Genetic variants associated with response to lithium treatment in bipolar disorder: A genome-wide association study

The Lancet

Volumn 387, Issue 10023, 2016, Pages 1085-1093

  Hou, Liping ^a   Heilbronner, Urs ^b,c   Degenhardt, Franziska ^d   Adli, Mazda ^e,f   Akiyama, Kazufumi ^g   Akula, Nirmala ^a   Ardau, Raffaella ^h   Arias, Bárbara ⁱ   Backlund, Lena ^j   Banzato, Claudio E M ^l   Benabarre, Antoni ⁱ   Bengesser, Susanne ^m   Bhattacharjee, Abesh Kumar ^o   Biernacka, Joanna M ^p   Birner, Armin ^m   Brichant Petitjean, Clara ^q   Bui, Elise T ^a   Cervantes, Pablo ^r   Chen, Guo Bo ^s   Chen, Hsi Chung ^t   Chillotti, Caterina ^h   Cichon, Sven ^d,v   Clark, Scott R ^w   Colom, Francesc ⁱ   Cousins, David A ^x   Cruceanu, Cristiana ^y   Czerski, Piotr M ^z   Dantas, Clarissa R ^l   Dayer, Alexandre ^aa   Étain, Bruno ^ab   Falkai, Peter ^b   Forstner, Andreas J ^d   Frisén, Louise ^j,k   Fullerton, Janice M ^ac,ad   Gard, Sébastien ^ae   Garnham, Julie S ^af   Goes, Fernando S ^ag   Grof, Paul ^ah   Gruber, Oliver ^c   Hashimoto, Ryota ^ai   Hauser, Joanna ^z   Herms, Stefan ^d,v   Hoffmann, Per ^d,v   Hofmann, Andrea ^d   Jamain, Stephane ^ab   Jiménez, Esther ⁱ   Kahn, Jean Pierre ^aj   Kassem, Layla ^a   Kittel Schneider, Sarah ^ak   Kliwicki, Sebastian ^z   König, Barbara ^al   Kusumi, Ichiro ^am   Lackner, Nina ^m   Laje, Gonzalo ^a   Landén, Mikael ^an,ao   Lavebratt, Catharina ^j   Leboyer, Marion ^ap   Leckband, Susan G ^j,aq   Jaramillo, Carlos A López ^ar   Macqueen, Glenda ^as   Manchia, Mirko ^h,af   Martinsson, Lina ^ao   Mattheisen, Manuel ^at   McCarthy, Michael J ^aq   McElroy, Susan L ^au   Mitjans, Marina ⁱ   Mondimore, Francis M ^ag   Monteleone, Palmiero ^av,aw   Nievergelt, Caroline M ^o   Nöthen, Markus M ^d   Ösby, Urban ^j   Ozaki, Norio ^ax   Perlis, Roy H ^ay   Pfennig, Andrea ^az   Reich Erkelenz, Daniela ^b   Rouleau, Guy A ^ba   Schofield, Peter R ^ac,ad   Schubert, K Oliver ^w   Schweizer, Barbara W ^ag   Seemüller, Florian ^b   Severino, Giovanni ^h   Shekhtman, Tatyana ^n,o   Shilling, Paul D ^o   Shimoda, Kazutaka ^g   Simhandl, Christian ^bb   Slaney, Claire M ^af   Smoller, Jordan W ^ay   Squassina, Alessio ^h   Stamm, Thomas ^e   Stopkova, Pavla ^bc   Tighe, Sarah K ^bd   Tortorella, Alfonso ^aw   Turecki, Gustavo ^y   Volkert, Julia ^ak   Witt, Stephanie ^be   Wright, Adam ^bf   Young, L Trevor ^bg   Zandi, Peter P ^bh   Potash, James B ^bd   Depaulo, J Raymond ^ag   Bauer, Michael ^az   Reininghaus, Eva Z ^m   Novák, Tomas ^bc   Aubry, Jean Michel ^aa   Maj, Mario ^aw   Baune, Bernhard T ^w   Mitchell, Philip B ^bf   Vieta, Eduard ⁱ   Frye, Mark A ^p   Rybakowski, Janusz K ^z   Kuo, Po Hsiu ^u   Kato, Tadafumi ^bi   Grigoroiu Serbanescu, Maria ^bj   Reif, Andreas ^ak   Del Zompo, Maria ^h   Bellivier, Frank ^q   Schalling, Martin ^j   Wray, Naomi R ^s   Kelsoe, John R ^n,o   Alda, Martin ^af,bc   Rietschel, Marcella ^be   McMahon, Francis J ^a   Schulze, Thomas G ^a,b,c,ag,be   more..

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^c UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

^d UNIVERSITY OF BONN   (Germany)

^e CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^f Vivantes Klinikum   (Germany)

^g DOKKYO MEDICAL UNIVERSITY   (Japan)

^h UNIVERSITY OF CAGLIARI   (Italy)

ⁱ UNIVERSITY OF BARCELONA   (Spain)

^j KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^k Child and Adolescent Psychiatry Research Center   (Sweden)

^l UNIVERSITY OF CAMPINAS   (Brazil)

^m MEDICAL UNIVERSITY OF GRAZ   (Austria)

ⁿ VETERANS AFFAIRS MEDICAL CENTER   (United States)

^o UNIVERSITY OF CALIFORNIA   (United States)

^p MAYO CLINIC   (United States)

^q UMR S 1144   (France)

^r MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^s UNIVERSITY OF QUEENSLAND   (Australia)

^t NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^u NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^v UNIVERSITY HOSPITAL BASEL   (Switzerland)

^w UNIVERSITY OF ADELAIDE   (Australia)

^x NEWCASTLE UNIVERSITY   (United Kingdom)

^y DOUGLAS MENTAL HEALTH UNIVERSITY INSTITUTE   (Canada)

^z POZNAN UNIVERSITY OF MEDICAL SCIENCES   (Poland)

^aa GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^ab INSERM U955   (France)

^ac NEUROSCIENCE RESEARCH AUSTRALIA   (Australia)

^ad UNIVERSITY OF NEW SOUTH WALES   (Australia)

^ae CENTRE HOSPITALIER CHARLES PERRENS   (France)

^af DALHOUSIE UNIVERSITY   (Canada)

^ag JOHNS HOPKINS UNIVERSITY   (United States)

^ah Mood Disorders Center of Ottawa   (Canada)

^ai OSAKA UNIVERSITY   (Japan)

^aj UNIVERSITÉ DE LORRAINE   (France)

^ak UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^al Landesklinikum Neunkirchen ^*  (Austria)

^am HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^an UNIVERSITY OF GOTHENBURG   (Sweden)

^ao KAROLINSKA INSTITUTE   (Sweden)

^ap Hopital Albert Chenevier   (France)

^aq VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

^ar UNIVERSIDAD DE ANTIOQUIA   (Colombia)

^as UNIVERSITY OF CALGARY   (Canada)

^at AARHUS UNIVERSITY   (Denmark)

^au UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^av UNIVERSITY OF SALERNO   (Italy)

^aw SECOND UNIVERSITY OF NAPLES   (Italy)

^ax NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^ay MASSACHUSETTS GENERAL HOSPITAL   (United States)

^az UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

^ba MCGILL UNIVERSITY   (Canada)

^bb BIPOLAR Zentrum Wiener Neustadt   (Austria)

^bc NATIONAL INSTITUTE OF MENTAL HEALTH   (Czech Republic)

^bd UNIVERSITY OF IOWA   (United States)

^be UNIVERSITY OF HEIDELBERG   (Germany)

^bf UNIVERSITY OF NEW SOUTH WALES   (Australia)

^bg UNIVERSITY OF TORONTO   (Canada)

^bh JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^bi RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

^bj Alexandru Obregia Psychiatric Hospital Bucharest   (Romania)

more..

Author keywords

[No Author keywords available]

Indexed keywords

GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; LITHIUM; LONG UNTRANSLATED RNA; GFRA2 PROTEIN, HUMAN; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR RECEPTOR; LITHIUM DERIVATIVE;

ADOLESCENT; ADULT; AGED; ALLELE; ARTICLE; BIPOLAR DISORDER; CHROMOSOME 21; FEMALE; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOMICS; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; MONOTHERAPY; PHENOTYPE; PRIORITY JOURNAL; RELAPSE; SINGLE NUCLEOTIDE POLYMORPHISM; TREATMENT RESPONSE; VERY ELDERLY; CLINICAL TRIAL; GENETIC VARIATION; GENETICS; GENOME-WIDE ASSOCIATION STUDY; MIDDLE AGED; MULTICENTER STUDY; PROSPECTIVE STUDY; TREATMENT OUTCOME;

BIPOLAR DISORDER; FEMALE; GENETIC VARIATION; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR RECEPTORS; HUMANS; LITHIUM COMPOUNDS; MALE; MIDDLE AGED; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; PROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 84961211119     PISSN: 01406736     EISSN: 1474547X     Source Type: Journal    
DOI: 10.1016/S0140-6736(16)00143-4     Document Type: Article

References (33)

1. KR Merikangas, HS Akiskal, J Angst et al. Lifetime and 12-month prevalence of bipolar spectrum disorder in the National Comorbidity Survey replication Arch Gen Psychiatry 64 2007 543 552
2. SC Dilsaver An estimate of the minimum economic burden of bipolar I and II disorders in the United States: 2009 J Affect Dis 129 2011 79 83
3. FK Goodwin, KR Jamison Manic-depressive illness: bipolar disorders and recurrent depression, 2nd edn 2007 Oxford University Press New York, NY
4. JR Geddes, DJ Miklowitz Treatment of bipolar disorder Lancet 381 2013 1672 1682
5. MS Bauer, L Mitchner What is a "mood stabilizer"? An evidence-based response Am J Psychiatry 161 2004 3 18
6. L Tondo, J Hennen, RJ Baldessarini Lower suicide risk with long-term lithium treatment in major affective illness: a meta-analysis Acta Psychiatr Scand 104 2001 163 172
7. RJ Baldessarini, L Tondo Does lithium treatment still work? Evidence of stable responses over three decades Arch Gen Psychiatry 57 2000 187 190
8. JK Rybakowski, M Chlopocka-Wozniak, A Suwalska The prophylactic effect of long-term lithium administration in bipolar patients entering treatment in the 1970s and 1980s Bipolar Dis 3 2001 63 67
9. J Garnham, A Munro, C Slaney et al. Prophylactic treatment response in bipolar disorder: results of a naturalistic observation study J Affect Dis 104 2007 185 190
10. N Kleindienst, R Engel, W Greil Which clinical factors predict response to prophylactic lithium? A systematic review for bipolar disorders Bipolar Dis 7 2005 404 417
11. A Duffy, M Alda, R Milin, P Grof A consecutive series of treated affected offspring of parents with bipolar disorder: is response associated with the clinical profile? Can J Psychiatry 52 2007 369 376
12. P Grof, A Duffy, P Cavazzoni et al. Is response to prophylactic lithium a familial trait? J Clin Psychiatry 6 2002 942 947
13. J Mendlewicz, P Verbanck, P Linkowski, J Wilmotte Lithium accumulation in erythrocytes of manic-depressive patients: an in vivo twin study Br J Psychiatry 133 1978 436 444
14. MJ McCarthy, SG Leckband, JR Kelsoe Pharmacogenetics of lithium response in bipolar disorder Pharmacogenomics 11 2010 1439 1465
15. A Can, TG Schulze, TD Gould Molecular actions and clinical pharmacogenetics of lithium therapy Pharmacol Biochem Behav 123 2014 3 16
16. RH Perlis, JW Smoller, MA Ferreira et al. A genomewide association study of response to lithium for prevention of recurrence in bipolar disorder Am J Psychiatry 166 2009 718 725
17. A Squassina, M Manchia, J Borg et al. Evidence for association of an ACCN1 gene variant with response to lithium treatment in Sardinian patients with bipolar disorder Pharmacogenomics 12 2011 1559 1569
18. CH Chen, CS Lee, MT Lee et al. Variant GADL1 and response to lithium therapy in bipolar I disorder N Engl J Med 370 2014 119 128
19. Consortium on Lithium Genetics Variant GADL1 and response to lithium in bipolar I disorder N Engl J Med 370 2014 1857 1859
20. M Ikeda, K Kondo, N Iwata Variant GADL1 and response to lithium in bipolar I disorder N Engl J Med 370 2014 1856 1857
21. C Cruceanu, M Alda, PA Dion, G Turecki, GA Rouleau No evidence for GADL1 variation as a bipolar disorder susceptibility factor in a Caucasian lithium-responsive cohort Am J Psychiatry 172 2015 94 95
22. TG Schulze, M Alda, M Adli et al. The International Consortium on Lithium Genetics (ConLiGen): an initiative by the NIMH and IGSLI to study the genetic basis of response to lithium treatment Neuropsychobiology 62 2010 72 78
23. M Manchia, M Adli, N Akula et al. Assessment of response to lithium maintenance treatment in bipolar disorder: a Consortium on Lithium Genetics (ConLiGen) report PLoS One 8 2013 e65636
24. B Howie, C Fuchsberger, M Stephens, J Marchini, GR Abecasis Fast and accurate genotype imputation in genome-wide association studies through pre-phasing Nat Genet 44 2012 955 959
25. O Delaneau, JF Zagury, J Marchini Improved whole-chromosome phasing for disease and population genetic studies Nat Methods 10 2013 5 6
26. C Fuchsberger, GR Abecasis, DA Hinds minimac2: faster genotype imputation Bioinformatics 31 2015 782 784
27. S Purcell, B Neale, K Todd-Brown et al. PLINK: a tool set for whole-genome association and population-based linkage analyses Am J Hum Genet 81 2007 559 575
28. CJ Willer, Y Li, GR Abecasis METAL: fast and efficient meta-analysis of genomewide association scans Bioinformatics 26 2010 2190 2191
29. Psychiatric GWAS Consortium Bipolar Disorder Working Group Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4 Nat Genet 43 2011 977 983
30. K Aberg, DE Adkins, J Bukszar et al. Genomewide association study of movement-related adverse antipsychotic effects Biol Psychiatry 67 2010 279 282
31. AK Malhotra, CU Correll, NI Chowdhury et al. Association between common variants near the melanocortin 4 receptor gene and severe antipsychotic drug-induced weight gain Arch Gen Psychiatry 69 2012 904 912
32. I Grande, M Berk, B Birmaher, E Vieta Bipolar disorder Lancet 2015 published online Sept 17. http://dx.doi.org/10.1016/s0140-6736(15)00241-X
33. CB Do, DA Hinds, U Francke, N Eriksson Comparison of family history and SNPs for predicting risk of complex disease PLoS Genet 8 2012 e1002973