Abnormalities of the bone marrow immune microenvironment in patients with immune thrombocytopenia

Annals of Hematology

Volumn 95, Issue 6, 2016, Pages 959-965

  Song, Yang ^a,b   Wang, Yu Tong ^a   Huang, Xiao Jun ^a,b   Kong, Yuan ^a  

^a PEKING UNIVERSITY PEOPLE S HOSPITAL   (China)

^b PEKING UNIVERSITY   (China)

Author keywords

Bone marrow; Immune; ITP; Microenvironment

Indexed keywords

ADULT; ARTICLE; BONE MARROW; CLINICAL ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; FEMALE; FLOW CYTOMETRY; HUMAN; IDIOPATHIC THROMBOCYTOPENIC PURPURA; MALE; MICROENVIRONMENT; PATHOGENESIS; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; TH1 CELL; TH17 CELL; TH2 CELL; ADOLESCENT; BLOOD; BONE MARROW CELL; IMMUNOLOGY; METABOLISM; MIDDLE AGED; PHYSIOLOGY; PURPURA, THROMBOCYTOPENIC, IDIOPATHIC; T LYMPHOCYTE SUBPOPULATION; TUMOR MICROENVIRONMENT; YOUNG ADULT;

CD34 ANTIGEN;

ADOLESCENT; ADULT; ANTIGENS, CD34; BONE MARROW; BONE MARROW CELLS; CELLULAR MICROENVIRONMENT; FEMALE; HUMANS; MALE; MIDDLE AGED; PURPURA, THROMBOCYTOPENIC, IDIOPATHIC; T-LYMPHOCYTE SUBSETS; YOUNG ADULT;

EID: 84961213303     PISSN: 09395555     EISSN: 14320584     Source Type: Journal    
DOI: 10.1007/s00277-016-2641-y     Document Type: Article

References (22)

1. McMillan R (1981) Chronic idiopathic thrombocytopenic purpura. N Engl J Med 304(19):1135–1147. doi:10.1056/NEJM198105073041904
2. Stasi R, Evangelista ML, Stipa E, Buccisano F, Venditti A, Amadori S (2008) Idiopathic thrombocytopenic purpura: current concepts in pathophysiology and management. Thromb Haemost 99(1):4–13. doi:10.1160/TH07-08-0513
3. Ji X, Zhang L, Peng J, Hou M (2014) T cell immune abnormalities in immune thrombocytopenia. J Hematol Oncol 7(1):72. doi:10.1186/s13045-014-0072-6
4. Wang L, Li Y, Hou M (2007) Idiopathic thrombocytopenic purpura and dysmegakaryocytopoiesis. Crit Rev Oncol Hematol 64(2):83–89. doi:10.1016/j.critrevonc.2007.05.007
5. Boulais PE, Frenette PS (2015) Making sense of hematopoietic stem cell niches. Blood 125(17):2621–2629. doi:10.1182/blood-2014-09-570192
6. Avecilla ST, Hattori K, Heissig B, Tejada R, Liao F, Shido K, Jin DK, Dias S, Zhang F, Hartman TE, Hackett NR, Crystal RG, Witte L, Hicklin DJ, Bohlen P, Eaton D, Lyden D, de Sauvage F, Rafii S (2004) Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis. Nat Med 10(1):64–71. doi:10.1038/nm973
7. Rafii S, Shapiro F, Pettengell R, Ferris B, Nachman RL, Moore MA, Asch AS (1995) Human bone marrow microvascular endothelial cells support long-term proliferation and differentiation of myeloid and megakaryocytic progenitors. Blood 86(9):3353–3363
8. Olsson B, Andersson PO, Jacobsson S, Carlsson L, Wadenvik H (2005) Disturbed apoptosis of T-cells in patients with active idiopathic thrombocytopenic purpura. Thromb Haemost 93(1):139–144. doi:10.1267/THRO05010139
9. Zhang XL, Peng J, Sun JZ, Guo CS, Yu Y, Wang ZG, Chu XX, Hou M (2008) Modulation of immune response with cytotoxic T-lymphocyte-associated antigen 4 immunoglobulin-induced anergic T cells in chronic idiopathic thrombocytopenic purpura. J Thromb Haemostasis JTH 6(1):158–165. doi:10.1111/j.1538-7836.2007.02804.x
10. Zhang XL, Peng J, Sun JZ, Liu JJ, Guo CS, Wang ZG, Yu Y, Shi Y, Qin P, Li SG, Zhang LN, Hou M (2009) De novo induction of platelet-specific CD4(+)CD25(+) regulatory T cells from CD4(+)CD25(-) cells in patients with idiopathic thrombocytopenic purpura. Blood 113(11):2568–2577. doi:10.1182/blood-2008-03-148288
11. Aslam R, Hu Y, Gebremeskel S, Segel GB, Speck ER, Guo L, Kim M, Ni H, Freedman J, Semple JW (2012) Thymic retention of CD4+CD25+FoxP3+ T regulatory cells is associated with their peripheral deficiency and thrombocytopenia in a murine model of immune thrombocytopenia. Blood 120(10):2127–2132. doi:10.1182/blood-2012-02-413526
12. Wang T, Zhao H, Ren H, Guo J, Xu M, Yang R, Han ZC (2005) Type 1 and type 2 T-cell profiles in idiopathic thrombocytopenic purpura. Haematologica 90(7):914–923
13. Li S, Wang L, Zhao C, Li L, Peng J, Hou M (2007) CD8+ T cells suppress autologous megakaryocyte apoptosis in idiopathic thrombocytopenic purpura. Br J Haematol 139(4):605–611. doi:10.1111/j.1365-2141.2007.06737.x
14. Rodeghiero F, Stasi R, Gernsheimer T, Michel M, Provan D, Arnold DM, Bussel JB, Cines DB, Chong BH, Cooper N, Godeau B, Lechner K, Mazzucconi MG, McMillan R, Sanz MA, Imbach P, Blanchette V, Kuhne T, Ruggeri M, George JN (2009) Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura of adults and children: report from an international working group. Blood 113(11):2386–2393. doi:10.1182/blood-2008-07-162503
15. Kong Y, Chang YJ, Wang YZ, Chen YH, Han W, Wang Y, Sun YQ, Yan CH, Wang FR, Liu YR, Xu LP, Liu DH, Huang XJ (2013) Association of an impaired bone marrow microenvironment with secondary poor graft function after allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transplant J Am Soc Blood Marrow Transplant 19(10):1465–1473. doi:10.1016/j.bbmt.2013.07.014
16. Kong Y, Hu Y, Zhang XH, Wang YZ, Mo XD, Zhang YY, Wang Y, Han W, Xu LP, Chang YJ, Huang XJ (2014) Association between an impaired bone marrow vascular microenvironment and prolonged isolated thrombocytopenia after allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transplant J Am Soc Blood Marrow Transplant 20(8):1190–1197. doi:10.1016/j.bbmt.2014.04.015
17. Olsson B, Ridell B, Carlsson L, Jacobsson S, Wadenvik H (2008) Recruitment of T cells into bone marrow of ITP patients possibly due to elevated expression of VLA-4 and CX3CR1. Blood 112(4):1078–1084. doi:10.1182/blood-2008-02-139402
18. Bateman EA, Ayers L, Sadler R, Lucas M, Roberts C, Woods A, Packwood K, Burden J, Harrison D, Kaenzig N, Lee M, Chapel HM, Ferry BL (2012) T cell phenotypes in patients with common variable immunodeficiency disorders: associations with clinical phenotypes in comparison with other groups with recurrent infections. Clin Exp Immunol 170(2):202–211. doi:10.1111/j.1365-2249.2012.04643.x
19. Zhang J, Ma D, Zhu X, Qu X, Ji C, Hou M (2009) Elevated profile of Th17, Th1 and Tc1 cells in patients with immune thrombocytopenic purpura. Haematologica 94(9):1326–1329. doi:10.3324/haematol.2009.007823
20. Liu F, Wu C, Yang X, Xiao H, Zhuo X, Cheng Z, Chen Q (2005) Polarization and apoptosis of T cell subsets in idiopathic thrombocytopenic purpura. Cell Mol Immunol 2(5):387–392
21. Kidd P (2003) Th1/Th2 balance: the hypothesis, its limitations, and implications for health and disease. Altern Med Rev J Clin Ther 8(3):223–246
22. Teke HU, Gunduz E, Akay OM, Gulbas Z (2013) Abnormality of regulatory T-cells in remission and non-remission idiopathic thrombocytopaenic purpura patients. Platelets 24(8):625–631. doi:10.3109/09537104.2012.748188