Antihypertensive Drug Use, Blood Pressure Variability, and Incident Stroke Risk in Older Adults: Three-City Cohort Study

Stroke

Volumn 47, Issue 5, 2016, Pages 1194-1200

  Tully, Phillip J ^a,b,f   Debette, Stephanie ^a,c,d   Dartigues, Jean François ^a   Helmer, Catherine ^a   Artero, Sylvaine ^e   Tzourio, Christophe ^a,f  

^a UNIVERSITÉ DE BORDEAUX   (France)

^b UNIVERSITY OF ADELAIDE   (Australia)

^c BORDEAUX UNIVERSITY HOSPITAL   (France)

^d BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e UNIV MONTPELLIER   (France)

^f INSERM   (France)

Author keywords

antihypertensive; blood pressure variability; hypertension; ischemic; stroke

Indexed keywords

ANGIOTENSIN RECEPTOR ANTAGONIST; ANTIHYPERTENSIVE AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT;

AGED; ARTICLE; BLOOD PRESSURE VARIABILITY; BRAIN ISCHEMIA; CEREBROVASCULAR ACCIDENT; COHORT ANALYSIS; DIASTOLIC BLOOD PRESSURE; DISEASE ASSOCIATION; DRUG USE; FEMALE; FOLLOW UP; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RISK ASSESSMENT; SYSTOLIC BLOOD PRESSURE; BLOOD PRESSURE; CHEMICALLY INDUCED; CLINICAL TRIAL; DRUG EFFECTS; FRANCE; INCIDENCE; MULTICENTER STUDY; RISK; STROKE; VERY ELDERLY;

ADRENERGIC BETA-ANTAGONISTS; AGED; AGED, 80 AND OVER; ANGIOTENSIN RECEPTOR ANTAGONISTS; ANTIHYPERTENSIVE AGENTS; BLOOD PRESSURE; COHORT STUDIES; FEMALE; FRANCE; HUMANS; HYPERTENSION; INCIDENCE; MALE; RISK; STROKE;

EID: 84961589239     PISSN: 00392499     EISSN: 15244628     Source Type: Journal    
DOI: 10.1161/STROKEAHA.115.012321     Document Type: Article

References (36)

1. Poulter NR, Prabhakaran D, Caulfield M. Hypertension. Lancet. 2015;386:801-812. doi: 10.1016/S0140-6736(14)61468-9.
2. Kuklina EV, Tong X, George MG, Bansil P. Epidemiology and prevention of stroke: a worldwide perspective. Expert Rev Neurother. 2012;12:199-208. doi: 10.1586/ern.11.99.
3. Aronow WS. Hypertension-related stroke prevention in the elderly. Curr Hypertens Rep. 2013;15:582-589. doi: 10.1007/s11906-013-0384-x.
4. James PA, Oparil S, Carter BL, Cushman WC, Dennison-Himmelfarb C, Handler J, et al. 2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8). JAMA. 2014;311:507-520. doi: 10.1001/jama.2013.284427.
5. Denker MG, Cohen DL. What is an appropriate blood pressure goal for the elderly: review of recent studies and practical recommendations. Clin Interv Aging. 2013;8:1505-1517. doi: 10.2147/CIA.S33087.
6. Kaiser EA, Lotze U, Schäfer HH. Increasing complexity: which drug class to choose for treatment of hypertension in the elderly? Clin Interv Aging. 2014;9:459-475. doi: 10.2147/CIA.S40154.
7. Blacher J, Halimi JM, Hanon O, Mourad JJ, Pathak A, Schnebert B, et al; French Society of Hypertension. Management of hypertension in adults: the 2013 French Society of Hypertension guidelines. Fundam Clin Pharmacol. 2014;28:1-9. doi: 10.1111/fcp.12044.
8. Rothwell PM. Limitations of the usual blood-pressure hypothesis and importance of variability, instability, and episodic hypertension. Lancet. 2010;375:938-948. doi: 10.1016/S0140-6736(10)60309-1.
9. Rothwell PM, Howard SC, Dolan E, O'Brien E, Dobson JE, Dahlöf B, et al. Prognostic significance of visit-to-visit variability, maximum systolic blood pressure, and episodic hypertension. Lancet. 2010;375:895-905. doi: 10.1016/S0140-6736(10)60308-X.
10. Webb AJ, Fischer U, Mehta Z, Rothwell PM. Effects of antihypertensive-drug class on interindividual variation in blood pressure and risk of stroke: a systematic review and meta-analysis. Lancet. 2010;375:906-915. doi: 10.1016/S0140-6736(10)60235-8.
11. Hata Y, Kimura Y, Muratani H, Fukiyama K, Kawano Y, Ashida T, et al. Office blood pressure variability as a predictor of brain infarction in elderly hypertensive patients. Hypertens Res. 2000;23:553-560.
12. Gao S, Hendrie HC, Wang C, Stump TE, Stewart JC, Kesterson J, et al. Redefined blood pressure variability measure and its association with mortality in elderly primary care patients. Hypertension. 2014;64:45-52. doi: 10.1161/HYPERTENSIONAHA.114.03576.
13. Schillaci G, Pucci G. The importance of instability and visit-to-visit variability of blood pressure. Expert Rev Cardiovasc Ther. 2010;8:1095-1097. doi: 10.1586/erc.10.84.
14. Webb AJ, Rothwell PM. Effect of dose and combination of antihypertensives on interindividual blood pressure variability: a systematic review. Stroke. 2011;42:2860-2865. doi: 10.1161/STROKEAHA.110.611566.
15. Rothwell PM, Howard SC, Dolan E, O'Brien E, Dobson JE, Dahlöf B, et al; ASCOT-BPLA and MRC Trial Investigators. Effects of beta blockers and calcium-channel blockers on within-individual variability in blood pressure and risk of stroke. Lancet Neurol. 2010;9:469-480. doi: 10.1016/S1474-4422(10)70066-1.
16. Chowdhury EK, Owen A, Krum H, Wing LM, Nelson MR, Reid CM; Second Australian National Blood Pressure Study Management Committee. Systolic blood pressure variability is an important predictor of cardiovascular outcomes in elderly hypertensive patients. J Hypertens. 2014;32:525-533. doi: 10.1097/HJH.0000000000000028.
17. The 3C Study Group. Vascular factors and risk of dementia: design of the three-city study and baseline characteristics of the study population. Neuroepidemiol. 2003;22:316-325.
18. Brindel P, Hanon O, Dartigues JF, Ritchie K, Lacombe JM, Ducimetière P, et al; 3C Study Investigators. Prevalence, awareness, treatment, and control of hypertension in the elderly: the Three City study. J Hypertens. 2006;24:51-58.
19. World Health Organization. Guidelines for ATC Classification and DDD Assignment. Oslo, Norway: Norwegian Institute of Public Health; 2002.
20. Tai C, Sun Y, Dai N, Xu D, Chen W, Wang J, et al. Prognostic significance of visit-to-visit systolic blood pressure variability: a meta-analysis of 77,299 patients. J Clin Hypertens (Greenwich). 2015;17:107-115. doi: 10.1111/jch.12484.
21. Alpérovitch A, Kurth T, Bertrand M, Ancelin ML, Helmer C, Debette S, et al. Primary prevention with lipid lowering drugs and long term risk of vascular events in older people: population based cohort study. BMJ. 2015;350:h2335.
22. Schutte R, Thijs L, Liu YP, Asayama K, Jin Y, Odili A, et al. Withinsubject blood pressure level-not variability-predicts fatal and nonfatal outcomes in a general population. Hypertension. 2012;60:1138-1147. doi: 10.1161/HYPERTENSIONAHA.112.202143.
23. Mancia G, Facchetti R, Parati G, Zanchetti A. Visit-to-visit blood pressure variability, carotid atherosclerosis, and cardiovascular events in the European Lacidipine Study on Atherosclerosis. Circulation. 2012;126:569-578. doi: 10.1161/CIRCULATIONAHA.112.107565.
24. Arashi H, Ogawa H, Yamaguchi J, Kawada-Watanabe E, Hagiwara N. Impact of visit-to-visit variability and systolic blood pressure control on subsequent outcomes in hypertensive patients with coronary artery disease (from the HIJ-CREATE substudy). Am J Cardiol. 2015;116:236-242. doi: 10.1016/j.amjcard.2015.04.011.
25. McMullan CJ, Lambers Heerspink HJ, Parving HH, Dwyer JP, Forman JP, de Zeeuw D. Visit-to-visit variability in blood pressure and kidney and cardiovascular outcomes in patients with type 2 diabetes and nephropathy: a post hoc analysis from the RENAAL study and the Irbesartan Diabetic Nephropathy Trial. Am J Kidney Dis. 2014;64:714-722. doi: 10.1053/j.ajkd.2014.06.008.
26. Suchy-Dicey AM, Wallace ER, Mitchell SV, Aguilar M, Gottesman RF, Rice K, et al. Blood pressure variability and the risk of all-cause mortality, incident myocardial infarction, and incident stroke in the cardiovascular health study. Am J Hypertens. 2013;26:1210-1217. doi: 10.1093/ajh/hpt092.
27. Yu JM, Kong QY, Schoenhagen P, Shen T, He YS, Wang JW, et al. The prognostic value of long-term visit-to-visit blood pressure variability on stroke in real-world practice: a dynamic cohort study in a large representative sample of Chinese hypertensive population. Int J Cardiol. 2014;177:995-1000. doi: 10.1016/j.ijcard.2014.09.149.
28. Shimbo D, Newman JD, Aragaki AK, La Monte MJ, Bavry AA, Allison M, et al. Association between annual visit-to-visit blood pressure variability and stroke in postmenopausal women: data from the Women's Health Initiative. Hypertension. 2012;60:625-630. doi: 10.1161/HYPERTENSIONAHA.112.193094.
29. Ding FH, Li Y, Li LH, Wang JG. Impact of heart rate on central hemodynamics and stroke: a meta-analysis of β-blocker trials. Am J Hypertens. 2013;26:118-125. doi: 10.1093/ajh/hps003.
30. Mitchell GF. Arterial stiffness and wave reflection: biomarkers of cardiovascular risk. Artery Res. 2009;3:56-64. doi: 10.1016/j.artres.2009.02.002.
31. Williams B, Lacy PS; CAFE and the ASCOT (Anglo-Scandinavian Cardiac Outcomes Trial) Investigators. Impact of heart rate on central aortic pressures and hemodynamics: analysis from the CAFE (Conduit Artery Function Evaluation) study: CAFE-Heart Rate. J Am Coll Cardiol. 2009;54:705-713. doi: 10.1016/j.jacc.2009.02.088.
32. Strauss MH, Hall A. Angiotensin receptor blockers should be regarded as first-line drugs for stroke prevention in both primary and secondary prevention settings: no. Stroke. 2009;40:3161-3162. doi: 10.1161/STROKEAHA.109.559062.
33. Lévy BI. Can angiotensin II type 2 receptors have deleterious effects in cardiovascular disease? Implications for therapeutic blockade of the renin-angiotensin system. Circulation. 2004;109:8-13. doi: 10.1161/01. CIR.0000096609.73772.C5.
34. Pringle E, Phillips C, Thijs L, Davidson C, Staessen JA, de Leeuw PW, et al; Syst-Eur investigators. Systolic blood pressure variability as a risk factor for stroke and cardiovascular mortality in the elderly hypertensive population. J Hypertens. 2003;21:2251-2257. doi: 10.1097/01. hjh.0000098144.70956.0f.
35. Tully PJ, Hanon O, Cosh S, Tzourio C. Diuretic antihypertensive drugs and incident dementia risk: A systematic review, meta-analysis and meta-regression of prospective studies [published online ahead of print February 16, 2016] J Hypertens. http://journals.lww.com/jhypertension/pages/articleviewer.aspx?year=9000&issue=00000&article=98092&typ e=abstract. Accessed Febuary 17, 2016.
36. Crichton GE, Elias MF, Dore GA, Torres RV, Robbins MA. Measurement-to-measurement blood pressure variability is related to cognitive performance: the Maine Syracuse study. Hypertension. 2014;64:1094-1101. doi: 10.1161/HYPERTENSIONAHA.114.04282.