511
    • (2009) Cancer Res. , vol.69 , pp. 7507-7511
    • Hirsch, H.A.1
  • 112
    • 79954460690 scopus 로고    scopus 로고
    • The anti-diabetic drug metformin suppresses self-renewal and proliferation of trastuzumab-resistant tumor-initiating breast cancer stem cells
    • A. Vazquez-Martin, and et al. The anti-diabetic drug metformin suppresses self-renewal and proliferation of trastuzumab-resistant tumor-initiating breast cancer stem cells Breast Cancer Res. Treat. 126 2011 355 364
    • (2011) Breast Cancer Res. Treat. , vol.126 , pp. 355-364
    • Vazquez-Martin, A.1
  • 113
    • 84864536555 scopus 로고    scopus 로고
    • Metformin-induced preferential killing of breast cancer initiating CD44+CD24-/low cells is sufficient to overcome primary resistance to trastuzumab in HER2+ human breast cancer xenografts
    • S. Cufi, and et al. Metformin-induced preferential killing of breast cancer initiating CD44+CD24-/low cells is sufficient to overcome primary resistance to trastuzumab in HER2+ human breast cancer xenografts Oncotarget 3 2012 395 398
    • (2012) Oncotarget , vol.3 , pp. 395-398
    • Cufi, S.1
  • 114
    • 84941241943 scopus 로고    scopus 로고
    • Studying pancreatic cancer stem cell characteristics for developing new treatment strategies
    • E. Lonardo, and et al. Studying pancreatic cancer stem cell characteristics for developing new treatment strategies J. Vis. Exp. 100 2015 e52801
    • (2015) J. Vis. Exp. , vol.100 , pp. e52801
    • Lonardo, E.1
  • 115
    • 84872294586 scopus 로고    scopus 로고
    • Metformin selectively affects human glioblastoma tumor-initiating cell viability: A role for metformin-induced inhibition of Akt
    • R. Wurth, and et al. Metformin selectively affects human glioblastoma tumor-initiating cell viability: A role for metformin-induced inhibition of Akt Cell Cycle 12 2013 145 156
    • (2013) Cell Cycle , vol.12 , pp. 145-156
    • Wurth, R.1
  • 116
    • 79955490053 scopus 로고    scopus 로고
    • Metformin decreases the dose of chemotherapy for prolonging tumor remission in mouse xenografts involving multiple cancer cell types
    • D. Iliopoulos, and et al. Metformin decreases the dose of chemotherapy for prolonging tumor remission in mouse xenografts involving multiple cancer cell types Cancer Res. 71 2011 3196 3201
    • (2011) Cancer Res. , vol.71 , pp. 3196-3201
    • Iliopoulos, D.1
  • 117
    • 84931058719 scopus 로고    scopus 로고
    • Metformin targets Axl and Tyro3 receptor tyrosine kinases to inhibit cell proliferation and overcome chemoresistance in ovarian cancer cells
    • N.Y. Kim, and et al. Metformin targets Axl and Tyro3 receptor tyrosine kinases to inhibit cell proliferation and overcome chemoresistance in ovarian cancer cells Int. J. Oncol. 47 2015 353 360
    • (2015) Int. J. Oncol. , vol.47 , pp. 353-360
    • Kim, N.Y.1
  • 118
    • 84930038234 scopus 로고    scopus 로고
    • Metformin potentiates rapamycin and cisplatin in gastric cancer in mice
    • G. Yu, and et al. Metformin potentiates rapamycin and cisplatin in gastric cancer in mice Oncotarget 6 2015 12748 12762
    • (2015) Oncotarget , vol.6 , pp. 12748-12762
    • Yu, G.1
  • 119
    • 84890118522 scopus 로고    scopus 로고
    • Metabolic regulation of cancer cell side population by glucose through activation of the Akt pathway
    • P.P. Liu, and et al. Metabolic regulation of cancer cell side population by glucose through activation of the Akt pathway Cell Death Differ. 21 2014 124 135
    • (2014) Cell Death Differ. , vol.21 , pp. 124-135
    • Liu, P.P.1
  • 120
    • 84876231133 scopus 로고    scopus 로고
    • The Warburg effect version 2.0: Metabolic reprogramming of cancer stem cells
    • J.A. Menendez, and et al. The Warburg effect version 2.0: metabolic reprogramming of cancer stem cells Cell Cycle 12 2013 1166 1179
    • (2013) Cell Cycle , vol.12 , pp. 1166-1179
    • Menendez, J.A.1
  • 121
    • 84871566320 scopus 로고    scopus 로고
    • Effective elimination of cancer stem cells by a novel drug combination strategy
    • S. Yuan, and et al. Effective elimination of cancer stem cells by a novel drug combination strategy Stem Cells 31 2013 23 34
    • (2013) Stem Cells , vol.31 , pp. 23-34
    • Yuan, S.1
  • 122
    • 84864532063 scopus 로고    scopus 로고
    • Metformin is synthetically lethal with glucose withdrawal in cancer cells
    • J.A. Menendez, and et al. Metformin is synthetically lethal with glucose withdrawal in cancer cells Cell Cycle 11 2012 2782 2792
    • (2012) Cell Cycle , vol.11 , pp. 2782-2792
    • Menendez, J.A.1
  • 123
    • 84872529696 scopus 로고    scopus 로고
    • Metformin inhibits the inflammatory response associated with cellular transformation and cancer stem cell growth
    • H.A. Hirsch, and et al. Metformin inhibits the inflammatory response associated with cellular transformation and cancer stem cell growth Proc. Natl. Acad. Sci. U. S. A. 110 2013 972 977
    • (2013) Proc. Natl. Acad. Sci. U. S. A. , vol.110 , pp. 972-977
    • Hirsch, H.A.1
  • 124
    • 84931265643 scopus 로고    scopus 로고
    • Loss of microRNA-27b contributes to breast cancer stem cell generation by activating ENPP1
    • R.U. Takahashi, and et al. Loss of microRNA-27b contributes to breast cancer stem cell generation by activating ENPP1 Nat. Commun. 6 2015 7318
    • (2015) Nat. Commun. , vol.6 , pp. 7318
    • Takahashi, R.U.1
  • 125
    • 84917706446 scopus 로고    scopus 로고
    • Metformin repositioning as antitumoral agent: Selective antiproliferative effects in human glioblastoma stem cells, via inhibition of CLIC1-mediated ion current
    • M. Gritti, and et al. Metformin repositioning as antitumoral agent: selective antiproliferative effects in human glioblastoma stem cells, via inhibition of CLIC1-mediated ion current Oncotarget 5 2014 11252 11268
    • (2014) Oncotarget , vol.5 , pp. 11252-11268
    • Gritti, M.1
  • 126
    • 84890535870 scopus 로고    scopus 로고
    • Functional role of CLIC1 ion channel in glioblastoma-derived stem/progenitor cells
    • M. Setti, and et al. Functional role of CLIC1 ion channel in glioblastoma-derived stem/progenitor cells J. Natl. Cancer Inst. 105 2013 1644 1655
    • (2013) J. Natl. Cancer Inst. , vol.105 , pp. 1644-1655
    • Setti, M.1
  • 127
    • 84941259367 scopus 로고    scopus 로고
    • Chloride channels in cancer: Focus on chloride intracellular channel 1 and 4 (CLIC! and CLIC4) proteins in tumor development and as novel therapeutic targets
    • M. Peretti, and et al. Chloride channels in cancer: focus on chloride intracellular channel 1 and 4 (CLIC! and CLIC4) proteins in tumor development and as novel therapeutic targets Biochim. Biophys. Acta 1848 10 2015 2523 2531
    • (2015) Biochim. Biophys. Acta , vol.1848 , Issue.10 , pp. 2523-2531
    • Peretti, M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.