Variation in complement protein C1q is not a major contributor to cognitive impairment in Parkinson's disease

Neuroscience Letters

Volumn 594, Issue , 2015, Pages 66-69

  Carbutt, Sophia ^a   Duff, Jennifer ^a   Yarnall, Alison ^b   Burn, David J ^b   Hudson, Gavin ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

Cognitive decline; Parkinson's disease

Indexed keywords

COMPLEMENT COMPONENT C1Q; COMPLEMENT COMPONENT C1Q A; COMPLEMENT COMPONENT C1Q B; COMPLEMENT COMPONENT C1Q C; UNCLASSIFIED DRUG;

AGED; ARTICLE; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; GENETIC VARIABILITY; HERITABILITY; HUMAN; MAJOR CLINICAL STUDY; MALE; NEUROPATHOLOGY; PARKINSON DISEASE; PRIORITY JOURNAL; CASE CONTROL STUDY; GENETIC ASSOCIATION STUDY; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; MIDDLE AGED; MILD COGNITIVE IMPAIRMENT; PSYCHOLOGY;

AGED; CASE-CONTROL STUDIES; COMPLEMENT C1Q; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; MIDDLE AGED; MILD COGNITIVE IMPAIRMENT; PARKINSON DISEASE;

EID: 84961290204     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2015.03.048     Document Type: Article

References (23)

1. Azzato E.M., Lee A.J., Teschendorff A., Ponder B.A., Pharoah P., Caldas C., Maia A.T. Common germ-line polymorphism of C1QA and breast cancer survival. Br. J. Cancer 2010, 102:1294-1299.
2. Benoit M.E., Hernandez M.X., Dinh M.L., Benavente F., Vasquez O., Tenner A.J. C1q-induced lrp1b and gpr6 proteins expressed early in Alzheimer disease mouse models, are essential for the c1q-mediated protection against amyloid-beta neurotoxicity. J. Biol. Chem. 2013, 288:654-665.
3. Bishop N.A., Lu T., Yankner B.A. Neural mechanisms of ageing and cognitive decline. Nature 2010, 464:529-535.
4. Cao C.W., Li P., Luan H.X., Chen W., Li C.H., Hu C.J., Zhang S.L., Zeng X.F., Zhang F.C., Li Y.Z., Zeng C.Q. Association study of C1qA polymorphisms with systemic lupus erythematosus in a Han population. Lupus 2012, 21:502-507.
5. Dardiotis E., Koutsou P., Zamba-Papanicolaou E., Vonta I., Hadjivassiliou M., Hadjigeorgiou G., Cariolou M., Christodoulou K., Kyriakides T. Complement C1Q polymorphisms modulate onset in familial amyloidotic polyneuropathy TTR Val30Met. J. Neurol. Sci. 2009, 284:158-162.
6. Emre M., Aarsland D., Albanese A., Byrne E.J., Deuschl G., De Deyn P.P., Durif F., Kulisevsky J., van Laar T., Lees A., Poewe W., Robillard A., Rosa M.M., Wolters E., Quarg P., Tekin S., Lane R. Rivastigmine for dementia associated with Parkinson's disease. N. Engl. J. Med. 2004, 351:2509-2518.
7. Hughes A.J., Daniel S.E., Kilford L., Lees A.J. Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. J. Neurol. Neurosurg. Psychiatry 1992, 55:181-184.
8. Kiezun A., Garimella K., Do R., Stitziel N.O., Neale B.M., McLaren P.J., Gupta N., Sklar P., Sullivan P.F., Moran J.L., Hultman C.M., Lichtenstein P., Magnusson P., Lehner T., Shugart Y.Y., Price A.L., de Bakker P.I., Purcell S.M., Sunyaev S.R. Exome sequencing and the genetic basis of complex traits. Nat. Genet. 2012, 44:623-630.
9. Loeffler D.A., Camp D.M., Conant S.B. Complement activation in the Parkinson's disease substantia nigra: an immunocytochemical study. J. Neuroinflamm. 2006, 3.
10. Nasreddine Z.S., Phillips N.A., Bedirian V., Charbonneau S., Whitehead V., Collin I., Cummings J.L., Chertkow H. The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. J. Am. Geriatr. Soc. 2005, 53:695-699.
11. Picconi B., Piccoli G., Calabresi P. Synaptic dysfunction in Parkinson's disease. Adv. Exp. Med. Biol. 2012, 970:553-572.
12. Purcell S., Cherny S.S., Sham P.C. Genetic power calculator: design of linkage and association genetic mapping studies of complex traits. Bioinformatics 2003, 19:149-150.
13. Rafiq S., Frayling T.M., Vyse T.J., Graham D.S.C., Eggleton P. Assessing association of common variation in the C1Q gene cluster with systemic lupus erythematosus. Clin. Exp. Immunol. 2010, 161:284-289.
14. Robbins T.W., James M., Owen A.M., Sahakian B.J., McInnes L., Rabbitt P. Cambridge Neuropsychological Test Automated Battery (CANTAB): a factor analytic study of a large sample of normal elderly volunteers. Dementia 1994, 5:266-281.
15. Roth M., Tym E., Mountjoy C.Q., Huppert F.A., Hendrie H., Verma S., Goddard R. CAMDEX. A standardised instrument for the diagnosis of mental disorder in the elderly with special reference to the early detection of dementia. Br. J. Psychiatry 1986, 149:698-709.
16. Selkoe D.J. Alzheimer's disease is a synaptic failure. Science 2002, 298:789-791.
17. Stevens B., Allen N.J., Vazquez L.E., Howell G.R., Christopherson K.S., Nouri N., Micheva K.D., Mehalow A.K., Huberman A.D., Stafford B., Sher A., Litke A.M., Lambris J.D., Smith S.J., John S.W.M., Barres B.A. The classical complement cascade mediates CNS synapse elimination. Cell 2007, 131:1164-1178.
18. Trouw L.A., Daha N., Kurreeman F.A., Bohringer S., Goulielmos G.N., Westra H.J., Zhernakova A., Franke L., Stahl E.A., Levarht E.W., Stoeken-Rijsbergen G., Verduijn W., Roos A., Li Y., Houwing-Duistermaat J.J., Huizinga T.W., Toes R.E. Genetic variants in the region of the C1q genes are associated with rheumatoid arthritis. Clin. Exp. Immunol. 2013, 173:76-83.
19. Wesnes K.A., McKeith I.G., Ferrara R., Emre M., Del Ser T., Spano P.F., Cicin-Sain A., Anand R., Spiegel R. Effects of rivastigmine on cognitive function in dementia with lewy bodies: a randomised placebo-controlled international study using the cognitive drug research computerised assessment system. Dement. Geriatr. Cogn. Disord. 2002, 13:183-192.
20. Yarnall A.J., Breen D.P., Duncan G.W., Khoo T.K., Coleman S.Y., Firbank M.J., Nombela C., Winder-Rhodes S., Evans J.R., Rowe J.B., Mollenhauer B., Kruse N., Hudson G., Chinnery P.F., O'Brien J.T., Robbins T.W., Wesnes K., Brooks D.J., Barker R.A., Burn D.J., Group I.-P.S. Characterizing mild cognitive impairment in incident Parkinson disease: the ICICLE-PD study. Neurology 2014, 82:308-316.
21. Yarnall A.J., Rochester L., Burn D.J. Mild cognitive impairment in Parkinson's disease. Age Ageing 2013, 42:567-576.
22. Zakharyan R., Khoyetsyan A., Arakelyan A., Boyajyan A., Gevorgyan A., Stahelova A., Mrazek F., Petrek M. Association of C1QB gene polymorphism with schizophrenia in Armenian population. BMC Med. Genet. 2011, 12:126.
23. Zawistowski M., Gopalakrishnan S., Ding J., Li Y., Grimm S., Zollner S. Extending rare-variant testing strategies: analysis of noncoding sequence and imputed genotypes. Am. J. Hum. Genet. 2010, 87:604-617.