Expression of chemokine receptor CCR7 is a negative prognostic factor for patients with gastric cancer: a meta-analysis

Gastric Cancer

Volumn 20, Issue 2, 2017, Pages 235-245

  Du, Peizhun ^a   Liu, Yongchao ^b   Ren, Hong ^a   Zhao, Jing ^a   Zhang, Xiaodan ^c   Patel, Rajan ^d   Hu, Chenen ^a   Gan, Jun ^a   Huang, Guangjian ^a  

^a FUDAN UNIVERSITY   (China)

^b TENTH PEOPLE S HOSPITAL OF TONGJI UNIVERSITY   (China)

^c OBSTETRICS AND GYNECOLOGY HOSPITAL OF FUDAN UNIVERSITY   (China)

^d Shady Grove Adventist Hospital   (United States)

Author keywords

CC chemokine receptor type 7; Meta analysis; Prognosis; Stomach neoplasms

Indexed keywords

CHEMOKINE RECEPTOR CCR7; CCR7 PROTEIN, HUMAN; TUMOR MARKER;

ADVANCED CANCER; AGE; ANTIGEN EXPRESSION; ARTICLE; CANCER PROGNOSIS; CANCER STAGING; CANCER SURVIVAL; CLINICAL FEATURE; HISTOLOGY; HUMAN; LYMPH NODE METASTASIS; LYMPH VESSEL METASTASIS; OVERALL SURVIVAL; PATHOLOGY; SENSITIVITY ANALYSIS; STOMACH CANCER; SURVIVAL RATE; SURVIVAL TIME; SYSTEMATIC REVIEW; TUMOR INVASION; TUMOR VOLUME; META ANALYSIS; METABOLISM; MORTALITY; PROGNOSIS; STOMACH TUMOR;

BIOMARKERS, TUMOR; HUMANS; PROGNOSIS; RECEPTORS, CCR7; STOMACH NEOPLASMS; SURVIVAL RATE;

EID: 84961208526     PISSN: 14363291     EISSN: 14363305     Source Type: Journal    
DOI: 10.1007/s10120-016-0602-8     Document Type: Article

References (36)

1. Hirao M, Onai N, Hiroishi K, Watkins SC, Matsushima K, Robbins PD, et al. CC chemokine receptor-7 on dendritic cells is induced after interaction with apoptotic tumor cells: critical role in migration from the tumor site to draining lymph nodes. Cancer Res. 2000;60:2209–17.
2. Dieu MC, Vanbervliet B, Vicari A, Bridon JM, Oldham E, Ait-Yahia S, et al. Selective recruitment of immature and mature dendritic cells by distinct chemokines expressed in different anatomic sites. J Exp Med. 1998;188:373–86.
3. Baekkevold ES, Yamanaka T, Palframan RT, Carlsen HS, Reinholt FP, von Andrian UH, et al. The CCR7 ligand elc (CCL19) is transcytosed in high endothelial venules and mediates T cell recruitment. J Exp Med. 2001;193:1105–12.
4. Gunn MD, Tangemann K, Tam C, Cyster JG, Rosen SD, Williams LT. A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes. Proc Natl Acad Sci U S A. 1998;95:258–63.
5. Das S, Sarrou E, Podgrabinska S, Cassella M, Mungamuri SK, Feirt N, et al. Tumor cell entry into the lymph node is controlled by CCL1 chemokine expressed by lymph node lymphatic sinuses. J Exp Med. 2013;210:1509–28.
6. Zlotnik A. Chemokines and cancer. Int J Cancer. 2006;119:2026–9.
7. Kwak MK, Hur K, Park DJ, Lee HJ, Lee HS, Kim WH, et al. Expression of chemokine receptors in human gastric cancer. Tumour Biol. 2005;26:65–70.
8. Arigami T, Natsugoe S, Uenosono Y, Yanagita S, Arima H, Hirata M, et al. CCR7 and CXCR4 expression predicts lymph node status including micrometastasis in gastric cancer. Int J Oncol. 2009;35:19–24.
9. + regulatory T cells are correlated with overall survival and lymph node metastasis in gastric cancer. PLoS One. 2013;8:e74430.
10. Zhang J, Zhou Y, Yang Y. CCR7 pathway induces epithelial-mesenchymal transition through up-regulation of Snail signaling in gastric cancer. Med Oncol. 2015;32:467.
11. Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol. 2010;25:603–5.
12. Higgins JP, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med. 2002;21:1539–58.
13. Ishigami S, Natsugoe S, Nakajo A, Tokuda K, Uenosono Y, Arigami T, et al. Prognostic value of CCR7 expression in gastric cancer. Hepatogastroenterology. 2007;54:1025–8.
14. Yan C, Zhu ZG, Yu YY, Ji J, Zhang Y, Ji YB, et al. Expression of vascular endothelial growth factor C and chemokine receptor CCR7 in gastric carcinoma and their values in predicting lymph node metastasis. World J Gastroenterol. 2004;10:783–90.
15. Deguchi K, Ichikawa D, Soga K, Watanabe K, Kosuga T, Takeshita H, et al. Clinical significance of vascular endothelial growth factors C and D and chemokine receptor CCR7 in gastric cancer. Anticancer Res. 2010;30:2361–6.
16. Wang WN, Chen Y, Zhang YD, Hu TH. The regulatory mechanism of CCR7 gene expression and its involvement in the metastasis and progression of gastric cancer. Tumour Biol. 2013;34:1865–71.
17. Zhao J, Wang G, Sun M. Expression and clinical significance of chemokine receptor CCRT in gastric carcinoma and its corresponding lymph node metastasis. Chin J Lab Diagn. 2007;11:468–70.
18. Chen Z. The expression and significance of chemokin receptor CCR6, CCR7 in gastric cancer [master's thesis]. Dalian Medical University; 2009.
19. Wang T. Expressions of chemokine receptors CXCR1, CXCR2 and CCR7 in gastic carcinoma and their relevance with metastasis [master's thesis]. Dalian Medical University; 2005.
20. Wen G, Guo Y. The expression of chemokine receptor CCR7 and CXCR4 in gastric cancer. Guangdong Med J. 2006;27:968–70.
21. Yan Y, Wu R, Shen X, Yang P, Wang Y. Overexpression of chemokine receptor CCR7 in gastric cancer tissue and cell lines. Chin J Gastroenterol. 2010;15:423–5.
22. Mashino K, Sadanaga N, Yamaguchi H, Tanaka F, Ohta M, Shibuta K, et al. Expression of chemokine receptor CCR7 is associated with lymph node metastasis of gastric carcinoma. Cancer Res. 2002;62:2937–41.
23. Ma H, Gao L, Li S, Qin J, Chen L, Liu X, et al. CCR7 enhances TGF-β1-induced epithelial-mesenchymal transition and is associated with lymph node metastasis and poor overall survival in gastric cancer. Oncotarget. 2015;6:24348–60.
24. Duval S, Tweedie R. Trim and fill: a simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. Biometrics. 2000;56:455–63.
25. Muller A, Homey B, Soto H, Ge N, Catron D, Buchanan ME, et al. Involvement of chemokine receptors in breast cancer metastasis. Nature. 2001;410:50–6.
26. Gunther K, Leier J, Henning G, Dimmler A, Weissbach R, Hohenberger W, et al. Prediction of lymph node metastasis in colorectal carcinoma by expression of chemokine receptor CCR7. Int J Cancer. 2005;116:726–33.
27. Comerford I, Harata-Lee Y, Bunting MD, Gregor C, Kara EE, McColl SR. A myriad of functions and complex regulation of the CCR7/CCL19/CCL21 chemokine axis in the adaptive immune system. Cytokine Growth Factor Rev. 2013;24:269–83.
28. Weber M, Hauschild R, Schwarz J, Moussion C, de Vries I, Legler DF, et al. Interstitial dendritic cell guidance by haptotactic chemokine gradients. Science. 2013;339:328–32.
29. Wang J, Zhang X, Thomas SM, Grandis JR, Wells A, Chen ZG, et al. Chemokine receptor 7 activates phosphoinositide-3 kinase-mediated invasive and prosurvival pathways in head and neck cancer cells independent of EGFR. Oncogene. 2005;24:5897–904.
30. Guo N, Liu F, Yang L, Huang J, Ding X, Sun C. Chemokine receptor 7 enhances cell chemotaxis and migration of metastatic squamous cell carcinoma of head and neck through activation of matrix metalloproteinase-9. Oncol Rep. 2014;32:794–800.
31. Li F, Zou Z, Suo N, Zhang Z, Wan F, Zhong G, et al. CCL21/CCR7 axis activating chemotaxis accompanied with epithelial-mesenchymal transition in human breast carcinoma. Med Oncol. 2014;31:180.
32. Thiery JP, Acloque H, Huang RY, Nieto MA. Epithelial-mesenchymal transitions in development and disease. Cell. 2009;139:871–90.
33. Shields JD, Fleury ME, Yong C, Tomei AA, Randolph GJ, Swartz MA. Autologous chemotaxis as a mechanism of tumor cell homing to lymphatics via interstitial flow and autocrine CCR7 signaling. Cancer Cell. 2007;11:526–38.
34. Sperveslage J, Frank S, Heneweer C, Egberts J, Schniewind B, Buchholz M, et al. Lack of CCR7 expression is rate limiting for lymphatic spread of pancreatic ductal adenocarcinoma. Int J Cancer. 2012;131:E371–81.
35. Mumtaz M, Wagsater D, Lofgren S, Hugander A, Zar N, Dimberg J. Decreased expression of the chemokine CCL21 in human colorectal adenocarcinomas. Oncol Rep. 2009;21:153–8.
36. Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315:629–34.