Aldehyde dehydrogenase-independent bioactivation of nitroglycerin in porcine and bovine blood vessels

Biochemical Pharmacology

Volumn 93, Issue 4, 2015, Pages 440-448

  Neubauer, Regina ^a   Wölkart, Gerald ^a   Opelt, Marissa ^a   Schwarzenegger, Christine ^a   Hofinger, Marielies ^a   Neubauer, Andrea ^a   Kollau, Alexander ^a   Schmidt, Kurt ^a   Schrammel, Astrid ^a   Mayer, Bernd ^a  

^a UNIVERSITY OF GRAZ   (Austria)

Author keywords

Aldehyde dehydrogenase 2; Denitration; Nitroglycerin; Protein expression; Vascular relaxation

Indexed keywords

ALDEHYDE DEHYDROGENASE; ALDEHYDE DEHYDROGENASE 3A1; ALDEHYDE DEHYDROGENASE ISOENZYME 2; CYTOCHROME P450; ENZYME INHIBITOR; GLUTATHIONE TRANSFERASE; GLYCERYL TRINITRATE; MESSENGER RNA; UNCLASSIFIED DRUG; ALDH2 PROTEIN, HUMAN;

ANIMAL TISSUE; ARTICLE; BLOOD VESSEL; BOVINAE; CHEMICAL REACTION; CONTROLLED STUDY; CORONARY ARTERY; CORONARY ARTERY DILATATION; DENITRATION; DRUG ACTIVITY; ENZYME INHIBITION; FEMALE; GENE EXPRESSION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SWINE; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; BOVINE; DOSE RESPONSE; DRUG EFFECTS; HUMAN; METABOLISM; ORGAN CULTURE TECHNIQUE; PHYSIOLOGY; PIG; SPECIES DIFFERENCE; SPRAGUE DAWLEY RAT; VASOCONSTRICTION; VASODILATATION;

ALDEHYDE DEHYDROGENASE; ANIMALS; CATTLE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FEMALE; HUMANS; MALE; NITROGLYCERIN; ORGAN CULTURE TECHNIQUES; RATS; RATS, SPRAGUE-DAWLEY; SPECIES SPECIFICITY; SWINE; VASOCONSTRICTION; VASODILATION;

EID: 84961290478     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2014.12.021     Document Type: Article

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