Association of Single-Nucleotide Polymorphisms in IL28B, but Not TNF-α, with Severity of Disease Caused by Andes Virus

Clinical Infectious Diseases

Volumn 61, Issue 12, 2015, Pages e62-e69

  Angulo, Jenniffer ^a   Pino, Karla ^a   Echeverría Chagas, Natalia ^f   Marco, Claudia ^b   Martínez Valdebenito, Constanza ^b   Galeno, Hector ^d   Villagra, Eliecer ^d   Vera, Lilian ^d   Lagos, Natalia ^d   Becerra, Natalia ^d   Mora, Judith ^d   Bermúdez, Andrea ^e   Cárcamo, Marcela ^e   Díaz, Janepsy ^e   Miquel, Juan Francisco ^c   Ferres, Marcela ^b   López Lastra, Marcelo ^a  

^a UNIVERSIDAD ANDRÉS BELLO   (Chile)

^b Laboratorio de Infectología   (Chile)

^c PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

^d Departamento Laboratorio Biomedico Nacional y de Referencia   (Chile)

^e INSTITUTO DE SALUD PÚBLICA DE CHILE   (Chile)

^f UNIVERSIDAD DE LA REPÚBLICA   (Uruguay)

Author keywords

ANDV; HCPS; IL28B; SNP; TNF alpha

Indexed keywords

INTERLEUKIN 28B; TUMOR NECROSIS FACTOR ALPHA; IL28B PROTEIN, HUMAN; INTERLEUKIN DERIVATIVE; TUMOR NECROSIS FACTOR;

ADOLESCENT; ADULT; AGED; ALLELE; ANDES VIRUS; ARTICLE; CHILD; DISABILITY SEVERITY; DISEASE COURSE; DNA EXTRACTION; FEMALE; GENE EXPRESSION; GENETIC ASSOCIATION; GENOTYPE; HANTAVIRUS PULMONARY SYNDROME; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; MALE; PATHOGENESIS; PRIORITY JOURNAL; SCHOOL CHILD; SINGLE NUCLEOTIDE POLYMORPHISM; VERY ELDERLY; CASE CONTROL STUDY; CHILE; GENETIC ASSOCIATION STUDY; GENETICS; GENOTYPING TECHNIQUE; HANTAVIRUS; HANTAVIRUS INFECTION; IMMUNOLOGY; INFANT; ISOLATION AND PURIFICATION; MIDDLE AGED; NEWBORN; PATHOLOGY; PRESCHOOL CHILD; SEVERITY OF ILLNESS INDEX; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; CHILE; FEMALE; GENETIC ASSOCIATION STUDIES; GENOTYPING TECHNIQUES; HANTAVIRUS; HANTAVIRUS INFECTIONS; HUMANS; INFANT; INFANT, NEWBORN; INTERLEUKINS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; SEVERITY OF ILLNESS INDEX; TUMOR NECROSIS FACTOR-ALPHA; YOUNG ADULT;

EID: 84961626601     PISSN: 10584838     EISSN: 15376591     Source Type: Journal    
DOI: 10.1093/cid/civ830     Document Type: Article

References (47)

1. Vaheri A, Strandin T, Hepojoki J, et al. Uncovering the mysteries of hantavirus infections. Nat Rev Microbiol 2013; 11:539-50.
2. Medina RA, Torres-Perez F, Galeno H, et al. Ecology, genetic diversity, and phylogeographic structure of Andes virus in humans and rodents in Chile. J Virol 2009; 83:2446-59.
3. Padula PJ, Edelstein A, Miguel SD, Lopez NM, Rossi CM, Rabinovich RD. Hantavirus pulmonary syndrome outbreak in Argentina: molecular evidence for person-to-person transmission of Andes virus. Virology 1998; 241:323-30.
4. Jonsson CB, Hooper J, Mertz G. Treatment of hantavirus pulmonary syndrome. Antiviral Res 2008; 78:162-9.
5. Macneil A, Nichol ST, Spiropoulou CF. Hantavirus pulmonary syndrome. Virus Res 2011; 162:138-47.
6. Toro J, Vega JD, Khan AS, et al. An outbreak of hantavirus pulmonary syndrome, Chile, 1997. Emerg Infect Dis 1998; 4:687-94.
7. Dolgin E. Hantavirus treatments advance amidst outbreak in US park. Nat Med 2012; 18:1448.
8. Charbonnel N, Pages M, Sironen T, et al. Immunogenetic factors affecting susceptibility of humans and rodents to hantaviruses and the clinical course of hantaviral disease in humans. Viruses 2014; 6:2214-41.
9. Borges AA, Donadi EA, Campos GM, et al. Association of -308G/A polymorphism in the tumor necrosis factor-α gene promoter with susceptibility to development of hantavirus cardiopulmonary syndrome in the Ribeirao Preto region, Brazil. Arch Virol 2010; 155:971-5.
10. Clark PJ, Thompson AJ, McHutchison JG. IL28B genomic-based treatment paradigms for patients with chronic hepatitis C infection: The future of personalized HCV therapies. Am J Gastroenterol 2011; 106:38-45.
11. Hayes CN, Imamura M, Aikata H, Chayama K. Genetics of IL28B and HCV-response to infection and treatment. Nat Rev Gastroenterol Hepatol 2012; 9:406-17.
12. Matsuura K, Watanabe T, Tanaka Y. Role of IL28B for chronic hepatitis C treatment toward personalized medicine. J Gastroenterol Hepatol 2014; 29:241-9.
13. Suppiah V, Moldovan M, Ahlenstiel G, et al. IL28B is associated with response to chronic hepatitis C interferon-α and ribavirin therapy. Nat Genet 2009; 41:1100-4.
14. Tanaka Y, Nishida N, Sugiyama M, et al. Genome-wide association of IL28B with response to pegylated interferon-α and ribavirin therapy for chronic hepatitis C. Nat Genet 2009; 41:1105-9.
15. Urban TJ, Thompson AJ, Bradrick SS, et al. IL28B genotype is associated with differential expression of intrahepatic interferon-stimulated genes in patients with chronic hepatitis C. Hepatology 2010; 52:1888-96.
16. Thomas DL, Thio CL, Martin MP, et al. Genetic variation in IL28B and spontaneous clearance of hepatitis C virus. Nature 2009; 461:798-801.
17. Kotenko SV. IFN-λs. Curr Opin Immunol 2011; 23:583-90.
18. O'Brien TR, Prokunina-Olsson L, Donnelly RP. IFN-λ4: The paradoxical new member of the interferon lambda family. J Interferon Cytokine Res 2014; 34:829-38.
19. Sheppard P, Kindsvogel W, Xu W, et al. IL-28, IL-29 and their class II cytokine receptor IL-28R. Nat Immunol 2003; 4:63-8.
20. Prescott J, Hall P, Acuna-Retamar M, et al. NewWorld hantaviruses activate IFNλ production in type I IFN-deficient Vero E6 cells. PLoS One 2010; 5:e11159.
21. Stoltz M, Ahlm C, Lundkvist A, Klingstrom J. Lambda interferon (IFN-λ) in serum is decreased in hantavirus-infected patients, and in vitro-established infection is insensitive to treatment with all IFNs and inhibits IFN-γ-induced nitric oxide production. J Virol 2007; 81:8685-91.
22. Wilson AG, Symons JA, McDowell TL, McDevitt HO, Duff GW. Effects of a polymorphism in the human tumor necrosis factor α promoter on transcriptional activation. Proc Natl Acad Sci U S A 1997; 94:3195-9.
23. Lee HW, Calisher C, Schmaljohn C, eds. Manual of hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome. WHO Collaborating Center for Virus Reference and Research (Hantaviruses), Asan Institute for Life Sciences, Seoul, Korea, 1999.
24. Padula PJ, Rossi CM, Della Valle MO, et al. Development and evaluation of a solid-phase enzyme immunoassay based on Andes hantavirus recombinant nucleoprotein. J Med Microbiol 2000; 49:149-55.
25. Angulo J, Pino K, Pavez C, et al. Genetic variations in host IL28B links to the detection of peripheral blood mononuclear cells-associated hepatitis C virus RNA in chronically infected patients. J Viral Hepat 2013; 20:263-72.
26. Miquel JF, Covarrubias C, Villaroel L, et al. Genetic epidemiology of cholesterol cholelithiasis among Chilean Hispanics, Amerindians, and Maoris. Gastroenterology 1998; 115:937-46.
27. Olmos P, Bastias MJ, Vollrath V, et al. C(-106)T polymorphism of the aldose reductase gene and the progression rate of diabetic retinopathy. Diabetes Res Clin Pract 2006; 74:175-82.
28. Nervi F, Miquel JF, Alvarez M, et al. Gallbladder disease is associated with insulin resistance in a high risk Hispanic population. J Hepatol 2006; 45:299-305.
29. Cariani E, Critelli R, Rota C, Luongo M, Trenti T, Villa E. Interleukin 28B genotype determination using DNA from different sources: A simple and reliable tool for the epidemiological and clinical characterization of hepatitis C. J Virol Methods 2011; 178:235-8.
30. Sullivan KM, Dean A, Soe MM. OpenEpi: A web-based epidemiologic and statistical calculator for public health. Public Health Rep. 2009; 124:471-4.
31. Rodriguez S, Gaunt TR, Day IN. Hardy-Weinberg equilibrium testing of biological ascertainment for Mendelian randomization studies. Am J Epidemiol 2009; 169:505-14.
32. Boroja M, Barrie JR, Raymond GS. Radiographic findings in 20 patients with hantavirus pulmonary syndrome correlated with clinical outcome. AJR Am J Roentgenol 2002; 178:159-63.
33. Manigold T, Mori A, Graumann R, et al. Highly differentiated, resting gn-specific memory CD8+ T cells persist years after infection by Andes hantavirus. PLoS Pathog 2010; 6:e1000779.
34. Brocato RL, Hammerbeck CD, Bell TM, Wells JB, Queen LA, Hooper JW. A lethal disease model for hantavirus pulmonary syndrome in immunosuppressed Syrian hamsters infected with Sin Nombre virus. J Virol 2013.
35. Prescott J, Safronetz D, Haddock E, Robertson S, Scott D, Feldmann H. The adaptive immune response does not influence hantavirus disease or persistence in the Syrian hamster. Immunology 2013; 140: 168-78.
36. Hammerbeck CD, Hooper JW. T cells are not required for pathogenesis in the Syrian hamster model of hantavirus pulmonary syndrome. J Virol 2011; 85:9929-44.
37. Kilpatrick ED, Terajima M, Koster FT, Catalina MD, Cruz J, Ennis FA. Role of specific CD8+ T cells in the severity of a fulminant zoonotic viral hemorrhagic fever, hantavirus pulmonary syndrome. J Immunol 2004; 172:3297-304.
38. Jewell NA, Cline T, Mertz SE, et al. Lambda interferon is the predominant interferon induced by influenza A virus infection in vivo. J Virol 2010; 84:11515-22.
39. Castillo C, Sanhueza L, Tager M, Munoz S, Ossa G, Vial P. Seroprevalence of antibodies against hantavirus in 10 communities of the IX Region of Chile where hantavirus infection were diagnosed [in Spanish]. Rev Med Chil 2002; 130:251-8.
40. Tager Frey M, Vial PC, Castillo CH, Godoy PM, Hjelle B, Ferres MG. Hantavirus prevalence in the IX Region of Chile. Emerg Infect Dis 2003; 9:827-32.
41. Mori M, Rothman AL, Kurane I, et al. High levels of cytokineproducing cells in the lung tissues of patients with fatal hantavirus pulmonary syndrome. J Infect Dis 1999; 179:295-302.
42. Bustamante EA, Levy H, Simpson SQ. Pleural fluid characteristics in hantavirus pulmonary syndrome. Chest 1997; 112:1133-6.
43. Linderholm M, Ahlm C, Settergren B, Waage A, Tarnvik A. Elevated plasma levels of tumor necrosis factor (TNF)-α, soluble TNF receptors, interleukin (IL)-6, and IL-10 in patients with hemorrhagic fever with renal syndrome. J Infect Dis 1996; 173:38-43.
44. Temonen M, Mustonen J, Helin H, Pasternack A, Vaheri A, Holthofer H. Cytokines, adhesion molecules, and cellular infiltration in nephropathia epidemica kidneys: an immunohistochemical study. Clin Immunol Immunopathol 1996; 78:47-55.
45. Cohen TS, Prince AS. Bacterial pathogens activate a common inflammatory pathway through IFNλ regulation of PDCD4. PLoS Pathog 2013; 9:e1003682.
46. Cohen TS, Prince AS. Activation of inflammasome signaling mediates pathology of acute P. aeruginosa pneumonia. J Clin Invest 2013; 123: 1630-7.
47. Kanerva M, Vaheri A, Mustonen J, Partanen J. High-producer allele of tumour necrosis factor-alpha is part of the susceptibility MHC haplotype in severe Puumala virus-induced nephropathia epidemica. Scand J Infect Dis 1998; 30:532-4.