Genistein alleviates testicular ischemia and reperfusion injury-induced spermatogenic damage and oxidative stress by suppressing abnormal testicular matrix metalloproteinase system via the notch 2/jagged 1/hes-1 and caspase-8 pathways

Journal of Physiology and Pharmacology

Volumn 67, Issue 1, 2016, Pages 129-137

  Al Maghrebi, May ^a   Renno, W M ^a  

^a Department of Biochemistry ^*  (Kuwait)

Author keywords

Apoptosis; Genistein; Inhibitors of metalloproteinases; Metalloproteinases; Notch pathway; Oxidative stress; Spermatogenesis; Testicular ischemia reperfusion

Indexed keywords

CASPASE 3; CASPASE 8; GELATINASE A; GELATINASE B; GENISTEIN; JAGGED1; MATRIX METALLOPROTEINASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; NOTCH2 RECEPTOR; SUPEROXIDE DISMUTASE; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TRANSCRIPTION FACTOR HES 1; ANTIOXIDANT; CASP8 PROTEIN, RAT; HES1 PROTEIN, RAT; JAG1 PROTEIN, RAT; NOTCH3 RECEPTOR; PROTEIN JAGGED 1;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ANTIOXIDANT ASSAY; APOPTOSIS; ARTERY OCCLUSION; ARTICLE; CELL DAMAGE; CONTROLLED STUDY; DNA DAMAGE; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION; GERM CELL; HISTOPATHOLOGY; MALE; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RAT; REPERFUSION INJURY; SPERMATOCYTE; SPERMATOGENESIS; TESTICULAR ISCHEMIA; TESTIS DISEASE; TUNEL ASSAY; ANIMAL; DRUG EFFECTS; METABOLISM; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT; TESTIS;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; CASPASE 8; GENISTEIN; JAGGED-1 PROTEIN; MALE; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MATRIX METALLOPROTEINASES; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, NOTCH3; REPERFUSION INJURY; SIGNAL TRANSDUCTION; SPERMATOGENESIS; TESTIS; TRANSCRIPTION FACTOR HES-1;

EID: 84961589503     PISSN: 08675910     EISSN: 18991505     Source Type: Journal    
DOI: None     Document Type: Article

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