Elevated levels of serum cholesterol are associated with better performance on tasks of episodic memory

Metabolic Brain Disease

Volumn 31, Issue 2, 2016, Pages 465-473

  Leritz, Elizabeth C ^a,b   McGlinchey, Regina E ^a,b   Salat, David H ^a,b,c   Milberg, William P ^a,b  

^a VA BOSTON HEALTHCARE SYSTEM   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Cerebrovascular health; Cerebrovascular risk; Cholesterol; Cognition

Indexed keywords

ANTILIPEMIC AGENT; APOLIPOPROTEIN E; CHOLESTEROL; GLUCOSE; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

ADULT; AGED; ARTICLE; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; COGNITION; COGNITIVE AGING; EDUCATIONAL STATUS; EPISODIC MEMORY; EXECUTIVE FUNCTION; FACTORIAL ANALYSIS; FEMALE; GENOTYPING TECHNIQUE; HUMAN; LANGUAGE ABILITY; LIPID ANALYSIS; MAJOR CLINICAL STUDY; MALE; MEASUREMENT; MENTAL PERFORMANCE; NEUROPSYCHOLOGICAL TEST; RISK ASSESSMENT; SYSTOLIC BLOOD PRESSURE; BLOOD; MIDDLE AGED; PHYSIOLOGY; RISK FACTOR; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; CHOLESTEROL; COGNITION; FEMALE; HUMANS; MALE; MEMORY, EPISODIC; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; RISK FACTORS; TRIGLYCERIDES;

EID: 84961185114     PISSN: 08857490     EISSN: 15737365     Source Type: Journal    
DOI: 10.1007/s11011-016-9797-y     Document Type: Article

References (54)

1. Babiker A, Dzeletovic S, Wiklund B, Pettersson N, Salonen J, Nyyssonen K, et al. (2005) Patients with atherosclerosis may have increased circulating levels of 27-hydroxycholesterol and cholestenoic acid. Scand J Clin Lab Invest 65(5):365–375
2. Badimon L, Vilahur G (2012) LDL-cholesterol versus HDL-cholesterol in the atherosclerotic plaque: inflammatory resolution versus thrombotic chaos. Ann N Y Acad Sci 1254:18–32
3. Bang OY, Saver JL, Liebeskind DS, Pineda S, Ovbiagele B (2008) Association of serum lipid indices with large artery atherosclerotic stroke. Neurology 70(11):841–847
4. Bender AR, Raz N (2012) Age-related differences in memory and executive functions in healthy APOE varepsilon4 carriers: the contribution of individual differences in prefrontal volumes and systolic blood pressure. Neuropsychologia 50(5):704–714
5. Bohnstedt M, Fox PJ, Kohatsu ND (1994) Correlates of mini-mental status examination scores among elderly demented patients: the influence of race-ethnicity. J Clin Epidemiol 47(12):1381–1387
6. Bryant FB, Yarnold PR (1995) Principle-components analysis and exploratory and confirmatory factor analysis. In: Grimm LG, Yarnold PR (eds) Reading and understanding multivariate statistics. American Psychological Association, Washington, D.C., pp. 99–136
7. Dahle CL, Jacobs BS, Raz N (2009) Aging, vascular risk, and cognition: blood glucose, pulse pressure, and cognitive performance in healthy adults. Psychol Aging 24(1):154–162
8. de Frias CM, Bunce D, Wahlin A, Adolfsson R, Sleegers K, Cruts M, et al. (2007) Cholesterol and triglycerides moderate the effect of apolipoprotein E on memory functioning in older adults. J Gerontol B Psychol Sci Soc Sci 62(2):112–118
9. Debette S, Seshadri S, Beiser A, Au R, Himali JJ, Palumbo C, et al. (2011) Midlife vascular risk factor exposure accelerates structural brain aging and cognitive decline. Neurology 77(5):461–468
10. Delano-Wood, L., Bondi, M. W., Jak, A. J., Horne, N. R., Schweinsburg, B. C., Frank, L. R., et al. (2008). Stroke risk modifies regional white matter differences in mild cognitive impairment. Neurobiol Aging 31(10), 1721–1731
11. Delis DC, Kramer J, Kaplan E, Ober B (2000) California verbal learning test-second edition. The Psychological Corporation, San Antonio
12. Elias PK, Elias MF, D'Agostino RB, Sullivan LM, Wolf PA (2005) Serum cholesterol and cognitive performance in the framingham heart study. Psychosom Med 67(1):24–30
13. Foley JM, Salat DH, Stricker NH, Zink TA, Grande LJ, McGlinchey RE, et al. (2014) Interactive effects of apolipoprotein E4 and diabetes risk on later myelinating white matter regions in neurologically healthy older aged adults. Am J Alzheimers Dis Other Demen 29(3):222–235
14. Fortuny LA, Briggs M, Newcombe F, Ratcliff G, Thomas C (1980) Measuring the duration of post traumatic amnesia. J Neurol Neurosurg Psychiatry 43(5):377–379
15. Gendle MH, Spaeth AM, Dollard SM, Novak CA (2008) Functional relationships between serum total cholesterol levels, executive control, and sustained attention. Nutr Neurosci 11(2):84–94
16. Gillum RF, Obisesan TO (2011) High-density lipoprotein cholesterol, cognitive function and mortality in a U.S. national cohort. Lipids Health Dis 10:26
17. Henderson VW, Guthrie JR, Dennerstein L (2003) Serum lipids and memory in a population based cohort of middle age women. J Neurol Neurosurg Psychiatry 74(11):1530–1535
18. Huang CQ, Dong BR, Wu HM, Zhang YL, Wu JH, Lu ZC, et al. (2009) Association of cognitive impairment with serum lipid/lipoprotein among Chinese nonagenarians and centenarians. Dement Geriatr Cogn Disord 27(2):111–116
19. Hughes TM, Kuller LH, Lopez OL, Becker JT, Evans RW, Sutton-Tyrrell K, et al. (2012) Markers of cholesterol metabolism in the brain show stronger associations with cerebrovascular disease than Alzheimer's disease. J Alzheimers Dis 30(1):53–61
20. Hughes TM, Rosano C, Evans RW, Kuller LH (2013) Brain cholesterol metabolism, oxysterols, and dementia. J Alzheimers Dis 33(4):891–911
21. Kaplan E, Goodglass H, Weintraub S (2001) Boston naming test. Lippincott Williams & Wilkins, Philadelphia
22. Khan U, Porteous L, Hassan A, Markus HS (2007) Risk factor profile of cerebral small vessel disease and its subtypes. J Neurol Neurosurg Psychiatry 78(7):702–706
23. Lee PH, Lim TS, Shin HW, Yong SW, Nam HS, Sohn YH (2009) Serum cholesterol levels and the risk of multiple system atrophy: a case-control study. Mov Disord 24(5):752–758
24. Leoni V, Caccia C (2013) 24S-hydroxycholesterol in plasma: a marker of cholesterol turnover in neurodegenerative diseases. Biochimie 95(3):595–612
25. Leritz EC, Salat DH, Milberg WP, Williams VJ, Chapman CE, Grande LJ, et al. (2010) Variation in blood pressure is associated with white matter microstructure but not cognition in African Americans. Neuropsychology 24(2):199–208
26. Leritz EC, Salat DH, Williams VJ, Schnyer DM, Rudolph JL, Lipsitz L, et al. (2011) Thickness of the human cerebral cortex is associated with metrics of cerebrovascular health in a normative sample of community dwelling older adults. NeuroImage 54(4):2659–2671
27. Merched A, Xia Y, Visvikis S, Serot JM, Siest G (2000) Decreased high-density lipoprotein cholesterol and serum apolipoprotein AI concentrations are highly correlated with the severity of Alzheimer's disease. Neurobiol Aging 21(1):27–30
28. Morley JE, Banks WA (2010) Lipids and cognition. J Alzheimers Dis 20(3):737–747
29. Packard CJ, Westendorp RG, Stott DJ, Caslake MJ, Murray HM, Shepherd J, et al. (2007) Association between apolipoprotein E4 and cognitive decline in elderly adults. J Am Geriatr Soc 55(11):1777–1785
30. Perna L, Mons U, Rujescu D, Kliegel M, Brenner H (2015) Apolipoprotein E e4 and cognitive function: a modifiable association? Results from two independent cohort studies. Dement Geriatr Cogn Disord 41(1–2):35–45
31. Presecki P, Muck-Seler D, Mimica N, Pivac N, Mustapic M, Stipcevic T, et al. (2011) Serum lipid levels in patients with Alzheimer's disease. Coll Anthropol 35(Suppl 1):115–120
32. Raz N, Rodrigue KM, Kennedy KM, Acker JD (2007) Vascular health and longitudinal changes in brain and cognition in middle-aged and older adults. Neuropsychology 21(2):149–157
33. Reijmer YD, van den Berg E, Dekker JM, Nijpels G, Stehouwer CD, Kappelle LJ, et al. (2012) Development of vascular risk factors over 15 years in relation to cognition: the hoorn study. J Am Geriatr Soc 60(8):1426–1433
34. Reitz C, Tang MX, Luchsinger J, Mayeux R (2004) Relation of plasma lipids to Alzheimer disease and vascular dementia. Arch Neurol 61(5):705–714
35. Reitz C, Luchsinger J, Tang MX, Manly J, Mayeux R (2005) Impact of plasma lipids and time on memory performance in healthy elderly without dementia. Neurology 64(8):1378–1383
36. Reitz C, Tang MX, Schupf N, Manly JJ, Mayeux R, Luchsinger JA (2010) Association of higher levels of high-density lipoprotein cholesterol in elderly individuals and lower risk of late-onset Alzheimer disease. Arch Neurol 67(12):1491–1497
37. Salat DH, Williams VJ, Leritz EC, Schnyer DM, Rudolph JL, Lipsitz LA, et al. (2012) Inter-individual variation in blood pressure is associated with regional white matter integrity in generally healthy older adults. NeuroImage 59(1):181–192
38. Sato N, Morishita R (2015) The roles of lipid and glucose metabolism in modulation of beta-amyloid, tau, and neurodegeneration in the pathogenesis of Alzheimer disease. Front Aging Neurosci 7:199
39. Sparks DL, Kryscio RJ, Connor DJ, Sabbagh MN, Sparks LM, Lin Y, et al. (2010) Cholesterol and cognitive performance in normal controls and the influence of elective statin use after conversion to mild cognitive impairment: results in a clinical trial cohort. Neurodegener Dis 7(1–3):183–186
40. Spreen O, Strauss E (1998) A compendium of neuropsychological tests. Oxford University Press, New York
41. Staekenborg SS, van Straaten EC, van der Flier WM, Lane R, Barkhof F, Scheltens P (2008) Small vessel versus large vessel vascular dementia: risk factors and MRI findings. J Neurol 255(11):1644–1651 discussion 1813-1644
42. Talayero BG, Sacks FM (2011) The role of triglycerides in atherosclerosis. Curr Cardiol Rep 13(6):544–552
43. van den Kommer TN, Dik MG, Comijs HC, Fassbender K, Lutjohann D, Jonker C (2009) Total cholesterol and oxysterols: early markers for cognitive decline in elderly? Neurobiol Aging 30(4):534–545
44. van den Kommer TN, Dik MG, Comijs HC, Jonker C, Deeg DJ (2010) The role of lipoproteins and inflammation in cognitive decline: do they interact? Neurobiol Aging 33(1):196.e1–196.e12
45. van Es AC, van der Grond J, de Craen AJ, Admiraal-Behloul F, Blauw GJ, van Buchem MA (2008) Risk factors for cerebral microbleeds in the elderly. Cerebrovasc Dis 26(4):397–403
46. van Exel E, de Craen AJ, Gussekloo J, Houx P, Bootsma-van der Wiel A, Macfarlane PW, et al. (2002) Association between high-density lipoprotein and cognitive impairment in the oldest old. Ann Neurol 51(6):716–721
47. Weber C, Noels H (2011) Atherosclerosis: current pathogenesis and therapeutic options. Nat Med 17(11):1410–1422
48. Wechsler D (1997) Wechsler memory scale - third edition. The Psychological Corporation, San Antonio
49. West R, Beeri MS, Schmeidler J, Hannigan CM, Angelo G, Grossman HT, et al. (2008) Better memory functioning associated with higher total and low-density lipoprotein cholesterol levels in very elderly subjects without the apolipoprotein e4 allele. Am J Geriatr Psychiatr 16(9):781–785
50. Williams VJ, Leritz EC, Shepel J, McGlinchey RE, Milberg WP, Rudolph JL, et al. (2013) Interindividual variation in serum cholesterol is associated with regional white matter tissue integrity in older adults. Hum Brain Mapp 34(8):1826–1841
51. Wolf H, Hensel A, Arendt T, Kivipelto M, Winblad B, Gertz HJ (2004) Serum lipids and hippocampal volume: the link to Alzheimer's disease? Ann Neurol 56(5):745–748
52. Yaffe K, Barrett-Connor E, Lin F, Grady D (2002) Serum lipoprotein levels, statin use, and cognitive function in older women. Arch Neurol 59(3):378–384
53. Yuan J, Wen G, Li Y, Liu C (2013) The occurrence of cerebrovascular atherosclerosis in Alzheimer's disease patients. Clin Interv Aging 8:581–584
54. Zheng L, Mack WJ, Chui HC, Heflin L, Mungas D, Reed B, et al. (2012) Coronary artery disease is associated with cognitive decline independent of changes on magnetic resonance imaging in cognitively normal elderly adults. J Am Geriatr Soc 60(3):499–504