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Volumn 8, Issue , 2015, Pages 335-345

Cytotoxic effect of lapatinib is restricted to human papillomavirus-positive head and neck squamous cell carcinoma cell lines

Author keywords

EGFR; HER2; HPV; Ionizing radiation; Lapatinib; Tyrosine kinase inhibitor

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; LAPATINIB; LIPOCORTIN 5; PROTEIN E6; PROTEIN E7; PROTEIN KINASE B;

EID: 84961289635     PISSN: None     EISSN: 11786930     Source Type: Journal    
DOI: 10.2147/OTT.S68235     Document Type: Article
Times cited : (15)

References (57)
  • 2
    • 21344466795 scopus 로고    scopus 로고
    • Medical treatment in head and neck cancer
    • Vermorken JB. Medical treatment in head and neck cancer. Ann Oncol. 2005;16(Suppl 2):ii258-ii264.
    • (2005) Ann Oncol , vol.16 , pp. ii258-ii264
    • Vermorken, J.B.1
  • 3
    • 39149104081 scopus 로고    scopus 로고
    • Incidence trends for human papillomavirus-related and-unrelated oral squamous cell carcinomas in the United States
    • Chaturvedi AK, Engels EA, Anderson WF, Gillison ML. Incidence trends for human papillomavirus-related and-unrelated oral squamous cell carcinomas in the United States. J Clin Oncol. 2008;26(4):612-619.
    • (2008) J Clin Oncol , vol.26 , Issue.4 , pp. 612-619
    • Chaturvedi, A.K.1    Engels, E.A.2    Anderson, W.F.3    Gillison, M.L.4
  • 4
    • 65449131740 scopus 로고    scopus 로고
    • The relationship between human papillomavirus status and other molecular prognostic markers in head and neck squamous cell carcinomas
    • Kong CS, Narasimhan B, Cao H, et al. The relationship between human papillomavirus status and other molecular prognostic markers in head and neck squamous cell carcinomas. Int J Radiat Oncol Biol Phys. 2009; 74(2):553-561.
    • (2009) Int J Radiat Oncol Biol Phys , vol.74 , Issue.2 , pp. 553-561
    • Kong, C.S.1    Narasimhan, B.2    Cao, H.3
  • 5
    • 84881424926 scopus 로고    scopus 로고
    • Enhanced radiation sensitivity in HPV-positive head and neck cancer
    • Kimple RJ, Smith MA, Blitzer GC, et al. Enhanced radiation sensitivity in HPV-positive head and neck cancer. Cancer Res. 2013;73(15): 4791-4800.
    • (2013) Cancer Res , vol.73 , Issue.15 , pp. 4791-4800
    • Kimple, R.J.1    Smith, M.A.2    Blitzer, G.C.3
  • 6
    • 84879014884 scopus 로고    scopus 로고
    • HNSCC cell lines positive for HPV and p16 possess higher cellular radiosensitivity due to an impaired DSB repair capacity
    • Rieckmann T, Tribius S, Grob TJ, et al. HNSCC cell lines positive for HPV and p16 possess higher cellular radiosensitivity due to an impaired DSB repair capacity. Radiother Oncol. 2013;107(2):242-246.
    • (2013) Radiother Oncol , vol.107 , Issue.2 , pp. 242-246
    • Rieckmann, T.1    Tribius, S.2    Grob, T.J.3
  • 7
    • 0034773992 scopus 로고    scopus 로고
    • The EGFR family and its ligands in human cancer: Signalling mechanisms and therapeutic opportunities
    • Yarden Y. The EGFR family and its ligands in human cancer: signalling mechanisms and therapeutic opportunities. Eur J Cancer. 2001;37:3-8.
    • (2001) Eur J Cancer , vol.37 , pp. 3-8
    • Yarden, Y.1
  • 8
    • 43249107216 scopus 로고    scopus 로고
    • Emerging perspectives in epidermal growth factor receptor targeting in head and neck cancer
    • Kim S, Grandis JR, Rinaldo A, Takes RP, Ferlito A. Emerging perspectives in epidermal growth factor receptor targeting in head and neck cancer. Head Neck. 2008;30(5):667-674.
    • (2008) Head Neck , vol.30 , Issue.5 , pp. 667-674
    • Kim, S.1    Grandis, J.R.2    Rinaldo, A.3    Takes, R.P.4    Ferlito, A.5
  • 9
    • 34547397409 scopus 로고    scopus 로고
    • Prognostic impact of HER-2/neu expression on squamous head and neck carcinomas
    • Cavalot A, Martone T, Roggero N, Brondino G, Pagano M, Cortesina G. Prognostic impact of HER-2/neu expression on squamous head and neck carcinomas. Head Neck. 2007;29(7):655-664.
    • (2007) Head Neck , vol.29 , Issue.7 , pp. 655-664
    • Cavalot, A.1    Martone, T.2    Roggero, N.3    Brondino, G.4    Pagano, M.5    Cortesina, G.6
  • 10
    • 34250155320 scopus 로고    scopus 로고
    • Epidermal growth factor receptor copy number alterations correlate with poor clinical outcome in patients with head and neck squamous cancer
    • Temam S, Kawaguchi H, El-Naggar AK, et al. Epidermal growth factor receptor copy number alterations correlate with poor clinical outcome in patients with head and neck squamous cancer. J Clin Oncol. 2007;25(16):2164-2170.
    • (2007) J Clin Oncol , vol.25 , Issue.16 , pp. 2164-2170
    • Temam, S.1    Kawaguchi, H.2    El-Naggar, A.K.3
  • 11
    • 33846641194 scopus 로고    scopus 로고
    • High EGFR expression predicts poor prognosis in patients with squamous cell carcinoma of the oral cavity and oropharynx: A TMA-based immunohistochemical analysis
    • Laimer K, Spizzo G, Gastl G, et al. High EGFR expression predicts poor prognosis in patients with squamous cell carcinoma of the oral cavity and oropharynx: a TMA-based immunohistochemical analysis. Oral Oncol. 2007;43(2):193-198.
    • (2007) Oral Oncol , vol.43 , Issue.2 , pp. 193-198
    • Laimer, K.1    Spizzo, G.2    Gastl, G.3
  • 12
    • 33748653109 scopus 로고    scopus 로고
    • Increased epidermal growth factor receptor gene copy number is associated with poor prognosis in head and neck squamous cell carcinomas
    • Chung CH, Ely K, McGavran L, et al. Increased epidermal growth factor receptor gene copy number is associated with poor prognosis in head and neck squamous cell carcinomas. J Clin Oncol. 2006;24(25): 4170-4176.
    • (2006) J Clin Oncol , vol.24 , Issue.25 , pp. 4170-4176
    • Chung, C.H.1    Ely, K.2    McGavran, L.3
  • 13
    • 49249095295 scopus 로고    scopus 로고
    • EGFR, p16, HPV Titer, Bcl-xL and p53, sex, and smoking as indicators of response to therapy and survival in oropharyngeal cancer
    • Kumar B, Cordell KG, Lee JS, et al. EGFR, p16, HPV Titer, Bcl-xL and p53, sex, and smoking as indicators of response to therapy and survival in oropharyngeal cancer. J Clin Oncol. 2008;26(19):3128-3137.
    • (2008) J Clin Oncol , vol.26 , Issue.19 , pp. 3128-3137
    • Kumar, B.1    Cordell, K.G.2    Lee, J.S.3
  • 14
    • 32144433159 scopus 로고    scopus 로고
    • Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck
    • Bonner JA, Harari PM, Giralt J, et al. Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. N Engl J Med. 2006;354(6):567-578.
    • (2006) N Engl J Med , vol.354 , Issue.6 , pp. 567-578
    • Bonner, J.A.1    Harari, P.M.2    Giralt, J.3
  • 16
    • 12144287534 scopus 로고    scopus 로고
    • United States food and drug administration drug approval summary: Gefitinib (ZD1839; Iressa) tablets
    • Cohen MH, Williams GA, Sridhara R, et al. United States food and drug administration drug approval summary: Gefitinib (ZD1839; Iressa) tablets. Clin Cancer Res. 2004;10(4):1212-1218.
    • (2004) Clin Cancer Res , vol.10 , Issue.4 , pp. 1212-1218
    • Cohen, M.H.1    Williams, G.A.2    Sridhara, R.3
  • 17
    • 77949445285 scopus 로고    scopus 로고
    • Antitumor effects of lapatinib (GW572016), a dual inhibitor of EGFR and HER-2, in combination with cisplatin or paclitaxel on head and neck squamous cell carcinoma
    • Kondo N, Tsukuda M, Ishiguro Y, et al. Antitumor effects of lapatinib (GW572016), a dual inhibitor of EGFR and HER-2, in combination with cisplatin or paclitaxel on head and neck squamous cell carcinoma. Oncol Rep. 2010;23(4):957-963.
    • (2010) Oncol Rep , vol.23 , Issue.4 , pp. 957-963
    • Kondo, N.1    Tsukuda, M.2    Ishiguro, Y.3
  • 18
    • 33746084112 scopus 로고    scopus 로고
    • Signaling via ErbB2 and ErbB3 associates with resistance and epidermal growth factor receptor (EGFR) amplification with sensitivity to EGFR inhibitor gefitinib in head and neck squamous cell carcinoma cells
    • Erjala K, Sundvall M, Junttila TT, et al. Signaling via ErbB2 and ErbB3 associates with resistance and epidermal growth factor receptor (EGFR) amplification with sensitivity to EGFR inhibitor gefitinib in head and neck squamous cell carcinoma cells. Clin Cancer Res. 2006;12(13): 4103-4111.
    • (2006) Clin Cancer Res , vol.12 , Issue.13 , pp. 4103-4111
    • Erjala, K.1    Sundvall, M.2    Junttila, T.T.3
  • 19
    • 0035476866 scopus 로고    scopus 로고
    • The characterization of novel, dual ErbB-2/EGFR, tyrosine kinase inhibitors potential therapy for cancer
    • Rusnak DW, Affleck K, Cockerill SG, et al. The characterization of novel, dual ErbB-2/EGFR, tyrosine kinase inhibitors potential therapy for cancer. Cancer Res. 2001;61(19):7196-7203.
    • (2001) Cancer Res , vol.61 , Issue.19 , pp. 7196-7203
    • Rusnak, D.W.1    Affleck, K.2    Cockerill, S.G.3
  • 20
    • 33845886440 scopus 로고    scopus 로고
    • Lapatinib plus capecitabine for HER2-positive advanced breast cancer
    • Geyer CE, Forster J, Lindquist D, et al. Lapatinib plus capecitabine for HER2-positive advanced breast cancer. N Engl J Med. 2006;355(26): 2733-2743.
    • (2006) N Engl J Med , vol.355 , Issue.26 , pp. 2733-2743
    • Geyer, C.E.1    Forster, J.2    Lindquist, D.3
  • 21
    • 61449122062 scopus 로고    scopus 로고
    • Phase I study of lapatinib in combination with chemoradiation in patients with locally advanced squamous cell carcinoma of the head and neck
    • Harrington KJ, El-Hariry IA, Holford CS, et al. Phase I study of lapatinib in combination with chemoradiation in patients with locally advanced squamous cell carcinoma of the head and neck. J Clin Oncol. 2009;27(7):1100-1107.
    • (2009) J Clin Oncol , vol.27 , Issue.7 , pp. 1100-1107
    • Harrington, K.J.1    El-Hariry, I.A.2    Holford, C.S.3
  • 22
    • 84871577219 scopus 로고    scopus 로고
    • Phase I study and biomarker analysis of lapatinib and concurrent radiation for locally advanced breast cancer
    • Kimple RJ, Horton JK, Livasy CA, et al. Phase I study and biomarker analysis of lapatinib and concurrent radiation for locally advanced breast cancer. Oncologist. 2012;17(12):1496-1503.
    • (2012) Oncologist , vol.17 , Issue.12 , pp. 1496-1503
    • Kimple, R.J.1    Horton, J.K.2    Livasy, C.A.3
  • 23
    • 84876106601 scopus 로고    scopus 로고
    • Randomised Phase II study of oral lapatinib combined with chemoradiotherapy in patients with advanced squamous cell carcinoma of the head and neck: Rationale for future randomised trials in human papilloma virus-negative disease
    • Harrington K, Berrier A, Robinson M, et al. Randomised Phase II study of oral lapatinib combined with chemoradiotherapy in patients with advanced squamous cell carcinoma of the head and neck: rationale for future randomised trials in human papilloma virus-negative disease. Eur J Cancer. 2013;49(7):1609-1618.
    • (2013) Eur J Cancer , vol.49 , Issue.7 , pp. 1609-1618
    • Harrington, K.1    Berrier, A.2    Robinson, M.3
  • 24
    • 36849054071 scopus 로고    scopus 로고
    • Human papillomavirus (HPV) genotype distribution in invasive cervical cancers in France: EDITH study
    • Prétet JL, Jacquard AC, Carcopino X, et al; EDITH Study Group. Human papillomavirus (HPV) genotype distribution in invasive cervical cancers in France: EDITH study. Int J Cancer. 2008;122(2):428-432.
    • (2008) Int J Cancer , vol.122 , Issue.2 , pp. 428-432
    • Prétet, J.L.1    Jacquard, A.C.2    Carcopino, X.3
  • 25
    • 80055077658 scopus 로고    scopus 로고
    • Inhibition of the epidermal growth factor receptor by erlotinib prevents immortalization of human cervical cells by Human Papillomavirus type 16
    • Woodworth CD, Diefendorf LP, Jette DF, et al. Inhibition of the epidermal growth factor receptor by erlotinib prevents immortalization of human cervical cells by Human Papillomavirus type 16. Virology. 2011;421(1):19-27.
    • (2011) Virology , vol.421 , Issue.1 , pp. 19-27
    • Woodworth, C.D.1    Diefendorf, L.P.2    Jette, D.F.3
  • 26
    • 17144371349 scopus 로고    scopus 로고
    • Mechanisms of enhanced radiation response following epidermal growth factor receptor signaling inhibition by erlotinib (Tarceva)
    • Chinnaiyan P, Huang S, Vallabhaneni G, et al. Mechanisms of enhanced radiation response following epidermal growth factor receptor signaling inhibition by erlotinib (Tarceva). Cancer Res. 2005;65(8):3328-3335.
    • (2005) Cancer Res , vol.65 , Issue.8 , pp. 3328-3335
    • Chinnaiyan, P.1    Huang, S.2    Vallabhaneni, G.3
  • 27
    • 0942268145 scopus 로고    scopus 로고
    • Effects of the EGFR/HER2 kinase inhibitor GW572016 on EGFR-and HER2-overexpressing breast cancer cell line proliferation, radiosensitization, and resistance
    • Zhou H, Kim Y-S, Peletier A, McCall W, Earp HS, Sartor CI. Effects of the EGFR/HER2 kinase inhibitor GW572016 on EGFR-and HER2-overexpressing breast cancer cell line proliferation, radiosensitization, and resistance. Int J Radiat Oncol Biol Phys. 2004;58(2):344-352.
    • (2004) Int J Radiat Oncol Biol Phys , vol.58 , Issue.2 , pp. 344-352
    • Zhou, H.1    Kim, Y.-S.2    Peletier, A.3    McCall, W.4    Earp, H.S.5    Sartor, C.I.6
  • 28
    • 70449686563 scopus 로고    scopus 로고
    • Mechanism of lapatinib-mediated radiosensitization of breast cancer cells is primarily by inhibition of the Raf.MEK.ERK mitogen-activated protein kinase cascade and radiosensitization of lapatinib-resistant cells restored by direct inhibition of MEK
    • Sambade MJ, Camp JT, Kimple RJ, Sartor CI, Shields JM. Mechanism of lapatinib-mediated radiosensitization of breast cancer cells is primarily by inhibition of the Raf.MEK.ERK mitogen-activated protein kinase cascade and radiosensitization of lapatinib-resistant cells restored by direct inhibition of MEK. Radiother Oncol. 2009;93(3): 639-644.
    • (2009) Radiother Oncol , vol.93 , Issue.3 , pp. 639-644
    • Sambade, M.J.1    Camp, J.T.2    Kimple, R.J.3    Sartor, C.I.4    Shields, J.M.5
  • 29
    • 84879785532 scopus 로고    scopus 로고
    • Cisplatin and fluorouracil with or without panitumumab in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck (SPECTRUM): An open-label phase 3 randomised trial
    • Vermorken JB, Stöhlmacher-Williams J, Davidenko I, et al. Cisplatin and fluorouracil with or without panitumumab in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck (SPECTRUM): an open-label phase 3 randomised trial. Lancet Oncol. 2013;14(8):697-710.
    • (2013) Lancet Oncol , vol.14 , Issue.8 , pp. 697-710
    • Vermorken, J.B.1    Stöhlmacher-Williams, J.2    Davidenko, I.3
  • 30
    • 84868345415 scopus 로고    scopus 로고
    • A phase II, randomized trial (CONCERT-1) of chemoradiotherapy (CRT) with or without panitumumab (pmab) in patients (pts) with unresected, locally advanced squamous cell carcinoma of the head and neck (LASCCHN)
    • (abstr 5502), Accessed April 25, 2014
    • Giralt J, Fortin A, Mesia R, et al. A phase II, randomized trial (CONCERT-1) of chemoradiotherapy (CRT) with or without panitumumab (pmab) in patients (pts) with unresected, locally advanced squamous cell carcinoma of the head and neck (LASCCHN). J Clin Oncol. 2012;30(suppl; abstr 5502). Available from: http://meetinglibrary.asco.org/content/93724-114. Accessed April 25, 2014.
    • (2012) J Clin Oncol , vol.30
    • Giralt, J.1    Fortin, A.2    Mesia, R.3
  • 31
    • 35148842941 scopus 로고    scopus 로고
    • Cell cycle-dependent and schedule-dependent antitumor effects of sorafenib combined with radiation
    • Plastaras JP, Kim SH, Liu YY, et al. Cell cycle-dependent and schedule-dependent antitumor effects of sorafenib combined with radiation. Cancer Res. 2007;67(19):9443-9454.
    • (2007) Cancer Res , vol.67 , Issue.19 , pp. 9443-9454
    • Plastaras, J.P.1    Kim, S.H.2    Liu, Y.Y.3
  • 32
    • 34447310595 scopus 로고    scopus 로고
    • Assessment of epidermal growth factor receptor (EGFR, ErbB1) and HER2 (ErbB2) protein expression levels and response to lapatinib (Tykerb, GW572016) in an expanded panel of human normal and tumour cell lines
    • Rusnak DW, Alligood KJ, Mullin RJ, et al. Assessment of epidermal growth factor receptor (EGFR, ErbB1) and HER2 (ErbB2) protein expression levels and response to lapatinib (Tykerb, GW572016) in an expanded panel of human normal and tumour cell lines. Cell Prolif. 2007;40(4):580-594.
    • (2007) Cell Prolif , vol.40 , Issue.4 , pp. 580-594
    • Rusnak, D.W.1    Alligood, K.J.2    Mullin, R.J.3
  • 33
    • 84875990922 scopus 로고    scopus 로고
    • The HPV16 E6 oncoprotein causes prolonged receptor protein tyrosine kinase signaling and enhances internalization of phosphorylated receptor species
    • Spangle JM, Munger K. The HPV16 E6 oncoprotein causes prolonged receptor protein tyrosine kinase signaling and enhances internalization of phosphorylated receptor species. PLoS Pathog. 2013;9(3):e1003237.
    • (2013) PLoS Pathog , vol.9 , Issue.3
    • Spangle, J.M.1    Munger, K.2
  • 34
    • 0028926718 scopus 로고
    • The E5 oncoprotein of human papillomavirus type 16 inhibits the acidification of endosomes in human keratinocytes
    • Straight SW, Herman B, McCance DJ. The E5 oncoprotein of human papillomavirus type 16 inhibits the acidification of endosomes in human keratinocytes. J Virol. 1995;69(5):3185-3192.
    • (1995) J Virol , vol.69 , Issue.5 , pp. 3185-3192
    • Straight, S.W.1    Herman, B.2    McCance, D.J.3
  • 35
    • 70449509655 scopus 로고    scopus 로고
    • Heterogeneity of tumour response to combined radiotherapy and EGFR inhibitors: Differences between antibodies and TK inhibitors
    • Krause M, Gurtner K, Deuse Y, Baumann M. Heterogeneity of tumour response to combined radiotherapy and EGFR inhibitors: differences between antibodies and TK inhibitors. Int J Radiat Biol. 2009;85(11):943-954.
    • (2009) Int J Radiat Biol , vol.85 , Issue.11 , pp. 943-954
    • Krause, M.1    Gurtner, K.2    Deuse, Y.3    Baumann, M.4
  • 36
    • 27544503230 scopus 로고    scopus 로고
    • Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: Results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer)
    • Thatcher N, Chang A, Parikh P, et al. Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer). Lancet. 2005;366(9496):1527-1537.
    • (2005) Lancet , vol.366 , Issue.9496 , pp. 1527-1537
    • Thatcher, N.1    Chang, A.2    Parikh, P.3
  • 37
    • 22044445517 scopus 로고    scopus 로고
    • Erlotinib in previously treated non-small-cell lung cancer
    • Shepherd FA, Rodrigues Pereira J, Ciuleanu T, et al; National Cancer Institute of Canada Clinical Trials Group. Erlotinib in previously treated non-small-cell lung cancer. N Engl J Med. 2005;353(2):123-132.
    • (2005) N Engl J Med , vol.353 , Issue.2 , pp. 123-132
    • Shepherd, F.A.1    Rodrigues Pereira, J.2    Ciuleanu, T.3
  • 38
    • 80051551247 scopus 로고    scopus 로고
    • Phase II trial of cetuximab in the treatment of persistent or recurrent squamous or non-squamous cell carcinoma of the cervix: A Gynecologic Oncology Group study
    • Santin AD, Sill MW, McMeekin DS, et al. Phase II trial of cetuximab in the treatment of persistent or recurrent squamous or non-squamous cell carcinoma of the cervix: a Gynecologic Oncology Group study. Gynecol Oncol. 2011;122(3):495-500.
    • (2011) Gynecol Oncol , vol.122 , Issue.3 , pp. 495-500
    • Santin, A.D.1    Sill, M.W.2    McMeekin, D.S.3
  • 39
    • 79955481029 scopus 로고    scopus 로고
    • Phase II study of cisplatin plus cetuximab in advanced, recurrent, and previously treated cancers of the cervix and evaluation of epidermal growth factor receptor immunohistochemical expression: A Gynecologic Oncology Group study
    • Farley J, Sill MW, Birrer M, et al. Phase II study of cisplatin plus cetuximab in advanced, recurrent, and previously treated cancers of the cervix and evaluation of epidermal growth factor receptor immunohistochemical expression: a Gynecologic Oncology Group study. Gynecol Oncol. 2011;121(2):303-308.
    • (2011) Gynecol Oncol , vol.121 , Issue.2 , pp. 303-308
    • Farley, J.1    Sill, M.W.2    Birrer, M.3
  • 40
    • 62749156047 scopus 로고    scopus 로고
    • Cetuximab, topotecan and cisplatin for the treatment of advanced cervical cancer: A phase II GINECO trial
    • Kurtz JE, Hardy-Bessard AC, Deslandres M, et al. Cetuximab, topotecan and cisplatin for the treatment of advanced cervical cancer: a phase II GINECO trial. Gynecol Oncol. 2009;113(1):16-20.
    • (2009) Gynecol Oncol , vol.113 , Issue.1 , pp. 16-20
    • Kurtz, J.E.1    Hardy-Bessard, A.C.2    Deslandres, M.3
  • 41
    • 33745519512 scopus 로고    scopus 로고
    • Phase I/II study of cetuximab in combination with cisplatin or carboplatin and fluorouracil in patients with recurrent or metastatic squamous cell carcinoma of the head and neck
    • Bourhis J, Rivera F, Mesia R, et al. Phase I/II study of cetuximab in combination with cisplatin or carboplatin and fluorouracil in patients with recurrent or metastatic squamous cell carcinoma of the head and neck. J Clin Oncol. 2006;24(18):2866-2872.
    • (2006) J Clin Oncol , vol.24 , Issue.18 , pp. 2866-2872
    • Bourhis, J.1    Rivera, F.2    Mesia, R.3
  • 42
    • 79952012758 scopus 로고    scopus 로고
    • Cisplatin-based chemoradiation plus cetuximab in locally advanced head and neck cancer: A phase II clinical study
    • Merlano M, Russi E, Benasso M, et al. Cisplatin-based chemoradiation plus cetuximab in locally advanced head and neck cancer: a phase II clinical study. Ann Oncol. 2011;22(3):712-717.
    • (2011) Ann Oncol , vol.22 , Issue.3 , pp. 712-717
    • Merlano, M.1    Russi, E.2    Benasso, M.3
  • 43
    • 23844523253 scopus 로고    scopus 로고
    • Phase II multicenter study of the antiepidermal growth factor receptor monoclonal antibody cetuximab in combination with platinum-based chemotherapy in patients with platinum-refractory metastatic and/or recurrent squamous cell carcinoma of the head and neck
    • Baselga J, Trigo JM, Bourhis J, et al. Phase II multicenter study of the antiepidermal growth factor receptor monoclonal antibody cetuximab in combination with platinum-based chemotherapy in patients with platinum-refractory metastatic and/or recurrent squamous cell carcinoma of the head and neck. J Clin Oncol. 2005;23(24):5568-5577.
    • (2005) J Clin Oncol , vol.23 , Issue.24 , pp. 5568-5577
    • Baselga, J.1    Trigo, J.M.2    Bourhis, J.3
  • 44
    • 33144461661 scopus 로고    scopus 로고
    • Phase III randomized trial of cisplatin plus placebo compared with cisplatin plus cetuximab in metastatic/recurrent head and neck cancer: An Eastern Cooperative Oncology Group study
    • Burtness B, Goldwasser MA, Flood W, Mattar B, Forastiere AA. Phase III randomized trial of cisplatin plus placebo compared with cisplatin plus cetuximab in metastatic/recurrent head and neck cancer: an Eastern Cooperative Oncology Group study. J Clin Oncol. 2005;23(34): 8646-8654.
    • (2005) J Clin Oncol , vol.23 , Issue.34 , pp. 8646-8654
    • Burtness, B.1    Goldwasser, M.A.2    Flood, W.3    Mattar, B.4    Forastiere, A.A.5
  • 45
    • 51649085865 scopus 로고    scopus 로고
    • Platinum-based chemotherapy plus cetuximab in head and neck cancer
    • Vermorken JB, Mesia R, Rivera F, et al. Platinum-based chemotherapy plus cetuximab in head and neck cancer. N Engl J Med. 2008;359(11): 1116-1127.
    • (2008) N Engl J Med , vol.359 , Issue.11 , pp. 1116-1127
    • Vermorken, J.B.1    Mesia, R.2    Rivera, F.3
  • 46
    • 37449004176 scopus 로고    scopus 로고
    • A phase II trial to evaluate gefitinib as second-or third-line treatment in patients with recurring locoregionally advanced or metastatic cervical cancer
    • Goncalves A, Fabbro M, Lhommé C, et al. A phase II trial to evaluate gefitinib as second-or third-line treatment in patients with recurring locoregionally advanced or metastatic cervical cancer. Gynecol Oncol. 2008;108(1):42-46.
    • (2008) Gynecol Oncol , vol.108 , Issue.1 , pp. 42-46
    • Goncalves, A.1    Fabbro, M.2    Lhommé, C.3
  • 47
    • 36849051467 scopus 로고    scopus 로고
    • Phase I trial of gefitinib in combination with radiation or chemoradiation for patients with locally advanced squamous cell head and neck cancer
    • Chen C, Kane M, Song J, et al. Phase I trial of gefitinib in combination with radiation or chemoradiation for patients with locally advanced squamous cell head and neck cancer. J Clin Oncol. 2007;25(31):4880-4886.
    • (2007) J Clin Oncol , vol.25 , Issue.31 , pp. 4880-4886
    • Chen, C.1    Kane, M.2    Song, J.3
  • 48
    • 84865184491 scopus 로고    scopus 로고
    • Phase II study of gefitinib adaptive dose escalation to skin toxicity in recurrent or metastatic squamous cell carcinoma of the head and neck
    • Perez CA, Song H, Raez LE, et al. Phase II study of gefitinib adaptive dose escalation to skin toxicity in recurrent or metastatic squamous cell carcinoma of the head and neck. Oral Oncol. 2012;48(9):887-892.
    • (2012) Oral Oncol , vol.48 , Issue.9 , pp. 887-892
    • Perez, C.A.1    Song, H.2    Raez, L.E.3
  • 49
    • 80051781911 scopus 로고    scopus 로고
    • Gefitinib plus cisplatin and radiotherapy in previously untreated head and neck squamous cell carcinoma: A phase II, randomized, double-blind, placebo-controlled study
    • Gregoire V, Hamoir M, Chen C, et al. Gefitinib plus cisplatin and radiotherapy in previously untreated head and neck squamous cell carcinoma: a phase II, randomized, double-blind, placebo-controlled study. Radiother Oncol. 2011;100(1):62-69.
    • (2011) Radiother Oncol , vol.100 , Issue.1 , pp. 62-69
    • Gregoire, V.1    Hamoir, M.2    Chen, C.3
  • 50
    • 77954737028 scopus 로고    scopus 로고
    • Epidermal growth factor receptor inhibitor gefitinib added to chemoradiotherapy in locally advanced head and neck cancer
    • Cohen EE, Haraf DJ, Kunnavakkam R, et al. Epidermal growth factor receptor inhibitor gefitinib added to chemoradiotherapy in locally advanced head and neck cancer. J Clin Oncol. 2010;28(20):3336-3343.
    • (2010) J Clin Oncol , vol.28 , Issue.20 , pp. 3336-3343
    • Cohen, E.E.1    Haraf, D.J.2    Kunnavakkam, R.3
  • 51
    • 58149151263 scopus 로고    scopus 로고
    • Phase I trial of erlotinib combined with cisplatin and radiotherapy for patients with locally advanced cervical squamous cell cancer
    • Nogueira-Rodrigues A, do Carmo CC, Viegas C, et al. Phase I trial of erlotinib combined with cisplatin and radiotherapy for patients with locally advanced cervical squamous cell cancer. Clin Cancer Res. 2008;14(19):6324-6329.
    • (2008) Clin Cancer Res , vol.14 , Issue.19 , pp. 6324-6329
    • Nogueira-Rodrigues, A.1    do Carmo, C.C.2    Viegas, C.3
  • 52
    • 69449086850 scopus 로고    scopus 로고
    • A phase II trial of erlotinib in recurrent squamous cell carcinoma of the cervix: A Gynecologic Oncology Group Study
    • Schilder RJ, Sill MW, Lee Y-C, Mannel R. A phase II trial of erlotinib in recurrent squamous cell carcinoma of the cervix: a Gynecologic Oncology Group Study. Int J Gynecol Cancer. 2009;19(5):929-933.
    • (2009) Int J Gynecol Cancer , vol.19 , Issue.5 , pp. 929-933
    • Schilder, R.J.1    Sill, M.W.2    Lee, Y.-C.3    Mannel, R.4
  • 53
    • 77958472983 scopus 로고    scopus 로고
    • Initial results of a Phase I dose-escalation trial of concurrent and maintenance erlotinib and reirradiation for recurrent and new primary head-and-neck cancer
    • Rusthoven KE, Feigenberg SJ, Raben D, et al. Initial results of a Phase I dose-escalation trial of concurrent and maintenance erlotinib and reirradiation for recurrent and new primary head-and-neck cancer. Int J Radiat Oncol Biol Phys. 2010;78(4):1020-1025.
    • (2010) Int J Radiat Oncol Biol Phys , vol.78 , Issue.4 , pp. 1020-1025
    • Rusthoven, K.E.1    Feigenberg, S.J.2    Raben, D.3
  • 54
    • 84859498036 scopus 로고    scopus 로고
    • Erlotinib and chemoradiation in patients with surgically resected locally advanced squamous cell carcinoma of the head and neck: A GICOR phase I trial
    • Arias de la Vega F, Contreras J, de Las Heras M, et al; Members of GICOR (Grupo de Investigación Clínica en Oncología Radioterápica) Group. Erlotinib and chemoradiation in patients with surgically resected locally advanced squamous cell carcinoma of the head and neck: a GICOR phase I trial. Ann Oncol. 2012;23(4):1005-1009.
    • (2012) Ann Oncol , vol.23 , Issue.4 , pp. 1005-1009
    • Arias de la Vega, F.1    Contreras, J.2    de Las Heras, M.3
  • 55
    • 1842772526 scopus 로고    scopus 로고
    • Multicenter phase II study of erlotinib, an oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with recurrent or metastatic squamous cell cancer of the head and neck
    • Soulieres D, Senzer NN, Vokes EE, Hidalgo M, Agarwala SS, Siu LL. Multicenter phase II study of erlotinib, an oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with recurrent or metastatic squamous cell cancer of the head and neck. J Clin Oncol. 2004;22(1): 77-85.
    • (2004) J Clin Oncol , vol.22 , Issue.1 , pp. 77-85
    • Soulieres, D.1    Senzer, N.N.2    Vokes, E.E.3    Hidalgo, M.4    Agarwala, S.S.5    Siu, L.L.6
  • 56
    • 77957195929 scopus 로고    scopus 로고
    • Phase I/II study of erlotinib combined with cisplatin and radiotherapy in patients with locally advanced squamous cell carcinoma of the head and neck
    • Herchenhorn D, Dias FL, Viegas CM, et al. Phase I/II study of erlotinib combined with cisplatin and radiotherapy in patients with locally advanced squamous cell carcinoma of the head and neck. Int J Radiat Oncol Biol Phys. 2010;78(3):696-702.
    • (2010) Int J Radiat Oncol Biol Phys , vol.78 , Issue.3 , pp. 696-702
    • Herchenhorn, D.1    Dias, F.L.2    Viegas, C.M.3
  • 57
    • 80052029219 scopus 로고    scopus 로고
    • Effects of lapatinib monotherapy: Results of a randomised phase II study in therapy-naive patients with locally advanced squamous cell carcinoma of the head and neck
    • Del Campo JM, Hitt R, Sebastian P, et al. Effects of lapatinib monotherapy: results of a randomised phase II study in therapy-naive patients with locally advanced squamous cell carcinoma of the head and neck. Br J Cancer. 2011;105(5):618-627.
    • (2011) Br J Cancer , vol.105 , Issue.5 , pp. 618-627
    • Del Campo, J.M.1    Hitt, R.2    Sebastian, P.3


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