Antioxidants and management of polycystic ovary syndrome in Iran: A systematic review of clinical trials

Iranian Journal of Reproductive Medicine

Volumn 13, Issue 1, 2015, Pages 1-8

  Amini, Leila ^a   Tehranian, Najmeh ^a   Movahedin, Mansoureh ^a   Tehrani, Fahimeh Ramezani ^b   Ziaei, Saeideh ^a  

^a TARBIAT MODARES UNIVERSITY   (Iran)

^b SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Antioxidant; Iran; Polycystic ovary syndrome; Vitamin

Indexed keywords

ACETYLCYSTEINE; ANTIOXIDANT; CALCITRIOL; CALCIUM; CLOMIFENE CITRATE; COLECALCIFEROL; FOLIC ACID; GENISTEIN; METFORMIN; OMEGA 3 FATTY ACID; PLACEBO; ZINC; CLOMIFENE;

ADJUVANT THERAPY; CLINICAL TRIAL (TOPIC); DATA BASE; DRUG EFFICACY; ENDOCRINE DISEASE; EVIDENCE BASED MEDICINE; HUMAN; IRAN; METABOLIC DISORDER; OVARY POLYCYSTIC DISEASE; REVIEW; SYSTEMATIC REVIEW; TREATMENT RESPONSE; ANTIOXIDANT ACTIVITY; INFERTILITY THERAPY; INTERVENTION STUDY; MEDICAL LITERATURE; MEDICAL TECHNOLOGY; META ANALYSIS; OUTCOME ASSESSMENT; OXIDATIVE STRESS; WEIGHT REDUCTION;

EID: 84924806487     PISSN: 16806433     EISSN: 20082177     Source Type: Journal    
DOI: None     Document Type: Review

References (57)

1. Teede HJ, Misso ML, Deeks AA, Moran LJ, Stuckey BGA, Wong JLA, et al. Assessment and management of polycystic ovary syndrome: summary of an evidence-based guideline. Med J Aust 2011; 195: 65.
2. Roe AH, Dokras A. The Diagnosis of Polycystic Ovary Syndrome in Adolescents. Rev Obstet Gynecol 2011; 4: 45-51.
3. Goodarzi MO, Dumesic DA, Chazenbalk G, Azziz R. Polycystic ovary syndrome: etiology, pathogenesis and diagnosis. Nat Rev Endocrinol 2011; 7: 219-231.
4. Raja-Khan N, Stener-Victorin E, Wu X, Legro RS. The physiological basis of complementary and alternative medicines for polycystic ovary syndrome. Am J Physiol Endocrinol Metab 2011; 301: E1-E10.
5. Stener-Victorin E, Holm G, Janson PO, Gustafson D, Wae M. Acupuncture and physical exercise for affective symptoms and health-related quality of life in polycystic ovary syndrome: secondary analysis from a randomized controlled trial. BMC Com Altern Med 2013, 13: 131.
6. Billhult A, Stener-Victorin E. Acupuncture with manual and low frequency electrical stimulation as experienced by women with polycystic ovary syndrome: a qualitative study. BMC Com Altern Med 2012, 12: 32.
7. Nidhi R, Padmalatha V, Nagarathna R, Amritanshu R. J Altern Com Med 2013; 19: 153-160.
8. Amini L, Sadeghi Avvalshahr H. [Complementary therapies in polycystic ovary syndrome]. Darmangar 2011; 30-31: 48. (In Persian)
9. Selimoglu H, Duran C, Kiyici S, Ersoy C, Guclu M, Ozkaya G, et al. The effect of vitamin D replacement therapy on insulin resistance and androgen levels in women with polycystic ovary syndrome. J Endocrinol Invest 2010; 33: 234-238.
10. Pal L, Berry A, Coraluzzi L, Kustan E, Danton C, Shaw J, et al. Therapeutic implications of vitamin D and Calcium in overweight women with Polycystic Ovary Syndrome. Gynecol Endocrinol 2012; 28: 965-968.
11. Oh R. Practical applications of fish oil (Ω-3 fatty acids) in primary care. J Am Board Fam Pract 2005; 18: 28-36.
12. Oner G, Muderris II. Efficacy of omega-3 in the treatment of polycystic ovary syndrome. J Obstet Gynaecol 2013; 33: 289-291.
13. Gayatri K, Saubhagya Kumar J, Basanta Kumar B. Metformin and N-acetyl Cysteine in Polycystic Ovarian Syndrome-A comparative study. Indian J Clin Med 2010; 1: 7-13.
14. Murri M, Luque-Ramırez M, Insenser M, Ojeda- Ojeda M, Escobar-Morreale HF. Circulating markers of oxidative stress and polycystic ovary syndrome (PCOS): a systematic review and meta-analysis. Hum Reprod Update 2013; 19: 268-288.
15. Al-kataan MA, Ibrahim MA, Al-jammas MHH, Shareef YS, Sulaiman MA. Serum Antioxidant Vitamins Changes in Women with Polycystic Ovarian Syndrome. J Bahrain Med Sci 2010; 22: 68-71.
16. Sekhon LH, Sajal G, Yesul K, Ashok A. Female Infertility and Antioxidants. Curr Women's Health Rev 2010; 6: 84-95.
17. Mohan SK, Priya VV. Lipid peroxidation, glutathione, ascorbic acid, vitamin E, antioxidant enzyme and serum homocysteine status in patients with polycystic ovary syndrome. Biol Med 2009; 1: 44-49.
18. Fenkci V, Fenkci S, Yilmazer M, Serteser M. Decreased total antioxidant status and increased oxidative stress in women with polycystic ovary syndrome may contribute to the risk of cardiovascular disease. Fertil Steril 2003; 80: 123-127.
19. Azziz R. Controversy in clinical endocrinology. Diagnosis of polycystic ovarian syndrome: the Rotterdam criteria are premature. J Clin Endocrinol Metab 2006; 91: 781-785.
20. Jonard S, Robert Y, Dewailly D. Revisiting the ovarian volume as a diagnostic criterion for polycystic ovaries. Hum Reprod 2005; 20: 2893-2898.
21. Sheehan MT. Polycystic Ovarian Syndrome: Diagnosis and Management. Clin Med Res 2004; 2: 13-27.
22. Lobo V, Patil A, Phatak A, Chandra N. Free radicals, antioxidants and functional foods: Impact on human health. Pharmacogn Rev 2010; 4: 118-126.
23. Bell S. Overview Of Antioxidants: Emphasis On Raisins. Int J Nutr Wellness 2009; 10.
24. Khani B, Mehrabian F, Khalesi E, Eshraghi A. Effect of soy phytoestrogen on metabolic and hormonal disturbance of women with polycystic ovary syndrome. JRMS 2011; 16: 297-302.
25. Kazerooni T, Asadi N, Dehbashi S, Zolghadri J. Effect of folic acid in women with and without insulin resistance who have hyperhomocysteinemic polycystic ovary syndrome. Int J Gynecol Obstet 2008; 101: 156-160.
26. Salehpour S, Akbari Sene A, Saharkhiz N, Sohrabi MR, Moghimian F. N-acetylcysteine as an adjuvant to clomiphene citrate for successful induction of ovulation in infertile patients with polycystic ovary syndrome. J Obstet Gynaecol Res 2012; 38: 1182-1186.
27. Salehpour S, Tohidi, Akhound MR, Amirzargar N. N Acetyl Cysteine, A novel Remedy for Poly Cystic Ovarian Syndrome. Int J Fertil Steril 2009; 3: 66-73.
28. Rashidi B, Haghollahi F, Shariat M, Zayerii F. The effects of calcium-vitamin D and metformin on Polycystic Ovary Syndrome:a pilot study. Taiwan J Obstet Gynecol 2009; 48: 142-147.
29. Mohammadi E, Rafraf M. Benefits of Omega-3 Fatty Acids Supplementation on Serum Paraoxonase 1 Activity and Lipids Ratios in Polycystic Ovary Syndrome. Health Prom Perspect 2012; 2: 197-204.
30. Pourteymour Fard Tabrizi F, Alipoor B, Sadagiani M, Ostadrahimi A. Effect of Zinc Supplementation on Cardiometabolic Risk Factors in Women with Polycystic Ovary Syndrome. J Cardiovasc Thorac Res 2010; 2: 11-20.
31. Bonakdaran Sh, Mazloom Khorasani Z, Davachi B, Shakeri MT. [Comparing the effect of active vitamin D and Metformin on clinical and metabolic outcomes in women with Polycystic Ovary Syndrome]. Iran J Obstet Gynecol Infertil 2012; 8: 16-24. (In Persian)
32. Mohammad Beigi R, Afkhamzadeh A, Daneshpour N. [The effect of calcum-Vitamin D on successful of induction ovulation in infertile women with Polycystic Ovary Syndrome]. Iran J Obstet Gynecol Infertil 2012; 15: 7-13. (In Persian)
33. Rafraf M, Mohammadi E, Farzadi L, Asghari-Jafarabadi, Sabour S. [Effects of ω-3 Fatty Acid Supplementation on Glycemic Status and High Sensitive C-Reactive Protein in Women with Polycystic Ovary Syndrome]. J Ardabil Univ Med Sci 2012; 12: 373-83. (In Persian)
34. Rafraf M, Mohammadi E, Farzadi L, Asghari-Jafarabadi. [Effects of Omega-3 Fatty Acid Supplement on Serum Lipid Profile and Markers of Oxidative Stress in Women with Polycystic Ovary Syndrome]. Iran J Obstet Gynecol Infertil 2012; 15: 1-10. (In Persian)
35. Costello MF, Eden JA., A systematic review of the reproductive system effects of metformin in patients with polycystic ovary syndrome. Fertil Steril 2003; 79: 1-13.
36. Mahmoudi T, Gourabi H, Ashrafi M, Yazdi RS, Ezabadi Z. Calciotropic hormones, insulin resistance, and the polycystic ovary syndrome. Fertil Steril 2010; 93: 1208-1214.
37. Selimoglu H, Duran C, Kiyici S, Ersoy C, Guclu M, Ozkaya G, et al. The effect of vitamin D replacement therapy on insulin resistance and androgen levels in women with polycystic ovary syndrome. J Endocrinol Invest 2010; 33: 234-238.
38. Liu E, Meigs JB, Pittas AG, Economos CD, McKeown NM, Booth SL, et al. Predicted 25-hydroxyvitamin D score and incident type 2 diabetes in the Framingham Offspring Study. Am J Clin Nutr 2010; 91: 1627-1633.
39. Firouzabadi Rd, Aflatoonian A, Modarresi S, Sekhavat L, MohammadTaheri S. Therapeutic effects of calcium & vitamin D supplementation in women with PCOS. Comp Ther Clin Pract 2012; 18: 85-88.
40. Thys-Jacobs S, Donovan D, Papadopoulos A, Sarrel P, Bilezikian JP. Vitamin D and calcium dysregulation in the polycystic ovarian syndrome. Steroids 1999; 64: 430-435.
41. Dhindsa G, Bhatia R, Dhindsa M, Bhatia V. Insulin resistance, insulin sensitization and inflammation in polycystic ovarian syndrome. JPGM 2004; 50: 140-144.
42. Kasim-Karakas SE, Almario RE, Gregory L, Wong R, Todd H, Lasley BL. Metabolic and endocrine effects of a polyunsaturated fatty acid-rich diet in Polycystic Ovary Syndrome. J Clin Endocrinol Metab 2004; 89: 615-620.
43. Ventura P, Panini R, Pasini MC, Scarpetta G, Salvioli G. N-Acetyl-cysteine reduces homocysteine plasma levels after single intravenous administration by increasing thiols urinary excretion. Pharmacol Res 1999; 40: 345-350.
44. Fulghesu AM, Ciampelli M, Muzj G, Belosi C, Selvaggi L, Ayala GF, et al. N-acetyl-cysteine treatment improves insulin sensitivity in women with polycystic ovary syndrome. Fertil Steril 2002; 77: 1128-1135.
45. Badawy A, State O, Abdelgawad S. N-Acetyl cysteine and clomiphene citrate for induction of ovulation in polycystic ovary syndrome: a cross-over trial. Acta Obstet Gynecol 2007; 86: 218-222.
46. Jefferson WN. Adult Ovarian Function Can Be Affected by High Levels of Soy. J Nutr 2010; 140: 2322s-2325s.
47. Velasquez MT, Bhathena SJ. Role of Dietary Soy Protein in Obesity. Int J Med Sci 2007; 4: 72-82.
48. Wiseman H, O’Reilly JD, Adlercreutz H, Mallet AI, Bowey EA, Rowland IR, et al. Isoflavone phytoestrogens consumed in soy decrease F(2)-isoprostane concentrations and increase resistance of low density lipoprotein to oxidation in humans. Am J Clin Nutr 2000; 72: 395-400.
49. Romualdi D, Costantini B, Campagna G, Lanzone A, Guido M. Is there a role for soy isoflavones in the therapeutic approach to polycystic ovary syndrome? Results from a pilot study. Fertil Steril 2008; 90: 1826-1833.
50. Grodnitskaya EE, Kurtser MA. Homocysteine metabolism in polycystic ovary syndrome. Gynecol Endocrinol 2012; 28: 186-189.
51. Moens AL, Claeys MJ, Wuyts FL, Goovaerts I, Van Hertbruggen E, Wendelen LC, et al. Effect of folic acid on endothelial function following acute myocardial infarction. Am J Cardiol 2007; 99: 476-478.
52. Shirodaria C, Antoniades C, Lee J, Jackson CE, Robson MD, Francis JM, et al. Global improvement of vascular function and redox state with low-dose folic acid: implications for folate therapy in patients with coronary artery disease. Circulation 2007; 115: 2262-2270.
53. Palomba S, Falbo A, Giallauria F, Russo T, Tolino A, Zullo F, et al. Effects of Metformin With or Without Supplementation With Folate on Homocysteine Levels and Vascular Endothelium of Women With Polycystic Ovary Syndrome. Diabetes Care 2010; 33: 246-251.
54. IZiNCG. Assessment of the risk of zinc deficiency in populations and options for its control. Food Nutr Bull 2004; 25: S94-S203.
55. Dosa MD, Adumitresi CR, Hangan LT, Nechifor M. Copper, Zinc and Magnesium in Non-Insulin-Dependent Diabetes Mellitus Treated with Metformin. Available at: http://dx.doi.org/10.5772/48230.
56. Beletate V, El Dib R, Atallah ÁN. Zinc supplementation for the prevention of type 2 diabetes mellitus. Cochrane Database Syst Rev 2007; (1):CD005525.
57. Sohrabvand F, Shirazi M, Shariat M. Fatemeh Mahdiyin1Serum zinc level in infertile women with and without polycystic ovary syndrome: a comparative study. Tehran Univ Med J 2013; 71: 157-163. (In Persian)