Facilitatory effects of anti-spastic medication on robotic locomotor training in people with chronic incomplete spinal cord injury

Journal of NeuroEngineering and Rehabilitation

Volumn 12, Issue 1, 2015, Pages

  Duffell, Lynsey D ^a   Brown, Geoffrey L ^b   Mirbagheri, Mehdi M ^a,b  

^a NORTHWESTERN UNIVERSITY   (United States)

^b REHABILITATION INSTITUTE OF CHICAGO   (United States)

Author keywords

Gait; Hypertonia; Kinematics; Locomotor; Muscle; Rehabilitation; Robotics; Spasticity; Spinal Cord Injury; Tizanidine

Indexed keywords

TIZANIDINE; CENTRAL MUSCLE RELAXANT; CLONIDINE;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FLEXOR MUSCLE; GAIT; GAIT ORTHOSIS; HUMAN; LOCOMOTOR TREADMILL TRAINING; MALE; MUSCLE EXERCISE; MUSCLE ISOMETRIC CONTRACTION; MUSCLE STRENGTH; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RANGE OF MOTION; ROBOTICS; SPINAL CORD INJURY; VELOCITY; WALKING SPEED; AGED; ANALOGS AND DERIVATIVES; BIOMECHANICS; COMPLICATION; DRUG EFFECTS; JOINT CHARACTERISTICS AND FUNCTIONS; LEARNING; LOCOMOTION; MIDDLE AGED; MUSCLE SPASTICITY; PATHOPHYSIOLOGY; SKELETAL MUSCLE; SPINAL CORD INJURIES; TREATMENT OUTCOME; WALKING;

ADULT; AGED; BIOMECHANICAL PHENOMENA; CLONIDINE; FEMALE; GAIT; HUMANS; ISOMETRIC CONTRACTION; LEARNING; LOCOMOTION; MALE; MIDDLE AGED; MUSCLE RELAXANTS, CENTRAL; MUSCLE SPASTICITY; MUSCLE STRENGTH; MUSCLE, SKELETAL; RANGE OF MOTION, ARTICULAR; ROBOTICS; SPINAL CORD INJURIES; TREATMENT OUTCOME; WALKING;

EID: 84961289393     PISSN: None     EISSN: 17430003     Source Type: Journal    
DOI: 10.1186/s12984-015-0018-4     Document Type: Article

References (45)

1. Sinkjaer T, Toft E, Andreassen S, Hornemann BC. Muscle stiffness in human ankle dorsiflexors: intrinsic and reflex components. J Neurophysiol. 1988;60:1110-21.
2. Hufschmidt A, Mauritz KH. Chronic transformation of muscle in spasticity: a peripheral contribution to increased tone. J Neurol Neurosurg Psychiatry. 1985;48:676-85.
3. Dietz V, Trippel M, Berger W. Reflex activity and muscle tone during elbow movements in patients with spastic paresis. Ann Neurol. 1991;30:767-79. doi:10.1002/ana.410300605.
4. Burke D, Ashby P. Are spinal "presynaptic" inhibitory mechanisms suppressed in spasticity? J Neurol Sci. 1972;15:321-6.
5. Faist M, Mazevet D, Dietz V, Pierrot-Deseilligny E. A quantitative assessment of presynaptic inhibition of Ia afferents in spastics. Differences in hemiplegics and paraplegics. Brain J Neurol. 1994;117:1449-55.
6. Winter DA. Overall principle of lower limb support during stance phase of gait. J Biomech. 1980;13:923-7.
7. Dietz V, Sinkjaer T. Spastic movement disorder: impaired reflex function and altered muscle mechanics. Lancet Neurol. 2007;6:725-33. doi:10.1016/s1474-4422 (07) 70193-x.
8. Maegele M, Muller S, Wernig A, Edgerton VR, Harkema SJ. Recruitment of spinal motor pools during voluntary movements versus stepping after human spinal cord injury. J Neurotrauma. 2002;19:1217-29. doi:10.1089/08977150260338010.
9. Norman K, Pepin A, Barbeau H. Effects of drugs on walking after spinal cord injury. Spinal Cord. 1998;36:699-715.
10. Little JW, Powers RK, Michelson P, Moore D, Robinson LR, Goldstein B. Electrodiagnosis of upper limb weakness in acute quadriplegia. Am J Phys Med Rehabil. 1994;73:15-22.
11. Mirbagheri MM, Barbeau H, Ladouceur M, Kearney RE. Intrinsic and reflex stiffness in normal and spastic, spinal cord injured subjects. Exp Brain Res. 2001;141:446-59. doi:10.1007/s00221-001-0901-z.
12. Corcos DM, Gottlieb GL, Penn RD, Myklebust B, Agarwal GC. Movement deficits caused by hyperexcitable stretch reflexes in spastic humans. Brain J Neurol. 1986;109:1043-58.
13. Eyre J, Miller S. Disturbance of voluntary movement. In: Thilman AF, Burke DJ, Rymer WZ, editors. Spasticity: mechanisms and management. Berling Heidelberg: Springer; 1993. p. 1970-3.
14. Nance PW, Bugaresti J, Shellenberger K, Sheremata W, Martinez-Arizala A. Efficacy and safety of tizanidine in the treatment of spasticity in patients with spinal cord injury. North American tizanidine study group. Neurology. 1994;44:S44-51. discussion S-2.
15. Knutsson E, Martensson A, Gransberg L. Antiparetic and antispastic effects induced by tizanidine in patients with spastic paresis. J Neurol Sci. 1982;53:187-204.
16. Lataste X, Emre M, Davis C, Groves L. Comparative profile of tizanidine in the management of spasticity. Neurology. 1994;44:S53-9.
17. Mathias CJ, Luckitt J, Desai P, Baker H, el Masri W, Frankel HL. Pharmacodynamics and pharmacokinetics of the oral antispastic agent tizanidine in patients with spinal cord injury. J Rehabil Res Dev. 1989;26:9-16.
18. Jankowska E, Lackberg ZS, Dyrehag LE. Effects of monoamines on transmission from group II muscle afferents in sacral segments in the cat. European J Neurosci. 1994;6:1058-61.
19. Taricco M, Pagliacci MC, Telaro E, Adone R. Pharmacological interventions for spasticity following spinal cord injury: results of a Cochrane systematic review. Europa Medicophysica. 2006;42:5-15.
20. Mirbagheri MM, Chen D, Rymer WZ. Quantification of the effects of an alpha-2 adrenergic agonist on reflex properties in spinal cord injury using a system identification technique. J Neuroengineer Rehabilitation. 2010;7:29. doi:10.1186/1743-0003-7-29.
21. Chau C, Barbeau H, Rossignol S. Effects of intrathecal alpha1- and alpha2-noradrenergic agonists and norepinephrine on locomotion in chronic spinal cats. J Neurophysiol. 1998;79:2941-63.
22. Grillner S. Locomotion in vertebrates: central mechanisms and reflex interaction. Physiol Rev. 1975;55:247-304.
23. Wirz M, Zemon DH, Rupp R, Scheel A, Colombo G, Dietz V, et al. Effectiveness of automated locomotor training in patients with chronic incomplete spinal cord injury: a multicenter trial. Arch Phys Med Rehabil. 2005;86:672-80. doi:10.1016/j.apmr.2004.08.004.
24. Field-Fote EC, Roach KE. Influence of a locomotor training approach on walking speed and distance in people with chronic spinal cord injury: a randomized clinical trial. Phys Ther. 2011;91:48-60. doi:10.2522/ptj.20090359.
25. Wirz M, van Hedel HJ, Rupp R, Curt A, Dietz V. Muscle force and gait performance: relationships after spinal cord injury. Arch Phys Med Rehabil. 2006;87:1218-22. doi:10.1016/j.apmr.2006.05.024.
26. Wernig A, Muller S. Laufband locomotion with body weight support improved walking in persons with severe spinal cord injuries. Paraplegia. 1992;30:229-38. doi:10.1038/sc.1992.61.
27. Gorassini MA, Norton JA, Nevett-Duchcherer J, Roy FD, Yang JF. Changes in locomotor muscle activity after treadmill training in subjects with incomplete spinal cord injury. J Neurophysiol. 2009;101:969-79. doi:10.1152/jn.91131.2008.
28. Mirbagheri MM, Kindig M, Niu X. Effects of robotic-locomotor training on stretch reflex function and muscular properties in individuals with spinal cord injury. Clin Neurophysiol. 2014;2014. doi: 10.1016/j.clinph.2014.09.010.
29. Morawietz C, Moffat F. Effects of locomotor training after incomplete spinal cord injury: a systematic review. Arch Phys Med Rehabil. 2013;94:2297-308. doi:10.1016/j.apmr.2013.06.023.
30. Alexeeva N, Sames C, Jacobs PL, Hobday L, Distasio MM, Mitchell SA, et al. Comparison of training methods to improve walking in persons with chronic spinal cord injury: a randomized clinical trial. J Spinal Cord Med. 2011;34:362-79. doi:10.1179/2045772311Y.0000000018.
31. Dobkin BH, Duncan PW. Should body weight-supported treadmill training and robotic-assistive steppers for locomotor training trot back to the starting gate? Neurorehabil Neural Repair. 2012;26:308-17. doi:10.1177/1545968312439687.
32. Hubli M, Dietz V. The physiological basis of neurorehabilitation-locomotor training after spinal cord injury. J Neuroengineer Rehabilitation. 2013;10:5. doi:10.1186/1743-0003-10-5.
33. Kapadia N, Masani K, Catharine Craven B, Giangregorio LM, Hitzig SL, Richards K, et al. A randomized trial of functional electrical stimulation for walking in incomplete spinal cord injury: Effects on walking competency. J Spinal Cord Med. 2014;37:511-24. doi:10.1179/2045772314y.0000000263.
34. Duffell LD, Brown GL, Mirbagheri MM. Interventions to reduce spasticity and improve function in people with chronic incomplete spinal cord injury: distinctions revealed by different analytical methods. Neurorehabil Neural Repair. 2014; In press.
35. Hornby TG, Zemon DH, Campbell D. Robotic-assisted, body-weight-supported treadmill training in individuals following motor incomplete spinal cord injury. Phys Ther. 2005;85:52-66.
36. Mirbagheri MM, Kindig M, Niu X, Varoqui D. Therapeutic effects of anti-spastic medication on neuromuscular abnormalities in SCI: a system identification approach. Conference proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society IEEE Engineering in Medicine and Biology Society Conference. 2013;2013:6203-6. doi:10.1109/embc.2013.6610970.
37. Niu X, Varoqui D, Kindig M, Mirbagheri MM. The effect of robot-assisted locomotor training on walking speed. Conference proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society IEEE Engineering in Medicine and Biology Society Conference. 2012;2012:3858-61. doi:10.1109/embc.2012.6346809.
38. Niu X, Patel C, Varoqui D, Mirbagheri MM. The effect of robot-assisted lokomotor training on gait recovery: a multivariate analysis. Conference proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society IEEE Engineering in Medicine and Biology Society Conference. 2011;2011:3542-5. doi:10.1109/iembs.2011.6090589.
39. Tsao CC, Mirbagheri MM. Upper limb impairments associated with spasticity in neurological disorders. J Neuroengineer Rehabilitation. 2007;4:45. doi:10.1186/1743-0003-4-45.
40. Beckerman H, Roebroeck ME, Lankhorst GJ, Becher JG, Bezemer PD, Verbeek AL. Smallest real difference, a link between reproducibility and responsiveness. Qual Life Res. 2001;10:571-8.
41. Visintin M, Barbeau H. The effects of body weight support on the locomotor pattern of spastic paretic patients. Canadian J Neurol Sci Le J Canadien Des Sci Neurol. 1989;16:315-25.
42. Wernig A, Muller S, Nanassy A, Cagol E. Laufband therapy based on 'rules of spinal locomotion' is effective in spinal cord injured persons. European J Neurosci. 1995;7:823-9.
43. Crone C, Johnsen LL, Biering-Sorensen F, Nielsen JB. Appearance of reciprocal facilitation of ankle extensors from ankle flexors in patients with stroke or spinal cord injury. Brain J Neurol. 2003;126:495-507.
44. Okuma Y, Mizuno Y, Lee RG. Reciprocal Ia inhibition in patients with asymmetric spinal spasticity. Clin Neurophysiol Off J Int Federation Clin Neurophysiol. 2002;113:292-7.
45. Yang JF, Musselman KE. Training to achieve over ground walking after spinal cord injury: a review of who, what, when, and how. J Spinal Cord Med. 2012;35:293-304. doi:10.1179/2045772312y.0000000036.