Patients with atherosclerosis may have increased circulating levels of 27-hydroxycholesterol and cholestenoic acid

Scandinavian Journal of Clinical and Laboratory Investigation

Volumn 65, Issue 5, 2005, Pages 365-376

  Babiker, Amir ^a   Dzeletovic, S ^a   Wiklund, B ^a   Pettersson, N ^a   Salonen, J ^b   Nyyssonen K ^b   Eriksson, M ^a   Diczfalusy, U ^a   Bjorkhem I ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

Anti atherogenic; Atherosclerosis; Cholesterol; CYP27A1; Metabolites

Indexed keywords

26 HYDROXYCHOLESTEROL; BIOCHEMICAL MARKER; CHOLESTENOIC ACID; CHOLESTEROL DERIVATIVE; STEROL 27 HYDROXYLASE; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; ATHEROSCLEROSIS; CONTROLLED STUDY; ENDARTERECTOMY; FEMALE; GAS CHROMATOGRAPHY; HUMAN; HYPERCHOLESTEROLEMIA; MACROPHAGE; MAJOR CLINICAL STUDY; MALE; PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY; PRIORITY JOURNAL; STATISTICAL ANALYSIS;

ARTERIOSCLEROSIS; CHOLESTENONES; CHOLESTEROL; FEMALE; HUMANS; HYDROXYCHOLESTEROLS; MALE;

EID: 23644442259     PISSN: 00365513     EISSN: 15027686     Source Type: Journal    
DOI: 10.1080/00365510510025746     Document Type: Article

References (26)

1. Andersson S, Davis DL, Dahlbäck H, Jörnvall H, Russell D. W Cloning, structure, and expression of the mitochondrial cytochrome P-450 sterol 26-hydroxylase, a bile biosynthetic enzyme. J Biol Chem 1989;264:8222-9.
2. Björkhem I, Andersson O, Diczfalusy U, Sevastik B, Xiu R-J, Duan C, et al. Atherosclerosis and sterol 27-hydroxylase: evidence for a role of this enzyme in elimination of cholesterol from human macrophages. Proc Natl Acad Sci USA 1994;91:8592-6.
3. Crisby M, Nilsson J, Kostulas V, Björkhem I, Diczfalusy U. Localization of sterol 27-hydroxylase immunoreactivity in human atherosclerotic plaques. Biochim Biophys Acta 1997;1344:278-85.
4. Björkhem I. Mechanism of degradation of the steroid side chain in the formation of bile acids. J Lipid Res 1992;33:455-71.
5. Björkhem I, Muri-Boberg K. Inborn errors in bile acid biosynthesis and storage of sterols other than cholesterol. In: Scriver CR, Beaudet AL, Sly WS, Valee D, editors. The metabolic basis of inherited diseases. New York, NY: McGraw-Hill; 1994. pp 2073-100.
6. Rosen H, Reshef A, Maeda N, Lippoldt A, Shpizen S, Triger L, et al. Markedly reduced bile acid synthesis but maintained levels of cholesterol and vitamin D metabolites in mice with disrupted sterol 27-hydroxylase gene. J Biol Chem 1998;273:14805-12.
7. Lund E, Andersson O, Zhang J, Babiker A, Ahlborg G, Diczfalusy U, et al. Importance of a novel oxidative mechanism for elimination of intracellular cholesterol in humans. Arterioscler Thromb Vasc Biol 1996;16:208-12.
8. Duane WC, Javitt NB. 27-Hydroxychloesterol production in normal human subjects. J Lipid Res 1999;40:1194-9.
9. Babiker A, Andersson O, Lindblom D, van der Linden J, Wiklund B, Lütjohann D, et al. Elimination of cholesterol as cholestenoic acid in human lung by sterol 27-hydroxylase: evidence that most of this steroid in the circulation is of pulmonary origin. Lipid Res 1999;40:1417-25.
10. Meaney S, Hassan M, Sakinis A, Lutjohann D, Von Bergmann K, Wennmalm Å, et al. Evidence that the major oxysterols in human circulation originate from distinct pools of cholesterol: a stable isotope study. J Lipid Res 2001;42:70-8.
11. Javitt NB. Biologic role(s) of the 25(R),26-hydroxycholesterol metabolic pathway. Biochim Biophys Acta 2000;1529:136-41.
12. Shanahan CM, Carpenter KL, Cary NR. A potential role for 27-hydroxylase in atherogenesis. Atherosclerosis 2001;154:269-76.
13. Harik-Khan R, Holmes RP. Estimation of 26-hydroxycholesterol in serum by high-performance liquid chromatography and measurement in patients with atherosclerosis. J Steroid Biochem 1990,36:351-5.
14. Dzeletovic S, Breuer O, Lund E, Diczfalusy U. Determination of cholesterol oxidation products in human plasma by isotope dilution-mass spectrometry. Anal Biochem 1995;225:73-80.
15. Babiker A, Andersson O, Lund E, Xiu R-J, Deeb S, Reshef A, et al. Elimination of cholesterol in macrophages and endothelial cells by the sterol 27-hydroxylase mechanism. Comparison with high density lipoprotein-mediated reverse cholesterol transport. J Biol Chem 1997;272:26253-61.
16. Salonen JT, Nyyssönen K, Salonen R, Porkkala-Sarataho E, Tuomainen TP, Diczfalusy U, et al. Lipoprotein oxidation and progression of carotid atherosclerosis. Circulation 1997;95:840-5.
17. Setchell K, Schwartz M, O'Conell NC, Lund EG, Davis DL, Lathe R, et al. Identification of a new inborn error of in bile acid synthesis: mutation of the oxysterol 7 alpha-hydroxlase gene causes severe neonatal liver disease. J Clin Invest 1998;102:1690-703.
18. Axelson M, Shoda J, Sjövall J, Toll A, Wikvall K. Cholesterol is converted to 7oc-hydroxy-3-oxo-4-cholestenoic acid in liver mitochondria. Evidence for mitochondrial sterol 7α-hydroxylase. J Biol Chem 1992;267:1701-4.
19. Shoda J, Toll A, Axelson M, Pieper F, Wikvall K, Sjövall J. Formation of 7α- and 7β-hydroxylated bile acid precursors from 27-hydroxycholesterol in human liver microsomes and mitochondria. Hepatology 1993;17:395-403.
20. Björkhem I, Nyberg B, Einarsson K. 7α-hydroxylation of 27-hydroxycholesterol in human liver microsomes. Biochim Biophys Acta 1992;1128:73-6.
21. Hasan S, Kushwaha RS. Differences in 27-hydroxycholesterol concentrations in plasma and liver of baboons with high and low responses to dietary cholesterol and fat. Biochim Biophys Acta 1993;20:299-302.
22. Twisk J, Hoekman MF, Mager WH, Moorman AF, deBoer PA, Scheja L, et al. Heterogeneous expression of cholesterol 7α-hydroxylase and sterol 27-hydroxylase genes in the rat liver lobulus. J Clin Invest 1995;95:1235-43.
23. Vlahcevic ZR, Jairath SK, Heuman DM, Stravitz RT, Hylemon PB, Avadhani NG, et al. Transcriptional regulation of hepatic sterol 27-hydroxylase by bile acids. Am J Physiol 1996;270:646-52.
24. Björkhem I, Gustafsson J. Mitochondrial co-hydroxylation of cholesterol side chain. J Biol Chem 1974;249:2528-35.
25. Björkhem I, Axen E, Wikvall K, Rudling M, Angelin B, Einarsson K. There is little or no coordinate regulation of sterol 27-hydroxycholesterol and cholesterol 7α-hydroxylase in man. Proc XIV International Bile Acid Meeting, Freiburg October 22-24, 1996.
26. Kushwaha RS, Guntupalli B, Jackson EM, McGill HJ. Effect of estrogen and progesterone on the expression of hepatic and extrahepatic sterol 27-hydroxylase in baboons (Papio sp). Arterioscler Thromb Vasc Biol 1996;16:1088-94.