Multiple breath washout analysis in infants: Quality assessment and recommendations for improvement

Physiological Measurement

Volumn 37, Issue 3, 2016, Pages L1-L15

  Anagnostopoulou, Pinelopi ^a   Egger, Barbara ^b   Lurà, Marco ^b   Usemann, Jakob ^a,b   Schmidt, Anne ^a,b   Gorlanova, Olga ^b   Korten, Insa ^a,b   Roos, Markus ^c   Frey, Urs ^b   Latzin, Philipp ^a,b  

^a UNIVERSITY OF BERN   (Switzerland)

^b UNIVERSITY CHILDREN S HOSPITAL   (Switzerland)

^c NM Numerical Modelling GmbH   (Switzerland)

Author keywords

Infant lung function; multiple breath washout; ultrasonic flowmeter

Indexed keywords

FLOW MEASUREMENT; FLOWMETERS;

'CURRENT; CLINICAL STUDY; FUNCTIONAL RESIDUAL CAPACITIES; INFANT LUNG FUNCTION; LUNG FUNCTION; MULTIPLE BREATH WASHOUT; QUALITY ASSESSMENT; SOFTWARE ALGORITHMS; SOFTWARE SETTINGS; WASHOUT MEASUREMENTS;

QUALITY CONTROL;

BREATH ANALYSIS; FUNCTIONAL RESIDUAL CAPACITY; HEALTH CARE PLANNING; HEALTH CARE QUALITY; HUMAN; INFANT; PROCEDURES; SIGNAL PROCESSING; SOFTWARE; STANDARD; TEMPERATURE;

BREATH TESTS; FUNCTIONAL RESIDUAL CAPACITY; HEALTH PLANNING GUIDELINES; HUMANS; INFANT; QUALITY ASSURANCE, HEALTH CARE; REFERENCE STANDARDS; SIGNAL PROCESSING, COMPUTER-ASSISTED; SOFTWARE; TEMPERATURE;

EID: 84961148208     PISSN: 09673334     EISSN: 13616579     Source Type: Journal    
DOI: 10.1088/0967-3334/37/3/L1     Document Type: Article

References (37)

1. Anagnostopoulou P et al 2015 False normal Lung clearance index in infants with cystic fibrosis due to software algorithms Pediatr. Pulmonol. 50 970-7
2. Belessis Y et al 2012 Early cystic fibrosis lung disease detected by bronchoalveolar lavage and lung clearance index Am. J. Respir. Crit. Care Med. 185 862-73
3. Beydon N et al 2007 An official American thoracic society/European respiratory society statement: pulmonary function testing in preschool children Am. J. Respir. Crit. Care Med. 175 1304-45
4. Davis S D et al 2010 Multicenter evaluation of infant lung function tests as cystic fibrosis clinical trial endpoints Am. J. Respir. Crit. Care Med. 182 1387-97
5. Ebdon A M, Skoric B, Robertson C and Ranganathan S 2013 Comparing analysis software versions in infant multiple breath washout Eur. Respir. J. 42 1099
6. Frey U, Stocks J, Sly P and Bates J 2000 Specification for signal processing and data handling used for infant pulmonary function testing. ERS/ATS Task Force on standards for infant respiratory function testing. European respiratory society/American thoracic society Eur. Respir. J. 16 1016-22
7. Fuchs O, Latzin P, Kuehni C E and Frey U 2012 Cohort profile: the Bern infant lung development cohort Int. J. Epidemiol. 41 366-76
8. Fuchs O, Latzin P, Thamrin C, Stern G, Frischknecht P, Singer F, Kieninger E, Proietti E, Riedel T and Frey U 2011 Normative data for lung function and exhaled nitric oxide in unsedated healthy infants Eur. Respir. J. 37 1208-16
9. Gonem S, Singer F, Corkill S, Singapuri A, Siddiqui S and Gustafsson P 2014 Validation of a photoacoustic gas analyser for the measurement of functional residual capacity using multiple-breath inert gas washout Respiration 87 462-8
10. Gray D M, Willemse L, Alberts A, Simpson S, Sly P D, Hall G L and Zar H J 2015b Lung function in African infants: a pilot study Pediatr. Pulmonol. 50 49-54
11. Gray D, Willemse L, Visagie A, Smith E, Czovek D, Sly P D, Hantos Z, Hall G L and Zar H J 2015a Lung function and exhaled nitric oxide in healthy unsedated African infants Respirology 20 1108-14
12. Gustafsson P M, Aurora P and Lindblad A 2003 Evaluation of ventilation maldistribution as an early indicator of lung disease in children with cystic fibrosis Eur. Respir. J. 22 972-9
13. Hall G L et al 2011 Air trapping on chest CT is associated with worse ventilation distribution in infants with cystic fibrosis diagnosed following newborn screening PLoS One 6 e23932
14. Hoo A F et al 2012 Lung function is abnormal in 3-month-old infants with cystic fibrosis diagnosed by newborn screening Thorax 67 874-81
15. Horsley A R, Gustafsson P M, Macleod K A, Saunders C, Greening A P, Porteous D J, Davies J C, Cunningham S, Alton E W and Innes J A 2008 Lung clearance index is a sensitive, repeatable and practical measure of airways disease in adults with cystic fibrosis Thorax 63 135-40
16. Hulskamp G, Lum S, Stocks J, Wade A, Hoo A F, Costeloe K, Hawdon J, Deeptha K and Pillow J J 2009 Association of prematurity, lung disease and body size with lung volume and ventilation inhomogeneity in unsedated neonates: a multicentre study Thorax 64 240-5
17. Kieninger E, Singer F, Fuchs O, Abbas C, Frey U, Regamey N, Casaulta C and Latzin P 2011 Long-term course of lung clearance index between infancy and school-age in cystic fibrosis subjects J. Cyst. Fibros. 10 487-90
18. Latzin P, Sauteur L, Thamrin C, Schibler A, Baldwin D, Hutten G J, Kyburz M, Kraemer R, Riedel T and Frey U 2007 Optimized temperature and deadspace correction improve analysis of multiple breath washout measurements by ultrasonic flowmeter in infants Pediatr. Pulmonol. 42 888-97
19. Lum S, Hoo A F, Hulskamp G, Wade A and Stocks J 2010 Potential misinterpretation of infant lung function unless prospective healthy controls are studied Pediatr. Pulmonol. 45 906-13
20. Matecki S et al 2015 Is the raised volume rapid thoracic compression technique ready for use in clinical trials in infants with cystic fibrosis? J. Cyst. Fibros. 15 10-20
21. Peterson-Carmichael S L, Rosenfeld M, Ascher S B, Hornik C P, Arets H G, Davis S D and Hall G L 2014 Survey of clinical infant lung function testing practices Pediatr. Pulmonol. 49 126-31
22. Ramsey B W et al 2012 Future directions in early cystic fibrosis lung disease research: an NHLBI workshop report Am. J. Respir. Crit. Care Med. 185 887-92
23. Robinson P D et al 2013 Consensus statement for inert gas washout measurement using multiple- and single- breath tests Eur. Respir. J. 41 507-22
24. Rosenfeld M et al 2013 An official American thoracic society workshop report: optimal lung function tests for monitoring cystic fibrosis, bronchopulmonary dysplasia, and recurrent wheezing in children less than 6 years of age Ann. Am. Thorac. Soc. 10 S1-11
25. Schmalisch G, Wilitzki S, Buhrer C and Fischer H S 2015 The lung clearance index in young infants: impact of tidal volume and dead space Physiol. Meas. 36 1601-13
26. Stahl M, Joachim C, Blessing K, Hammerling S, Sommerburg O, Latzin P and Mall M A 2014 Multiple breath washout is feasible in the clinical setting and detects abnormal lung function in infants and young children with cystic fibrosis Respiration 87 357-63
27. Stanojevic S, Wade A, Stocks J, Hankinson J, Coates A L, Pan H, Rosenthal M, Corey M, Lebecque P and Cole T J 2008 Reference ranges for spirometry across all ages: a new approach Am. J. Respir. Crit. Care Med. 177 253-60
28. Stick S, Tiddens H, Aurora P, Gustafsson P, Ranganathan S, Robinson P, Rosenfeld M, Sly P and Ratjen F 2013 Early intervention studies in infants and preschool children with cystic fibrosis: are we ready? Eur. Respir. J. 42 527-38
29. Stocks J and Lum S 2012 Kendig and Chernick's Disorders of the Respiratory Tract in Children 8th edn ed R W Wilmott et al (Philadelphia, PA: Saunders) pp 169-210
30. Stocks J, Modi N and Tepper R 2010 Need for healthy control subjects when assessing lung function in infants with respiratory disease Am. J. Respir. Crit. Care Med. 182 1340-2
31. Stocks J, Thia L P and Sonnappa S 2012 Evaluation and use of childhood lung function tests in cystic fibrosis Curr. Opin. Pulm. Med. 18 602-8
32. Subbarao P et al 2015 Multiple-breath washout as a lung function test in cystic fibrosis. A cystic fibrosis foundation workshop report Ann. Am. Thorac. Soc. 12 932-9
33. Subbarao P, Stanojevic S, Brown M, Jensen R, Rosenfeld M, Davis S, Brumback L, Gustafsson P and Ratjen F 2013 Lung clearance index as an outcome measure for clinical trials in young children with cystic fibrosis. A pilot study using inhaled hypertonic saline Am. J. Respir. Crit. Care Med. 188 456-60
34. Thamrin C, Hardaker K and Robinson P D 2015 Multiple breath washout: from renaissance to enlightenment? Pediatr. Pulmonol. (doi: 10.1002/ppul.23316)
35. Vogt B, Falkenberg C, Weiler N and Frerichs I 2014 Pulmonary function testing in children and infants Physiol. Meas. 35 R59-90
36. Vukcevic D, Carlin J B, King L, Hall G L, Ponsonby A L, Sly P D, Vuillermin P, Ranganathan S and Barwon Infant Study Investigator G 2015 The influence of sighing respirations on infant lung function measured using multiple breath washout gas mixing techniques Physiol. Rep. 3 e12347
37. Wauer J, Leier T U, Henschen M, Wauer R R and Schmalisch G 2003 In vitro validation of an ultrasonic flowmeter in order to measure the functional residual capacity in newborns Physiol. Meas. 24 355-65