Glycemic control and fracture risk in elderly patients with diabetes

Diabetes Research and Clinical Practice

Volumn 115, Issue , 2016, Pages 47-53

  Conway, Baqiyyah N ^a   Long, Dustin M ^a   Figaro, M Kathleen ^b   May, Michael E ^c  

^a WEST VIRGINIA UNIVERSITY   (United States)

^b Iowa   (United States)

^c VANDERBILT UNIVERSITY   (United States)

Author keywords

Diabetes; Fracture; Geriatric; Glycemic control; HbA1c; Hypoglycemia

Indexed keywords

HEMOGLOBIN A1C; ANTIDIABETIC AGENT; GLUCOSE BLOOD LEVEL; GLYCOSYLATED HEMOGLOBIN; HEMOGLOBIN A1C PROTEIN, HUMAN;

AGED; ARTICLE; BODY MASS; COHORT ANALYSIS; DIABETES MELLITUS; FEMALE; FOLLOW UP; FRACTURE; GERIATRIC PATIENT; GLYCEMIC CONTROL; HEMOGLOBIN BLOOD LEVEL; HUMAN; MAJOR CLINICAL STUDY; MALE; PROSPECTIVE STUDY; RISK FACTOR; BLOOD; DIABETES MELLITUS, TYPE 2; FRACTURES, BONE; GLUCOSE BLOOD LEVEL; KAPLAN MEIER METHOD; METABOLISM; RISK; VERY ELDERLY;

AGED; AGED, 80 AND OVER; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; FEMALE; FRACTURES, BONE; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; HYPOGLYCEMIC AGENTS; KAPLAN-MEIER ESTIMATE; MALE; PROSPECTIVE STUDIES; RISK;

EID: 84961589599     PISSN: 01688227     EISSN: 18728227     Source Type: Journal    
DOI: 10.1016/j.diabres.2016.03.009     Document Type: Article

References (36)

1. Ensrud K.E. Epidemiology of fracture risk with advancing age. J Gerontol A Biol Sci Med Sci 2013, 68(10 (October)):1236-1242. PubMed PMID: 23833201. Epub 2013/07/09. eng.
2. Burge R., Dawson-Hughes B., Solomon D.H., Wong J.B., King A., Tosteson A. Incidence and economic burden of osteoporosis-related fractures in the United States, 2005-2025. J Bone Miner Res 2007, 22(3 (March)):465-475. PubMed PMID: 17144789. Epub 2006/12/06. eng.
3. Becker D.J., Kilgore M.L., Morrisey M.A. The societal burden of osteoporosis. Curr Rheumatol Rep 2010, 12(3 (June)):186-191. PubMed PMID: 20425518. Epub 2010/04/29. eng.
4. Bliuc D., Nguyen N.D., Milch V.E., Nguyen T.V., Eisman J.A., Center J.R. Mortality risk associated with low-trauma osteoporotic fracture and subsequent fracture in men and women. JAMA 2009, 301(5 (February)):513-521. PubMed PMID: 19190316. Epub 2009/02/05. eng.
5. Center J.R., Nguyen T.V., Schneider D., Sambrook P.N., Eisman J.A. Mortality after all major types of osteoporotic fracture in men and women: an observational study. Lancet 1999, 353(9156 (March)):878-882. PubMed PMID: 10093980. Epub 1999/03/27. eng.
6. Braithwaite R.S., Col N.F., Wong J.B. Estimating hip fracture morbidity, mortality and costs. J Am Geriatr Soc 2003, 51(3 (March)):364-370. PubMed PMID: 12588580. Epub 2003/02/18. eng.
7. Yamaguchi T., Sugimoto T. Bone metabolism and fracture risk in type 2 diabetes mellitus [Review]. Endocr J 2011, 58(8):613-624. PubMed PMID: 21778617. Epub 2011/07/23. eng.
8. Janghorbani M., Van Dam R.M., Willett W.C., Hu F.B. Systematic review of type 1 and type 2 diabetes mellitus and risk of fracture. Am J Epidemiol 2007, 166(5 (September)):495-505. PubMed PMID: 17575306. Epub 2007/06/19. eng.
9. Blotter R.H., Connolly E., Wasan A., Chapman M.W. Acute complications in the operative treatment of isolated ankle fractures in patients with diabetes mellitus. Foot Ankle Int 1999, 20(11 (November)):687-694. PubMed PMID: 10582843. Epub 1999/12/03. eng.
10. Flynn J.M., Rodriguez-del Rio F., Piza P.A. Closed ankle fractures in the diabetic patient. Foot Ankle Int 2000, 21(4 (April)):311-319. PubMed PMID: 10808971. Epub 2000/05/16. eng.
11. Norris R., Parker M. Diabetes mellitus and hip fracture: a study of 5966 cases. Injury 2011, 42(11 (November)):1313-1316. PubMed PMID: 21489532. Epub 2011/04/15. eng.
12. Huang Y.F., Shyu Y.I., Liang J., Chen M.C., Cheng H.S., Wu C.C. Diabetes and health outcomes among older Taiwanese with hip fracture. Rejuvenation Res 2012, 15(5 (October)):476-482. PubMed PMID: 22998328. Epub 2012/09/25. eng.
13. Perlman M.H., Thordarson D.B. Ankle fusion in a high risk population: an assessment of nonunion risk factors. Foot Ankle Int 1999, 20(8 (August)):491-496. PubMed PMID: 10473059. Epub 1999/09/03. eng.
14. Nathan D.M. The diabetes control and complications trial/epidemiology of diabetes interventions and complications study at 30 years: overview. Diabetes Care 2014, 37(1):9-16. PubMed PMID: 24356592. Pubmed Central PMCID: PMC3867999. Epub 2013/12/21. eng.
15. Puar T.H., Khoo J.J., Cho L.W., Xu Y., Chen Y.T., Chuo A.M., et al. Association between glycemic control and hip fracture. J Am Geriatr Soc 2012, 60(8 (August)):1493-1497. PubMed PMID: 22862735. Epub 2012/08/07. eng.
16. Johnston S.S., Conner C., Aagren M., Ruiz K., Bouchard J. Association between hypoglycaemic events and fall-related fractures in Medicare-covered patients with type 2 diabetes. Diabetes Obes Metab 2012, 14(7 (July)):634-643. PubMed PMID: 22335246. Epub 2012/02/18. eng.
17. McNair P., Madsbad S., Christiansen C., Christensen M.S., Faber O.K., Binder C., et al. Bone loss in diabetes: effects of metabolic state. Diabetologia 1979, 17(5 (November)):283-286. PubMed PMID: 387503. Epub 1979/11/01. eng.
18. McNair P., Madsbad S., Christensen M.S., Christiansen C., Faber O.K., Binder C., et al. Bone mineral loss in insulin-treated diabetes mellitus: studies on pathogenesis. Acta Endocrinol (Copenh) 1979, 90(3 (March)):463-472. PubMed PMID: 425786. Epub 1979/03/01. eng.
19. Roden D.M., Pulley J.M., Basford M.A., Bernard G.R., Clayton E.W., Balser J.R., et al. Development of a large-scale de-identified DNA biobank to enable personalized medicine. Clin Pharmacol Ther 2008, 84(3 (September)):362-369. PubMed PMID: 18500243. Pubmed Central PMCID: PMC3763939. Epub 2008/05/27. eng.
20. Pulley J., Clayton E., Bernard G.R., Roden D.M., Masys D.R. Principles of human subjects protections applied in an opt-out, de-identified biobank. Clin Transl Sci 2010, 3(1 (February)):42-48. PubMed PMID: 20443953. Pubmed Central PMCID: PMC3075971. Epub 2010/05/07. eng.
21. Schwartz A.V., Vittinghoff E., Bauer D.C., Hillier T.A., Strotmeyer E.S., Ensrud K.E., et al. Association of BMD and FRAX score with risk of fracture in older adults with type 2 diabetes. JAMA 2011, 305(21 (June)):2184-2192. PubMed PMID: 21632482. Pubmed Central PMCID: PMC3287389. Epub 2011/06/03. eng.
22. Vestergaard P. Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes - a meta-analysis. Osteoporos Int 2007, 18(4 (April)):427-444. PubMed PMID: 17068657. Epub 2006/10/28. eng.
23. Strotmeyer E.S., Cauley J.A., Schwartz A.V., Nevitt M.C., Resnick H.E., Bauer D.C., et al. Nontraumatic fracture risk with diabetes mellitus and impaired fasting glucose in older white and black adults: the health, aging, and body composition study. Arch Intern Med 2005, 165(14 (July)):1612-1617. PubMed PMID: 16043679. Epub 2005/07/27. eng.
24. Hein G., Weiss C., Lehmann G., Niwa T., Stein G., Franke S. Advanced glycation end product modification of bone proteins and bone remodelling: hypothesis and preliminary immunohistochemical findings. Ann Rheum Dis 2006, 65(1 (January)):101-104. PubMed PMID: 16344492. Pubmed Central PMCID: PMC1797982. Epub 2005/12/14. eng.
25. Saito M., Fujii K., Soshi S., Tanaka T. Reductions in degree of mineralization and enzymatic collagen cross-links and increases in glycation-induced pentosidine in the femoral neck cortex in cases of femoral neck fracture. Osteoporos Int 2006, 17(7):986-995. PubMed PMID: 16552468. Epub 2006/03/23. eng.
26. Schwartz A.V., Hillier T.A., Sellmeyer D.E., Resnick H.E., Gregg E., Ensrud K.E., et al. Older women with diabetes have a higher risk of falls: a prospective study. Diabetes Care 2002, 25(10 (October)):1749-1754. PubMed PMID: 12351472. Epub 2002/09/28. eng.
27. Kahn S.E., Haffner S.M., Heise M.A., Herman W.H., Holman R.R., Jones N.P., et al. Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy. N Engl J Med 2006, 355(23 (December)):2427-2443. PubMed PMID: 17145742. Epub 2006/12/06. eng.
28. Thrailkill K.M., Lumpkin C.K., Bunn R.C., Kemp S.F., Fowlkes J.L. Is insulin an anabolic agent in bone? Dissecting the diabetic bone for clues. Am J Physiol Endocrinol Metab 2005, 289(5 (November)):E735-E745. PubMed PMID: 16215165. Pubmed Central PMCID: Pmc2387001. Epub 2005/10/11. eng.
29. Standards of medical care in diabetes-2014. Diabetes Care 2014, 37(Suppl. 1 (January)):S14-S80. PubMed PMID: 24357209. Epub 2013/12/21. eng.
30. Schneider A.L., Williams E.K., Brancati F.L., Blecker S., Coresh J., Selvin E. Diabetes and risk of fracture-related hospitalization: the Atherosclerosis Risk in Communities Study. Diabetes Care 2013, 36(5 (May)):1153-1158. PubMed PMID: 23248194. Pubmed Central PMCID: Pmc3631877. Epub 2012/12/19. eng.
31. Oei L., Zillikens M.C., Dehghan A., Buitendijk G.H., Castano-Betancourt M.C., Estrada K., et al. High bone mineral density and fracture risk in type 2 diabetes as skeletal complications of inadequate glucose control: the Rotterdam Study. Diabetes Care 2013, 36(6 (June)):1619-1628. PubMed PMID: 23315602. Pubmed Central PMCID: Pmc3661786. Epub 2013/01/15. eng.
32. Li C.I., Liu C.S., Lin W.Y., Meng N.H., Chen C.C., Yang S.Y., et al. Glycated hemoglobin level and risk of hip fracture in older people with type 2 diabetes: a competing risk analysis of Taiwan Diabetes Cohort Study. J Bone Miner Res 2015, 30(7 (July)):1338-1346. PubMed PMID: 25598134. Epub 2015/01/20. eng.
33. Schwartz A.V., Margolis K.L., Sellmeyer D.E., Vittinghoff E., Ambrosius W.T., Bonds D.E., et al. Intensive glycemic control is not associated with fractures or falls in the ACCORD randomized trial. Diabetes Care 2012, 35(7 (July)):1525-1531. PubMed PMID: 22723583. Pubmed Central PMCID: PMC3379596. Epub 2012/06/23. eng.
34. Kanazawa I., Yamaguchi T., Yamamoto M., Sugimoto T. Relationship between treatments with insulin and oral hypoglycemic agents versus the presence of vertebral fractures in type 2 diabetes mellitus. J Bone Miner Metab 2010, 28(5 (September)):554-560. PubMed PMID: 20177722. Epub 2010/02/24. eng.
35. Vestergaard P., Rejnmark L., Mosekilde L. Relative fracture risk in patients with diabetes mellitus, and the impact of insulin and oral antidiabetic medication on relative fracture risk. Diabetologia 2005, 48(7 (July)):1292-1299. PubMed PMID: 15909154. Epub 2005/05/24. eng.
36. Schwartz A.V., Vittinghoff E., Sellmeyer D.E., Feingold K.R., de Rekeneire N., Strotmeyer E.S., et al. Diabetes-related complications, glycemic control, and falls in older adults. Diabetes Care 2008, 31(3 (March)):391-396. PubMed PMID: 18056893. Pubmed Central PMCID: PMC2288549. Epub 2007/12/07. eng.