Factors Associated with Complications of Clostridium difficile Infection in a Multicenter Prospective Cohort

Clinical Infectious Diseases

Volumn 61, Issue 12, 2015, Pages 1781-1788

  Abou Chakra, Claire Nour ^a   McGeer, Allison ^b   Labbe, Annie Claude ^c   Simor, Andrew E ^d   Gold, Wayne L ^e   Muller, Matthew P ^f   Powis, Jeff ^g   Katz, Kevin ^h   Garneau, Julian R ^a   Fortier, Louis Charles ^a   Pepin, Jacques ^a   Cadarette, Suzanne M ⁱ   Valiquette, Louis ^a  

^a UNIVERSITY OF SHERBROOKE   (Canada)

^b MOUNT SINAI HOSPITAL   (Canada)

^c MAISONNEUVE ROSEMONT HOSPITAL   (Canada)

^d SUNNYBROOK RESEARCH INSTITUTE   (Canada)

^e TORONTO GENERAL HOSPITAL   (Canada)

^f ST MICHAEL'S HOSPITAL   (Canada)

^g TORONTO EAST GENERAL HOSPITAL   (Canada)

^h NORTH YORK GENERAL HOSPITAL   (Canada)

ⁱ UNIVERSITY OF TORONTO   (Canada)

Author keywords

Clostridium difficile; complications; mortality; ribotype 027; risk factors

Indexed keywords

ALBUMIN; C REACTIVE PROTEIN; METRONIDAZOLE; VANCOMYCIN;

ADULT; AGE; AGED; ARTICLE; BACTERIUM ISOLATE; BREATHING RATE; CANADA; CLOSTRIDIUM DIFFICILE INFECTION; COHORT ANALYSIS; FEMALE; HEART RATE; HEMICOLECTOMY; HOSPITAL PATIENT; HUMAN; INTENSIVE CARE UNIT; INTESTINE PERFORATION; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MULTICENTER STUDY; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROSPECTIVE STUDY; RIBOTYPING; RISK FACTOR; TOTAL COLON RESECTION; TOXIC MEGACOLON; UREA NITROGEN BLOOD LEVEL; ADOLESCENT; CLASSIFICATION; CLINICAL TRIAL; COMPLICATION; GENETICS; INTENSIVE CARE; INTESTINAL PERFORATION; ISOLATION AND PURIFICATION; MEGACOLON, TOXIC; MORTALITY; PEPTOCLOSTRIDIUM DIFFICILE; PROGNOSIS; PSEUDOMEMBRANOUS COLITIS; RISK ASSESSMENT; VERY ELDERLY; YOUNG ADULT;

ADOLESCENT; ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; CANADA; CLOSTRIDIUM DIFFICILE; CRITICAL CARE; ENTEROCOLITIS, PSEUDOMEMBRANOUS; FEMALE; HUMANS; INTESTINAL PERFORATION; MALE; MEGACOLON, TOXIC; MIDDLE AGED; PROGNOSIS; PROSPECTIVE STUDIES; RIBOTYPING; RISK ASSESSMENT; YOUNG ADULT;

EID: 84961589576     PISSN: 10584838     EISSN: 15376591     Source Type: Journal    
DOI: 10.1093/cid/civ749     Document Type: Article

References (39)

1. Kwon JH, Olsen MA, Dubberke ER. The morbidity, mortality, and costs associated with Clostridium difficile infection. Infect Dis Clin North Am 2015; 29:123-34.
2. Nanwa N, Kendzerska T, Krahn M, et al. The economic impact of Clostridium difficile infection: A systematic review. Am J Gastroenterol 2015; 110:511-9.
3. Gerding DN, Lessa FC. The epidemiology of Clostridium difficile infection inside and outside health care institutions. Infect Dis Clin North Am 2015; 29:37-50.
4. Bauer MP, NotermansDW, Van Benthem BH, et al. Clostridium difficile infection in Europe: A hospital-based survey. Lancet 2011; 377:63-73.
5. Lessa FC, Gould CV, Mcdonald LC. Current status of Clostridium difficile infection epidemiology. Clin Infect Dis 2012; 55(suppl 2):S65-70.
6. Henrich TJ, Krakower D, Bitton A, Yokoe DS. Clinical risk factors for severe Clostridium difficile-associated disease. Emerg Infect Dis 2009; 15:415-22.
7. Pepin J, Valiquette L, Alary ME, et al. Clostridium difficile-associated diarrhea in a region of Quebec from 1991 to 2003: A changing pattern of disease severity. CMAJ 2004; 171:466-72.
8. Cloud J, Noddin L, Pressman A, Hu M, Kelly C. Clostridium difficile strain NAP-1 is not associated with severe disease in a nonepidemic setting. Clin Gastroenterol Hepatol 2009; 7:868-73.
9. Khanna S, Aronson SL, Kammer PP, Baddour LM, Pardi DS. Gastric acid suppression and outcomes in Clostridium difficile infection: A population-based study. Mayo Clin Proc 2012; 87:636-42.
10. Morrison RH, Hall NS, Said M, et al. Risk factors associated with complications and mortality in patients with Clostridium difficile infection. Clin Infect Dis 2011; 53:1173-8.
11. Rao K, Micic D, Natarajan M, et al. Clostridium difficile ribotype 027: relationship to age, detectability of toxins A or B in stool with rapid testing, severe infection, and mortality. Clin Infect Dis 2015; 61: 233-41.
12. Stewart DB, Hollenbeak CS. Clostridium difficile colitis: factors associated with outcome and assessment of mortality at a national level. J Gastrointest Surg 2011; 15:1548-55.
13. Gasperino J, Garala M, CohenHW, Kvetan V, Currie B. Investigation of critical care unit utilization and mortality in patients infected with Clostridium difficile. J Crit Care 2010; 25:282-6.
14. Abou Chakra CN, Pepin J, Sirard S, Valiquette L. Risk factors for recurrence, complications and mortality in Clostridium difficile infection: A systematic review. PLoS One 2014; 9:e98400.
15. Cohen SH, Gerding DN, Johnson S, et al. Clinical practice guidelines for Clostridium difficile infection in adults: 2010 update by the Society for Healthcare Epidemiology of America (SHEA) and the Infectious Diseases Society of America (IDSA). Infect Control Hosp Epidemiol 2010; 31:431-55.
16. Gan SI, Beck PL. A new look at toxic megacolon: an update and review of incidence, etiology, pathogenesis, and management. Am J Gastroenterol 2003; 98:2363-71.
17. Mcdonald LC, Coignard B, Dubberke E, Song X, Horan T, Kutty PK. Recommendations for surveillance of Clostridium difficile-associated disease. Infect Control Hosp Epidemiol 2007; 28:140-5.
18. Byrn JC, Maun DC, Gingold DS, Baril DT, Ozao JJ, Divino CM. Predictors of mortality after colectomy for fulminant Clostridium difficile colitis. Arch Surg 2008; 143:150-4.
19. Hosten AO. BUN and creatinine. In: Walker HK, Hall WD, Hurst JW, eds. Clinical Methods: The History, Physical, and Laboratory Examinations. Boston: Butterworths, 1990.
20. Gatta A, Verardo A, Bolognesi M. Hypoalbuminemia. Intern Emerg Med 2012; 7(suppl 3):S193-9.
21. Walk ST, Micic D, Jain R, et al. Clostridium difficile ribotype does not predict severe infection. Clin Infect Dis 2012; 55:1661-8.
22. Rao K, Walk ST, Micic D, et al. Procalcitonin levels associate with severity of Clostridium difficile infection. PLoS One 2013; 8:e58265.
23. See I, Mu Y, Cohen J, et al. NAP1 strain type predicts outcomes from Clostridium difficile infection. Clin Infect Dis 2014; 58:1394-400.
24. Schumann P, Pukall R. The discriminatory power of ribotyping as automatable technique for differentiation of bacteria. Syst Appl Microbiol 2013; 36:369-75.
25. Kurka H, Ehrenreich A, Ludwig W, et al. Sequence similarity of Clostridium difficile strains by analysis of conserved genes and genome content is reflected by their ribotype affiliation. PLoS One 2014; 9:e86535.
26. Huber CA, Foster NF, Riley TV, Paterson DL. Challenges for standardization of Clostridium difficile typing methods. J Clin Microbiol 2013; 51:2810-4.
27. Knetsch CW, Lawley TD, Hensgens MP, Corver J,Wilcox MW, Kuijper EJ. Current application and future perspectives of molecular typing methods to study Clostridium difficile infections. Euro Surveill 2013; 18:20381.
28. Eyre DW, Cule ML, Wilson DJ, et al. Diverse sources of C. difficile infection identified on whole-genome sequencing. N Engl J Med 2013; 369:1195-205.
29. Martin H, Willey B, Low DE, et al. Characterization of Clostridium difficile strains isolated from patients in Ontario, Canada, from 2004 to 2006. J Clin Microbiol 2008; 46:2999-3004.
30. Hubert B, Loo VG, Bourgault AM, et al. A portrait of the geographic dissemination of the Clostridium difficile North American pulsed-field type 1 strain and the epidemiology of C. difficile-associated disease in Quebec. Clin Infect Dis 2007; 44:238-44.
31. Sirard S, Valiquette L, Fortier LC. Lack of association between clinical outcome of Clostridium difficile infections, strain type, and virulenceassociated phenotypes. J Clin Microbiol 2011; 49:4040-6.
32. Soes LM, Brock I, Persson S, Simonsen J, Pribil Olsen KE, Kemp M. Clinical features of Clostridium difficile infection and molecular characterization of the isolated strains in a cohort of Danish hospitalized patients. Eur J Clin Microbiol Infect Dis 2012; 31:185-92.
33. Novak-Weekley SM, Marlowe EM, Miller JM, et al. Clostridium difficile testing in the clinical laboratory by use of multiple testing algorithms. J Clin Microbiol 2010; 48:889-93.
34. Little RJA, Rubin DB. Statistical analysis with missing data. 2nd ed. Hoboken: Wiley Interscience, 2002.
35. Peduzzi P, Concato J, Kemper E, Holford TR, Feinstein AR. A simulation study of the number of events per variable in logistic regression analysis. J Clin Epidemiol 1996; 49:1373-9.
36. Gilca R, Frenette C, Theriault N, Fortin E, Villeneuve J. Attributing cause of death for patients with Clostridium difficile infection. Emerg Infect Dis 2012; 18:1707-8.
37. Hota SS, Achonu C, Crowcroft NS, Harvey BJ, Lauwers A, Gardam MA. Determining mortality rates attributable to Clostridium difficile infection. Emerg Infect Dis 2012; 18:305-7.
38. Mlangeni DA, Harris MD, Franklin L, Hunt P, Karas JA, Enoch DA. Death certificates provide a poor estimation of attributable mortality due to Clostridium difficile when compared to a death review panel using defined criteria. J Hosp Infect 2011; 77:370-1.
39. LaupacisA, Sekar N, StiellIG.Clinical predictionrules.Areviewand suggestedmodifications of methodological standards. JAMA 1997; 277:488-94.