The lung clearance index in young infants: Impact of tidal volume and dead space

Physiological Measurement

Volumn 36, Issue 7, 2015, Pages 1601-1613

  Schmalisch, Gerd ^a   Wilitzki, Silke ^a   Bührer, Christoph ^a   Fischer, Hendrik S ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

infants; lung clearance index; lung injury; modeling; multiple breath washout techniques

Indexed keywords

SULFUR HEXAFLUORIDE;

DEAD SPACE; FUNCTIONAL RESIDUAL CAPACITIES; INFANT; LUNG CLEARANCE INDEX; LUNG INJURY; LUNG VOLUME; MODELING; MULTIPLE-BREATH WASHOUT TECHNIQUE; TIDAL VOLUME; VENTILATION INHOMOGENEITY;

BIOLOGICAL ORGANS;

ABNORMAL RESPIRATORY SOUND; BIOLOGICAL MODEL; HUMAN; INFANT; LUNG; LUNG FUNCTION TEST; PATHOPHYSIOLOGY; PHYSIOLOGY; RETROSPECTIVE STUDY; SLEEP;

HUMANS; INFANT; LUNG; MODELS, BIOLOGICAL; RESPIRATORY FUNCTION TESTS; RESPIRATORY SOUNDS; RETROSPECTIVE STUDIES; SLEEP;

EID: 84937887621     PISSN: 09673334     EISSN: 13616579     Source Type: Journal    
DOI: 10.1088/0967-3334/36/7/1601     Document Type: Article

References (40)

1. Aurora P, Bush A, Gustafsson P, Oliver C, Wallis C, Price J, Stroobant J, Carr S and Stocks J 2005a Multiple-breath washout as a marker of lung disease in preschool children with cystic fibrosis Am. J. Respir. Crit. Care Med. 171 249-56
2. Aurora P, Kozlowska W and Stocks J 2005b Gas mixing efficiency from birth to adulthood measured by multiple-breath washout Respir. Physiol. Neurobiol. 148 125-39
3. Becklake R R 1952 A new index of the intrapulmonary mixture of inspired air Thorax 7 111-6
4. Belessis Y et al 2012 Early cystic fibrosis lung disease detected by bronchoalveolar lavage and lung clearance index Am. J. Respir. Crit. Care Med. 185 862-73
5. Bland J M and Altman D G 1986 Statistical methods for assessing agreement between two methods of clinical measurement Lancet 1 307-10
6. Edelman N H, Mittman C, Norris A H and Shock N W 1968 Effects of respiratory pattern on age differences in ventilation uniformity J. Appl. Physiol. 24 49-53
7. Fenton T R and Kim J H 2013 A systematic review and meta-analysis to revise the Fenton growth chart for preterm infants BMC Pediatr. 13 59
8. Fouzas S, Hacki C, Latzin P, Proietti E, Schulzke S, Frey U and Delgado-Eckert E 2014 Volumetric capnography in infants with bronchopulmonary dysplasia J. Pediatr. 164 283-8
9. Fowler W S, Cornish E R J and Kety S S 1952 Lung function studies VIII Analysis of alveolar ventilation by pulmonary N2 clearance curves J. Clin. Invest. 31 40-50
10. Gustafsson P M, Aurora P and Lindblad A 2003 Evaluation of ventilation maldistribution as an early indicator of lung disease in children with cystic fibrosis Eur. Respir. J. 22 972-9
11. Habib R H and Lutchen K R 1991 Moment analysis of a multibreath nitrogen washout based on an alveolar gas dilution number Am. Rev. Respir. Dis. 144 513-9
12. Haidopoulou K, Lum S, Turcu S, Guinard C, Aurora P, Stocks J and Sonnappa S 2012 Alveolar LCI vs standard LCI in detecting early CF lung disease Respir. Physiol. Neurobiol. 180 247-51
13. Horsley A 2009 Lung clearance index in the assessment of airways disease Respir. Med. 103 793-9
14. Hülskamp G, Lum S, Stocks J, Wade A, Hoo A F, Costeloe K, Hawdon J, Deeptha K and Pillow J J 2009 Association of prematurity, lung disease and body size with lung volume and ventilation inhomogeneity in unsedated neonates: a multicentre study Thorax 64 240-5
15. Landolfo F, Savignoni F, Capolupo I, Columbo C, Calzolari F, Giliberti P, Chukhlantseva N, Bagolan P and Dotta A 2013 Functional residual capacity (FRC) and lung clearance index (LCI) in mechanically ventilated infants application in the newborn with congenital diaphragmatic hernia (CDH) J. Pediatr. Surg. 48 1459-62
16. Larsson A, Jonmarker C and Werner O 1988 Ventilation inhomogeneity during controlled ventilation which index should be used? J. Appl. Physiol. 65 2030-9
17. Latzin P, Sauteur L, Thamrin C, Schibler A, Baldwin D, Hutten G J, Kyburz M, Kraemer R, Riedel T and Frey U 2007 Optimized temperature and deadspace correction improve analysis of multiple breath washout measurements by ultrasonic flowmeter in infants Pediatr. Pulmonol. 42 888-97
18. Latzin P and Thompson B 2014 Validation of multiple-breath washout equipment from bench to clinic and possible pitfalls Respiration 87 456-8
19. Lum S et al 2013 Age and height dependence of lung clearance index and functional residual capacity Eur. Respir. J. 41 1371-7
20. Mahmoud R A, Roehr C C and Schmalisch G 2011 Current methods of non-invasive ventilatory support for neonates Paediatr. Respir. Rev. 12 196-205
21. Pillow J J, Frerichs I and Stocks J 2006 Lung function tests in neonates and infants with chronic lung disease global and regional ventilation inhomogeneity Pediatr. Pulmonol. 41 105-21
22. Pillow J J, Ljungberg H, Hulskamp G and Stocks J 2004 Functional residual capacity measurements in healthy infants: ultrasonic flow meter versus a mass spectrometer Eur. Respir. J. 23 763-8
23. Proquitte H, Freiberger O, Yilmaz S, Bamberg C, Degenhardt P, Roehr C C, Wauer R R and Schmalisch G 2010 The effect of surgery on lung volume and conventional monitoring parameters in ventilated newborn infants Eur. Respir. J. 35 1072-8
24. Proquitte H, Kusztrich A, Auwarter V, Pragst F, Wauer R R and Schmalisch G 2006 Functional residual capacity measurement by heptafluoropropane in ventilated newborn lungs: in vitro and in vivo validation Crit. Care Med. 34 1789-95
25. Puder L C, Fischer H S, Wilitzki S, Usemann J, Godfrey S and Schmalisch G 2014 Validation of computerized wheeze detection in young infants during the first months of life BMC Pediatr. 14 257
26. Robinson P D et al 2013 Consensus statement for inert gas washout measurement using multiple- and single- breath tests Eur. Respir. J. 41 507-22
27. Saidel G M, Salmon R B and Chester E H 1975 Moment analysis of multibreath lung washout J. Appl. Physiol. 38 328-34
28. Sandberg K L, Lindstrom D P, Sjoqvist B A, Parker R A and Cotton R B 1997 Surfactant replacement therapy improves ventilation inhomogeneity in infants with respiratory distress syndrome Pediatr. Pulmonol. 24 337-43
29. Schibler A and Henning R 2001 Measurement of functional residual capacity in rabbits and children using an ultrasonic flow meter Pediatr. Res. 49 581-8
30. Schmalisch G, Proquitte H, Roehr C C and Wauer R R 2006 The effect of changing ventilator settings on indices of ventilation inhomogeneity in small ventilated lungs BMC Pulm. Med. 6 20
31. Schmalisch G, Wauer R R, Foitzik B and Patzak A 2003 Influence of preterm onset of inspiration on tidal breathing parameters in infants with and without CLD Respir. Physiolo. Neurobiol. 135 39-46
32. Schmalisch G, Wilitzki S, Roehr C C, Proquitte H and Buhrer C 2013 Differential effects of immaturity and neonatal lung disease on the lung function of very low birth weight infants at 48-52 postconceptional weeks Pediatr. Pulmonol. 48 1214-23
33. Schulzke S M, Deeptha K, Sinhal S, Baldwin D N and Pillow J J 2008 Nasal versus face mask for multiple-breath washout technique in preterm infants Pediatr. Pulmonol. 43 858-65
34. Schulzke S M, Hall G L, Nathan E A, Simmer K, Nolan G and Pillow J 2010 Lung volume and ventilation inhomogenity in preterm infants at 15-18 months corrected age J. Pediatr. 156 542-9
35. Shao H, Sandberg K and Hjalmarson O 1998 Impaired gas mixing and low lung volume in preterm infants with mild chronic lung disease Pediatr. Res. 43 536-41
36. Stark A R, Cohlan B A, Waggener T B, Frantz I D and Kosch P C 1987 Regulation of end-expiratory lung volume during sleep in premature infants J. Appl. Physiol. 62 1117-23
37. Subbarao P, Stanojevic S, Brown M, Jensen R, Rosenfeld M, Davis S, Brumback L, Gustafsson P and Ratjen F 2013 Lung clearance index as an outcome measure for clinical trials in young children with cystic fibrosis A pilot study using inhaled hypertonic saline Am. J. Respir. Crit. Care Med. 188 456-60
38. Voigt M, Schneider K T and Jahrig K 1996 Analysis of a 1992 birth sample in Germany. New percentile values of the body weight of newborn infants Geburtshilfe Frauenheilkd. 56 550-8
39. Wauer J, Leier T U, Henschen M, Wauer R R and Schmalisch G 2003 In vitro validation of an ultrasonic flowmeter in order to measure the functional residual capacity in newborns Physiol. Meas. 24 355-65
40. Yoder B A, Stoddard R A, Li M, King J, Dirnberger D R and Abbasi S 2013 Heated, humidified high-flow nasal cannula versus nasal CPAP for respiratory support in neonates Pediatrics 131 e1482-90