Epidemiology of fracture risk with advancing age

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 68, Issue 10, 2013, Pages 1236-1242

  Ensrud, Kristine E ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Aging; Epidemiology; Fractures

Indexed keywords

AGE; AGED; AGING; BONE DENSITY; ECONOMICS; EPIDEMIOLOGY; FEMALE; FRACTURE; HEALTH CARE COST; HUMAN; INCIDENCE; MALE; REVIEW; RISK FACTOR; UNITED STATES; FRACTURES, BONE;

AGING; EPIDEMIOLOGY; FRACTURES;

AGE FACTORS; AGED; BONE DENSITY; FEMALE; FRACTURES, BONE; HEALTH CARE COSTS; HUMANS; INCIDENCE; MALE; RISK FACTORS; UNITED STATES;

EID: 84885001724     PISSN: 10795006     EISSN: 1758535X     Source Type: Journal    
DOI: 10.1093/gerona/glt092     Document Type: Article

References (86)

1. NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy. Osteoporosis prevention, diagnosis, and therapy. JAMA. 2001;285:785-795.
2. Johnell O, Kanis JA. An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. Osteoporos Int. 2006;17:1726-1733. (Pubitemid 44607392)
3. Burge R, Dawson-Hughes B, Solomon DH, Wong JB, King A, Tosteson A. Incidence and economic burden of osteoporosis-related fractures in the United States, 2005-2025. J Bone Miner Res. 2007;22:465-475. (Pubitemid 46797130)
4. World Health Organization. Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. Report of a WHO Study Group. World Health Organ Tech Rep Ser. 1994;843:1-129.
5. Lewis CE, Ewing SK, Taylor BC, et al.; Osteoporotic Fractures in Men (MrOS) Study Research Group. Predictors of non-spine fracture in elderly men: the MrOS study. J Bone Miner Res. 2007;22:211-219.
6. Nguyen TV, Eisman JA, Kelly PJ, Sambrook PN. Risk factors for osteoporotic fractures in elderly men. Am J Epidemiol. 1996;144:255-263. (Pubitemid 26313502)
7. Seeley DG, Browner WS, Nevitt MC, Genant HK, Scott JC, Cummings SR. Which fractures are associated with low appendicular bone mass in elderly women? The Study of Osteoporotic Fractures Research Group. Ann Intern Med. 1991;115:837-842.
8. Stone KL, Seeley DG, Lui LY, et al.; Osteoporotic Fractures Research Group. BMD at multiple sites and risk of fracture of multiple types: long-term results from the Study of Osteoporotic Fractures. J Bone Miner Res. 2003;18:1947-1954.
9. Marshall D, Johnell O, Wedel H. Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fractures. BMJ. 1996;312:1254-1259. (Pubitemid 26147662)
10. Burger H, de Laet CE, van Daele PL, et al. Risk factors for increased bone loss in an elderly population: the Rotterdam Study. Am J Epidemiol. 1998;147:871-879.
11. Cawthon PM, Ewing SK, McCulloch CE, et al.; Osteoporotic Fractures in Men (MrOS) Research Group. Loss of hip BMD in older men: the osteoporotic fractures in men (MrOS) study. J Bone Miner Res. 2009;24:1728-1735.
12. Ensrud KE, Palermo L, Black DM, et al. Hip and calcaneal bone loss increase with advancing age: longitudinal results from the study of osteoporotic fractures. J Bone Miner Res. 1995;10:1778-1787.
13. Hannan MT, Felson DT, Dawson-Hughes B, et al. Risk factors for longitudinal bone loss in elderly men and women: the Framingham Osteoporosis Study. J Bone Miner Res. 2000;15:710-720. (Pubitemid 30174025)
14. Jones G, Nguyen T, Sambrook P, Kelly PJ, Eisman JA. Progressive loss of bone in the femoral neck in elderly people: longitudinal findings from the Dubbo osteoporosis epidemiology study. BMJ. 1994;309:691-695. (Pubitemid 24285219)
15. Melton LJ 3rd, Khosla S, Atkinson EJ, Oconnor MK, Ofallon WM, Riggs BL. Cross-sectional versus longitudinal evaluation of bone loss in men and women. Osteoporos Int. 2000;11:592-599.
16. Seeman E. Pathogenesis of bone fragility in women and men. Lancet. 2002;359:1841-1850. (Pubitemid 34607063)
17. Augat P, Schorlemmer S. The role of cortical bone and its microstructure in bone strength. Age Ageing. 2006;35(suppl 2):ii27-ii31. (Pubitemid 44687506)
18. Diez-Perez A, Güerri R, Nogues X, et al. Microindentation for in vivo measurement of bone tissue mechanical properties in humans. J Bone Miner Res. 2010;25:1877-1885.
19. Marshall LM, Lang TF, Lambert LC, Zmuda JM, Ensrud KE, Orwoll ES; Osteoporotic Fractures in Men (MrOS) Research Group. Dimensions and volumetric BMD of the proximal femur and their relation to age among older U.S. men. J Bone Miner Res. 2006;21:1197-1206. (Pubitemid 44128332)
20. Seeman E. Periosteal bone formation-a neglected determinant of bone strength. N Engl J Med. 2003;349:320-323. (Pubitemid 36886235)
21. Seeman E, Delmas PD. Bone quality-the material and structural basis of bone strength and fragility. N Engl J Med. 2006;354:2250-2261.
22. Zebaze RM, Ghasem-Zadeh A, Bohte A, et al. Intracortical remodelling and porosity in the distal radius and post-mortem femurs of women: a cross-sectional study. Lancet. 2010;375:1729-1736.
23. Tinetti ME, Speechley M, Ginter SF. Risk factors for falls among elderly persons living in the community. N Engl J Med. 1988;319:1701-1707. (Pubitemid 19019577)
24. de Rekeneire N, Visser M, Peila R, et al. Is a fall just a fall: correlates of falling in healthy older persons. The Health, Aging and Body Composition Study. J Am Geriatr Soc. 2003;51:841-846. (Pubitemid 36693436)
25. Faulkner KA, Chan BK, Cauley JA, et al.; Osteoporotic Fractures in Men (MrOS) Research Group. Histories including number of falls may improve risk prediction for certain non-vertebral fractures in older men. Inj Prev. 2009;15:307-311.
26. Rubenstein LZ, Josephson KR. The epidemiology of falls and syncope. Clin Geriatr Med. 2002;18:141-158. (Pubitemid 34693161)
27. Berry SD, Kiel DP. Falls as risk factors for fracture. In: Marcus R, Feldman D, Nelson DA, Rosen CJ, eds. Osteoporosis. 3rd ed. San Diego, CA: Academic Press; 2008: 911-921.
28. Rubenstein LZ. Falls in older people: epidemiology, risk factors and strategies for prevention. Age Ageing. 2006;35(suppl 2):ii37-ii41. (Pubitemid 44687508)
29. Wehren LE. The epidemiology of osteoporosis and fractures in geriatric medicine. Clin Geriatr Med. 2003;19:245-258. (Pubitemid 36514517)
30. Nevitt MC, Cummings SR, Hudes ES. Risk factors for injurious falls: a prospective study. J Gerontol. 1991;46:M164-M170.
31. Boufous S, Finch C, Lord S, Close J. The increasing burden of pelvic fractures in older people, New South Wales, Australia. Injury. 2005;36:1323-1329. (Pubitemid 41427212)
32. Cummings SR, Kelsey JL, Nevitt MC, O'Dowd KJ. Epidemiology of osteoporosis and osteoporotic fractures. Epidemiol Rev. 1985;7: 178-208. (Pubitemid 15236006)
33. Kelsey JL, Browner WS, Seeley DG, Nevitt MC, Cummings SR. Risk factors for fractures of the distal forearm and proximal humerus. The Study of Osteoporotic Fractures Research Group. Am J Epidemiol. 1992;135:477-489.
34. Nyberg L, Gustafson Y, Berggren D, Brännström B, Bucht G. Falls leading to femoral neck fractures in lucid older people. J Am Geriatr Soc. 1996;44:156-160. (Pubitemid 26050974)
35. Robinson CM, Hill RM, Jacobs N, Dall G, Court-Brown CM. Adult distal humeral metaphyseal fractures: epidemiology and results of treatment. J Orthop Trauma. 2003;17:38-47. (Pubitemid 36097829)
36. Schwartz AV, Nevitt MC, Brown BW Jr, Kelsey JL. Increased falling as a risk factor for fracture among older women: the study of osteoporotic fractures. Am J Epidemiol. 2005;161:180-185. (Pubitemid 40096793)
37. Seeley DG, Kelsey J, Jergas M, Nevitt MC. Predictors of ankle and foot fractures in older women. The Study of Osteoporotic Fractures Research Group. J Bone Miner Res. 1996;11:1347-1355. (Pubitemid 26282536)
38. Chrcanovic BR, Freire-Maia B, Souza LN, Araújo VO, Abreu MH. Facial fractures: a 1-year retrospective study in a hospital in Belo Horizonte. Braz Oral Res. 2004;18:322-328.
39. Kelsey JL, Keegan TH, Prill MM, Quesenberry CP Jr, Sidney S. Risk factors for fracture of the shafts of the tibia and fibula in older individuals. Osteoporos Int. 2006;17:143-149. (Pubitemid 41798039)
40. Cummings SR, Nevitt MC. A hypothesis: the causes of hip fractures. J Gerontol. 1989;44:M107-M111. (Pubitemid 19186290)
41. Greenspan SL, Myers ER, Kiel DP, Parker RA, Hayes WC, Resnick NM. Fall direction, bone mineral density, and function: risk factors for hip fracture in frail nursing home elderly. Am J Med. 1998;104:539-545. (Pubitemid 28328766)
42. Nevitt MC, Cummings SR. Type of fall and risk of hip and wrist fractures: the study of osteoporotic fractures. The Study of Osteoporotic Fractures Research Group. J Am Geriatr Soc. 1993;41:1226-1234. (Pubitemid 23324873)
43. Schwartz AV, Kelsey JL, Sidney S, Grisso JA. Characteristics of falls and risk of hip fracture in elderly men. Osteoporos Int. 1998;8:240-246. (Pubitemid 28427073)
44. Wei TS, Hu CH, Wang SH, Hwang KL. Fall characteristics, functional mobility and bone mineral density as risk factors of hip fracture in the community-dwelling ambulatory elderly. Osteoporos Int. 2001;12:1050-1055. (Pubitemid 34105977)
45. Palvanen M, Kannus P, Parkkari J, et al. The injury mechanisms of osteoporotic upper extremity fractures among older adults: a controlled study of 287 consecutive patients and their 108 controls. Osteoporos Int. 2000;11:822-831. (Pubitemid 32049471)
46. Dhanwal DK, Dennison EM, Harvey NC, Cooper C. Epidemiology of hip fracture: Worldwide geographic variation. Indian J Orthop. 2011;45:15-22.
47. Kanis JA, Johnell O, De Laet C, Jonsson B, Oden A, Ogelsby AK. International variations in hip fracture probabilities: implications for risk assessment. J Bone Miner Res. 2002;17:1237-1244. (Pubitemid 34680500)
48. Cooper C, Campion G, Melton LJ 3rd. Hip fractures in the elderly: a world-wide projection. Osteoporos Int. 1992;2:285-289.
49. Cooper C, Cole ZA, Holroyd CR, et al.; IOF CSA Working Group on Fracture Epidemiology. Secular trends in the incidence of hip and other osteoporotic fractures. Osteoporos Int. 2011;22:1277-1288.
50. Brauer CA, Coca-Perraillon M, Cutler DM, Rosen AB. Incidence and mortality of hip fractures in the United States. JAMA. 2009;302:1573-1579.
51. Melton LJ 3rd, Kearns AE, Atkinson EJ, et al. Secular trends in hip fracture incidence and recurrence. Osteoporos Int. 2009;20:687-694.
52. Leslie WD, O'Donnell S, Jean S, et al.; Osteoporosis Surveillance Expert Working Group. Trends in hip fracture rates in Canada. JAMA. 2009;302:883-889.
53. Cummings SR, Black DM, Nevitt MC, et al. Bone density at various sites for prediction of hip fractures. The Study of Osteoporotic Fractures Research Group. Lancet. 1993;341:72-75. (Pubitemid 23028113)
54. Cummings SR, Nevitt MC, Browner WS, et al. Risk factors for hip fracture in white women. Study of Osteoporotic Fractures Research Group. N Engl J Med. 1995;332:767-773.
55. Faulkner KA, Cauley JA, Studenski SA, et al.; Study of Osteoporotic Fractures Research Group. Lifestyle predicts falls independent of physical risk factors. Osteoporos Int. 2009;20:2025-2034.
56. Youm T, Koval KJ, Kummer FJ, Zuckerman JD. Do all hip fractures result from a fall? Am J Orthop (Belle Mead NJ). 1999;28:190-194.
57. Cummings SR, Melton LJ. Epidemiology and outcomes of osteoporotic fractures. Lancet. 2002;359:1761-1767.
58. Ensrud KE, Ewing SK, Taylor BC, et al.; Study of Osteoporotic Fractures Research Group. Frailty and risk of falls, fracture, and mortality in older women: the study of osteoporotic fractures. J Gerontol A Biol Sci Med Sci. 2007;62:744-751. (Pubitemid 350143606)
59. Ensrud KE, Ewing SK, Taylor BC, et al. Comparison of 2 frailty indexes for prediction of falls, disability, fractures, and death in older women. Arch Intern Med. 2008;168:382-389. (Pubitemid 351347130)
60. Ensrud KE, Ewing SK, Cawthon PM, et al.; Osteoporotic Fractures in Men Research Group. A comparison of frailty indexes for the prediction of falls, disability, fractures, and mortality in older men. J Am Geriatr Soc. 2009;57:492-498.
61. Ensrud KE, Ewing SK, Stone KL, Cauley JA, Bowman PJ, Cummings SR; Study of Osteoporotic Fractures Research Group. Intentional and unintentional weight loss increase bone loss and hip fracture risk in older women. J Am Geriatr Soc. 2003;51:1740-1747. (Pubitemid 37543360)
62. Taylor BC, Schreiner PJ, Stone KL, et al. Long-term prediction of incident hip fracture risk in elderly white women: study of osteoporotic fractures. J Am Geriatr Soc. 2004;52:1479-1486. (Pubitemid 39209595)
63. Schousboe JT, Vokes T, Broy SB, et al. Vertebral Fracture Assessment: the 2007 ISCD Official Positions. J Clin Densitom. 2008;11:92-108. (Pubitemid 351602190)
64. Riggs BL, Melton LJ 3rd. The worldwide problem of osteoporosis: insights afforded by epidemiology. Bone. 1995;17(suppl 1):S505-S511.
65. Cooper C, Atkinson EJ, O'Fallon WM, Melton LJ 3rd. Incidence of clinically diagnosed vertebral fractures: a population-based study in Rochester, Minnesota, 1985-1989. J Bone Miner Res. 1992;7:221-227.
66. Fink HA, Milavetz DL, Palermo L, et al.; Fracture Intervention Trial Research Group. What proportion of incident radiographic vertebral deformities is clinically diagnosed and vice versa? J Bone Miner Res. 2005;20:1216-1222. (Pubitemid 40863810)
67. Melton LJ 3rd, Lane AW, Cooper C, Eastell R, O'Fallon WM, Riggs BL. Prevalence and incidence of vertebral deformities. Osteoporos Int. 1993;3:113-119. (Pubitemid 23125371)
68. O'Neill TW, Felsenberg D, Varlow J, Cooper C, Kanis JA, Silman AJ. The prevalence of vertebral deformity in european men and women: the European Vertebral Osteoporosis Study. J Bone Miner Res. 1996;11:1010-1018. (Pubitemid 26200053)
69. Nevitt MC, Cummings SR, Stone KL, et al. Risk factors for a firstincident radiographic vertebral fracture in women < or = 65 years of age: the study of osteoporotic fractures. J Bone Miner Res. 2005;20:131-140. (Pubitemid 41716228)
70. Freitas SS, Barrett-Connor E, Ensrud KE, et al.; Osteoporotic Fractures in Men (MrOS) Research Group. Rate and circumstances of clinical vertebral fractures in older men. Osteoporos Int. 2008;19:615-623.
71. Ettinger B, Black DM, Nevitt MC, et al. Contribution of vertebral deformities to chronic back pain and disability. The Study of Osteoporotic Fractures Research Group. J Bone Miner Res. 1992;7: 449-456.
72. Silverman SL, Minshall ME, Shen W, Harper KD, Xie S; Health- Related Quality of Life Subgroup of the Multiple Outcomes of Raloxifene Evaluation Study. The relationship of health-related quality of life to prevalent and incident vertebral fractures in postmenopausal women with osteoporosis: results from the Multiple Outcomes of Raloxifene Evaluation Study. Arthritis Rheum. 2001;44:2611-2619. (Pubitemid 33049339)
73. Fink HA, Ensrud KE, Nelson DB, et al. Disability after clinical fracture in postmenopausal women with low bone density: the fracture intervention trial (FIT). Osteoporos Int. 2003;14:69-76. (Pubitemid 36267903)
74. Nevitt MC, Ettinger B, Black DM, et al. The association of radiographically detected vertebral fractures with back pain and function: a prospective study. Ann Intern Med. 1998;128:793-800. (Pubitemid 28267711)
75. Ensrud KE, Thompson DE, Cauley JA, et al. Prevalent vertebral deformities predict mortality and hospitalization in older women with low bone mass. Fracture Intervention Trial Research Group. J Am Geriatr Soc. 2000;48:241-249. (Pubitemid 30164205)
76. Kelsey JL, Browner WS, Seeley DG, Nevitt MC, Cummings SR. Risk factors for fractures of the distal forearm and proximal humerus. The Study of Osteoporotic Fractures Research Group. Am J Epidemiol. 1992;135:477-489.
77. Silman AJ. Risk factors for Colles' fracture in men and women: results from the European Prospective Osteoporosis Study. Osteoporos Int. 2003;14:213-218. (Pubitemid 40826234)
78. Vogt MT, Cauley JA, Tomaino MM, Stone K, Williams JR, Herndon JH. Distal radius fractures in older women: a 10-year follow-up study of descriptive characteristics and risk factors. The study of osteoporotic fractures. J Am Geriatr Soc. 2002;50:97-103. (Pubitemid 34053029)
79. Mackey DC, Lui LY, Cawthon PM, et al.; Study of Osteoporotic Fractures (SOF) and Osteoporotic Fractures in Men Study (MrOS) Research Groups. High-trauma fractures and low bone mineral density in older women and men. JAMA. 2007;298:2381-2388.
80. Barrett-Connor E, Nielson CM, Orwoll E, Bauer DC, Cauley JA; Osteoporotic Fractures in Men Study Group. Epidemiology of rib fractures in older men: Osteoporotic Fractures in Men (MrOS) prospective cohort study. BMJ. 2010;340:c1069.
81. FitzGerald G, Boonen S, Compston JE, et al.; GLOW Investigators. Differing risk profiles for individual fracture sites: evidence from the Global Longitudinal Study of Osteoporosis in Women (GLOW). J Bone Miner Res. 2012;27:1907-1915.
82. Prieto-Alhambra D, Avilés FF, Judge A, et al. Burden of pelvis fracture: a population-based study of incidence, hospitalisation and mortality. Osteoporos Int. 2012;23:2797-2803.
83. Roux C, Wyman A, Hooven FH, et al.; GLOW investigators. Burden of non-hip, non-vertebral fractures on quality of life in postmenopausal women: the Global Longitudinal study of Osteoporosis in Women (GLOW). Osteoporos Int. 2012;23:2863-2871.
84. Ensrud KE, Cauley J, Lipschutz R, Cummings SR. Weight change and fractures in older women. Study of Osteoporotic Fractures Research Group. Arch Intern Med. 1997;157:857-863.
85. Kelsey JL, Samelson EJ. Variation in risk factors for fractures at different sites. Curr Osteoporos Rep. 2009;7:127-133.
86. Melton LJ 3rd, Cummings SR. Heterogeneity of age-related fractures: implications for epidemiology. Bone Miner. 1987;2:321-331. (Pubitemid 17117239)