Knock-down of endogenous bornavirus-like nucleoprotein 1 inhibits cell growth and induces apoptosis in human oligodendroglia cells

International Journal of Molecular Sciences

Volumn 17, Issue 4, 2016, Pages

  He, Peng ^a   Sun, Lin ^a   Zhu, Dan ^a   Zhang, Hong ^a   Zhang, Liang ^a   Guo, Yujie ^a   Liu, Siwen ^a   Zhou, Jingjing ^a   Xu, Xiaoyan ^a   Xie, Peng ^a  

^a CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; cDNA array; Cell proliferation; Endogenous bornavirus like nucleoprotein 1; RNA interference

Indexed keywords

LENTIVIRUS VECTOR; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN P53; SHORT HAIRPIN RNA; APOPTOSIS REGULATORY PROTEIN; BASIC LEUCINE ZIPPER TRANSCRIPTION FACTOR; CREB3L2 PROTEIN, HUMAN; EBLN1 PROTEIN, HUMAN; NUCLEOPROTEIN; ONCOSTATIN M RECEPTOR BETA; OSMR PROTEIN, HUMAN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; RND3 PROTEIN, HUMAN; SMALL INTERFERING RNA;

APOPTOSIS; ARTICLE; CELL GROWTH; CELL MIGRATION; CELL MIGRATION ASSAY; CELL PROLIFERATION; COLONY FORMATION; CONTROLLED STUDY; DOWN REGULATION; ENDOGENOUS BORNAVIRUS LIKE NUCLEOPROTEIN 1 GENE; FLOW CYTOMETRY; G2 PHASE CELL CYCLE CHECKPOINT; GENE; GENE EXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; LENTIVIRUS INFECTION; MICROARRAY ANALYSIS; MRNA EXPRESSION ASSAY; OLIGODENDROGLIA; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; WOUND HEALING; ANTAGONISTS AND INHIBITORS; CELL LINE; CYTOLOGY; GENETICS; GLIOMA; M PHASE CELL CYCLE CHECKPOINT; METABOLISM; PATHOLOGY; REAL TIME POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION;

APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTORS; CELL LINE; CELL PROLIFERATION; DOWN-REGULATION; G2 PHASE CELL CYCLE CHECKPOINTS; GLIOMA; HUMANS; M PHASE CELL CYCLE CHECKPOINTS; MITOGEN-ACTIVATED PROTEIN KINASES; NUCLEOPROTEINS; OLIGODENDROGLIA; ONCOSTATIN M RECEPTOR BETA SUBUNIT; REAL-TIME POLYMERASE CHAIN REACTION; RHO GTP-BINDING PROTEINS; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 84961615178     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms17040435     Document Type: Article

References (44)

1. Feschotte, C. Virology: Bornavirus enters the genome. Nature 2010, 463, 39-40.[CrossRef] [PubMed]
2. Young, G.R.; Stoye, J.P.; Kassiotis, G. Are human endogenous retroviruses pathogenic? An approach to testing the hypothesis. BioEssays 2013, 35, 794-803.[CrossRef] [PubMed]
3. Suntsova, M.; Garazha, A.; Ivanova, A.; Kaminsky, D.; Zhavoronkov, A.; Buzdin, A. Molecular functions of human endogenous retroviruses in health and disease. Cell. Mol. Life Sci. 2015, 72, 3653-3675.[CrossRef] [PubMed]
4. Huang, W.; Li, S.; Hu, Y.; Yu, H.; Luo, F.; Zhang, Q.; Zhu, F. Implication of the ENV gene of the human endogenous retrovirus W family in the expression of BDNF and DRD3 and development of recent-onset schizophrenia. Schizophr. Bull. 2011, 37, 988-1000.[CrossRef] [PubMed]
5. Balestrieri, E.; Pitzianti, M.; Matteucci, C.; D’Agati, E.; Sorrentino, R.; Baratta, A.; Caterina, R.; Zenobi, R.; Curatolo, P.; Garaci, E. et al. Human endogenous retroviruses and ADHD. World J. Biol. Psychiatry 2014, 15, 499-504.[CrossRef] [PubMed]
6. Downey, R.F.; Sullivan, F.J.; Wang-Johanning, F.; Ambs, S.; Giles, F.J.; Glynn, S.A. Human endogenous retrovirus K and cancer: Innocent bystander or tumorigenic accomplice? HERV-K activation in cancer and impact on tumor biology. Int. J. Cancer 2015, 137, 1249-1257.[CrossRef] [PubMed]
7. Goering, W.; Schmitt, K.; Dostert, M.; Schaal, H.; Deenen, R.; Mayer, J.; Schulz, W.A. Human endogenous retrovirus HERV-K(HML-2) activity in prostate cancer is dominated by a few loci: HERV-K expression in prostate cancer. Prostate 2015, 75, 1958-1971.[CrossRef] [PubMed]
8. Horie, M.; Honda, T.; Suzuki, Y.; Kobayashi, Y.; Daito, T.; Oshida, T.; Ikuta, K.; Jern, P.; Gojobori, T.; Coffin, J. et al. Endogenous non-retroviral RNA virus elements in mammalian genomes. Nature 2010, 463, 84-87.[CrossRef] [PubMed]
9. Cubitt, B.; Oldstone, C.; de la Torre, J.C. Sequence and genome organization of Borna disease virus. J. Virol. 1994, 68, 1382-1396. [PubMed]
10. Tomonaga, K.; Kobayashi, T.; Ikuta, K. Molecular and cellular biology of Borna disease virus infection. Microbes Infect. 2002, 4, 491-500.[CrossRef]
11. Bode, L.; Dürrwald, R.; Rantam, F.A.; Ferszt, R.; Ludwig, H. First isolates of infectious human Borna disease virus from patients with mood disorders. Mol. Psychiatry 1996, 1, 200-212. [PubMed]
12. Li, Q.; Wang, Z.; Zhu, D.; Xu, M.; Chen, X.; Peng, D.; Iwata, Y.; Xie, P. Detection and analysis of Borna disease virus in Chinese patients with neurological disorders. Eur. J. Neurol. 2009, 16, 399-403.[CrossRef] [PubMed]
13. Nakamura, Y.; Takahashi, H.; Shoya, Y.; Nakaya, T.; Watanabe, M.; Tomonaga, K.; Iwahashi, K.; Ameno, K.; Momiyama, N.; Taniyama, H. et al. Isolation of Borna disease virus from human brain tissue. J. Virol. 2000, 74, 4601-4611.[CrossRef] [PubMed]
14. Wensman, J.J.; Jäderlund, K.H.; Holst, B.S.; Berg, M. Borna disease virus infection in cats. Vet. J. 2014, 201, 142-149.[CrossRef] [PubMed]
15. Zhang, L.; Xu, M.M.; Zeng, L.; Liu, S.; Liu, X.; Wang, X.; Li, D.; Huang, R.Z.; Zhao, L.B.; Zhan, Q.L. et al. Evidence for Borna disease virus infection in neuropsychiatric patients in three western China provinces. Eur. J. Clin. Microbiol. Infect. Dis. 2014, 33, 621-627.[CrossRef] [PubMed]
16. Nobach, D.; Bourg, M.; Herzog, S.; Lange-Herbst, H.; Encarnação, J.A.; Eickmann, M.; Herden, C. Shedding of infectious borna disease virus-1 in living bicolored white-toothed shrews. PLoS ONE 2015, 10, e0137018.[CrossRef] [PubMed]
17. Liu, S.; Bode, L.; Zhang, L.; He, P.; Huang, R.; Sun, L.; Chen, S.; Zhang, H.; Guo, Y.; Zhou, J. et al. GC-MS-based metabonomic profiling displayed differing effects of borna disease virus natural strain Hu-H1 and laboratory strain V infection in rat cortical neurons. Int. J. Mol. Sci. 2015, 16, 19347-19368.[CrossRef] [PubMed]
18. Bonnaud, E.M.; Szelechowski, M.; Bétourné, A.; Foret, C.; Thouard, A.; Gonzalez-Dunia, D.; Malnou, C.E. Borna disease virus phosphoprotein modulates epigenetic signaling in neurons to control viral replication. J. Virol. 2015, 89, 5996-6008.[CrossRef] [PubMed]
19. Rudolph, M.G.; Kraus, I.; Dickmanns, A.; Eickmann, M.; Garten, W.; Ficner, R. Crystal structure of the Borna disease virus nucleoprotein. Structure 2003, 11, 1219-1226.[CrossRef] [PubMed]
20. Planz, O.; Pleschka, S.; Oesterle, K.; Berberich-Siebelt, F.; Ehrhardt, C.; Stitz, L.; Ludwig, S. Borna disease virus nucleoprotein interacts with the Cdc2-cyclin B1 complex. J. Virol. 2003, 77, 11186-11192.[CrossRef] [PubMed]
21. Song, W.; Kao, W.; Zhai, A.; Qian, J.; Li, Y.; Zhang, Q.; Zhao, H.; Hu, Y.; Li, H.; Zhang, F. Borna disease virus nucleoprotein inhibits type I interferon induction through the interferon regulatory factor 7 pathway. Biochem. Biophys. Res. Commun. 2013, 438, 619-623.[CrossRef] [PubMed]
22. Belyi, V.A.; Levine, A.J.; Skalka, A.M. Unexpected Inheritance: Multiple integrations of ancient bornavirus and ebolavirus/marburgvirus sequences in vertebrate genomes. PLoS Pathog. 2010, 6, e1001030.[CrossRef] [PubMed]
23. Fujino, K.; Horie, M.; Honda, T.; Merriman, D.K.; Tomonaga, K. Inhibition of Borna disease virus replication by an endogenous bornavirus-like element in the ground squirrel genome. Proc. Natl. Acad. Sci. USA 2014, 111, 13175-13180.[CrossRef] [PubMed]
24. Parrish, N.F.; Fujino, K.; Shiromoto, Y.; Iwasaki, Y.W.; Ha, H.; Xing, J.; Makino, A.; Kuramochi-Miyagawa, S.; Nakano, T.; Siomi, H. et al. piRNAs derived from ancient viral processed pseudogenes as transgenerational sequence-specific immune memory in mammals. RNA 2015, 21, 1691-1703.[CrossRef] [PubMed]
25. Sofuku, K.; Parrish, N.F.; Honda, T.; Tomonaga, K. Transcription profiling demonstrates epigenetic control of non-retroviral RNA virus-derived elements in the human genome. Cell Rep. 2015, 12, 1548-1554.[CrossRef] [PubMed]
26. Bautista, J.R.; Schwartz, G.J.; De La Torre, J.C.; Moran, T.H.; Carbone, K.M. Early and persistent abnormalities in rats with neonatally acquired Borna disease virus infection. Brain Res. Bull. 1994, 34, 31-40.[CrossRef]
27. Lancaster, K.; Dietz, D.; Moran, T.; Pletnikov, M. Abnormal social behaviors in young and adult rats neonatally infected with Borna disease virus. Behav. Brain Res. 2007, 176, 141-148.[CrossRef] [PubMed]
28. Solbrig, M.V. Animal models of CNS viral disease: Examples from Borna disease virus models. Interdiscip. Perspect. Infect. Dis. 2010, 2010, 1-6.[CrossRef] [PubMed]
29. Haga, S.; Yoshimura, M.; Motoi, Y.; Arima, K.; Aizawa, T.; Ikuta, K.; Tashiro, M.; Ikeda, K. Detection of Borna disease virus genome in normal human brain tissue. Brain Res. 1997, 770, 307-309.[CrossRef]
30. Mazaheri-Tehrani, E.; Maghsoudi, N.; Shams, J.; Soori, H.; Atashi, H.; Motamedi, F.; Bode, L.; Ludwig, H. Borna disease virus (BDV) infection in psychiatric patients and healthy controls in Iran. Virol. J. 2014, 11, 161.[CrossRef] [PubMed]
31. Liu, X.; Bode, L.; Zhang, L.; Wang, X.; Liu, S.; Zhang, L.; Huang, R.; Wang, M.; Yang, L.; Chen, S. et al. Health care professionals at risk of infection with Borna disease virus—Evidence from a large hospital in China (Chongqing). Virol. J. 2015, 12, 39.[CrossRef] [PubMed]
32. Stacey, K.J.; Sagulenko, V. A clear link between endogenous retroviral LTR activity and Hodgkin’s lymphoma. Cell Res. 2010, 20, 869-871.[CrossRef] [PubMed]
33. Schmidt, K.L.M.; Vangsted, A.J.; Hansen, B.; Vogel, U.B.; Hermansen, N.E.U.; Jensen, S.B.; Laska, M.J.; Nexø, B.A. Synergy of two human endogenous retroviruses in multiple myeloma. Leuk. Res. 2015, 39, 1125-1128.[CrossRef] [PubMed]
34. Williams, B.L.; Hornig, M.; Yaddanapudi, K.; Lipkin, W.I. Hippocampal poly(ADP-ribose) polymerase 1 and caspase 3 activation in neonatal bornavirus infection. J. Virol. 2008, 82, 1748-1758.[CrossRef] [PubMed]
35. Poenisch, M.; Burger, N.; Staeheli, P.; Bauer, G.; Schneider, U. Protein X of borna disease virus inhibits apoptosis and promotes viral persistence in the central nervous systems of newborn-infected rats. J. Virol. 2009, 83, 4297-4307.[CrossRef] [PubMed]
36. Li, D.; Lei, Y.; Deng, J.; Zhou, C.; Zhang, Y.; Li, W.; Huang, H.; Cheng, S.; Zhang, H.; Zhang, L.; et al. Human but not laboratory borna disease virus inhibits proliferation and induces apoptosis in human oligodendrocytes in vitro. PLoS ONE 2013, 8, e66623.
37. Ma, W.; Wong, C.C.L.; Tung, E.K.K.; Wong, C.M.; Ng, I.O.L. RhoE is frequently down-regulated in hepatocellular carcinoma (HCC) and suppresses HCC invasion through antagonizing the Rho/ Rho-Kinase/Myosin phosphatase target pathway. Hepatology 2013, 57, 152-161.[CrossRef] [PubMed]
38. Tang, Y.; Hu, C.; Yang, H.; Cao, L.; Li, Y.; Deng, P.; Huang, L. Rnd3 regulates lung cancer cell proliferation through notch signaling. PLoS ONE 2014, 9, e111897.[CrossRef] [PubMed]
39. Hernández-Sánchez, M.; Poch, E.; Guasch, R.M.; Ortega, J.; López-Almela, I.; Palmero, I.; Pérez-Roger, I. RhoE is required for contact inhibition and negatively regulates tumor initiation and progression. Oncotarget 2015, 6, 17479-17490.[CrossRef] [PubMed]
40. Liu, B.; Lin, X.; Yang, X.; Dong, H.; Yue, X.; Andrade, K.C.; Guo, Z.; Yang, J.; Wu, L.; Zhu, X. et al. Downregulation of RND3/RhoE in glioblastoma patients promotes tumorigenesis through augmentation of notch transcriptional complex activity. Cancer Med. 2015, 4, 1404-1416.[CrossRef] [PubMed]
41. David, E.; Tirode, F.; Baud’huin, M.; Guihard, P.; Laud, K.; Delattre, O.; Heymann, M.F.; Heymann, D.; Redini, F.; Blanchard, F. Oncostatin M is a growth factor for ewing sarcoma. Am. J. Pathol. 2012, 181, 1782-1795.[CrossRef] [PubMed]
42. Natesh, K.; Bhosale, D.; Desai, A.; Chandrika, G.; Pujari, R.; Jagtap, J.; Chugh, A.; Ranade, D.; Shastry, P. Oncostatin-M differentially regulates mesenchymal and proneural signature genes in gliomas via STAT3 Signaling. Neoplasia 2015, 17, 225-237.[CrossRef] [PubMed]
43. Izumi, S.; Saito, A.; Kanemoto, S.; Kawasaki, N.; Asada, R.; Iwamoto, H.; Oki, M.; Miyagi, H.; Ochi, M.; Imaizumi, K. The endoplasmic reticulum stress transducer BBF2H7 suppresses apoptosis by activating the ATF5-MCL1 pathway in growth plate cartilage. J. Biol. Chem. 2012, 287, 36190-36200.[CrossRef] [PubMed]
44. Sheng, Z.; Li, L.; Zhu, L.J.; Smith, T.W.; Demers, A.; Ross, A.H.; Moser, R.P.; Green, M.R. A genome-wide RNA interference screen reveals an essential CREB3L2-ATF5-MCL1 survival pathway in malignant glioma with therapeutic implications. Nat. Med. 2010, 16, 671-677.[CrossRef] [PubMed]