Stability and Reproducibility Underscore Utility of RT-QuIC for Diagnosis of Creutzfeldt-Jakob Disease

Molecular Neurobiology

Volumn 53, Issue 3, 2016, Pages 1896-1904

  Cramm, Maria ^a   Schmitz, Matthias ^a   Karch, André ^a   Mitrova, Eva ^b   Kuhn, Franziska ^c   Schroeder, Bjoern ^c   Raeber, Alex ^c   Varges, Daniela ^a   Kim, Yong Sun ^d   Satoh, Katsuya ^e   Collins, Steven ^f   Zerr, Inga ^a  

^a UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

^b SLOVAK MEDICAL UNIVERSITY   (Slovakia)

^c Thermo Fisher Scientific   (United States)

^d Hallym University   (South Korea)

^e NAGASAKI UNIVERSITY GRADUATE SCHOOL OF BIOMEDICAL SCIENCES   (Japan)

^f UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Cerebrospinal fluid; Creutzfeldt Jakob disease; Diagnostic test; Prion protein; Real time quaking induced conversion

Indexed keywords

PRION PROTEIN; PROTEIN 14 3 3; RECOMBINANT PROTEIN; TAU PROTEIN;

ARTICLE; BLOOD; CEREBROSPINAL FLUID ANALYSIS; CONTAMINATION; CONTROLLED STUDY; CREUTZFELDT JAKOB DISEASE; DIAGNOSTIC TEST; DIAGNOSTIC VALUE; ERYTHROCYTE; FALSE NEGATIVE RESULT; FALSE POSITIVE RESULT; FATAL FAMILIAL INSOMNIA; FEMALE; FREEZE THAWING; GENETIC CREUTZFELDT JAKOB DISEASE; HUMAN; HUMAN CELL; INTERRATER RELIABILITY; MAJOR CLINICAL STUDY; MALE; REAL TIME QUAKING INDUCED CONVERSION; REPRODUCIBILITY; SENSITIVITY ANALYSIS; SENSITIVITY AND SPECIFICITY; SPORADIC CREUTZFELDT JAKOB DISEASE; STABILITY; STATISTICAL PARAMETERS; STORAGE TEMPERATURE; VALIDITY; ADOLESCENT; ADULT; AGED; BIOASSAY; CEREBROSPINAL FLUID; CREUTZFELDT-JAKOB SYNDROME; METABOLISM; MIDDLE AGED; PRESERVATION; PROCEDURES; TIME FACTOR; VERY ELDERLY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BIOLOGICAL ASSAY; CREUTZFELDT-JAKOB SYNDROME; FEMALE; HUMANS; MALE; MIDDLE AGED; PRESERVATION, BIOLOGICAL; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TAU PROTEINS; TIME FACTORS; YOUNG ADULT;

EID: 84961339430     PISSN: 08937648     EISSN: 15591182     Source Type: Journal    
DOI: 10.1007/s12035-015-9133-2     Document Type: Article

References (13)

1. Gambetti P, Parchi P, Chen SG (2003) Hereditary Creutzfeldt-Jakob disease and fatal familial insomnia. Clin Lab Med 23:43–64
2. Parchi P, Giese A, Capellari S et al (1999) Classification of sporadic Creutzfeldt-Jakob disease based on molecular and phenotypic analysis of 300 subjects. Ann Neurol 46:224–233
3. Kovács GG, Puopolo M, Ladogana A et al (2005) Genetic prion disease: the EUROCJD experience. Hum Genet 118:166–174
4. McGuire LI, Peden AH, Orrú CD et al (2012) Real time quaking-induced conversion analysis of cerebrospinal fluid in sporadic Creutzfeldt-Jakob disease. Ann Neurol 72:278–285
5. Atarashi R, Satoh K, Sano K et al (2011) Ultrasensitive human prion detection in cerebrospinal fluid by real-time quaking-induced conversion. Nat Med 17:175–178
6. Sano K, Satoh K, Atarashi R et al (2013) Early detection of abnormal prion protein in genetic human prion diseases now possible using real-time QUIC assay. PLoS ONE 8:e54915
7. Cramm M, Schmitz M, Karch A et al (2015) Characteristic CSF Prion-seeding efficiency in humans with prion diseases. Mol Neurobiol 51:396–405
8. Orrú CD, Wilham JM, Raymond LD et al (2011) Prion disease blood test using immunoprecipitation and improved quaking induced conversion. MBio 2:e00078–00011
9. Wilham JM, Orrú CD, Bessen RA et al (2010) Rapid end-point quantitation of prion seeding activity with sensitivity comparable to bioassays. PLoS Pathog 6:e1001217
10. Youden WJ (1950) Index for rating diagnostic tests. Cancer 3:32–35
11. Jensen M, Hartmann T, Engvall B et al (2000) Quantification of Alzheimer amyloid beta peptides ending at residues 40 and 42 by novel ELISA systems. Mol Med 6:291–302
12. Vanderstichele H, Van Kerschaver E, Hesse C et al (2000) Standardization of measurement of beta-amyloid (1-42) in cerebrospinal fluid and plasma. Amyloid 7:245–258
13. Schoonenboom NS, Mulder C, Vanderstichele H et al (2005) Effects of processing and storage conditions on amyloid beta (1-42) and tau concentrations in cerebrospinal fluid: implications for use in clinical practice. Clin Chem 51:189–195