Unconventional endocannabinoid signaling governs sperm activation via the sex hormone progesterone

Science

Volumn 352, Issue 6285, 2016, Pages 555-559

  Miller, Melissa R ^a   Mannowetz, Nadja ^a   Iavarone, Anthony T ^b   Safavi, Rojin ^a   Gracheva, Elena O ^c   Smith, James F ^d   Hill, Rose Z ^a   Bautista, Diana M ^a   Kirichok, Yuriy ^d   Lishko, Polina V ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 ARACHIDONOYLGLYCEROL; ACID PHOSPHATASE PROSTATE ISOENZYME; ALPHA BETA HYDROLASE DOMAIN CONTAINING PROTEIN 2; CALCIUM CHANNEL; ENDOCANNABINOID; ENZYME; FATTY ACID AMIDASE; HYDROLASE; LYSOPHOSPHOLIPID; PROGESTERONE; PROGESTERONE RECEPTOR; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG; ABHD2 PROTEIN, HUMAN; ACYLGLYCEROL; ARACHIDONIC ACID DERIVATIVE; CALCIUM; CATSPER1 PROTEIN, HUMAN; GLYCERYL 2-ARACHIDONATE;

BIOCHEMISTRY; CALCIUM; CELLS AND CELL COMPONENTS; ENZYME ACTIVITY; GENOME; MEMBRANE; NEUROLOGY; PROTEIN; SEX HORMONE; SPERM;

ACROSOME; ACROSOME REACTION; ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; CELL MEMBRANE; CONTROLLED STUDY; ENZYME ACTIVATION; FERTILIZATION; HUMAN; HUMAN CELL; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEMINAL PLASMA; SIGNAL TRANSDUCTION; SPERM; SPERMATOZOON; SPERMATOZOON MOTILITY; SPERMATOZOON TAIL; ADULT; ANIMAL; C57BL MOUSE; CALCIUM SIGNALING; DEFICIENCY; DRUG EFFECTS; GENETICS; METABOLISM; MOUSE; PHYSIOLOGY; RAT; WISTAR RAT; YOUNG ADULT;

ADULT; ANIMALS; ARACHIDONIC ACIDS; CALCIUM; CALCIUM CHANNELS; CALCIUM SIGNALING; CELL MEMBRANE; ENDOCANNABINOIDS; FERTILIZATION; GLYCERIDES; HUMANS; HYDROLASES; MALE; MICE; MICE, INBRED C57BL; PROGESTERONE; RATS; RATS, WISTAR; RECEPTORS, PROGESTERONE; SPERM MOTILITY; SPERMATOZOA; YOUNG ADULT;

EID: 84961393718     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aad6887     Document Type: Article

References (24)

1. G. Tononi, C. Cirelli, Neuron 81, 12-34 (2014).
2. J. H. Benington, H. C. Heller, Prog. Neurobiol. 45, 347-360 (1995).
3. V. Hinard et al., J. Neurosci. 32, 12506-12517 (2012).
4. C. B. Saper, T. E. Scammell, J. Lu, Nature 437, 1257-1263 (2005).
5. J. O'Donnell, D. Zeppenfeld, E. McConnell, S. Pena, M. Nedergaard, Neurochem. Res. 37, 2496-2512 (2012).
6. M. Steriade, D. A. McCormick, T. J. Sejnowski, Science 262, 679-685 (1993).
7. G. G. Somjen, Ions in the Brain: Normal Function, Seizures, and Stroke (Oxford Univ. Press, 2004).
8. J. Seigneur, D. Kroeger, D. A. Nita, F. Amzica, Cereb. Cortex 16, 655-668 (2006).
9. S. M. Rothman, Science 220, 536-537 (1983).
10. L. Xie et al., Science 342, 373-377 (2013).
11. M. Anderová et al., Glia 35, 189-203 (2001).
12. C. B. Saper, P. M. Fuller, N. P. Pedersen, J. Lu, T. E. Scammell, Neuron 68, 1023-1042 (2010).
13. A. J. Hansen, Physiol. Rev. 65, 101-148 (1985).
14. L. Sun et al., Magnes. Res. 22, 266-272 (2009).
15. A. M. Romani, Arch. Biochem. Biophys. 512, 1-23 (2011).
16. W. W. Anderson, D. V. Lewis, H. S. Swartzwelder, W. A. Wilson, Brain Res. 398, 215-219 (1986).
17. G. F. Gilestro, G. Tononi, C. Cirelli, Science 324, 109-112 (2009).
18. B. Abbasi et al., J. Res. Med. Sci. 17, 1161-1169 (2012).
19. I. Slutsky et al., Neuron 65, 165-177 (2010).
20. B. Lu et al., Neuron 68, 488-499 (2010).
21. J. Schummers, H. Yu, M. Sur, Science 320, 1638-1643 (2008).
22. H. Sontheimer, Glia 11, 156-172 (1994).
23. A. Torres et al., Sci. Signal. 5, ra8 (2012).
24. A. S. Thrane et al., Proc. Natl. Acad. Sci. U.S.A. 109, 18974-18979 (2012).